Mixed-variable problems are inevitable in engineering. However, few researches pay attention to discrete variables. This paper proposed a mixed-variable experimental design method (ODCD): first, the design variables w...Mixed-variable problems are inevitable in engineering. However, few researches pay attention to discrete variables. This paper proposed a mixed-variable experimental design method (ODCD): first, the design variables were divided into discrete variables and continuous variables;then, the DVD method was employed for handling discrete variables, the LHD method was applied for continuous variables, and finally, a Columnwise-Pairwise Algorithm was used for the overall optimization of the design matrix. Experimental results demonstrated that the ODCD method outperforms in terms of the sample space coverage performance.展开更多
As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the...As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the population in SMO is not abundant.Thus,this paper focuses on how to reconstruct SMO to improve its performance,and a novel spider monkey optimization algorithm with opposition-based learning and orthogonal experimental design(SMO^(3))is developed.A position updatingmethod based on the historical optimal domain and particle swarmfor Local Leader Phase(LLP)andGlobal Leader Phase(GLP)is presented to improve the diversity of the population of SMO.Moreover,an opposition-based learning strategy based on self-extremum is proposed to avoid suffering from premature convergence and getting stuck at locally optimal values.Also,a local worst individual elimination method based on orthogonal experimental design is used for helping the SMO algorithm eliminate the poor individuals in time.Furthermore,an extended SMO^(3)named CSMO^(3)is investigated to deal with constrained optimization problems.The proposed algorithm is applied to both unconstrained and constrained functions which include the CEC2006 benchmark set and three engineering problems.Experimental results show that the performance of the proposed algorithm is better than three well-known SMO algorithms and other evolutionary algorithms in unconstrained and constrained problems.展开更多
Experimentation has come a long in helping researchers achieve breakthroughs in their different scientific areas and engineering happens to be one of those areas with the most impact from experimental advancement. The...Experimentation has come a long in helping researchers achieve breakthroughs in their different scientific areas and engineering happens to be one of those areas with the most impact from experimental advancement. The need for valid experimental results free from biases and confounding conclusions has prompted the development of new experimental techniques that takes consideration of all applicable factor and combinations in providing answers on a research topic, and the Factorial Experimental design credited to Sir Ronald Fisher is one technique yielding highly valid results. This paper uses the factorial design of experiments to research the flexural impact of polyvinyl acetate fiber and layered concrete in construction. The experiment considered two levels of fiber contents and two levels of layers, and prepared samples with all combinations of the variable factors. The samples were tested after 7 days from casting for flexural strength and an advance statistical analysis was performed on the flexural responses of the samples using R-program. The results from the analyses revealed the significance of the variables to the flexural strength of the samples, as well as their interactions. The experiment concluded that based on the number of layers and fiber content used for the experiment, casting concrete in layers does have a significant negative effect on the flexural strength of concrete, and the failure pattern of concrete members under flexural load in evidently influenced by the material composition of the concrete, and that it can be evidently influenced by casting the concrete in layers.展开更多
In response to the main problems in commonly used model selection methods,a method was proposed to apply the concept of experimental design to the optimization of uncertain reservoir models.Firstly,based on the actual...In response to the main problems in commonly used model selection methods,a method was proposed to apply the concept of experimental design to the optimization of uncertain reservoir models.Firstly,based on the actual situation of the oil field,the uncertain variables were determined that affect the geological reserves of the model and their possible range of variation,and experimental design was used to determine the modeling plan.Then,multiple geological models were established and reserves were calculated,and multiple regression was performed between uncertain variables and the corresponding geological reserves of the model.Finally,Monte Carlo simulation technology was applied to determine the parameters of the P10,P50,and P90 models for probabilistic reserves,and P10,P50,and P90 models were established.This method is not only more objective and time-saving in the application process,but also can determine the main geological variables that affect geological reserves,providing a new idea for evaluating the uncertainty of geological reserves.展开更多
The computer system platform course is a comprehensive platform course formed by modifying and optimizing the content of the relevant basic courses of computer major to meet the requirement for basic computer knowledg...The computer system platform course is a comprehensive platform course formed by modifying and optimizing the content of the relevant basic courses of computer major to meet the requirement for basic computer knowledge in digital media technology major.The scope and extent of the course content make its experimental design more challenging.By considering the scope of contents,the difficulty of experiments,and the rationality of intrinsic logic,the experiments covering from operating system to computer network are designed.The relevance and continuity of the experiments are ensured,so as to achieve the goals of promoting students’understanding of key concepts,improving their hands-on ability,cultivating their interest,and guiding their self-learning within the limited class time.展开更多
