Background:To analyze the epidemiological characteristics of varicella epidemics in Chongqing Municipality from 2014 to 2021,and to provide a scientific basis for the formulation of varicella prevention and control me...Background:To analyze the epidemiological characteristics of varicella epidemics in Chongqing Municipality from 2014 to 2021,and to provide a scientific basis for the formulation of varicella prevention and control measures.Methods:Data on the incidence of varicella outbreaks and vaccination data in Chongqing from 2014 to 2021 were collected through the China Disease Control and Prevention Information System and statistically analyzed using descriptive epidemiological methods.Results:From 2014 to 2021,213,715 cases of varicella were reported in Chongqing Municipality,with an average annual incidence rate of 86.26/100,000,with a statistically significant difference(χ^(2)=24,972.069,P<0.001);varicella incidence is seasonal,with peaks in May/June and October/December each year,presenting a“double-peak distribution”.The average annual incidence rate of varicella in municipal districts was 90.74/100,000,which was higher than that of counties 69.62/100,000 and autonomous counties 84.04/100,000;the average annual incidence rate of varicella in males was 89.37/100,000,and in females,82.22/100,000,with the difference not being statistically significant;the age of onset of the disease was mainly in the group of people under 15 years of age,with a total of 190,021 cases reported(88.9%),with 5-9 years old(35.7%)as the high incidence age group.The incidence occupation was dominated by students in 133,733 cases(62.6%).Conclusion:The overall varicella epidemic in Chongqing is on the rise,and has obvious seasonal,regional and population distribution characteristics.The prevention and control of varicella epidemic should be strengthened,the publicity of varicella vaccine should be increased,and it is recommended that varicella vaccine should be included in the national immunization program.展开更多
Objective To clarify the epidemiological characteristics and spatial distribution patterns of human norovirus outbreaks in China, identify high-risk areas, and provide guidance for epidemic prevention and control.Meth...Objective To clarify the epidemiological characteristics and spatial distribution patterns of human norovirus outbreaks in China, identify high-risk areas, and provide guidance for epidemic prevention and control.Methods This study analyzed 964 human norovirus outbreaks involving 50,548 cases in 26 provinces reported from 2012 to 2018. Epidemiological analysis and spatiotemporal scanning analysis were conducted to analyze the distribution of norovirus outbreaks in China.Results The outbreaks showed typical seasonality, with more outbreaks in winter and fewer in summer, and the total number of infected cases increased over time. Schools, especially middle schools and primary schools, are the most common settings of norovirus outbreaks, with the major transmission route being life contact. More outbreaks occurred in southeast coastal areas in China and showed significant spatial aggregation. The highly clustered areas of norovirus outbreaks have expanded northeast over time.Conclusion By identifying the epidemiological characteristics and high-risk areas of norovirus outbreaks, this study provides important scientific support for the development of preventive and control measures for norovirus outbreaks, which is conducive to the administrative management of high-risk settings and reduction of disease burden in susceptible areas.展开更多
Objective:To analyze the epidemiological characteristics of COVID-19 cases(Omicron variant BA5.1.3)in a hotel Fangcang shelter hospital in Sanya,Hainan Province,and provide basis for optimizing epidemic prevention and...Objective:To analyze the epidemiological characteristics of COVID-19 cases(Omicron variant BA5.1.3)in a hotel Fangcang shelter hospital in Sanya,Hainan Province,and provide basis for optimizing epidemic prevention and control strategies.Methods:The epidemiological data of COVID-19 cases admitted to a hotel Fangcang shelter hospital in Sanya from August 10 to August 30 in 2022 were collected for descriptive epidemiological analysis.Results:By August 30,703 cases of COVID-19 had been treated in the hotel Fangcang shelter hospital.The epidemiological characteristics analysis showed that 328 cases were male,accounting for 46.7%,and 375 cases were female,accounting for 53.3%.The ratio of male to female was 0.87:1.The age range was 8 months to 85 years old,with a median of 37(20,49)years old.The majority of people aged 31-59 years old,accounting for 51.4%.Asymptomatic infection accounted for 39.8%,and mild infection accounted for 60.2%,the main clinical symptoms were cough 24.8%(105/423),fever 18.7%(79/423).8.8%of the infected people had a history of chronic basic diseases,and hypertension and diabetes were the most common.There were 416 infected patients discharged from hospital,and the median total hospital stay was 14(10,15)days.The proportion of people who did not receive COVID-19 vaccine was 10.1%,the proportion of people who completed one,two and three vaccination was 5.0%,36.3%and 48.6%respectively,and the proportion of people who completed two and three vaccinations among people ≥60 years old was only 10.1%and 8.8%.Conclusion:This strain was the novel coronavirus variant BA5.1.3,which was reported for the first time in China.It was more infectious and insidious,and generally susceptible to people of all ages.Therefore,it is necessary to strengthen personal prevention and control,and did a good job of external anti input and internal anti diffusion,and strengthen nucleic acid detection to realize timely detection and early treatment,and strengthen COVID-19 vaccination,to improve vaccination rate and reduce infection rate.展开更多
Objective We aimed to assess the features of notifiable infectious diseases found commonly in foreign nationals in China between 2004 and 2017 to improve public health policy and responses for infectious diseases.Meth...Objective We aimed to assess the features of notifiable infectious diseases found commonly in foreign nationals in China between 2004 and 2017 to improve public health policy and responses for infectious diseases.Methods We performed a descriptive study of notifiable infectious diseases among foreigners reported from 2004 to 2017 in China using data from the Chinese National Notifiable Infectious Disease Reporting System(NNIDRIS). Demographic, temporal-spatial distribution were described and analyzed.Results A total of 67,939 cases of 33 different infectious diseases were reported among foreigners.These diseases were seen in 31 provinces of China and originated from 146 countries of the world. The infectious diseases with the highest incidence number were human immunodeficiency virus(HIV) of18,713 cases, hepatitis B(6,461 cases), hand, foot, and mouth disease(6,327 cases). Yunnan province had the highest number of notifiable infectious diseases in foreigners. There were different trends of the major infectious diseases among foreign cases seen in China and varied among provinces.Conclusions This is the first description of the epidemiological characteristic of notifiable infectious diseases among foreigners in China from 2004 to 2017. These data can be used to better inform policymakers about national health priorities for future research and control strategies.展开更多
Objective:To understand the epidemic characters of COVID-19 epidemic in Hainan province of tropical China and provid evidences for the prevention and control of the epidemic.Methods:Data on the COVID-19 epidemic colle...Objective:To understand the epidemic characters of COVID-19 epidemic in Hainan province of tropical China and provid evidences for the prevention and control of the epidemic.Methods:Data on the COVID-19 epidemic collected from Health Commission of Hainan Province were analyzed by using the methods of retrospective descriptive epidemiology.Results:From January 22nd to February 21st,2020,COVID-19 was diagnosed in 168 confirmed cases(including 8 severe cases)in Hainan Province with the temporary fatality rate of 2.38%of 4 deaths,and 96 cases discharged from hospital,with the cure rate of 57.14%.The cases were distributed in altogether 15 cities and counties in Hainan Province,among which 121 cases were distributed in Sanya,Haikou,Danzhou and Wanning,accounting for 72.02%of the total number of cases.Cases in Sanya City were mainly found in Tianya district and Jiyang district,accounting for 69.81%of the total number of cases in Sanya.Cases in Haikou City were mainly found in Qiongshan district and Xiuying district,accounting for 72.5%of the total number of cases in Haikou.Among the patients,there were 81 males and 87 females,with a male-to-female ratio of 1.1;the youngest age was 3 months,the oldest was 79 years old,80%of the patients were in the age group of 30 to 69 years old,and the number of children and adolescents under 20 years old were relatively low.Conclusion:The daily number of new confirmed cases showed a gradual downward trend in Hainan province,and the epidemic situation was in transition from imported to local renewal,mainly in close contact between family members.With the increase of personnel mobility such as the resumption of work by enterprises and the return of migrant workers to the island,there is a risk of agglomeration epidemic.Prevention and control work in urban and rural areas should take a two-pronged approach.Amid preventing imported cases,more proactive measures should be taken to prevent and control the spread of local cases.展开更多
