This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and geodatabases.The proposed approach can aid decision makers ...This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and geodatabases.The proposed approach can aid decision makers in land management and territorial planning,by first screening for areas with a higher debris flow susceptibility.Five environmental predisposing factors,namely,bedrock lithology,fracture network,quaternary deposits,slope inclination,and hydrographic network,were selected as independent parameters and their mutual interactions were described and quantified using the Rock Engineering System(RES)methodology.For each parameter,specific indexes were proposed,aiming to provide a final synthetic and representative index of debris flow susceptibility at the basin scale.The methodology was tested in four basins located in the Upper Susa Valley(NW Italian Alps)where debris flow events are the predominant natural hazard.The proposed matrix can represent a useful standardized tool,universally applicable,since it is independent of type and characteristic of the basin.展开更多
A new approach for prediction of face advance rete (FAR) prior to mining operation and determination of the operation efficiency after mining operation in retreat longwall mining panel is presented based upon the conc...A new approach for prediction of face advance rete (FAR) prior to mining operation and determination of the operation efficiency after mining operation in retreat longwall mining panel is presented based upon the concepts of rock engineering system (RES). For this purpose, six longwall panels considered in Parvadeh-I coal mine. Seven major effective parameters on FAR was selected including coal mine roof rating, gas propagation, safety factor of longwall face, ratio of joint spacing to cutting depth at longwall face, longwall face inclination, panel width, floor rock mass rating. To performance evaluation of the presented model, the relationship between the average vulnerability indexes of advance operation with FAR was determined in considered panels with coefficient of determination (R2) equal to 0.884 that indicate relatively acceptable correlation and compatibility. Investigations of the research indicated that it is possible to determine the actual operation efficiency under fair conditions by a RES-based model. The inevitable reduction of FAR for each longwall panel was determined by presented model that the difference amount between the maximum possible practical face advance rate (FARmpp) and recorded actual face advance rate (FARa) indicate the operation efficiency. Applied approach in this paper can be used to prediction of FAR in retreat longwall mining panel for same conditions that can have many benefits, including better and more accurate planning for the sales market and mine operation. Also, presented method in this paper can be applied as a useful tool to determination of actual operation efficiency for other sections and extraction methods in coal mines.展开更多
Classical rock mass classification systems are not applicable to carbonate rocks,especially when these are affected by karst processes.Their applications to such settings could therefore result in outcomes not represe...Classical rock mass classification systems are not applicable to carbonate rocks,especially when these are affected by karst processes.Their applications to such settings could therefore result in outcomes not representative of the real stress-strain behavior.In this study,we propose a new classification of carbonate rock masses for engineering purposes,by adapting the rock engineering system(RES) method by Hudson for fractured and karstified rock masses,in order to highlight the problems of implementation of geomechanical models to carbonate rocks.This new approach allows a less rigid classification for carbonate rock masses,taking into account the local properties of the outcrops,the site conditions and the type of engineering work as well.展开更多
An algorithm for global optimization of a class of nonconvex MINLP problems is devel-oped and presented in this paper.By partitioning the variables,dual representation of the primal ofsubproblems and outer-approximati...An algorithm for global optimization of a class of nonconvex MINLP problems is devel-oped and presented in this paper.By partitioning the variables,dual representation of the primal ofsubproblems and outer-approximation strategy are used to develop a representative relaxed iterativeproblem.Then the original MINLP problem is replaced by a series of subproblems and relaxediterative problems.By exploiting the particular form of the nonconvex MINLP problem,the feasibleregion of this problem is explicitly included in the representative problem,thus the inconvenienceencountered with the GBD method can be avoided.The proposed method is illustrated andinterpreted geometrically with an example problem.展开更多
This paper proposes a new engineering disciplin─Engineering System Theory. It dis cusses rendered background, research objects and contents of the engineering system theory briefly. Finally, the met-discipline standi...This paper proposes a new engineering disciplin─Engineering System Theory. It dis cusses rendered background, research objects and contents of the engineering system theory briefly. Finally, the met-discipline standing of the engineering system theory in the whole knowledge system of engineering science and its development potential are pointed out.展开更多