The inverse heat conduction method is one of methods to identify the casting simulation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized funct...The inverse heat conduction method is one of methods to identify the casting simulation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized functional was established, and the functional was solved by the sensitivity coefficient and Newtonaphson iteration method. Moreover, the orthogonal experimental design was used to estimate the appropriate initial value and variation domain of each variable to decrease the number of iteration and improve the identification accuracy and efficiency. It illustrated a detailed case of AlSiTMg sand mold casting and the temperature measurement experiment was done. The physical properties of sand mold and the interracial heat transfer coefficient were identified at the meantime. The results indicated that the new regularization method was efficient in overcoming the ill-posedness of the inverse heat conduction problem and improving the stability and accuracy of the solutions.展开更多
Experimental design was applied in the optimization of crude oil adsorption from saline waste water using raw bagasse.The application of response surface methodology(RSM) was presented with temperature,salinity of wat...Experimental design was applied in the optimization of crude oil adsorption from saline waste water using raw bagasse.The application of response surface methodology(RSM) was presented with temperature,salinity of water,pH,adsorbent dose,and initial oil content as factors.A quadratic model could be used to approximate the mathematical relationship of crude oil removal on the five significant independent variables.Predicted values and experimental values are found to be in good agreement with R2 of 97.44%.The result of optimization shows that the maximum crude oil removal is equal to 67.38% under the optimal condition of temperature of 46.53 °C,salinity of 37.2 g/L,pH of 3,adsorbent dose of 9 g/L and initial oil content of 300×10-6.展开更多
Iterated local search(ILS)is used to construct the optimal experimental designs for multi-dimensional constrained spaces,in which the inner loop is based on the stochastic coordinate-exchange(SCE)algorithm.Every time ...Iterated local search(ILS)is used to construct the optimal experimental designs for multi-dimensional constrained spaces,in which the inner loop is based on the stochastic coordinate-exchange(SCE)algorithm.Every time a local optimal solution is found by the SCE algorithm,the perturbation operator is applied to it,and then a new solution is explored in the areas where the exchange of coordinates may produce improvement,so as to retain the features and attributes of the current optimal solution and avoid the defects of random restart.We implement the iterated local coordinate-exchange algorithm for experimental designs in the multi-dimensional constrained spaces.In addition,sensitivity analysis was conducted to analyze the impacts of the parameters on the performance of the proposed algorithm.Also we compared the performance of the proposed algorithm to the SCE algorithm using the random restart strategy.The analysis shows that the proposed algorithm is better than the SCE algorithm in terms of efficiency and quality,especially in the experimental designs for high-dimensional constrained space.展开更多
New HPLC method was developed for determination of amlodipine and valsartan in their binary mixture as a part of routine control of combined formulations. The method was validated to meet official requirements includi...New HPLC method was developed for determination of amlodipine and valsartan in their binary mixture as a part of routine control of combined formulations. The method was validated to meet official requirements including selectivity, stability, linearity, precision and accuracy. Chromatography was carried out using a LiChrospher RP-18 column, a mixture containing acetonitrile, phosphate buffer of pH 3.5 and methanol (45:45:10, v/v/v) and new fluorescence detection at 255 nm for excitation and 448 nm for emission. The effect of methanol content, pH of the buffer, flow rate, detection wavelengths and column temperature was estimated in robustness study, according to a plan defined by the Plackett-Burman design. For identification of significant effects, both graphical and statistical methods were used. Ro-bustness for dissolution test was checked estimating the effects of paddle speed, temperature and pH of dissolution medium. The method was proved to complying with all official guidelines. Therefore, it is suitable for determination of amlodipine and valsartan in their binary mixtures for different analytical and pharmaceutical purposes.展开更多
Method validation presents a detailed investigation of analytical method and provision of the evidence that the method, when correctly applied, produces results that fit to the purpose. In order to achieve the method ...Method validation presents a detailed investigation of analytical method and provision of the evidence that the method, when correctly applied, produces results that fit to the purpose. In order to achieve the method validation scope efficiently, experimental design presents a very useful tool. The greatest benefits of such approach could be seen in robustness testing through the provision of very useful data about the control of the chromatograp6hic system during the routine application. In this paper, robustness testing of the LC method proposed for the determination of raloxifene hydrochloride and its four impurities was done employing Plackett-Burman design. Applying this design, the effect of five real factors （acetonitrile content, sodium dodecyl sulfate content, column temperature, pH of the mobile phase and flow rate） on the corresponding resolution factors was investigated through twelve experiments. Furthermore, the insignificance intervals for significant factors were calculated and the parameters for system suitability tests were defined. Eventually, the other validation parameters were tested and the effectiveness of the proposed analytical method with a high degree of accuracy was confirmed.展开更多