<strong>Introduction:</strong> The coronavirus disease 2019 (COVID-19) was declared as pandemic by WHO by March 11th. First case reported in Oman was on 24th February 2020 and later the country went throug...<strong>Introduction:</strong> The coronavirus disease 2019 (COVID-19) was declared as pandemic by WHO by March 11th. First case reported in Oman was on 24th February 2020 and later the country went through stages of epidemic progression. This study describes the sociodemographic and epidemiological characteristics of confirmed COVID-19 cases in Muscat governorate and related outcomes. <strong>Materials and Methods:</strong> This is a descriptive, exploratory analysis of all lab confirmed COVID 19 cases that were reported from 1st February to 31st May 2020. Data for the study was primarily extracted from notifications system established for surveillance (Tarassud). Secondary data sources were, contact listings and hospital medical records.<strong> Results:</strong> 11,648 initial cases of confirmed COVID-19 infections were included. The mean age was 35 years, 84.7% (N = 9862) were males, 25.9% (N = 3017) were Omanis, and 74.1% (N = 8631) were expatriates of which Indian origin were the majority (37%). Fever and cough were the most common presentations (46.3% and 29.5% respectively). Diabetes and hypertension were the most common comorbidities (4.9% and 4.6% respectively). Hospital admission was required for 7% (N = 811) of the total reported cases, out of them 171 cases (21%) were admitted to ICU, where 107 (13.2%) were ventilated. The case fatality rate (CFR) was 0.9%. 158 clusters containing 2949 contacts were identified from case records and categorised into 3 groups based on their exposure settings. The incubation period measured was 8 days (IQR 4.0 - 15.0) for workplace, 8 days (IQR 4 - 17) for dormitory and 4 days (IQR 2.0 - 7.0) for family groups. The secondary attack rate (SAR) estimated was 41.6% (95% CI: 0.34 - 0.48), 52% (95% CI: 0.40 - 0.63) and 33% (95% CI: 0.27 - 0.38) for workplace, dormitory and family groups, respectively. <strong>Conclusion:</strong> Results of this study, determine the transmission trend of COVID-19 in a country with high immigrant population. These findings could be utilised for further response planning in similar settings.展开更多
Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorab...Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.展开更多
Background:With the progress of globalization,international mobility increases,greatly facilitating cross-border transmission of respiratory infectious diseases(RIDs).This study aimed to analyze the epidemiological ch...Background:With the progress of globalization,international mobility increases,greatly facilitating cross-border transmission of respiratory infectious diseases(RIDs).This study aimed to analyze the epidemiological characteristics and factors influencing imported RIDs,with the goal of providing evidence to support adoption of high-tech,intel-ligent methods to early find imported RIDs and prevent their spread in China.Methods:We obtained data of imported RIDs cases from 2014 to 2018 from the Inbound Sentinel Network of Customs and the National Notifiable Diseases Reporting System in China.We analyzed spatial,temporal,and population distribution characteristics of the imported RIDs.We developed an index to describe seasonality.Pearson correlation coefficients were used to examine associations between independent variables and imported cases.Data analyses and visualizations were conducted with R software.Results:From a total of 1409265253 inbound travelers,31732(2.25/100000)imported RIDs cases were reported.RIDs cases were imported from 142 countries and five continents.The incidence of imported RIDs was nearly 5 times higher in 2018(2.81/100000)than in 2014(0.58/100000).Among foreigners,incidence rates were higher among males(5.32/100000),0–14-year-olds(15.15/100000),and cases originating in Oceania(11.10/100000).The vast majority(90.3%)of imported RIDs were influenza,with seasonality consistent with annual seasonality of influenza.The spatial distribution of imported RIDs was different between Chinese citizens and foreigners.Increases in inbound travel volume and the number of influenza cases in source countries were associated with the number of imported RIDs.Conclusions:Our study documented importation of RIDs into China from 142 countries.Inbound travel poses a significant risks bringing important RIDs to China.It is urgent to strengthen surveillance at customs of inbound travelers and establish an intelligent surveillance and early warning system to prevent importation of RIDs to China for preventing further spread within China.展开更多
BACKGROUND Pneumonia of uncertain cause has been reported in Wuhan,China since the beginning of early December 2019.In early January 2020,a novel strain ofβ-coronavirus was identified by the Chinese Center for Diseas...BACKGROUND Pneumonia of uncertain cause has been reported in Wuhan,China since the beginning of early December 2019.In early January 2020,a novel strain ofβ-coronavirus was identified by the Chinese Center for Disease Control and Prevention from the pharyngeal swab specimens of patients,which was recently named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).There is evidence of human-to-human transmission and familial cluster outbreak of SARSCoV-2 infection.The World Health Organization(WHO)recently declared the SARS-CoV-2 epidemic a global health emergency.As of February 17,2020,71329 laboratory-confirmed cases(in 25 countries,including the United States and Germany)have been reported globally.Other than its rapid transmission,the epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)remain unclear.In December 2019,coronavirus disease(named COVID-19 by the WHO)associated with the SARS-CoV-2 emerged in Wuhan,China and spread quickly across the country.AIM To analyze the epidemiological and clinical characteristics of confirmed cases of this disease in Liaoning province,a Chinese region about 1800 km north of Wuhan.METHODS The clinical data of 56 laboratory-confirmed COVID-19 cases due to 2019-nCoV infection were analyzed.The cases originated from eight cities in Liaoning province.RESULTS The median age of the patients was 45 years,and 57.1%of them were male.No patient had been in direct contact with wild animals.Among them,23 patients(41.1%)had resided in or traveled to Wuhan,27 cases(48.2%)had been in contact with confirmed COVID-19 patients,5 cases(8.9%)had been in contact with confirmed patients with a contact history to COVID-19 patients,and 1 case(1.8%)had no apparent history of exposure.Fever(75.0%)and cough(60.7%)were the most common symptoms.The typical manifestations in lung computed tomography(CT)included ground-glass opacity and patchy shadows,with 67.8%of them being bilateral.Among the patients in the cohort,78.6%showed reduction in their lymphocyte counts,57.1%showed increases in their C-reactive protein levels,and 50.0%showed decreases in their blood albumin levels.Eleven patients(19.6%)were admitted to intensive care unit,2 patients(3.5%)progressed to acute respiratory distress syndrome,4 patients(7.1%)were equipped with non-invasive mechanical ventilation,and 1 patient(1.8)received extracorporeal membrane oxygenation support.There were 5 mild cases(5/56,8.9%),40 moderate cases(40/56,71.4%),10 severe cases(10/56,17.9%),and 1 critical case(1/56,1.8%).No deaths were reported.CONCLUSION SARS-CoV-2 can be transmitted among humans.Most COVID-19 patients show symptoms of fever,cough,lymphocyte reduction,and typical lung CT manifestations.Most are moderate cases.The seriousness of the disease(as indicated by blood oxygen saturation,respiratory rate,oxygenation index,blood lymphocyte count,and lesions shown in lung CT)is related to history of living in or traveling to Wuhan,underlying diseases,admittance to intensive care unit,and mechanical ventilation.展开更多