Computer-integrated manufacturing (CIM) and revers e engineering (RE) have changed drastically the concept of product re-design, pla nning and manufacture of components. However, the main problems currently facing the...Computer-integrated manufacturing (CIM) and revers e engineering (RE) have changed drastically the concept of product re-design, pla nning and manufacture of components. However, the main problems currently facing the developers of reverse engineering system, is the time consuming digitis ation of 3D data and the conversion of large amounts of data into a concise and manageable format and linking it to a CAD/CAM system. Automated 3-D profile gen eration, measurements and inspection of manufactured component represents one of the important functions in reverse engineering and in the improvements in produ ct quality in rapid product developments. The paper presents a novel methodology for the development of a reverse enginee ring technique for use in the rapid product development in a CIM environment . The system developed provides integration, data capture and manipulation, dat a transfer between a CAD, CAM, Computer-aided inspection (CAI) and a 3-D profi le scanning system. An efficient scanning strategy has been developed for scann ing and surfaces data acquisition. The products were scanned using a laser scann ing system with a dedicated scan control card and the associated software packag es. A versatile rig was developed for the ease of data gathering of the profile scanning process. The surface data collected was then used to build a mathematic al surface model, which was then used to develop a virtual 3-D model of the pro duct. The resulting surface model provides the geometrical input to the subseque nt machining operation using either a CNC system or other manufacturing operatio n e.g. dies casting/mould casting etc. The prototypes developed were inspected u sing a state-of-the art CNC-CMM that was integrated to the CAD/CAM system. Si nce the scanning/digitised data captured by laser scanning probes requires no ma nual editing, significant time saving over most non-contact probe systems was a chieved. Since the creation of an accurate CAD model of a redesigned component o r a prototype constitute a major element of the total turnaround time; maximum r eturn can be achieved by increasing the efficiency of the redesigning process. T he paper also outlines with a case study the application of the developed system . The system developed offers the flexibility of using the concept of reverse en gineering of a variety of components with the complimentary facility of integrat ion between CAD/CAM Computer-aided Inspection (CAI) systems and a scanning syst em. The developed reverse engineering application in an integrated manufacturing system can increase the consistency, improve cost-efficiency, reduce produ ct turn around and skill levels required to redesign, reengineer and prototyping components and products.展开更多
Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical translation.High levels of deadly reactive oxygen radicals(ROS)and proi...Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical translation.High levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’viability.Based on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC therapy.This system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective layer.In this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for transplantation.Meanwhile,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate healing.The engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 days.This vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.展开更多
The challenge of transitioning from temporary humanitarian settlements to more sustainable human settlements is due to a significant increase in the number of forcibly displaced people over recent decades, difficultie...The challenge of transitioning from temporary humanitarian settlements to more sustainable human settlements is due to a significant increase in the number of forcibly displaced people over recent decades, difficulties in providing social services that meet the required standards, and the prolongation of emergencies. Despite this challenging context, short-term considerations continue to guide their planning and management rather than more integrated, longer-term perspectives, thus preventing viable, sustainable development. Over the years, the design of humanitarian settlements has not been adapted to local contexts and perspectives, nor to the dynamics of urbanization and population growth and data. In addition, the current approach to temporary settlement harms the environment and can strain limited resources. Inefficient land use and ad hoc development models have compounded difficulties and generated new challenges. As a result, living conditions in settlements have deteriorated over the last few decades and continue to pose new challenges. The stakes are such that major shortcomings have emerged along the way, leading to disruption, budget overruns in a context marked by a steady decline in funding. However, some attempts have been made to shift towards more sustainable approaches, but these have mainly focused on vague, sector-oriented themes, failing to consider systematic and integration views. This study is a contribution in addressing these shortcomings by designing a model-driving solution, emphasizing an integrated system conceptualized as a system of systems. This paper proposes a new methodology for designing an integrated and sustainable human settlement model, based on Model-Based Systems Engineering and a Systems Modeling Language to provide valuable insights toward sustainable solutions for displaced populations aligning with the United Nations 2030 agenda for sustainable development.展开更多
Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technologi...Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technological revolution and industrial transformation to higher education,cultivating top-notch innovative intellectuals with comprehensive engineering qualities,meeting the requirements of being able to solve complex engineering problems rather than just cognitive capabilities,forming two core courses through reconstructing and reshaping the core courses of the major.The core courses include Drive,Measurement,and Control I and Drive,Measurement,and Control II,which highlight the comprehensive framework of mechanical and electronic engineering professional knowledge,continuing the comprehensive practical course system based on the unity of knowledge and practice,following the trend of new engineering,highlighting the practicality of professional innovation,assisting engineering education reform,and promoting high-quality development of new engineering professionals cultivation.展开更多