Different Ziegler-Natta catalysts were employed to polymerize ethylene. To investigate the influences of reaction parameters, namely Al/Ti molar ratio, hydrogen and processing parameters, i.e. ethylene pressure and te...Different Ziegler-Natta catalysts were employed to polymerize ethylene. To investigate the influences of reaction parameters, namely Al/Ti molar ratio, hydrogen and processing parameters, i.e. ethylene pressure and temperature, a Taguchi experimental design was worked out. An L27 orthogonal array was chosen to take the above-mentioned parameters and relevant interactions into account. Response surface method was the tool used to analyze the experimental design results. Al/Ti, ethylene pressure and temperature were selected as experimental design factors, and catalyst activity and polymerization yield were the response parameters. Increasing pressure, due to an increment in monomer accessibility, and rising Al/Ti, because of higher reduction in the catalysts, cause an increase in both polymerization yield and catalyst activity. Nonetheless, a higher temperature, thanks to reducing ethylene solubility in the slurry medium and partially catalyst destruction, lead to a reduction in both response parameters. A synergistic effect was also observed between temperature and pressure. All catalyst activities will reduce in the presence of hydrogen. Molecular weight also shows a decline in the presence of hydrogen as a transfer agent. However, the polydispersity index remains approximately intact. Using SEM, various morphologies, owing to different catalyst morphologies, were seen for the polyethylene.展开更多
The effect of formulation variables on in-vitro release and permeation properties of carvedilol from transdermal patch was studied by varying one factor at a time as preliminary study.Based on these results,design of ...The effect of formulation variables on in-vitro release and permeation properties of carvedilol from transdermal patch was studied by varying one factor at a time as preliminary study.Based on these results,design of experiments technique was applied followed by regression analysis and response surface methodology to optimize formulation variables.Central Composite IV model design was used with four formulation variables:drug loading,matrix thickness,adhesive layer thickness,and propylene glycol concentration.Nineteen formulations were prepared according to the design;and the effect of formulation variables was studied on in-vitro release and permeation profiles of these formulations.In all cases,the permeation profiles paralleled in-vitro release profiles.The drug released at 7 h and 24 h was used as release response parameters while permeation flux obtained was employed as permeation response parameter.All four formulation variables were found to be significant for release properties and three of these exhibited significant effect on permeation profile of carvedilol across artificial membrane.Constrained optimization,using 47.9%of cumulative carvedilol released at 7 h and 99.8%at 24 h as well as 25.7 mg/cm2/h of permeation flux,was applied to obtain desired release and permeation profiles.Experimentally,carvedilol was observed to release from the optimized formulation with 51.4%drug release at 7 h and 98.5%at 24 h with an observed flux value of 27.4 mg/cm2/h across artificial membrane,which showed an excellent agreement with the predicted values.The results of this investigation show that the quadratic mathematical model developed could be used to further predict formulations with desirable release and permeation properties.展开更多
For mistakes taken in pesticide bioassays, teaching experimental design is improved in the paper, so as to let students explore and analyze in teaching experiments to get a deeper understanding of theoretical knowledg...For mistakes taken in pesticide bioassays, teaching experimental design is improved in the paper, so as to let students explore and analyze in teaching experiments to get a deeper understanding of theoretical knowledge, thereby effectively avoiding frequently-taken mistakes in pesticide bioassays.展开更多
The penetration modeling of an adhesive into the fiber requires the measurement of various properties of resin and fiber： the resin viscosity, its surface tension, the penetration depth and the timber pore radius. Th...The penetration modeling of an adhesive into the fiber requires the measurement of various properties of resin and fiber： the resin viscosity, its surface tension, the penetration depth and the timber pore radius. This study is based on the screening technique that identifies the factors sensed by the experimenter. In order to determine the optimum processing conditions and find the combination of parameters that maximize the productivity in the experimental phase, a geometric illustration of the response has been made. The results are： the pores radius （4 μm）, surface tension （62.5 mN/m）, depth （10 μm） and viscosity （2,000 Cp）.展开更多
This study was concerned on the influence of cooking liquor parameters i.e. active alkali （AA） and sulfidity, on the properties of pulp produced from Thai bamboo by means of multivariate analysis. The investigated p...This study was concerned on the influence of cooking liquor parameters i.e. active alkali （AA） and sulfidity, on the properties of pulp produced from Thai bamboo by means of multivariate analysis. The investigated pulp properties were cooking yield and viscosity. The experiments were performed according to a face centered cube experimental design. Then, multiple linear regression （MLR） of independent and dependent variables were conducted with SPSS software using least square method. In order to optimize process, Pareto-Optimality method was employed. The obtained regression models were characterized by both descriptive and predictive ability （R^2 ≥ 95% and Rcv^2 ≥ 93%） and allowed the kraft pulping process with an acceptable viscosity （ 1110- 1 190 ml/g） and a total yield about 50% at a sulfidity level of 20-30% with 18% AA. Results indicated that high sulfidity at a lower AA could get high viscosity and relatively low kappa number for pulps. Also oxygen delignification was studied in this research.展开更多