Background Respiratory infectious diseases(RIDs)remain a pressing public health concern,posing a signifcant threat to the well-being and lives of individuals.This study delves into the incidence of seven primary RIDs ...Background Respiratory infectious diseases(RIDs)remain a pressing public health concern,posing a signifcant threat to the well-being and lives of individuals.This study delves into the incidence of seven primary RIDs dur‑ing the period 2017-2021,aiming to gain deeper insights into their epidemiological characteristics for the purpose of enhancing control and prevention strategies.Methods Data pertaining to seven notifable RIDs,namely,seasonal infuenza,pulmonary tuberculosis(PTB),mumps,scarlet fever,pertussis,rubella and measles,in the mainland of China between 2017 and 2021 were obtained from the National Notifable Disease Reporting System(NNDRS).Joinpoint regression software was utilized to analyze temporal trends,while SaTScan software with a Poisson probability model was used to assess seasonal and spatial patterns.Results A total of 11,963,886 cases of the seven RIDs were reported during 2017-2021,and yielding a fve-year aver‑age incidence rate of 170.73 per 100,000 individuals.Among these RIDs,seasonal infuenza exhibited the highest aver‑age incidence rate(94.14 per 100,000),followed by PTB(55.52 per 100,000),mumps(15.16 per 100,000),scarlet fever(4.02 per 100,000),pertussis(1.10 per 100,000),rubella(0.59 per 100,000),and measles(0.21 per 100,000).Males experi‑enced higher incidence rates across all seven RIDs.PTB incidence was notably elevated among farmers and individu‑als aged over 65,whereas the other RIDs primarily afected children and students under 15 years of age.The inci‑dences of PTB and measles exhibited a declining trend from 2017 to 2021(APC=−7.53%,P=0.009;APC=−40.87%,P=0.02),while the other fve RIDs peaked in 2019.Concerning seasonal and spatial distribution,the seven RIDs displayed distinct characteristics,with variations observed for the same RIDs across diferent regions.The proportion of laboratory-confrmed cases fuctuated among the seven RIDs from 2017 to 2021,with measles and rubella exhibit‑ing higher proportions and mumps and scarlet fever showing lower proportions.Conclusions The incidence of PTB and measles demonstrated a decrease in the mainland of China between 2017 and 2021,while the remaining fve RIDs reached a peak in 2019.Overall,RIDs continue to pose a signifcant public health challenge.Urgent action is required to bolster capacity-building eforts and enhance control and prevention strategies for RIDs,taking into account regional disparities and epidemiological nuances.With the rapid advancement of high-tech solutions,the development and efective implementation of a digital/intelligent RIDs control and pre‑vention system are imperative to facilitate precise surveillance,early warnings,and swift responses.展开更多
Objective:To analyze the epidemiological characteristics of asymptomatic SARS-CoV-2 novel coronavirus infection cases in Yinchuan City,Ningxia.Methods:Cases of asymptomatic SARSCoV-2 novel coronavirus infections disco...Objective:To analyze the epidemiological characteristics of asymptomatic SARS-CoV-2 novel coronavirus infection cases in Yinchuan City,Ningxia.Methods:Cases of asymptomatic SARSCoV-2 novel coronavirus infections discovered in Yinchuan City from February 2020 to April 2020 were taken as the research subjects,epidemiological and laboratory examination data were collected,and statistics and analysis were conducted.Results:Among the 10 cases of asymptomatic infection,6 were males and 4 were females,with an average age of(34.3±2.1)years;2 cases had a history of living in Hubei,8 cases had a history of close contact with confirmed cases;6 cases had no other underlying diseases while the other 4 cases were accompanied by one or more underlying diseases;6 cases were diagnosed as asymptomatic infection by serum-specific IgM antibody detection;4 cases were diagnosed as asymptomatic infection by throat swab testing;there were 4 cases with alanine base transferase level higher than the normal range,2 cases with aspartate aminotransferase level higher than the normal range,and 3 cases with D-dimer level out of the normal range.Conclusion:The asymptomatic SARS-CoV-2 novel coronavirus infection has certain clinical characteristics;it is infectious and has insidious characteristics.Even if medical observation is dismissed,monitoring is still needed to prevent the pandemic from rebounding.展开更多
Background and Objective:In Guangxi province,from 1970s to 1990s,the mortality of primary liver cancer(PLC) ranked the first among a variety of malignant tumors.Investigating the epidemiological characteristics of PLC...Background and Objective:In Guangxi province,from 1970s to 1990s,the mortality of primary liver cancer(PLC) ranked the first among a variety of malignant tumors.Investigating the epidemiological characteristics of PLC is very important for developing reasonable and effective treatment strategy,allocating health resources rationally,and evaluating the quality of PLC prevention and control.This study was to analyze the mortality and epidemiological characteristics of PLC in Guangxi province between 2004 and 2005.Methods:Multi-stage stratified cluster random sampling method was used to select 9 counties(cities or urban areas) as sample points.The residents' death causes between 2004 and 2005 were analyzed,and the epidemiological characteristics of PLC were investigated.Results:In the period of 2004-2005,the crude mortality of PLC was 34.39/100 000 in Guangxi province population(55.30/100 000 in men and 13.21/100 000 in women).The national population-standardized mortality in 1964 was 22.17/100 000.The man-to-woman ratio of mortality was 4.19:1.PLC ranked as the first death cause among a variety of malignant tumors,and PLC-related death accounted for 30.70% of all tumor-related death cases.Age-specific mortality of PLC was increased with age,rising significantly from 30-year-old(from 25-year-old in men and from 40-year-old in women),and reached a peak at 75-year-old.Conclusions:The mortality of PLC shows a decreasing trend in Guangxi province in the early 21st century,and the starting age of PLC death peak postpones about 10 years than that in 1990s.It shows that the comprehensive prevention and control measures of PLC implemented in Guangxi province are fruitful.However,the PLC mortality in Guangxi province is still significantly higher than the national average level,and it still ranks as the first death cause in a variety of malignant tumors in Guangxi province.PLC mainly occurs in middle-aged and elderly people.The prevention and treatment research of PLC still has a long way to go.展开更多
The coronavirus disease 2019(COVID-19)pandemic,caused by the novel virus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in December 2019 in China and has led to a global public health emergency.Prev...The coronavirus disease 2019(COVID-19)pandemic,caused by the novel virus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in December 2019 in China and has led to a global public health emergency.Previously,it was known as 2019-nCoV and caused disease mainly through respiratory pathways.The COVID-19 outbreak is ranked third globally as the most highly pathogenic disease of the twenty-first century,after the outbreak of SARS-CoV and Middle East respiratory syndrome in 2002 and 2012,respectively.Clinical,laboratory,and diagnostic methodology have been demonstrated in some observational studies.No systematic reviews on COVID-19 have been published regarding the integration of COVID-19 outbreaks(monitoring,fate and treatment)with environmental and human health perspectives.Accordingly,this review systematically addresses environmental aspects of COVID-19 outbreak such as the origin of SARS-CoV-2,epidemiological characteristics,diagnostic methodology,treatment options and technological advancement for the prevention of COVID-19 outbreaks.Finally,we integrate COVID-19 outbreaks(monitoring,fate and treatment)with environmental and human health perspectives.We believe that this review will help to understand the SARS-CoV-2 outbreak as a multipurpose document,not only for the scientific community but also for global citizens.Countries should adopt emergency preparedness such as prepare human resources,infrastructure and facilities to treat severe COVID-19 as the virus spreads rapidly globally.展开更多
The emergence and prevalence of multidrug-resistant Acinetobacter baumannii(MRAB)poses a huge challenge to clinical treatment.To investigate the genetic and epidemiologic characteristics of MRAB in Liaocheng,China,and...The emergence and prevalence of multidrug-resistant Acinetobacter baumannii(MRAB)poses a huge challenge to clinical treatment.To investigate the genetic and epidemiologic characteristics of MRAB in Liaocheng,China,and to explore potential resistance mechanisms,56 MRAB strains were collected from the clinical departments of seven hospitals in Liaocheng between 2020 and 2022.Molecular typing,antimicrobial resistance patterns,and epidemiological characteristics were determined by genome sequencing and comparative genome analysis.Sequence type(ST)540 was the most prevalent ST of the 56 MRAB in Liaocheng,and most strains(92.86%)were grouped into CC92.Core genome multilocus sequence typing subdivided the strains according to the number of allelic differences and could distinguish different outbreaks caused by ST540 isolates in the hospitals.All the isolates harbored blaOXA-23 and blaADC-25,and at least 92.86%of the isolates were resistant to 10 antibiotics.The major MRAB epidemic clone detected in Liaocheng was ST540,which was different from the results reported in other regions in China.Furthermore,several inter-hospital transmissions of ST540 isolates were observed.The findings highlight the urgent need for effective nosocomial infection control measures and the continuous surveillance of ST540 MRAB in Liaocheng.展开更多