The report of the Chinese 20th National Congress put forward“strengthening the construction and management of textbooks”for the first time,which indicates the importance of textbook construction and highlights the v...The report of the Chinese 20th National Congress put forward“strengthening the construction and management of textbooks”for the first time,which indicates the importance of textbook construction and highlights the vital position of textbooks in the overall development of the country.From the perspective of textbook quality,and based on the research and analysis of the policy requirements and current evaluation indicators of higher education textbooks,this paper establishes the textbook quality evaluation index system composed of basic indicators and evaluation indicators.This system is based on the principles of science,comprehensiveness,operability,and target-oriented approach.It provides a relatively scientific,objective,and fair reference system for the management and evaluation of textbooks.展开更多
With the advancement of the construction of emerging engineering education,the reform of practical teaching has become an important task of higher engineering education.This article takes the course“Linux Operating S...With the advancement of the construction of emerging engineering education,the reform of practical teaching has become an important task of higher engineering education.This article takes the course“Linux Operating System Fundamentals”as an example to explore practical teaching reform in the context of emerging engineering education.By analyzing the current situation and problems in course practical teaching,we proposed practical teaching reforms such as online experiments,practical content updates,project-based engineering practices,and diversified evaluation models,and designed corresponding implementation plans.Practice has proved that this reform can improve students’learning interest and engineering practical skills,and cultivate outstanding engineers with innovative spirit and practical skills.展开更多
Distributed System Course is a professional computer course of Harbin Institute of Technology.With the guidance of the education strategy under the background of New Engineering,we adhere to the concept of cultivating...Distributed System Course is a professional computer course of Harbin Institute of Technology.With the guidance of the education strategy under the background of New Engineering,we adhere to the concept of cultivating diverse and innovative outstanding engineering and technology talents.This course conducts research on the teaching content,teaching mode,and evaluation system.It combines the traditional teaching mode with the online teaching mode,as well as problem-driven theories with practice,and adopts a diversified evaluation system.The research of the course has fully mobilized students’learning enthusiasm,improved teaching quality,and achieved significant teaching results.展开更多
Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds bas...Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative medicine.This paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future challenges.We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM.Moreover,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications.Finally,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.展开更多
Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of...Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue regeneration.We experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and differentiation.The resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)printing.Morphological studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural stability.The scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue engineering.The tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of gelatin.The enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue regeneration.In vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold surface.In addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its potential for use in bone-tissue engineering.展开更多
Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. ...Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties of various bioactive materials, followed by the introduction of applications based on biochemistry and cell molecules, and discuss the emerging role of biomaterials in promoting neural regeneration. Further, we summarize the adaptive biomaterials infused with exosomes produced from stem cells and stem cells themselves for the treatment of traumatic brain injury. Finally, we present the main limitations of biomaterials for the treatment of traumatic brain injury and offer insights into their future potential.展开更多
Lithium-ion thermoelectrochemical cell(LTEC), featuring simultaneous energy conversion and storage, has emerged as promising candidate for low-grade heat harvesting. However, relatively poor thermosensitivity and heat...Lithium-ion thermoelectrochemical cell(LTEC), featuring simultaneous energy conversion and storage, has emerged as promising candidate for low-grade heat harvesting. However, relatively poor thermosensitivity and heat-to-current behavior limit the application of LTECs using LiPF_6 electrolyte. Introducing additives into bulk electrolyte is a reasonable strategy to solve such problem by modifying the solvation structure of electrolyte ions. In this work, we develop a dual-salt electrolyte with fluorosurfactant(FS) additive to achieve high thermopower and durability of LTECs during the conversion of low-grade heat into electricity. The addition of FS induces a unique Li~+ solvation with the aggregated double anions through a crowded electrolyte environment,resulting in an enhanced mobility kinetics of Li~+ as well as boosted thermoelectrochemical performances. By coupling optimized electrolyte with graphite electrode, a high thermopower of 13.8 mV K^(-1) and a normalized output power density of 3.99 mW m^(–2) K^(–2) as well as an outstanding output energy density of 607.96 J m^(-2) can be obtained.These results demonstrate that the optimization of electrolyte by regulating solvation structure will inject new vitality into the construction of thermoelectrochemical devices with attractive properties.展开更多