Due to the scarcity of fossil fuels in the world, there is increasing interest in the commercial production of biodiesel, which leads to obtaining large amounts of glycerol as a byproduct. If not disposed of properly,...Due to the scarcity of fossil fuels in the world, there is increasing interest in the commercial production of biodiesel, which leads to obtaining large amounts of glycerol as a byproduct. If not disposed of properly, glycerol can generate environmental impact. One of the promises, the application of the crude glycerol is the production of citric acid by microbial fermentation. Citric acid is industrially produced by a submerged fermentation process with Aspergillus niger, using sucrose as carbon source, but due to increased demand for citric acid, alternative processes using renewable sources or waste materials as substrates and the cultivation of yeast strains are being studied. The aim of the study was to determine the best culture condition for maximum citric acid synthesis and lower isocitric acid production from crude glycerol through experimental design tool. For this purpose, the yeast strain Yarrowia lipolytica IMUFRJ-50682 was cultivated in nitrogen-limited glycerol-based media. Therefore, glycerol and yeast extract concentrations and agitation speed were evaluated as independent variables. With pure glycerol, the highest citric acid production achieved was 16.5 g/L with an isocitric acid production of 7.7% （in relation to citric acid）. With crude glycerol, citric acid production reduced to 6.7 g/L because of higher biomass yield. Therefore, an increase in the initial carbon to nitrogen molar ratio from 714 to 1,561 was necessary to increase citric acid production to 9.2 g/L, reducing isocitric acid production and to achieve a yield of 0.41 g of citric acid per glycerol consumed. In this condition, less nitrogen source was used, reducing production costs.展开更多
The Statistical Experimental Design techniques are the most powerful tools for the chemical reactors experimental modeling. Empirical models can be formulated for representing the chemical behavior of reactors with th...The Statistical Experimental Design techniques are the most powerful tools for the chemical reactors experimental modeling. Empirical models can be formulated for representing the chemical behavior of reactors with the minimal effort in the necessary number of experimental runs, hence, minimizing the consumption of chemicals and the consumption of time due to the reduction in the number of experimental runs and increasing the certainty of the results. Four types of nonthermal plasma reactors were assayed seeking for the highest efficiency in obtaining hydrogen and ethylene. Three different geometries for AC high voltage driven reactors, and only a single geometry for a DC high voltage pulse driven reactor were studied. According to the fundamental principles of chemical kinetics and considering an analogy among the reaction rate and the applied power to the plasma reactor, the four reactors are modeled following the classical chemical reactors design to understand if the behavior of the nonthermal plasma reactors can be regarded as the chemical reactors following the flow patterns of PFR (Plug Flow Reactor) or CSTR (Continuous Stirred Tank Reactor). Dehydrogenation is a common elimination reaction that takes place in nonthermal plasmas. Owing to this characteristic, a paraffinic heavy oil with an average molecular weight corresponding to C15 was used to study the production of light olefins and hydrogen.展开更多
DOE （design of experiments） is a systematic, rigorous approach to engineering problem-solving that applies principles and techniques at the data collection stage so as to ensure the generation of valid, defensible, ...DOE （design of experiments） is a systematic, rigorous approach to engineering problem-solving that applies principles and techniques at the data collection stage so as to ensure the generation of valid, defensible, and supportable engineering conclusions. This paper presents a comparison of three different experimental designs （full experimental design, fractional design and Taguchi design） aimed at studying the effects of cutting parameters variations on surface finish. The results revealed that the effects obtained by analyzing both fractional and Taguchi designs were comparable to the main effects and two-level interactions obtained by the full factorial design. Thus, we conclude that full factorial design appear to be reliable and more economical since they permit to reduce by a factor the amount of time and effort required to conduct the experimental design without losing valuable information. Thus, we conclude that full factorial design appear to be reliable and more economical and without losing valuable information.展开更多
The aim of this study was to determine the optimum design mix to produce pre-cast concrete blocks by a completely random experimental design (CRED) with mixture and process variables. The polymerized concrete was stud...The aim of this study was to determine the optimum design mix to produce pre-cast concrete blocks by a completely random experimental design (CRED) with mixture and process variables. The polymerized concrete was studied its composition: Cement, and water defined as the mixture compounds. To choose the best model, all the possible models were assessed through the ANOVA, which tested each possible model. The linear-linear model was preferred, since that do not present evidence of lack of fit, and it is capable of relating how to react the process variables, when are changed the variable mixture condition levels. The optimum experimental condition, obtained for the polymerized concrete, was: The size of the polystyrene beads was 4.8 mm sized polystyrene beads, 5.0% polystyrene that replaced the aggregate, 18.3% cement, 73.4% aggregate and 8.3% water. In this condition, the blocks made with polymerized concrete show a compressive strength above 15 Mpa, allowing its utilization in paving.展开更多