Background:Hinggan League is located in the Northeast of the Inner Mongolia Autonomous Region,the historically endemic area of animal and human brucellosis.In this study,the epidemiological characteristics of human br...Background:Hinggan League is located in the Northeast of the Inner Mongolia Autonomous Region,the historically endemic area of animal and human brucellosis.In this study,the epidemiological characteristics of human brucellosis were analyzed,and the genotypic profile and antimicrobial susceptibilities of Brucella melitensis strains isolated from humans in Hinggan League were investigated.Methods:The epidemic characteristics were described using case number,constituent ratio,and rate.The 418 human blood samples were collected and tested by bacteriology,and suspect colonies were isolated and identified by conventional biotyping assays,the VITEK 2.0 microbial identification system,and AMOS(Brucella abortus,B.melitensis,B.ovis,and B.suis)-PCR.Subsequently,all strains were genotyped using multiple-locus variable-number tandem repeat analysis(MLVA)assays,and the antimicrobial susceptibility pattern of Brucella strains against the 10 most commonly used antibiotics was determined by microdilution method.Results:A total of 22848 cases of human brucellosis were reported from 2004 to 2019,with an annual average incidence of 87.2/100000.The incidence rates in developed areas of animal husbandry(Horqin Youyi Qianqi[161.2/100000]and Horqin Youyi Zhongqi[112.1/100000])were significantly higher than those in forest areas(Arxan[19.2/100000])(χ2=32.561,P<0.001).In addition,peak morbidity occurred during May–August,accounting for 72.6%(16582/22848)of cases.The highest number of cases occurred in the 40+age group,accounting for 44.4%(10137/22484)of cases,and morbidity in males was significantly higher than that in females in all age groups(χ2=299.97,P<0.001),the most common occupation was farmers.A total of 54 B.melitensis strains were divided into 37 genotypes(GT1–37)with 80–100%genetic similarity.All 25 strains were sensitive to seven tested antibiotics,phenotypic resistance to cotrimoxazole and azithromycin was observed in 5(20%)and 25(100%)of the isolates,respectively.Conclusions:Human brucellosis exhibited a significant increasing trend and B.melitensis is the main pathogen responsible for human brucellosis in this region.Improved surveillance of infected animals(sheep)and limiting their transfer and trade are optional strategies for decreasing the incidence of this disease.展开更多
Human astrovirus(HAstV)is one of the main pathogens that cause sporadic cases of acute gastroenteritis,sometimes leading to outbreaks.This study aimed to elucidate the epidemiological and etiological character-istics ...Human astrovirus(HAstV)is one of the main pathogens that cause sporadic cases of acute gastroenteritis,sometimes leading to outbreaks.This study aimed to elucidate the epidemiological and etiological character-istics of HAstV outbreaks worldwide.Literature on HAstV outbreaks published before January 2022 was retrieved from the China National Knowledge Infrastructure,WanFang,WeiPu,PubMed,and Web of Science databases.Date,region,population,settings,transmission modes,clinical symptoms,and etiological characteristics of the outbreaks were collected and analyzed.Thirty-one articles on 32 HAstV outbreaks reported between November 1978 and October 2018 were included.The outbreaks mainly occurred in autumn(14/32,43.75%),and more of them were reported in 1996,2004,and 2017.Outbreaks were primarily dis-tributed in the Northern Hemisphere and mainly occurred in nursery centers and kindergartens(9/29,31.03%),hospitals(5/29,17.24%),and schools(4/29,13.79%).Viral genotypes were identified during 19 outbreaks,and HAstV-1 was predominant(8/19,42.10%).Eleven outbreaks were caused by mixed infection,and norovirus(9/11,81.82%)and rotavirus(5/11,45.45%)were the most common mixed pathogens.The transmission routes were reported in 9 outbreaks of mixed infection,and most(7/9)were related to water-borne and foodborne transmission.Although HAstV outbreaks are infrequently reported,it is necessary to con-sider HAstV in norovirus-negative gastroenteritis outbreaks.In addition,local Centers for Disease Control and Prevention should have the capacity to handle HAstV outbreaks and identify pathogens.展开更多
Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an ext...Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD.展开更多
Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research a...Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods: Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results: There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%;χ^(2) = 210.97,P < 0.05), with anRR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%;χ^(2)= 6.40,P < 0.05), with anRR of 1.93 (95%CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95%CI: 1.083-1.772,P= 0.009) and advanced age (OR: 1.095, 95%CI: 1.031-1.163,P= 0.01).Conclusions: The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality.展开更多
A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues.Moreover,vaccination breakthrough infection and reinfection in convalesce...A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues.Moreover,vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases have been reported.Further,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants emerged with mutations in spike(S)gene,the target of most current vaccines.Importantly,the mutations exhibit a trend of immune escape from the vaccination.Herein the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains elusive.We performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of COVID-19.In addition,we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation respectively.We found that vaccination coverage was negatively related to the infections,severe cases,and deaths of COVID-19 respectively.With the increasing vaccination coverage,the lineage diversity of SARS-CoV-2 dampened,but the rapid mutation rates of the S gene were identified,and the vaccination could be one of the explanations for driving mutations in S gene.Moreover,new epidemics resurged in several countries with high vaccination coverage,questioning their current pandemic control strategies.Hence,integrated vaccination and non-pharmacological interventions are critical to control the pandemic.Furthermore,novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility.展开更多
The modelling is widely used in determining the best strategies for the mitigation of the impact of infectious diseases.Currently,the modelling of a complex system such as the spread of COVID-19 infection is among the...The modelling is widely used in determining the best strategies for the mitigation of the impact of infectious diseases.Currently,the modelling of a complex system such as the spread of COVID-19 infection is among the topical issues.The aim of this article is graphbased modelling of the COVID-19 infection spread.The article investigates the studies related to the modelling of COVID-19 pandemic and analyses the factors affecting the spread of the disease and its main characteristics.We propose a conceptual model of COVID-19 epidemic by considering the social distance,the duration of contact with an infected person and their location-based demographic characteristics.Based on the hypothetical scenario of the spread of the virus,a graph model of the process are developed starting from the first confirmed infection case to human-to-human transmission of the virus and visualized by considering the epidemiological characteristics of COVID-19.The application of graph for the pandemic modelling allows for considering multiple factors affecting the epidemiological process and conducting numerical experiments.The advantage of this approach is justified with the fact that it enables the reverse analysis the spread as a result of the dynamic record of detected cases of the infection in the model.This approach allows for to determining undetected cases of infection based on the social distance and duration of contact and eliminating the uncertainty significantly.Note that social,economic,demographic factors,the population density,mental values and etc.affect the increase in number of cases of infection and hence,the research was not able to consider all factors.In future research will analyze multiple factors impacting the number of infections and their use in the models will be considered.展开更多
基金supported by the Center for Public Health Security Research 2022 Policy Research Project(ggwsaqyjzx202205).