Interfacial solar evaporation holds immense potential for brine desalination with low carbon footprints and high energy utilization.Hydrogels,as a tunable material platform from the molecular level to the macroscopic ...Interfacial solar evaporation holds immense potential for brine desalination with low carbon footprints and high energy utilization.Hydrogels,as a tunable material platform from the molecular level to the macroscopic scale,have been considered the most promising candidate for solar evaporation.However,the simultaneous achievement of high evaporation efficiency and satisfactory tolerance to salt ions in brine remains a challenging scientific bottleneck,restricting the widespread application.Herein,we report ionization engineering,which endows polymer chains of hydrogels with electronegativity for impeding salt ions and activating water molecules,fundamentally overcoming the hydrogel salt-impeded challenge and dramatically expediting water evaporating in brine.The sodium dodecyl benzene sulfonate-modified carbon black is chosen as the solar absorbers.The hydrogel reaches a ground-breaking evaporation rate of 2.9 kg m−2 h−1 in 20 wt%brine with 95.6%efficiency under one sun irradiation,surpassing most of the reported literature.More notably,such a hydrogel-based evaporator enables extracting clean water from oversaturated salt solutions and maintains durability under different high-strength deformation or a 15-day continuous operation.Meantime,on the basis of the cation selectivity induced by the electronegativity,we first propose an all-day system that evaporates during the day and generates salinity-gradient electricity using waste-evaporated brine at night,anticipating pioneer a new opportunity for all-day resource-generating systems in fields of freshwater and electricity.展开更多
Garnet solid electrolytes are one of the most promising electrolytes for solid-state batteries.However,Li_(2)CO_(3) is a critical issue that hinders the practical application of garnet-based solid-state lithium-ion ba...Garnet solid electrolytes are one of the most promising electrolytes for solid-state batteries.However,Li_(2)CO_(3) is a critical issue that hinders the practical application of garnet-based solid-state lithium-ion batteries.There are two sources of Li_(2)CO_(3) contamination.The main one is the aging of garnet electrolytes in the atmosphere.Garnet electrolytes can react with H_(2)O and CO_(2) in the air to form Li_(2)CO_(3),which reduces ion conductivity,increases electrode/garnet electrolyte interface resistance,and deteriorates the electrochemical performance of the battery.Various strategies,such as elemental doping,grain boundary manipulation,and interface engineering,have been suggested to address these issues.The other is the passivation layer(Li_(2)CO_(3),Li_3N,LiOH,Li_(2)O) formed on the surface of the lithium foil after long-term storage,which is ignored by most researchers.To better understand the current strategies and future trends to address the Li_(2)CO_(3) problem,this perspective provides a systematic review of journals published in this field from 2020-2023.展开更多
Nickel-manganese binary layered oxides with high working potential and low cost are potential candidates for sodium-ion batteries,but their electrochemical properties are highly related to compositional diversity.Dive...Nickel-manganese binary layered oxides with high working potential and low cost are potential candidates for sodium-ion batteries,but their electrochemical properties are highly related to compositional diversity.Diverse composite materials with various phase structures of P3,P2/P3,P2,P2/O3,and P2/P3/O3 were synthesized by manipulating the sodium content and calcination conditions,leading to the construction of a synthetic phase diagram for Na_(x)Ni_(0.25)Mn_(0.75)O_(2)(0.45≤x≤1.1).Then,we compared the electrochemical characteristics and structural evolution during the desodiation/sodiation process of P2,P2/P3,P2/03,and P2/P3/O3-Na_(x)Ni_(0.25)Mn_(0.75)O_(2).Among them,P2/P3-Na0.75Ni0.25Mn0.75O2exhibits the best rate capability of 90.9 mA h g^(-1)at 5 C,with an initial discharge capacity of 142.62 mA h g^(-1)at 0.1 C and a capacity retention rate of 78.25%after 100 cycles at 1 C in the voltage range of 2-4.3 V.The observed superior sodium storage performance of P2/P3 hybrids compared to other composite phases can be attributed to the enhanced Na^(+)transfer dynamic,reduction of the Jahn-teller effect,and improved reaction reversibility induced by the synergistic effect of P2 and P3 phases.The systematic research and exploration of phases in Na_(x)Ni_(0.25)Mn_(0.75)O_(2)provide new sights into high-performance nickel-manganese binary layered oxide for sodium-ion batteries.展开更多
文摘This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and geodatabases.The proposed approach can aid decision makers in land management and territorial planning,by first screening for areas with a higher debris flow susceptibility.Five environmental predisposing factors,namely,bedrock lithology,fracture network,quaternary deposits,slope inclination,and hydrographic network,were selected as independent parameters and their mutual interactions were described and quantified using the Rock Engineering System(RES)methodology.For each parameter,specific indexes were proposed,aiming to provide a final synthetic and representative index of debris flow susceptibility at the basin scale.The methodology was tested in four basins located in the Upper Susa Valley(NW Italian Alps)where debris flow events are the predominant natural hazard.The proposed matrix can represent a useful standardized tool,universally applicable,since it is independent of type and characteristic of the basin.