Experimental Design and Data Processing is an important core professional basic course for food science majors.This course is theoretical and practical,and there are many formulas,abstract contents and difficult to un...Experimental Design and Data Processing is an important core professional basic course for food science majors.This course is theoretical and practical,and there are many formulas,abstract contents and difficult to understand,and there are some problems in the teaching process,such as students1 poor interest in learning,insufficient mastery of what they have learned,and inability to combine theory with practice organically.Through analyzing the existing problems,this paper puts forward some reform measures for the teaching mode of experimental design and data processing by using the intelligent teaching of Superstar platform.展开更多
文摘Mixed-variable problems are inevitable in engineering. However, few researches pay attention to discrete variables. This paper proposed a mixed-variable experimental design method (ODCD): first, the design variables were divided into discrete variables and continuous variables;then, the DVD method was employed for handling discrete variables, the LHD method was applied for continuous variables, and finally, a Columnwise-Pairwise Algorithm was used for the overall optimization of the design matrix. Experimental results demonstrated that the ODCD method outperforms in terms of the sample space coverage performance.
基金supported by the First Batch of Teaching Reform Projects of Zhejiang Higher Education“14th Five-Year Plan”(jg20220434)Special Scientific Research Project for Space Debris and Near-Earth Asteroid Defense(KJSP2020020202)+1 种基金Natural Science Foundation of Zhejiang Province(LGG19F030010)National Natural Science Foundation of China(61703183).
文摘As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the population in SMO is not abundant.Thus,this paper focuses on how to reconstruct SMO to improve its performance,and a novel spider monkey optimization algorithm with opposition-based learning and orthogonal experimental design(SMO^(3))is developed.A position updatingmethod based on the historical optimal domain and particle swarmfor Local Leader Phase(LLP)andGlobal Leader Phase(GLP)is presented to improve the diversity of the population of SMO.Moreover,an opposition-based learning strategy based on self-extremum is proposed to avoid suffering from premature convergence and getting stuck at locally optimal values.Also,a local worst individual elimination method based on orthogonal experimental design is used for helping the SMO algorithm eliminate the poor individuals in time.Furthermore,an extended SMO^(3)named CSMO^(3)is investigated to deal with constrained optimization problems.The proposed algorithm is applied to both unconstrained and constrained functions which include the CEC2006 benchmark set and three engineering problems.Experimental results show that the performance of the proposed algorithm is better than three well-known SMO algorithms and other evolutionary algorithms in unconstrained and constrained problems.
文摘Experimentation has come a long in helping researchers achieve breakthroughs in their different scientific areas and engineering happens to be one of those areas with the most impact from experimental advancement. The need for valid experimental results free from biases and confounding conclusions has prompted the development of new experimental techniques that takes consideration of all applicable factor and combinations in providing answers on a research topic, and the Factorial Experimental design credited to Sir Ronald Fisher is one technique yielding highly valid results. This paper uses the factorial design of experiments to research the flexural impact of polyvinyl acetate fiber and layered concrete in construction. The experiment considered two levels of fiber contents and two levels of layers, and prepared samples with all combinations of the variable factors. The samples were tested after 7 days from casting for flexural strength and an advance statistical analysis was performed on the flexural responses of the samples using R-program. The results from the analyses revealed the significance of the variables to the flexural strength of the samples, as well as their interactions. The experiment concluded that based on the number of layers and fiber content used for the experiment, casting concrete in layers does have a significant negative effect on the flexural strength of concrete, and the failure pattern of concrete members under flexural load in evidently influenced by the material composition of the concrete, and that it can be evidently influenced by casting the concrete in layers.
基金supported by Tangshan Normal University Scientific Research Fund Project (2019A08)Hebei Provincial Natural Science Youth Fund Project (D2022105002).
文摘In response to the main problems in commonly used model selection methods,a method was proposed to apply the concept of experimental design to the optimization of uncertain reservoir models.Firstly,based on the actual situation of the oil field,the uncertain variables were determined that affect the geological reserves of the model and their possible range of variation,and experimental design was used to determine the modeling plan.Then,multiple geological models were established and reserves were calculated,and multiple regression was performed between uncertain variables and the corresponding geological reserves of the model.Finally,Monte Carlo simulation technology was applied to determine the parameters of the P10,P50,and P90 models for probabilistic reserves,and P10,P50,and P90 models were established.This method is not only more objective and time-saving in the application process,but also can determine the main geological variables that affect geological reserves,providing a new idea for evaluating the uncertainty of geological reserves.