文摘Background:To analyze the epidemiological characteristics of varicella epidemics in Chongqing Municipality from 2014 to 2021,and to provide a scientific basis for the formulation of varicella prevention and control measures.Methods:Data on the incidence of varicella outbreaks and vaccination data in Chongqing from 2014 to 2021 were collected through the China Disease Control and Prevention Information System and statistically analyzed using descriptive epidemiological methods.Results:From 2014 to 2021,213,715 cases of varicella were reported in Chongqing Municipality,with an average annual incidence rate of 86.26/100,000,with a statistically significant difference(χ^(2)=24,972.069,P<0.001);varicella incidence is seasonal,with peaks in May/June and October/December each year,presenting a“double-peak distribution”.The average annual incidence rate of varicella in municipal districts was 90.74/100,000,which was higher than that of counties 69.62/100,000 and autonomous counties 84.04/100,000;the average annual incidence rate of varicella in males was 89.37/100,000,and in females,82.22/100,000,with the difference not being statistically significant;the age of onset of the disease was mainly in the group of people under 15 years of age,with a total of 190,021 cases reported(88.9%),with 5-9 years old(35.7%)as the high incidence age group.The incidence occupation was dominated by students in 133,733 cases(62.6%).Conclusion:The overall varicella epidemic in Chongqing is on the rise,and has obvious seasonal,regional and population distribution characteristics.The prevention and control of varicella epidemic should be strengthened,the publicity of varicella vaccine should be increased,and it is recommended that varicella vaccine should be included in the national immunization program.
基金supported by the National Natural Science Foundation of China[grant number 81903377]Young Scholar Foundation of NIEH[grant number 19qnjj]。
文摘Objective To clarify the epidemiological characteristics and spatial distribution patterns of human norovirus outbreaks in China, identify high-risk areas, and provide guidance for epidemic prevention and control.Methods This study analyzed 964 human norovirus outbreaks involving 50,548 cases in 26 provinces reported from 2012 to 2018. Epidemiological analysis and spatiotemporal scanning analysis were conducted to analyze the distribution of norovirus outbreaks in China.Results The outbreaks showed typical seasonality, with more outbreaks in winter and fewer in summer, and the total number of infected cases increased over time. Schools, especially middle schools and primary schools, are the most common settings of norovirus outbreaks, with the major transmission route being life contact. More outbreaks occurred in southeast coastal areas in China and showed significant spatial aggregation. The highly clustered areas of norovirus outbreaks have expanded northeast over time.Conclusion By identifying the epidemiological characteristics and high-risk areas of norovirus outbreaks, this study provides important scientific support for the development of preventive and control measures for norovirus outbreaks, which is conducive to the administrative management of high-risk settings and reduction of disease burden in susceptible areas.
基金Hainan Province Science and Technology Special Fund(ZDKJ2021038)。
文摘Objective:To analyze the epidemiological characteristics of COVID-19 cases(Omicron variant BA5.1.3)in a hotel Fangcang shelter hospital in Sanya,Hainan Province,and provide basis for optimizing epidemic prevention and control strategies.Methods:The epidemiological data of COVID-19 cases admitted to a hotel Fangcang shelter hospital in Sanya from August 10 to August 30 in 2022 were collected for descriptive epidemiological analysis.Results:By August 30,703 cases of COVID-19 had been treated in the hotel Fangcang shelter hospital.The epidemiological characteristics analysis showed that 328 cases were male,accounting for 46.7%,and 375 cases were female,accounting for 53.3%.The ratio of male to female was 0.87:1.The age range was 8 months to 85 years old,with a median of 37(20,49)years old.The majority of people aged 31-59 years old,accounting for 51.4%.Asymptomatic infection accounted for 39.8%,and mild infection accounted for 60.2%,the main clinical symptoms were cough 24.8%(105/423),fever 18.7%(79/423).8.8%of the infected people had a history of chronic basic diseases,and hypertension and diabetes were the most common.There were 416 infected patients discharged from hospital,and the median total hospital stay was 14(10,15)days.The proportion of people who did not receive COVID-19 vaccine was 10.1%,the proportion of people who completed one,two and three vaccination was 5.0%,36.3%and 48.6%respectively,and the proportion of people who completed two and three vaccinations among people ≥60 years old was only 10.1%and 8.8%.Conclusion:This strain was the novel coronavirus variant BA5.1.3,which was reported for the first time in China.It was more infectious and insidious,and generally susceptible to people of all ages.Therefore,it is necessary to strengthen personal prevention and control,and did a good job of external anti input and internal anti diffusion,and strengthen nucleic acid detection to realize timely detection and early treatment,and strengthen COVID-19 vaccination,to improve vaccination rate and reduce infection rate.
基金sponsored by National Science and Technology Major Project No. 2016ZX10004222-001。
文摘Objective We aimed to assess the features of notifiable infectious diseases found commonly in foreign nationals in China between 2004 and 2017 to improve public health policy and responses for infectious diseases.Methods We performed a descriptive study of notifiable infectious diseases among foreigners reported from 2004 to 2017 in China using data from the Chinese National Notifiable Infectious Disease Reporting System(NNIDRIS). Demographic, temporal-spatial distribution were described and analyzed.Results A total of 67,939 cases of 33 different infectious diseases were reported among foreigners.These diseases were seen in 31 provinces of China and originated from 146 countries of the world. The infectious diseases with the highest incidence number were human immunodeficiency virus(HIV) of18,713 cases, hepatitis B(6,461 cases), hand, foot, and mouth disease(6,327 cases). Yunnan province had the highest number of notifiable infectious diseases in foreigners. There were different trends of the major infectious diseases among foreign cases seen in China and varied among provinces.Conclusions This is the first description of the epidemiological characteristic of notifiable infectious diseases among foreigners in China from 2004 to 2017. These data can be used to better inform policymakers about national health priorities for future research and control strategies.
文摘Objective:To understand the epidemic characters of COVID-19 epidemic in Hainan province of tropical China and provid evidences for the prevention and control of the epidemic.Methods:Data on the COVID-19 epidemic collected from Health Commission of Hainan Province were analyzed by using the methods of retrospective descriptive epidemiology.Results:From January 22nd to February 21st,2020,COVID-19 was diagnosed in 168 confirmed cases(including 8 severe cases)in Hainan Province with the temporary fatality rate of 2.38%of 4 deaths,and 96 cases discharged from hospital,with the cure rate of 57.14%.The cases were distributed in altogether 15 cities and counties in Hainan Province,among which 121 cases were distributed in Sanya,Haikou,Danzhou and Wanning,accounting for 72.02%of the total number of cases.Cases in Sanya City were mainly found in Tianya district and Jiyang district,accounting for 69.81%of the total number of cases in Sanya.Cases in Haikou City were mainly found in Qiongshan district and Xiuying district,accounting for 72.5%of the total number of cases in Haikou.Among the patients,there were 81 males and 87 females,with a male-to-female ratio of 1.1;the youngest age was 3 months,the oldest was 79 years old,80%of the patients were in the age group of 30 to 69 years old,and the number of children and adolescents under 20 years old were relatively low.Conclusion:The daily number of new confirmed cases showed a gradual downward trend in Hainan province,and the epidemic situation was in transition from imported to local renewal,mainly in close contact between family members.With the increase of personnel mobility such as the resumption of work by enterprises and the return of migrant workers to the island,there is a risk of agglomeration epidemic.Prevention and control work in urban and rural areas should take a two-pronged approach.Amid preventing imported cases,more proactive measures should be taken to prevent and control the spread of local cases.
