Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer's disease(AD). Exposure to lead during the critical phase of brain development has been linked with mental retardatio...Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer's disease(AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life. This study was aimed to investigate the effects of lead exposure of pregnant mice on the expressions of insulin-degrading enzyme(IDE) and nerve growth factor(NGF) in the hippocampus of their offspring. Blood samples were collected from the tail vein, and after anesthetizing the pups, the brain was excised on postnatal day 21. Lead concentrations were determined by graphite furnace atomic absorption spectrophotometry, and the expressions of IDE and NGF were determined by immunohistochemistry and Western blotting. Results showed that the reduction in IDE and NGF expression in the hippocampus of pups might be associated with impairment of learning and memory and dementia induced by maternal lead exposure during pregnancy and lactation.展开更多
This paper reviews wind loading codes and standards in the Asia-Pacific Region,in particular in the 15 countries and areas.A general description of wind loading model is given as a famous wind loading chain described ...This paper reviews wind loading codes and standards in the Asia-Pacific Region,in particular in the 15 countries and areas.A general description of wind loading model is given as a famous wind loading chain described by four variables including velocity pressure,exposure factor,pressure coefficient,and gust response factor.Through the APEC-WW Workshops and the extensive calculations for three examples of low,medium and high rise buildings,these four important variables of wind loads are evaluated and compared with statistical parameters,mean values and coefficients of variation.The main results of the comparison show some differences among the 15 economies,and the reasons and further incorporation are discussed and suggested.展开更多
基金supported by the National Natural Science Foundation of China(NSFC),No.31201878,81172716,and U1204804Post Doctoral Foundation of China,No.2015M572109Post Doctoral Fund of Henan province,No.2014049
文摘Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer's disease(AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life. This study was aimed to investigate the effects of lead exposure of pregnant mice on the expressions of insulin-degrading enzyme(IDE) and nerve growth factor(NGF) in the hippocampus of their offspring. Blood samples were collected from the tail vein, and after anesthetizing the pups, the brain was excised on postnatal day 21. Lead concentrations were determined by graphite furnace atomic absorption spectrophotometry, and the expressions of IDE and NGF were determined by immunohistochemistry and Western blotting. Results showed that the reduction in IDE and NGF expression in the hippocampus of pups might be associated with impairment of learning and memory and dementia induced by maternal lead exposure during pregnancy and lactation.
基金This study was partially supported by the Natural Science Foundation of China(Grant Nos.90715039 and 51021140005)the grant SLDRCE09-A-01.
文摘This paper reviews wind loading codes and standards in the Asia-Pacific Region,in particular in the 15 countries and areas.A general description of wind loading model is given as a famous wind loading chain described by four variables including velocity pressure,exposure factor,pressure coefficient,and gust response factor.Through the APEC-WW Workshops and the extensive calculations for three examples of low,medium and high rise buildings,these four important variables of wind loads are evaluated and compared with statistical parameters,mean values and coefficients of variation.The main results of the comparison show some differences among the 15 economies,and the reasons and further incorporation are discussed and suggested.
