期刊文献+
共找到88,244篇文章
< 1 2 250 >
每页显示 20 50 100
Dynamic Update Scheme of Spectrum Information Based on Spectrum Opportunity Incentive in the Database-Assisted Dynamic Spectrum Management
1
作者 Zhang Yu Chen Yong +1 位作者 He Panfeng Cai Yueming 《China Communications》 SCIE CSCD 2024年第3期75-90,共16页
To solve the problem of delayed update of spectrum information(SI) in the database assisted dynamic spectrum management(DB-DSM), this paper studies a novel dynamic update scheme of SI in DB-DSM. Firstly, a dynamic upd... To solve the problem of delayed update of spectrum information(SI) in the database assisted dynamic spectrum management(DB-DSM), this paper studies a novel dynamic update scheme of SI in DB-DSM. Firstly, a dynamic update mechanism of SI based on spectrum opportunity incentive is established, in which spectrum users are encouraged to actively assist the database to update SI in real time. Secondly, the information update contribution(IUC) of spectrum opportunity is defined to describe the cost of accessing spectrum opportunity for heterogeneous spectrum users, and the profit of SI update obtained by the database from spectrum allocation. The process that the database determines the IUC of spectrum opportunity and spectrum user selects spectrum opportunity is mapped to a Hotelling model. Thirdly, the process of determining the IUC of spectrum opportunities is further modelled as a Stackelberg game by establishing multiple virtual spectrum resource providers(VSRPs) in the database. It is proved that there is a Nash Equilibrium in the game of determining the IUC of spectrum opportunities by VSRPs. Finally, an algorithm of determining the IUC based on a genetic algorithm is designed to achieve the optimal IUC. The-oretical analysis and simulation results show that the proposed method can quickly find the optimal solution of the IUC, and ensure that the spectrum resource provider can obtain the optimal profit of SI update. 展开更多
关键词 database-assisted dynamic spectrum management HOTELLING information updating contribution spectrum information updating STACKELBERG
下载PDF
An Image Fingerprint and Attention Mechanism Based Load Estimation Algorithm for Electric Power System
2
作者 Qing Zhu Linlin Gu Huijie Lin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期577-591,共15页
With the rapid development of electric power systems,load estimation plays an important role in system operation and planning.Usually,load estimation techniques contain traditional,time series,regression analysis-base... With the rapid development of electric power systems,load estimation plays an important role in system operation and planning.Usually,load estimation techniques contain traditional,time series,regression analysis-based,and machine learning-based estimation.Since the machine learning-based method can lead to better performance,in this paper,a deep learning-based load estimation algorithm using image fingerprint and attention mechanism is proposed.First,an image fingerprint construction is proposed for training data.After the data preprocessing,the training data matrix is constructed by the cyclic shift and cubic spline interpolation.Then,the linear mapping and the gray-color transformation method are proposed to form the color image fingerprint.Second,a convolutional neural network(CNN)combined with an attentionmechanism is proposed for training performance improvement.At last,an experiment is carried out to evaluate the estimation performance.Compared with the support vector machine method,CNN method and long short-term memory method,the proposed algorithm has the best load estimation performance. 展开更多
关键词 Load estimation deep learning attention mechanism image fingerprint construction
下载PDF
Correction:Brillouin scattering spectrum for liquid detection and applications in oceanography
3
作者 Yuanqing Wang Jinghao Zhang +6 位作者 Yongchao Zheng Yangrui Xu Jiaqi Xu Jiao Jiao Yun Su Hai-Feng Lü Kun Liang 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第1期47-47,共1页
After publication of this article1,it was brought to our at-tention that the mathematical expressions‘‰’were mis-takenly replaced by‘%’for salinities.Details are listed below.1.In the last sentence in abstract,“... After publication of this article1,it was brought to our at-tention that the mathematical expressions‘‰’were mis-takenly replaced by‘%’for salinities.Details are listed below.1.In the last sentence in abstract,“approximately 0.1℃and 0.5%”should be“approximately 0.1℃and 0.5‰”. 展开更多
关键词 SCATTERING LISTED spectrum
下载PDF
Floquet spectrum and universal dynamics of a periodically driven two-atom system
4
作者 谢文柱 周正强 +2 位作者 李轩 崔思淼 孙明远 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期436-443,共8页
We investigate the Floquet spectrum and excitation properties of a two-ultracold-atom system with periodically driven interaction in a three-dimensional harmonic trap.The interaction between the atoms is changed by va... We investigate the Floquet spectrum and excitation properties of a two-ultracold-atom system with periodically driven interaction in a three-dimensional harmonic trap.The interaction between the atoms is changed by varying the s-wave scattering length in two ways,the cosine and the square-wave modulations.It is found that as the driving frequency increases,the Floquet spectrum exhibits two main features for both modulations,the accumulating and the spreading of the quasienergy levels,which further lead to different dynamical behaviors.The accumulation is associated with collective excitations and the persistent growth of the energy,while the spread indicates that the energy is bounded at all times.The initial scattering length,the driving frequency and amplitude can all significantly change the Floquet spectrum as well as the dynamics.However,the corresponding relation between them is valid universally.Finally,we propose a mechanism for selectively exciting the system to one specific state by using the avoided crossing of two quasienergy levels,which could guide preparation of a desired state in experiments. 展开更多