文摘<strong>Introduction:</strong> The coronavirus disease 2019 (COVID-19) was declared as pandemic by WHO by March 11th. First case reported in Oman was on 24th February 2020 and later the country went through stages of epidemic progression. This study describes the sociodemographic and epidemiological characteristics of confirmed COVID-19 cases in Muscat governorate and related outcomes. <strong>Materials and Methods:</strong> This is a descriptive, exploratory analysis of all lab confirmed COVID 19 cases that were reported from 1st February to 31st May 2020. Data for the study was primarily extracted from notifications system established for surveillance (Tarassud). Secondary data sources were, contact listings and hospital medical records.<strong> Results:</strong> 11,648 initial cases of confirmed COVID-19 infections were included. The mean age was 35 years, 84.7% (N = 9862) were males, 25.9% (N = 3017) were Omanis, and 74.1% (N = 8631) were expatriates of which Indian origin were the majority (37%). Fever and cough were the most common presentations (46.3% and 29.5% respectively). Diabetes and hypertension were the most common comorbidities (4.9% and 4.6% respectively). Hospital admission was required for 7% (N = 811) of the total reported cases, out of them 171 cases (21%) were admitted to ICU, where 107 (13.2%) were ventilated. The case fatality rate (CFR) was 0.9%. 158 clusters containing 2949 contacts were identified from case records and categorised into 3 groups based on their exposure settings. The incubation period measured was 8 days (IQR 4.0 - 15.0) for workplace, 8 days (IQR 4 - 17) for dormitory and 4 days (IQR 2.0 - 7.0) for family groups. The secondary attack rate (SAR) estimated was 41.6% (95% CI: 0.34 - 0.48), 52% (95% CI: 0.40 - 0.63) and 33% (95% CI: 0.27 - 0.38) for workplace, dormitory and family groups, respectively. <strong>Conclusion:</strong> Results of this study, determine the transmission trend of COVID-19 in a country with high immigrant population. These findings could be utilised for further response planning in similar settings.
基金supported by the National Natural Science Foundation of China (82002130)supported by the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-026)
文摘Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.
基金funded by the National Natural Science Foundation of China(No.91846302)the National Science and Technology Major Project(No.2016ZX10004222).
文摘Background:With the progress of globalization,international mobility increases,greatly facilitating cross-border transmission of respiratory infectious diseases(RIDs).This study aimed to analyze the epidemiological characteristics and factors influencing imported RIDs,with the goal of providing evidence to support adoption of high-tech,intel-ligent methods to early find imported RIDs and prevent their spread in China.Methods:We obtained data of imported RIDs cases from 2014 to 2018 from the Inbound Sentinel Network of Customs and the National Notifiable Diseases Reporting System in China.We analyzed spatial,temporal,and population distribution characteristics of the imported RIDs.We developed an index to describe seasonality.Pearson correlation coefficients were used to examine associations between independent variables and imported cases.Data analyses and visualizations were conducted with R software.Results:From a total of 1409265253 inbound travelers,31732(2.25/100000)imported RIDs cases were reported.RIDs cases were imported from 142 countries and five continents.The incidence of imported RIDs was nearly 5 times higher in 2018(2.81/100000)than in 2014(0.58/100000).Among foreigners,incidence rates were higher among males(5.32/100000),0–14-year-olds(15.15/100000),and cases originating in Oceania(11.10/100000).The vast majority(90.3%)of imported RIDs were influenza,with seasonality consistent with annual seasonality of influenza.The spatial distribution of imported RIDs was different between Chinese citizens and foreigners.Increases in inbound travel volume and the number of influenza cases in source countries were associated with the number of imported RIDs.Conclusions:Our study documented importation of RIDs into China from 142 countries.Inbound travel poses a significant risks bringing important RIDs to China.It is urgent to strengthen surveillance at customs of inbound travelers and establish an intelligent surveillance and early warning system to prevent importation of RIDs to China for preventing further spread within China.
文摘BACKGROUND Pneumonia of uncertain cause has been reported in Wuhan,China since the beginning of early December 2019.In early January 2020,a novel strain ofβ-coronavirus was identified by the Chinese Center for Disease Control and Prevention from the pharyngeal swab specimens of patients,which was recently named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).There is evidence of human-to-human transmission and familial cluster outbreak of SARSCoV-2 infection.The World Health Organization(WHO)recently declared the SARS-CoV-2 epidemic a global health emergency.As of February 17,2020,71329 laboratory-confirmed cases(in 25 countries,including the United States and Germany)have been reported globally.Other than its rapid transmission,the epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)remain unclear.In December 2019,coronavirus disease(named COVID-19 by the WHO)associated with the SARS-CoV-2 emerged in Wuhan,China and spread quickly across the country.AIM To analyze the epidemiological and clinical characteristics of confirmed cases of this disease in Liaoning province,a Chinese region about 1800 km north of Wuhan.METHODS The clinical data of 56 laboratory-confirmed COVID-19 cases due to 2019-nCoV infection were analyzed.The cases originated from eight cities in Liaoning province.RESULTS The median age of the patients was 45 years,and 57.1%of them were male.No patient had been in direct contact with wild animals.Among them,23 patients(41.1%)had resided in or traveled to Wuhan,27 cases(48.2%)had been in contact with confirmed COVID-19 patients,5 cases(8.9%)had been in contact with confirmed patients with a contact history to COVID-19 patients,and 1 case(1.8%)had no apparent history of exposure.Fever(75.0%)and cough(60.7%)were the most common symptoms.The typical manifestations in lung computed tomography(CT)included ground-glass opacity and patchy shadows,with 67.8%of them being bilateral.Among the patients in the cohort,78.6%showed reduction in their lymphocyte counts,57.1%showed increases in their C-reactive protein levels,and 50.0%showed decreases in their blood albumin levels.Eleven patients(19.6%)were admitted to intensive care unit,2 patients(3.5%)progressed to acute respiratory distress syndrome,4 patients(7.1%)were equipped with non-invasive mechanical ventilation,and 1 patient(1.8)received extracorporeal membrane oxygenation support.There were 5 mild cases(5/56,8.9%),40 moderate cases(40/56,71.4%),10 severe cases(10/56,17.9%),and 1 critical case(1/56,1.8%).No deaths were reported.CONCLUSION SARS-CoV-2 can be transmitted among humans.Most COVID-19 patients show symptoms of fever,cough,lymphocyte reduction,and typical lung CT manifestations.Most are moderate cases.The seriousness of the disease(as indicated by blood oxygen saturation,respiratory rate,oxygenation index,blood lymphocyte count,and lesions shown in lung CT)is related to history of living in or traveling to Wuhan,underlying diseases,admittance to intensive care unit,and mechanical ventilation.