文摘The computer system platform course is a comprehensive platform course formed by modifying and optimizing the content of the relevant basic courses of computer major to meet the requirement for basic computer knowledge in digital media technology major.The scope and extent of the course content make its experimental design more challenging.By considering the scope of contents,the difficulty of experiments,and the rationality of intrinsic logic,the experiments covering from operating system to computer network are designed.The relevance and continuity of the experiments are ensured,so as to achieve the goals of promoting students’understanding of key concepts,improving their hands-on ability,cultivating their interest,and guiding their self-learning within the limited class time.
文摘The inverse heat conduction method is one of methods to identify the casting simulation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized functional was established, and the functional was solved by the sensitivity coefficient and Newtonaphson iteration method. Moreover, the orthogonal experimental design was used to estimate the appropriate initial value and variation domain of each variable to decrease the number of iteration and improve the identification accuracy and efficiency. It illustrated a detailed case of AlSiTMg sand mold casting and the temperature measurement experiment was done. The physical properties of sand mold and the interracial heat transfer coefficient were identified at the meantime. The results indicated that the new regularization method was efficient in overcoming the ill-posedness of the inverse heat conduction problem and improving the stability and accuracy of the solutions.
文摘Experimental design was applied in the optimization of crude oil adsorption from saline waste water using raw bagasse.The application of response surface methodology(RSM) was presented with temperature,salinity of water,pH,adsorbent dose,and initial oil content as factors.A quadratic model could be used to approximate the mathematical relationship of crude oil removal on the five significant independent variables.Predicted values and experimental values are found to be in good agreement with R2 of 97.44%.The result of optimization shows that the maximum crude oil removal is equal to 67.38% under the optimal condition of temperature of 46.53 °C,salinity of 37.2 g/L,pH of 3,adsorbent dose of 9 g/L and initial oil content of 300×10-6.
基金This work was supported by the National Natural Science Foundation of China(72171231).
文摘Iterated local search(ILS)is used to construct the optimal experimental designs for multi-dimensional constrained spaces,in which the inner loop is based on the stochastic coordinate-exchange(SCE)algorithm.Every time a local optimal solution is found by the SCE algorithm,the perturbation operator is applied to it,and then a new solution is explored in the areas where the exchange of coordinates may produce improvement,so as to retain the features and attributes of the current optimal solution and avoid the defects of random restart.We implement the iterated local coordinate-exchange algorithm for experimental designs in the multi-dimensional constrained spaces.In addition,sensitivity analysis was conducted to analyze the impacts of the parameters on the performance of the proposed algorithm.Also we compared the performance of the proposed algorithm to the SCE algorithm using the random restart strategy.The analysis shows that the proposed algorithm is better than the SCE algorithm in terms of efficiency and quality,especially in the experimental designs for high-dimensional constrained space.
文摘New HPLC method was developed for determination of amlodipine and valsartan in their binary mixture as a part of routine control of combined formulations. The method was validated to meet official requirements including selectivity, stability, linearity, precision and accuracy. Chromatography was carried out using a LiChrospher RP-18 column, a mixture containing acetonitrile, phosphate buffer of pH 3.5 and methanol (45:45:10, v/v/v) and new fluorescence detection at 255 nm for excitation and 448 nm for emission. The effect of methanol content, pH of the buffer, flow rate, detection wavelengths and column temperature was estimated in robustness study, according to a plan defined by the Plackett-Burman design. For identification of significant effects, both graphical and statistical methods were used. Ro-bustness for dissolution test was checked estimating the effects of paddle speed, temperature and pH of dissolution medium. The method was proved to complying with all official guidelines. Therefore, it is suitable for determination of amlodipine and valsartan in their binary mixtures for different analytical and pharmaceutical purposes.
基金the Ministry of Education and Science ofthe Republic of Serbia for supporting these investigations through the Project 172052
文摘Method validation presents a detailed investigation of analytical method and provision of the evidence that the method, when correctly applied, produces results that fit to the purpose. In order to achieve the method validation scope efficiently, experimental design presents a very useful tool. The greatest benefits of such approach could be seen in robustness testing through the provision of very useful data about the control of the chromatograp6hic system during the routine application. In this paper, robustness testing of the LC method proposed for the determination of raloxifene hydrochloride and its four impurities was done employing Plackett-Burman design. Applying this design, the effect of five real factors （acetonitrile content, sodium dodecyl sulfate content, column temperature, pH of the mobile phase and flow rate） on the corresponding resolution factors was investigated through twelve experiments. Furthermore, the insignificance intervals for significant factors were calculated and the parameters for system suitability tests were defined. Eventually, the other validation parameters were tested and the effectiveness of the proposed analytical method with a high degree of accuracy was confirmed.