关键词 Floquet spectrum universal dynamics two-atom system avoided crossing
原文传递
Construction of a Cu@hollow TS-1 nanoreactor based on a hierarchical full-spectrum solar light utilization strategy for photothermal synergistic artificial photosynthesis
5
作者 Sixian Zhu Qiao Zhao +5 位作者 Hongxia Guo Li Liu Xiao Wang Xiwei Qi Xianguang Meng Wenquan Cui 《Carbon Energy》 SCIE EI CAS CSCD 2024年第2期25-36,共12页
The artificial photosynthesis technology has been recognized as a promising solution for CO_(2) utilization.Photothermal catalysis has been proposed as a novel strategy to promote the efficiency of artificial photosyn... The artificial photosynthesis technology has been recognized as a promising solution for CO_(2) utilization.Photothermal catalysis has been proposed as a novel strategy to promote the efficiency of artificial photosynthesis by coupling both photochemistry and thermochemistry.However,strategies for maximizing the use of solar spectra with different frequencies in photothermal catalysis are urgently needed.Here,a hierarchical full-spectrum solar light utilization strategy is proposed.Based on this strategy,a Cu@hollow titanium silicalite-1 zeolite(TS-1)nanoreactor with spatially separated photo/thermal catalytic sites is designed to realize high-efficiency photothermal catalytic artificial photosynthesis.The space-time yield of alcohol products over the optimal catalyst reached 64.4μmol g−1 h−1,with the selectivity of CH3CH2OH of 69.5%.This rationally designed hierarchical utilization strategy for solar light can be summarized as follows:(1)high-energy ultraviolet light is utilized to drive the initial and difficult CO_(2) activation step on the TS-1 shell;(2)visible light can induce the localized surface plasmon resonance effect on plasmonic Cu to generate hot electrons for H2O dissociation and subsequent reaction steps;and(3)low-energy near-infrared light is converted into heat by the simulated greenhouse effect by cavities to accelerate the carrier dynamics.This work provides some scientific and experimental bases for research on novel,highly efficient photothermal catalysts for artificial photosynthesis. 展开更多
关键词 artificial photosynthesis full spectrum NANOREACTORS photothermal catalysis
下载PDF
Blockchain-Based MCS Detection Framework of Abnormal Spectrum Usage for Satellite Spectrum Sharing Scenario
6
作者 Ning Yang Heng Wang +3 位作者 Jingming Hu Bangning Zhang Daoxing Guo Yuan Liu 《China Communications》 SCIE CSCD 2024年第2期32-48,共17页
In this paper, the problem of abnormal spectrum usage between satellite spectrum sharing systems is investigated to support multi-satellite spectrum coexistence. Given the cost of monitoring, the mobility of low-orbit... In this paper, the problem of abnormal spectrum usage between satellite spectrum sharing systems is investigated to support multi-satellite spectrum coexistence. Given the cost of monitoring, the mobility of low-orbit satellites, and the directional nature of their signals, traditional monitoring methods are no longer suitable, especially in the case of multiple power level. Mobile crowdsensing(MCS), as a new technology, can make full use of idle resources to complete a variety of perceptual tasks. However, traditional MCS heavily relies on a centralized server and is vulnerable to single point of failure attacks. Therefore, we replace the original centralized server with a blockchain-based distributed service provider to enable its security. Therefore, in this work, we propose a blockchain-based MCS framework, in which we explain in detail how this framework can achieve abnormal frequency behavior monitoring in an inter-satellite spectrum sharing system. Then, under certain false alarm probability, we propose an abnormal spectrum detection algorithm based on mixed hypothesis test to maximize detection probability in single power level and multiple power level scenarios, respectively. Finally, a Bad out of Good(BooG) detector is proposed to ease the computational pressure on the blockchain nodes. Simulation results show the effectiveness of the proposed framework. 展开更多
关键词 blockchain hypothesis test mobile crowdsensing satellite communication spectrum sharing
下载PDF
Periodic signal extraction of GNSS height time series based on adaptive singular spectrum analysis
7
作者 Chenfeng Li Peibing Yang +1 位作者 Tengxu Zhang Jiachun Guo 《Geodesy and Geodynamics》 EI CSCD 2024年第1期50-60,共11页
Singular spectrum analysis is widely used in geodetic time series analysis.However,when extracting time-varying periodic signals from a large number of Global Navigation Satellite System(GNSS)time series,the selection... Singular spectrum analysis is widely used in geodetic time series analysis.However,when extracting time-varying periodic signals from a large number of Global Navigation Satellite System(GNSS)time series,the selection of appropriate embedding window size and principal components makes this method cumbersome and inefficient.To improve the efficiency and accuracy of singular spectrum analysis,this paper proposes an adaptive singular spectrum analysis method by combining spectrum analysis with a new trace matrix.The running time and correlation analysis indicate that the proposed method can adaptively set the embedding window size to extract the time-varying periodic signals from GNSS time series,and the extraction efficiency of a single time series is six times that of singular spectrum analysis.The method is also accurate and more suitable for time-varying periodic signal analysis of global GNSS sites. 展开更多