文摘Background Respiratory infectious diseases(RIDs)remain a pressing public health concern,posing a signifcant threat to the well-being and lives of individuals.This study delves into the incidence of seven primary RIDs dur‑ing the period 2017-2021,aiming to gain deeper insights into their epidemiological characteristics for the purpose of enhancing control and prevention strategies.Methods Data pertaining to seven notifable RIDs,namely,seasonal infuenza,pulmonary tuberculosis(PTB),mumps,scarlet fever,pertussis,rubella and measles,in the mainland of China between 2017 and 2021 were obtained from the National Notifable Disease Reporting System(NNDRS).Joinpoint regression software was utilized to analyze temporal trends,while SaTScan software with a Poisson probability model was used to assess seasonal and spatial patterns.Results A total of 11,963,886 cases of the seven RIDs were reported during 2017-2021,and yielding a fve-year aver‑age incidence rate of 170.73 per 100,000 individuals.Among these RIDs,seasonal infuenza exhibited the highest aver‑age incidence rate(94.14 per 100,000),followed by PTB(55.52 per 100,000),mumps(15.16 per 100,000),scarlet fever(4.02 per 100,000),pertussis(1.10 per 100,000),rubella(0.59 per 100,000),and measles(0.21 per 100,000).Males experi‑enced higher incidence rates across all seven RIDs.PTB incidence was notably elevated among farmers and individu‑als aged over 65,whereas the other RIDs primarily afected children and students under 15 years of age.The inci‑dences of PTB and measles exhibited a declining trend from 2017 to 2021(APC=−7.53%,P=0.009;APC=−40.87%,P=0.02),while the other fve RIDs peaked in 2019.Concerning seasonal and spatial distribution,the seven RIDs displayed distinct characteristics,with variations observed for the same RIDs across diferent regions.The proportion of laboratory-confrmed cases fuctuated among the seven RIDs from 2017 to 2021,with measles and rubella exhibit‑ing higher proportions and mumps and scarlet fever showing lower proportions.Conclusions The incidence of PTB and measles demonstrated a decrease in the mainland of China between 2017 and 2021,while the remaining fve RIDs reached a peak in 2019.Overall,RIDs continue to pose a signifcant public health challenge.Urgent action is required to bolster capacity-building eforts and enhance control and prevention strategies for RIDs,taking into account regional disparities and epidemiological nuances.With the rapid advancement of high-tech solutions,the development and efective implementation of a digital/intelligent RIDs control and pre‑vention system are imperative to facilitate precise surveillance,early warnings,and swift responses.
基金Autonomous Region's Key Research and Development Program of Science and Technology to Support the"Prevention and Control of the Pneumonia Epidemic due to Novel Coronavirus Infection"Special Project"Novel Coronavirus Infection Induced Pneumonia"(No.2020BEG03057)(2019-nCoV)Research on the Clinical Characteristics and Prevention and Treatment of Patients with Atypical SymptomsAutonomous Region's Key Research and Development Program to Support the Special Project of"Prevention and Control of Pneumonia Epidemic due to Novel Coronavirus Infection","Research on Process Optimization of Pneumonia Screening,Quarantine and Quarantine Release of Novel Coronavirus InfectionH(No.2020BEG03058)。
文摘Objective:To analyze the epidemiological characteristics of asymptomatic SARS-CoV-2 novel coronavirus infection cases in Yinchuan City,Ningxia.Methods:Cases of asymptomatic SARSCoV-2 novel coronavirus infections discovered in Yinchuan City from February 2020 to April 2020 were taken as the research subjects,epidemiological and laboratory examination data were collected,and statistics and analysis were conducted.Results:Among the 10 cases of asymptomatic infection,6 were males and 4 were females,with an average age of(34.3±2.1)years;2 cases had a history of living in Hubei,8 cases had a history of close contact with confirmed cases;6 cases had no other underlying diseases while the other 4 cases were accompanied by one or more underlying diseases;6 cases were diagnosed as asymptomatic infection by serum-specific IgM antibody detection;4 cases were diagnosed as asymptomatic infection by throat swab testing;there were 4 cases with alanine base transferase level higher than the normal range,2 cases with aspartate aminotransferase level higher than the normal range,and 3 cases with D-dimer level out of the normal range.Conclusion:The asymptomatic SARS-CoV-2 novel coronavirus infection has certain clinical characteristics;it is infectious and has insidious characteristics.Even if medical observation is dismissed,monitoring is still needed to prevent the pandemic from rebounding.
基金Research Programs of Ministry of Health and Ministry of Science Mandatory items (No 2006-209, No 2006-84)National ‘Eleventh Five-Year’ Sci-Tech Research Plan Major Project (No S200853)Project of Ministry of Health and Cancer Foundation of China (No 2006009)
文摘Background and Objective:In Guangxi province,from 1970s to 1990s,the mortality of primary liver cancer(PLC) ranked the first among a variety of malignant tumors.Investigating the epidemiological characteristics of PLC is very important for developing reasonable and effective treatment strategy,allocating health resources rationally,and evaluating the quality of PLC prevention and control.This study was to analyze the mortality and epidemiological characteristics of PLC in Guangxi province between 2004 and 2005.Methods:Multi-stage stratified cluster random sampling method was used to select 9 counties(cities or urban areas) as sample points.The residents' death causes between 2004 and 2005 were analyzed,and the epidemiological characteristics of PLC were investigated.Results:In the period of 2004-2005,the crude mortality of PLC was 34.39/100 000 in Guangxi province population(55.30/100 000 in men and 13.21/100 000 in women).The national population-standardized mortality in 1964 was 22.17/100 000.The man-to-woman ratio of mortality was 4.19:1.PLC ranked as the first death cause among a variety of malignant tumors,and PLC-related death accounted for 30.70% of all tumor-related death cases.Age-specific mortality of PLC was increased with age,rising significantly from 30-year-old(from 25-year-old in men and from 40-year-old in women),and reached a peak at 75-year-old.Conclusions:The mortality of PLC shows a decreasing trend in Guangxi province in the early 21st century,and the starting age of PLC death peak postpones about 10 years than that in 1990s.It shows that the comprehensive prevention and control measures of PLC implemented in Guangxi province are fruitful.However,the PLC mortality in Guangxi province is still significantly higher than the national average level,and it still ranks as the first death cause in a variety of malignant tumors in Guangxi province.PLC mainly occurs in middle-aged and elderly people.The prevention and treatment research of PLC still has a long way to go.
文摘The coronavirus disease 2019(COVID-19)pandemic,caused by the novel virus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in December 2019 in China and has led to a global public health emergency.Previously,it was known as 2019-nCoV and caused disease mainly through respiratory pathways.The COVID-19 outbreak is ranked third globally as the most highly pathogenic disease of the twenty-first century,after the outbreak of SARS-CoV and Middle East respiratory syndrome in 2002 and 2012,respectively.Clinical,laboratory,and diagnostic methodology have been demonstrated in some observational studies.No systematic reviews on COVID-19 have been published regarding the integration of COVID-19 outbreaks(monitoring,fate and treatment)with environmental and human health perspectives.Accordingly,this review systematically addresses environmental aspects of COVID-19 outbreak such as the origin of SARS-CoV-2,epidemiological characteristics,diagnostic methodology,treatment options and technological advancement for the prevention of COVID-19 outbreaks.Finally,we integrate COVID-19 outbreaks(monitoring,fate and treatment)with environmental and human health perspectives.We believe that this review will help to understand the SARS-CoV-2 outbreak as a multipurpose document,not only for the scientific community but also for global citizens.Countries should adopt emergency preparedness such as prepare human resources,infrastructure and facilities to treat severe COVID-19 as the virus spreads rapidly globally.
基金funded by the Shandong Medical and Health Science and Technology Development Program,grant number 202212061076.
文摘The emergence and prevalence of multidrug-resistant Acinetobacter baumannii(MRAB)poses a huge challenge to clinical treatment.To investigate the genetic and epidemiologic characteristics of MRAB in Liaocheng,China,and to explore potential resistance mechanisms,56 MRAB strains were collected from the clinical departments of seven hospitals in Liaocheng between 2020 and 2022.Molecular typing,antimicrobial resistance patterns,and epidemiological characteristics were determined by genome sequencing and comparative genome analysis.Sequence type(ST)540 was the most prevalent ST of the 56 MRAB in Liaocheng,and most strains(92.86%)were grouped into CC92.Core genome multilocus sequence typing subdivided the strains according to the number of allelic differences and could distinguish different outbreaks caused by ST540 isolates in the hospitals.All the isolates harbored blaOXA-23 and blaADC-25,and at least 92.86%of the isolates were resistant to 10 antibiotics.The major MRAB epidemic clone detected in Liaocheng was ST540,which was different from the results reported in other regions in China.Furthermore,several inter-hospital transmissions of ST540 isolates were observed.The findings highlight the urgent need for effective nosocomial infection control measures and the continuous surveillance of ST540 MRAB in Liaocheng.
