Enhancer of rudimentary homolog(ERH)is a small,highly conserved protein among eukaryotes.Since its discovery nearly 20 years ago,its molecular function has remained enigmatic.It has been implicated to play a role in t...Enhancer of rudimentary homolog(ERH)is a small,highly conserved protein among eukaryotes.Since its discovery nearly 20 years ago,its molecular function has remained enigmatic.It has been implicated to play a role in transcriptional regulation and in cell cycle.We recently showed that ERH binds to the Sm complex and is required for the mRNA splicing of the mitotic motor protein CENP-E.Fur-thermore,cancer cells driven by mutations in the KRAS oncogene are particularly sensitive to RNAi-mediated suppression of ERH function,and ERH expression is inversely correlated with survival in colorectal cancer pa-tients whose tumors harbor KRAS mutation.These recent fi ndings indicate that ERH plays an important role in cell cycle through its mRNA splicing activity and is critically required for genomic stability and cancer cell survival.展开更多
基金This work is supported by the Liver Disease Prevention and Treatment Research Foundation of Taiwan to M.Z.W.by the Intramural Pro-gram of the U.S.National Cancer Institute to J.L..
文摘Enhancer of rudimentary homolog(ERH)is a small,highly conserved protein among eukaryotes.Since its discovery nearly 20 years ago,its molecular function has remained enigmatic.It has been implicated to play a role in transcriptional regulation and in cell cycle.We recently showed that ERH binds to the Sm complex and is required for the mRNA splicing of the mitotic motor protein CENP-E.Fur-thermore,cancer cells driven by mutations in the KRAS oncogene are particularly sensitive to RNAi-mediated suppression of ERH function,and ERH expression is inversely correlated with survival in colorectal cancer pa-tients whose tumors harbor KRAS mutation.These recent fi ndings indicate that ERH plays an important role in cell cycle through its mRNA splicing activity and is critically required for genomic stability and cancer cell survival.