文摘A new approach for prediction of face advance rete (FAR) prior to mining operation and determination of the operation efficiency after mining operation in retreat longwall mining panel is presented based upon the concepts of rock engineering system (RES). For this purpose, six longwall panels considered in Parvadeh-I coal mine. Seven major effective parameters on FAR was selected including coal mine roof rating, gas propagation, safety factor of longwall face, ratio of joint spacing to cutting depth at longwall face, longwall face inclination, panel width, floor rock mass rating. To performance evaluation of the presented model, the relationship between the average vulnerability indexes of advance operation with FAR was determined in considered panels with coefficient of determination (R2) equal to 0.884 that indicate relatively acceptable correlation and compatibility. Investigations of the research indicated that it is possible to determine the actual operation efficiency under fair conditions by a RES-based model. The inevitable reduction of FAR for each longwall panel was determined by presented model that the difference amount between the maximum possible practical face advance rate (FARmpp) and recorded actual face advance rate (FARa) indicate the operation efficiency. Applied approach in this paper can be used to prediction of FAR in retreat longwall mining panel for same conditions that can have many benefits, including better and more accurate planning for the sales market and mine operation. Also, presented method in this paper can be applied as a useful tool to determination of actual operation efficiency for other sections and extraction methods in coal mines.
基金supported by MIUR (Italian Ministry of Education,University and Research Grant 15034/ 2007) under Grant 2010 ex MURST 60%"Modelli geologico-tecnici, idrogeologici e geofisici per la tutela e la valorizzazione delle risorse naturali,ambientali e culturali"(coordinator G.F.Andriani) and Grant 2013 ex MURST 60%"Ricerche stratigrafico-sedimentologiche di base ed applicate per it riconoscimento,la gestione e la tutela delle georisorse e dei beni storico/culturali e geoambientali"(coordinator M.Tropeano)the project Interreg Ⅲ A-"WET SYS B" 200-2006(responsible G.F.Andriani),with the financial contribution by the European Community
文摘Classical rock mass classification systems are not applicable to carbonate rocks,especially when these are affected by karst processes.Their applications to such settings could therefore result in outcomes not representative of the real stress-strain behavior.In this study,we propose a new classification of carbonate rock masses for engineering purposes,by adapting the rock engineering system(RES) method by Hudson for fractured and karstified rock masses,in order to highlight the problems of implementation of geomechanical models to carbonate rocks.This new approach allows a less rigid classification for carbonate rock masses,taking into account the local properties of the outcrops,the site conditions and the type of engineering work as well.
基金Supported by the National Natural Science Foundation of China
文摘An algorithm for global optimization of a class of nonconvex MINLP problems is devel-oped and presented in this paper.By partitioning the variables,dual representation of the primal ofsubproblems and outer-approximation strategy are used to develop a representative relaxed iterativeproblem.Then the original MINLP problem is replaced by a series of subproblems and relaxediterative problems.By exploiting the particular form of the nonconvex MINLP problem,the feasibleregion of this problem is explicitly included in the representative problem,thus the inconvenienceencountered with the GBD method can be avoided.The proposed method is illustrated andinterpreted geometrically with an example problem.
文摘This paper proposes a new engineering disciplin─Engineering System Theory. It dis cusses rendered background, research objects and contents of the engineering system theory briefly. Finally, the met-discipline standing of the engineering system theory in the whole knowledge system of engineering science and its development potential are pointed out.
文摘Computer-integrated manufacturing (CIM) and revers e engineering (RE) have changed drastically the concept of product re-design, pla nning and manufacture of components. However, the main problems currently facing the developers of reverse engineering system, is the time consuming digitis ation of 3D data and the conversion of large amounts of data into a concise and manageable format and linking it to a CAD/CAM system. Automated 3-D profile gen eration, measurements and inspection of manufactured component represents one of the important functions in reverse engineering and in the improvements in produ ct quality in rapid product developments. The paper presents a novel methodology for the development of a reverse enginee ring technique for use in the rapid product development in a CIM environment . The system developed provides integration, data capture and manipulation, dat a transfer between a CAD, CAM, Computer-aided inspection (CAI) and a 3-D profi le scanning system. An efficient scanning strategy has been developed for scann ing and surfaces data acquisition. The products were scanned using a laser scann ing system with a dedicated scan control card and the associated software packag es. A versatile rig was developed for the ease of data gathering of the profile scanning process. The surface data collected was then used to build a mathematic al surface model, which was then used to develop a virtual 3-D model of the pro duct. The resulting surface model provides the geometrical input to the subseque nt machining operation using either a CNC system or other manufacturing operatio n e.g. dies casting/mould casting etc. The prototypes developed were inspected u sing a state-of-the art CNC-CMM that was integrated to the CAD/CAM system. Si nce the scanning/digitised data captured by laser scanning probes requires no ma nual editing, significant time saving over most non-contact probe systems was a chieved. Since the creation of an accurate CAD model of a redesigned component o r a prototype constitute a major element of the total turnaround time; maximum r eturn can be achieved by increasing the efficiency of the redesigning process. T he paper also outlines with a case study the application of the developed system . The system developed offers the flexibility of using the concept of reverse en gineering of a variety of components with the complimentary facility of integrat ion between CAD/CAM Computer-aided Inspection (CAI) systems and a scanning syst em. The developed reverse engineering application in an integrated manufacturing system can increase the consistency, improve cost-efficiency, reduce produ ct turn around and skill levels required to redesign, reengineer and prototyping components and products.