文摘Different Ziegler-Natta catalysts were employed to polymerize ethylene. To investigate the influences of reaction parameters, namely Al/Ti molar ratio, hydrogen and processing parameters, i.e. ethylene pressure and temperature, a Taguchi experimental design was worked out. An L27 orthogonal array was chosen to take the above-mentioned parameters and relevant interactions into account. Response surface method was the tool used to analyze the experimental design results. Al/Ti, ethylene pressure and temperature were selected as experimental design factors, and catalyst activity and polymerization yield were the response parameters. Increasing pressure, due to an increment in monomer accessibility, and rising Al/Ti, because of higher reduction in the catalysts, cause an increase in both polymerization yield and catalyst activity. Nonetheless, a higher temperature, thanks to reducing ethylene solubility in the slurry medium and partially catalyst destruction, lead to a reduction in both response parameters. A synergistic effect was also observed between temperature and pressure. All catalyst activities will reduce in the presence of hydrogen. Molecular weight also shows a decline in the presence of hydrogen as a transfer agent. However, the polydispersity index remains approximately intact. Using SEM, various morphologies, owing to different catalyst morphologies, were seen for the polyethylene.
基金The authors acknowledge financial assistance and research facilities provided by College of Pharmacy and Health Sciences,St.John’s University to carry out this research。
文摘The effect of formulation variables on in-vitro release and permeation properties of carvedilol from transdermal patch was studied by varying one factor at a time as preliminary study.Based on these results,design of experiments technique was applied followed by regression analysis and response surface methodology to optimize formulation variables.Central Composite IV model design was used with four formulation variables:drug loading,matrix thickness,adhesive layer thickness,and propylene glycol concentration.Nineteen formulations were prepared according to the design;and the effect of formulation variables was studied on in-vitro release and permeation profiles of these formulations.In all cases,the permeation profiles paralleled in-vitro release profiles.The drug released at 7 h and 24 h was used as release response parameters while permeation flux obtained was employed as permeation response parameter.All four formulation variables were found to be significant for release properties and three of these exhibited significant effect on permeation profile of carvedilol across artificial membrane.Constrained optimization,using 47.9%of cumulative carvedilol released at 7 h and 99.8%at 24 h as well as 25.7 mg/cm2/h of permeation flux,was applied to obtain desired release and permeation profiles.Experimentally,carvedilol was observed to release from the optimized formulation with 51.4%drug release at 7 h and 98.5%at 24 h with an observed flux value of 27.4 mg/cm2/h across artificial membrane,which showed an excellent agreement with the predicted values.The results of this investigation show that the quadratic mathematical model developed could be used to further predict formulations with desirable release and permeation properties.
基金Supported by Construction Project of " National Teaching Team of Plant Protection" in 2008Construction Project of National " Plant Protection Specialty"( TS11138)Provincial Excellent Course Construction Project of Pesticide Science in Yunnan Province
文摘For mistakes taken in pesticide bioassays, teaching experimental design is improved in the paper, so as to let students explore and analyze in teaching experiments to get a deeper understanding of theoretical knowledge, thereby effectively avoiding frequently-taken mistakes in pesticide bioassays.
文摘The penetration modeling of an adhesive into the fiber requires the measurement of various properties of resin and fiber： the resin viscosity, its surface tension, the penetration depth and the timber pore radius. This study is based on the screening technique that identifies the factors sensed by the experimenter. In order to determine the optimum processing conditions and find the combination of parameters that maximize the productivity in the experimental phase, a geometric illustration of the response has been made. The results are： the pores radius （4 μm）, surface tension （62.5 mN/m）, depth （10 μm） and viscosity （2,000 Cp）.
文摘This study was concerned on the influence of cooking liquor parameters i.e. active alkali （AA） and sulfidity, on the properties of pulp produced from Thai bamboo by means of multivariate analysis. The investigated pulp properties were cooking yield and viscosity. The experiments were performed according to a face centered cube experimental design. Then, multiple linear regression （MLR） of independent and dependent variables were conducted with SPSS software using least square method. In order to optimize process, Pareto-Optimality method was employed. The obtained regression models were characterized by both descriptive and predictive ability （R^2 ≥ 95% and Rcv^2 ≥ 93%） and allowed the kraft pulping process with an acceptable viscosity （ 1110- 1 190 ml/g） and a total yield about 50% at a sulfidity level of 20-30% with 18% AA. Results indicated that high sulfidity at a lower AA could get high viscosity and relatively low kappa number for pulps. Also oxygen delignification was studied in this research.