基金This study was supported by the National Key R&D Program of China(Grant No.2019YFC1200705)the China Special Grant for the Prevention and Control of Infectious Diseases(Grant Nos.2018ZX10734401 and 2018ZX10734404)the Nature Science Fund of Inner Mongolia Autonomous Region(Grant No.2018MS08004).
文摘Background:Hinggan League is located in the Northeast of the Inner Mongolia Autonomous Region,the historically endemic area of animal and human brucellosis.In this study,the epidemiological characteristics of human brucellosis were analyzed,and the genotypic profile and antimicrobial susceptibilities of Brucella melitensis strains isolated from humans in Hinggan League were investigated.Methods:The epidemic characteristics were described using case number,constituent ratio,and rate.The 418 human blood samples were collected and tested by bacteriology,and suspect colonies were isolated and identified by conventional biotyping assays,the VITEK 2.0 microbial identification system,and AMOS(Brucella abortus,B.melitensis,B.ovis,and B.suis)-PCR.Subsequently,all strains were genotyped using multiple-locus variable-number tandem repeat analysis(MLVA)assays,and the antimicrobial susceptibility pattern of Brucella strains against the 10 most commonly used antibiotics was determined by microdilution method.Results:A total of 22848 cases of human brucellosis were reported from 2004 to 2019,with an annual average incidence of 87.2/100000.The incidence rates in developed areas of animal husbandry(Horqin Youyi Qianqi[161.2/100000]and Horqin Youyi Zhongqi[112.1/100000])were significantly higher than those in forest areas(Arxan[19.2/100000])(χ2=32.561,P<0.001).In addition,peak morbidity occurred during May–August,accounting for 72.6%(16582/22848)of cases.The highest number of cases occurred in the 40+age group,accounting for 44.4%(10137/22484)of cases,and morbidity in males was significantly higher than that in females in all age groups(χ2=299.97,P<0.001),the most common occupation was farmers.A total of 54 B.melitensis strains were divided into 37 genotypes(GT1–37)with 80–100%genetic similarity.All 25 strains were sensitive to seven tested antibiotics,phenotypic resistance to cotrimoxazole and azithromycin was observed in 5(20%)and 25(100%)of the isolates,respectively.Conclusions:Human brucellosis exhibited a significant increasing trend and B.melitensis is the main pathogen responsible for human brucellosis in this region.Improved surveillance of infected animals(sheep)and limiting their transfer and trade are optional strategies for decreasing the incidence of this disease.
基金This work was supported by Capital’s Funds for Health Improvement and Research(2020-2-1011,2022-1G-3014)High-level Public Health Technical Talents Construction Project(Academic Leader 02-07).
文摘Human astrovirus(HAstV)is one of the main pathogens that cause sporadic cases of acute gastroenteritis,sometimes leading to outbreaks.This study aimed to elucidate the epidemiological and etiological character-istics of HAstV outbreaks worldwide.Literature on HAstV outbreaks published before January 2022 was retrieved from the China National Knowledge Infrastructure,WanFang,WeiPu,PubMed,and Web of Science databases.Date,region,population,settings,transmission modes,clinical symptoms,and etiological characteristics of the outbreaks were collected and analyzed.Thirty-one articles on 32 HAstV outbreaks reported between November 1978 and October 2018 were included.The outbreaks mainly occurred in autumn(14/32,43.75%),and more of them were reported in 1996,2004,and 2017.Outbreaks were primarily dis-tributed in the Northern Hemisphere and mainly occurred in nursery centers and kindergartens(9/29,31.03%),hospitals(5/29,17.24%),and schools(4/29,13.79%).Viral genotypes were identified during 19 outbreaks,and HAstV-1 was predominant(8/19,42.10%).Eleven outbreaks were caused by mixed infection,and norovirus(9/11,81.82%)and rotavirus(5/11,45.45%)were the most common mixed pathogens.The transmission routes were reported in 9 outbreaks of mixed infection,and most(7/9)were related to water-borne and foodborne transmission.Although HAstV outbreaks are infrequently reported,it is necessary to con-sider HAstV in norovirus-negative gastroenteritis outbreaks.In addition,local Centers for Disease Control and Prevention should have the capacity to handle HAstV outbreaks and identify pathogens.
基金supported by grants from the Key Technologies Research and Development Program from the Ministry of Science and Technology(grant numbers:2018ZX10713002,2017ZX10104001,and 2018ZX10713001-003).
文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD.
基金QC acknowledges the support provided by the National Science and Technology Major Project of China(2018ZX10101002-003-002)YZ and ZYS acknowledge the support provided by the Public Health Emergency Response Mechanism Operation Program of Chinese Center for Disease Control and Prevention(131031001000210001).
文摘Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods: Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results: There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%;χ^(2) = 210.97,P < 0.05), with anRR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%;χ^(2)= 6.40,P < 0.05), with anRR of 1.93 (95%CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95%CI: 1.083-1.772,P= 0.009) and advanced age (OR: 1.095, 95%CI: 1.031-1.163,P= 0.01).Conclusions: The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality.
基金We thank the important work of SARS-CoV-2 genome data producers globally and especially the COVID-19 genomics UK(COG-UK)consortium contributing sequence data to the GISAID database.This work was supported by the Beijing Natural Science Foundation(M22029)National Key R&D Program of China(2021YFC2301300)+5 种基金Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB29010102)and National Natural Science Foundation of China(NSFC)(82161148010)J.Y.is supported by Special Program of China Postdoctoral Science Foundation(2020T130123ZX)Y.B.is supported by the NSFC Outstanding Young Scholars(31822055)Youth Innovation Promotion Association of CAS(Y2021034)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202208).
文摘A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues.Moreover,vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases have been reported.Further,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants emerged with mutations in spike(S)gene,the target of most current vaccines.Importantly,the mutations exhibit a trend of immune escape from the vaccination.Herein the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains elusive.We performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of COVID-19.In addition,we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation respectively.We found that vaccination coverage was negatively related to the infections,severe cases,and deaths of COVID-19 respectively.With the increasing vaccination coverage,the lineage diversity of SARS-CoV-2 dampened,but the rapid mutation rates of the S gene were identified,and the vaccination could be one of the explanations for driving mutations in S gene.Moreover,new epidemics resurged in several countries with high vaccination coverage,questioning their current pandemic control strategies.Hence,integrated vaccination and non-pharmacological interventions are critical to control the pandemic.Furthermore,novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility.
文摘The modelling is widely used in determining the best strategies for the mitigation of the impact of infectious diseases.Currently,the modelling of a complex system such as the spread of COVID-19 infection is among the topical issues.The aim of this article is graphbased modelling of the COVID-19 infection spread.The article investigates the studies related to the modelling of COVID-19 pandemic and analyses the factors affecting the spread of the disease and its main characteristics.We propose a conceptual model of COVID-19 epidemic by considering the social distance,the duration of contact with an infected person and their location-based demographic characteristics.Based on the hypothetical scenario of the spread of the virus,a graph model of the process are developed starting from the first confirmed infection case to human-to-human transmission of the virus and visualized by considering the epidemiological characteristics of COVID-19.The application of graph for the pandemic modelling allows for considering multiple factors affecting the epidemiological process and conducting numerical experiments.The advantage of this approach is justified with the fact that it enables the reverse analysis the spread as a result of the dynamic record of detected cases of the infection in the model.This approach allows for to determining undetected cases of infection based on the social distance and duration of contact and eliminating the uncertainty significantly.Note that social,economic,demographic factors,the population density,mental values and etc.affect the increase in number of cases of infection and hence,the research was not able to consider all factors.In future research will analyze multiple factors impacting the number of infections and their use in the models will be considered.