基金supported by National Natural Science Foundation of China(Nos.92068110,81973272 and 92068111)Shanghai Science and Technology Committee(Nos.20JC1411800,and 23S41900100,China)+4 种基金Programs of Shanghai Academic/Technology Research Leader(Nos.21XD1400200 and 21XD1422200,China)Innovation Program of Shanghai Municipal Education Commission(2023ZKZD21,China)the fund of Research Grant for Health Science and Technology of Shanghai Municipal Commission of Health Committee(No.20214Y0268,China)Science and Technology Development Fund of Shanghai Pudong New Area(No.PKJ2020-Y49,China)the Project of Key Medical Specialty and Treatment Center of Pudong Hospital of Fudan University(No.Zdzk2020-15,China)。
文摘Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical translation.High levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’viability.Based on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC therapy.This system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective layer.In this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for transplantation.Meanwhile,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate healing.The engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 days.This vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.
文摘The challenge of transitioning from temporary humanitarian settlements to more sustainable human settlements is due to a significant increase in the number of forcibly displaced people over recent decades, difficulties in providing social services that meet the required standards, and the prolongation of emergencies. Despite this challenging context, short-term considerations continue to guide their planning and management rather than more integrated, longer-term perspectives, thus preventing viable, sustainable development. Over the years, the design of humanitarian settlements has not been adapted to local contexts and perspectives, nor to the dynamics of urbanization and population growth and data. In addition, the current approach to temporary settlement harms the environment and can strain limited resources. Inefficient land use and ad hoc development models have compounded difficulties and generated new challenges. As a result, living conditions in settlements have deteriorated over the last few decades and continue to pose new challenges. The stakes are such that major shortcomings have emerged along the way, leading to disruption, budget overruns in a context marked by a steady decline in funding. However, some attempts have been made to shift towards more sustainable approaches, but these have mainly focused on vague, sector-oriented themes, failing to consider systematic and integration views. This study is a contribution in addressing these shortcomings by designing a model-driving solution, emphasizing an integrated system conceptualized as a system of systems. This paper proposes a new methodology for designing an integrated and sustainable human settlement model, based on Model-Based Systems Engineering and a Systems Modeling Language to provide valuable insights toward sustainable solutions for displaced populations aligning with the United Nations 2030 agenda for sustainable development.
文摘Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technological revolution and industrial transformation to higher education,cultivating top-notch innovative intellectuals with comprehensive engineering qualities,meeting the requirements of being able to solve complex engineering problems rather than just cognitive capabilities,forming two core courses through reconstructing and reshaping the core courses of the major.The core courses include Drive,Measurement,and Control I and Drive,Measurement,and Control II,which highlight the comprehensive framework of mechanical and electronic engineering professional knowledge,continuing the comprehensive practical course system based on the unity of knowledge and practice,following the trend of new engineering,highlighting the practicality of professional innovation,assisting engineering education reform,and promoting high-quality development of new engineering professionals cultivation.
文摘The report of the Chinese 20th National Congress put forward“strengthening the construction and management of textbooks”for the first time,which indicates the importance of textbook construction and highlights the vital position of textbooks in the overall development of the country.From the perspective of textbook quality,and based on the research and analysis of the policy requirements and current evaluation indicators of higher education textbooks,this paper establishes the textbook quality evaluation index system composed of basic indicators and evaluation indicators.This system is based on the principles of science,comprehensiveness,operability,and target-oriented approach.It provides a relatively scientific,objective,and fair reference system for the management and evaluation of textbooks.