文摘Due to the scarcity of fossil fuels in the world, there is increasing interest in the commercial production of biodiesel, which leads to obtaining large amounts of glycerol as a byproduct. If not disposed of properly, glycerol can generate environmental impact. One of the promises, the application of the crude glycerol is the production of citric acid by microbial fermentation. Citric acid is industrially produced by a submerged fermentation process with Aspergillus niger, using sucrose as carbon source, but due to increased demand for citric acid, alternative processes using renewable sources or waste materials as substrates and the cultivation of yeast strains are being studied. The aim of the study was to determine the best culture condition for maximum citric acid synthesis and lower isocitric acid production from crude glycerol through experimental design tool. For this purpose, the yeast strain Yarrowia lipolytica IMUFRJ-50682 was cultivated in nitrogen-limited glycerol-based media. Therefore, glycerol and yeast extract concentrations and agitation speed were evaluated as independent variables. With pure glycerol, the highest citric acid production achieved was 16.5 g/L with an isocitric acid production of 7.7% （in relation to citric acid）. With crude glycerol, citric acid production reduced to 6.7 g/L because of higher biomass yield. Therefore, an increase in the initial carbon to nitrogen molar ratio from 714 to 1,561 was necessary to increase citric acid production to 9.2 g/L, reducing isocitric acid production and to achieve a yield of 0.41 g of citric acid per glycerol consumed. In this condition, less nitrogen source was used, reducing production costs.
文摘The Statistical Experimental Design techniques are the most powerful tools for the chemical reactors experimental modeling. Empirical models can be formulated for representing the chemical behavior of reactors with the minimal effort in the necessary number of experimental runs, hence, minimizing the consumption of chemicals and the consumption of time due to the reduction in the number of experimental runs and increasing the certainty of the results. Four types of nonthermal plasma reactors were assayed seeking for the highest efficiency in obtaining hydrogen and ethylene. Three different geometries for AC high voltage driven reactors, and only a single geometry for a DC high voltage pulse driven reactor were studied. According to the fundamental principles of chemical kinetics and considering an analogy among the reaction rate and the applied power to the plasma reactor, the four reactors are modeled following the classical chemical reactors design to understand if the behavior of the nonthermal plasma reactors can be regarded as the chemical reactors following the flow patterns of PFR (Plug Flow Reactor) or CSTR (Continuous Stirred Tank Reactor). Dehydrogenation is a common elimination reaction that takes place in nonthermal plasmas. Owing to this characteristic, a paraffinic heavy oil with an average molecular weight corresponding to C15 was used to study the production of light olefins and hydrogen.
文摘DOE （design of experiments） is a systematic, rigorous approach to engineering problem-solving that applies principles and techniques at the data collection stage so as to ensure the generation of valid, defensible, and supportable engineering conclusions. This paper presents a comparison of three different experimental designs （full experimental design, fractional design and Taguchi design） aimed at studying the effects of cutting parameters variations on surface finish. The results revealed that the effects obtained by analyzing both fractional and Taguchi designs were comparable to the main effects and two-level interactions obtained by the full factorial design. Thus, we conclude that full factorial design appear to be reliable and more economical since they permit to reduce by a factor the amount of time and effort required to conduct the experimental design without losing valuable information. Thus, we conclude that full factorial design appear to be reliable and more economical and without losing valuable information.
文摘The aim of this study was to determine the optimum design mix to produce pre-cast concrete blocks by a completely random experimental design (CRED) with mixture and process variables. The polymerized concrete was studied its composition: Cement, and water defined as the mixture compounds. To choose the best model, all the possible models were assessed through the ANOVA, which tested each possible model. The linear-linear model was preferred, since that do not present evidence of lack of fit, and it is capable of relating how to react the process variables, when are changed the variable mixture condition levels. The optimum experimental condition, obtained for the polymerized concrete, was: The size of the polystyrene beads was 4.8 mm sized polystyrene beads, 5.0% polystyrene that replaced the aggregate, 18.3% cement, 73.4% aggregate and 8.3% water. In this condition, the blocks made with polymerized concrete show a compressive strength above 15 Mpa, allowing its utilization in paving.
基金The foundation for Teaching Research Project of Hubei University of Technology in Hubei Province in 2020(grant number 2020017).
文摘Experimental Design and Data Processing is an important core professional basic course for food science majors.This course is theoretical and practical,and there are many formulas,abstract contents and difficult to understand,and there are some problems in the teaching process,such as students1 poor interest in learning,insufficient mastery of what they have learned,and inability to combine theory with practice organically.Through analyzing the existing problems,this paper puts forward some reform measures for the teaching mode of experimental design and data processing by using the intelligent teaching of Superstar platform.