基金2023 China University of Geosciences(Beijing)Undergraduate Education Quality Improvement Plan Construction Project,including“Linux Operating System”Practical Teaching Reform(Project number:JG202215)“University Computer”Online Experiment Construction(Project number:JG202216)+1 种基金CUGB-Zhonggong Computer Science and Technology Off-Campus Practical Teaching Base(Project number:SSJJD202201)Ministry of Education Fund Project:Research and Development of Computer Vision Practical Courses Based on Deep Learning(Project number:2022BC003)。
文摘With the advancement of the construction of emerging engineering education,the reform of practical teaching has become an important task of higher engineering education.This article takes the course“Linux Operating System Fundamentals”as an example to explore practical teaching reform in the context of emerging engineering education.By analyzing the current situation and problems in course practical teaching,we proposed practical teaching reforms such as online experiments,practical content updates,project-based engineering practices,and diversified evaluation models,and designed corresponding implementation plans.Practice has proved that this reform can improve students’learning interest and engineering practical skills,and cultivate outstanding engineers with innovative spirit and practical skills.
文摘Distributed System Course is a professional computer course of Harbin Institute of Technology.With the guidance of the education strategy under the background of New Engineering,we adhere to the concept of cultivating diverse and innovative outstanding engineering and technology talents.This course conducts research on the teaching content,teaching mode,and evaluation system.It combines the traditional teaching mode with the online teaching mode,as well as problem-driven theories with practice,and adopts a diversified evaluation system.The research of the course has fully mobilized students’learning enthusiasm,improved teaching quality,and achieved significant teaching results.
基金supported by the National Natural Science Foundation of China(52003113,31900950,82102334,82002313,82072444)the National Key Research&Development Program of China(2018YFC2001502,2018YFB1105705)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(2021A1515010745,2020A1515110356,2023A1515011986)the Shenzhen Fundamental Research Program(JCYJ20190808120405672)the Key Program of the National Natural Science Foundation of Zhejiang Province(LZ22C100001)the Natural Science Foundation of Shanghai(20ZR1469800)the Integration Innovation Fund of Shanghai Jiao Tong University(2021JCPT03),the Science and Technology Projects of Guangzhou City(202102020359)the Zigong Key Science and Technology Plan(2022ZCNKY07).SXC thanks the financial support under the Startup Grant of the University of Chinese Academy of Sciences(WIUCASQD2021026).HW thanks the Futian Healthcare Research Project(FTWS2022013)the financial support of China Postdoctoral Science Foundation(2021TQ0118).SL thanks the financial support of China Postdoctoral Science Foundation(2022M721490).
文摘Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative medicine.This paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future challenges.We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM.Moreover,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications.Finally,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.
基金The authors are thankful to Ministry of Human Resource Development(presently Ministry of Education),Government of India,New Delhi,for providing research facility by sanctioning Center of Excellence(F.No.5-6/2013-TS VII)in Tissue Engineering and Center of Excellence in Orthopedic Tissue Engineering and Rehabilitation funded by World Bank under TEQIP-II.
文摘Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue regeneration.We experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and differentiation.The resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)printing.Morphological studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural stability.The scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue engineering.The tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of gelatin.The enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue regeneration.In vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold surface.In addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its potential for use in bone-tissue engineering.
基金supported by the Sichuan Science and Technology Program,No.2023YFS0164 (to JC)。
文摘Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties of various bioactive materials, followed by the introduction of applications based on biochemistry and cell molecules, and discuss the emerging role of biomaterials in promoting neural regeneration. Further, we summarize the adaptive biomaterials infused with exosomes produced from stem cells and stem cells themselves for the treatment of traumatic brain injury. Finally, we present the main limitations of biomaterials for the treatment of traumatic brain injury and offer insights into their future potential.
基金supported by the Leading Edge Technology of Jiangsu Province (BK20220009, BK20202008)Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)。
文摘Lithium-ion thermoelectrochemical cell(LTEC), featuring simultaneous energy conversion and storage, has emerged as promising candidate for low-grade heat harvesting. However, relatively poor thermosensitivity and heat-to-current behavior limit the application of LTECs using LiPF_6 electrolyte. Introducing additives into bulk electrolyte is a reasonable strategy to solve such problem by modifying the solvation structure of electrolyte ions. In this work, we develop a dual-salt electrolyte with fluorosurfactant(FS) additive to achieve high thermopower and durability of LTECs during the conversion of low-grade heat into electricity. The addition of FS induces a unique Li~+ solvation with the aggregated double anions through a crowded electrolyte environment,resulting in an enhanced mobility kinetics of Li~+ as well as boosted thermoelectrochemical performances. By coupling optimized electrolyte with graphite electrode, a high thermopower of 13.8 mV K^(-1) and a normalized output power density of 3.99 mW m^(–2) K^(–2) as well as an outstanding output energy density of 607.96 J m^(-2) can be obtained.These results demonstrate that the optimization of electrolyte by regulating solvation structure will inject new vitality into the construction of thermoelectrochemical devices with attractive properties.
基金the National Natural Science Foundation of China(Grant No.52076028).
文摘Interfacial solar evaporation holds immense potential for brine desalination with low carbon footprints and high energy utilization.Hydrogels,as a tunable material platform from the molecular level to the macroscopic scale,have been considered the most promising candidate for solar evaporation.However,the simultaneous achievement of high evaporation efficiency and satisfactory tolerance to salt ions in brine remains a challenging scientific bottleneck,restricting the widespread application.Herein,we report ionization engineering,which endows polymer chains of hydrogels with electronegativity for impeding salt ions and activating water molecules,fundamentally overcoming the hydrogel salt-impeded challenge and dramatically expediting water evaporating in brine.The sodium dodecyl benzene sulfonate-modified carbon black is chosen as the solar absorbers.The hydrogel reaches a ground-breaking evaporation rate of 2.9 kg m−2 h−1 in 20 wt%brine with 95.6%efficiency under one sun irradiation,surpassing most of the reported literature.More notably,such a hydrogel-based evaporator enables extracting clean water from oversaturated salt solutions and maintains durability under different high-strength deformation or a 15-day continuous operation.Meantime,on the basis of the cation selectivity induced by the electronegativity,we first propose an all-day system that evaporates during the day and generates salinity-gradient electricity using waste-evaporated brine at night,anticipating pioneer a new opportunity for all-day resource-generating systems in fields of freshwater and electricity.
基金funded by The Central Government Guides Local Science and Technology Development Special Fund Projects(Grant No.YDZJSX2022B003)the Shanxi Province Science and Technology Major Projects(Grant No.202101120401008)。
文摘Garnet solid electrolytes are one of the most promising electrolytes for solid-state batteries.However,Li_(2)CO_(3) is a critical issue that hinders the practical application of garnet-based solid-state lithium-ion batteries.There are two sources of Li_(2)CO_(3) contamination.The main one is the aging of garnet electrolytes in the atmosphere.Garnet electrolytes can react with H_(2)O and CO_(2) in the air to form Li_(2)CO_(3),which reduces ion conductivity,increases electrode/garnet electrolyte interface resistance,and deteriorates the electrochemical performance of the battery.Various strategies,such as elemental doping,grain boundary manipulation,and interface engineering,have been suggested to address these issues.The other is the passivation layer(Li_(2)CO_(3),Li_3N,LiOH,Li_(2)O) formed on the surface of the lithium foil after long-term storage,which is ignored by most researchers.To better understand the current strategies and future trends to address the Li_(2)CO_(3) problem,this perspective provides a systematic review of journals published in this field from 2020-2023.
基金supported by project from the National Natural Science Foundation of China(21805018)by the Sichuan Science and Technology Program(2022ZHCG0018,2023NSFSC0117,2023ZHCG0060)+1 种基金the Yibin Science and Technology Program(2022JB005)project funded by the China Postdoctoral Science Foundation(2022M722704)。
文摘Nickel-manganese binary layered oxides with high working potential and low cost are potential candidates for sodium-ion batteries,but their electrochemical properties are highly related to compositional diversity.Diverse composite materials with various phase structures of P3,P2/P3,P2,P2/O3,and P2/P3/O3 were synthesized by manipulating the sodium content and calcination conditions,leading to the construction of a synthetic phase diagram for Na_(x)Ni_(0.25)Mn_(0.75)O_(2)(0.45≤x≤1.1).Then,we compared the electrochemical characteristics and structural evolution during the desodiation/sodiation process of P2,P2/P3,P2/03,and P2/P3/O3-Na_(x)Ni_(0.25)Mn_(0.75)O_(2).Among them,P2/P3-Na0.75Ni0.25Mn0.75O2exhibits the best rate capability of 90.9 mA h g^(-1)at 5 C,with an initial discharge capacity of 142.62 mA h g^(-1)at 0.1 C and a capacity retention rate of 78.25%after 100 cycles at 1 C in the voltage range of 2-4.3 V.The observed superior sodium storage performance of P2/P3 hybrids compared to other composite phases can be attributed to the enhanced Na^(+)transfer dynamic,reduction of the Jahn-teller effect,and improved reaction reversibility induced by the synergistic effect of P2 and P3 phases.The systematic research and exploration of phases in Na_(x)Ni_(0.25)Mn_(0.75)O_(2)provide new sights into high-performance nickel-manganese binary layered oxide for sodium-ion batteries.