关键词 GNSS Time series Singular spectrum analysis Trace matrix Periodic signal
原文传递
AWeb Application Fingerprint Recognition Method Based on Machine Learning
8
作者 Yanmei Shi Wei Yu +1 位作者 Yanxia Zhao Yungang Jia 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期887-906,共20页
Web application fingerprint recognition is an effective security technology designed to identify and classify web applications,thereby enhancing the detection of potential threats and attacks.Traditional fingerprint r... Web application fingerprint recognition is an effective security technology designed to identify and classify web applications,thereby enhancing the detection of potential threats and attacks.Traditional fingerprint recognition methods,which rely on preannotated feature matching,face inherent limitations due to the ever-evolving nature and diverse landscape of web applications.In response to these challenges,this work proposes an innovative web application fingerprint recognition method founded on clustering techniques.The method involves extensive data collection from the Tranco List,employing adjusted feature selection built upon Wappalyzer and noise reduction through truncated SVD dimensionality reduction.The core of the methodology lies in the application of the unsupervised OPTICS clustering algorithm,eliminating the need for preannotated labels.By transforming web applications into feature vectors and leveraging clustering algorithms,our approach accurately categorizes diverse web applications,providing comprehensive and precise fingerprint recognition.The experimental results,which are obtained on a dataset featuring various web application types,affirm the efficacy of the method,demonstrating its ability to achieve high accuracy and broad coverage.This novel approach not only distinguishes between different web application types effectively but also demonstrates superiority in terms of classification accuracy and coverage,offering a robust solution to the challenges of web application fingerprint recognition. 展开更多
关键词 Web application fingerprint recognition unsupervised learning clustering algorithm feature extraction automated testing network security
下载PDF
Fingerprint Study of Polygonati Rhizoma with Steaming and Exposing to the Sun Alternatively for Different Times
9
作者 Min WANG Chenying YE +3 位作者 Qian WANG Ting HE Shenggao YIN Gailian ZHOU 《Medicinal Plant》 2024年第2期18-20,共3页
[Objectives]To explore the influence of different times of steaming and exposing to the sun on the fingerprint of Polygonati Rhizoma by studying the HPLC fingerprint of Polygonati Rhizoma processed products with diffe... [Objectives]To explore the influence of different times of steaming and exposing to the sun on the fingerprint of Polygonati Rhizoma by studying the HPLC fingerprint of Polygonati Rhizoma processed products with different times of steaming and exposing to the sun,and to provide a basis for the determination of the best processing technology of Polygonati Rhizoma.[Methods]SETSAIL II AQ-C 18(5μm×250 mm×4.6 mm)was used as the column,the column temperature was 30℃,pure water(A)and acetonitrile(B)were eluted gradually,0-10 min,B(5%-10%),10-30 min,B(10%-35%),30-40 min,B(35%-60%),40-45 min,B(60%-100%),flow rate 1 mL/min,absorption wavelength 200 nm.[Results]The relative retained peak area RSDs of the common peaks in the precision,reproducibility and stability tests were all less than 5%.There were 17 common peaks in the fingerprint of nine batches of samples,and the retention time of Peak 2 was basically the same as that of the reference peak of 5-HMF.Peak 4 mainly existed in the chromatogram of Sample 3 to Sample 5,peaks 5 and 11 mainly existed after Sample 3,peaks 9,14 and 16 mainly existed after Sample 6,and peaks 12 and 17 mainly existed after Sample 4.[Conclusions]A total of 17 common peaks were obtained,and the Peak 2 was the designated peak,and the chemical components of each processed product were different. 展开更多
关键词 Polygonati Rhizoma PROCESSING HPLC fingerprint
下载PDF
Occurrence of K1 and K2 serotypes and genotypic characteristics of extended spectrumβ-lactamases-producing Klebsiella pneumoniae isolated from selected hospitals in Malaysia
10
作者 Nurul Syazrah Anuar Hazmin Hazman +5 位作者 Sharven Raj Jeyakumar Mohd Nasir Mohd Desa Hasni Idayu Saidi Siti Norbaya Masri Nur Afiza Aziz Nurshahira Sulaiman 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第1期30-38,共9页
Objective:To determine the distribution,phenotypic and genetic background of extended spectrumβ-lactamases(ESBL)-producing Klebsiella(K.)pneumoniae clinical isolates associated with K1 and K2 serotypes in two selecte... Objective:To determine the distribution,phenotypic and genetic background of extended spectrumβ-lactamases(ESBL)-producing Klebsiella(K.)pneumoniae clinical isolates associated with K1 and K2 serotypes in two selected hospitals in Malaysia.Methods:A total of 192 K.pneumoniae isolates were collected and subjected to antibiotic susceptibility,hypermucoviscosity test and multiplex PCR to detect the presence of K1-and K2-serotype associated genes.Multilocus sequence typing(MLST)was performed on ESBL-producing K.pneumoniae isolates presented with K1 and K2 serotypes,followed by phylogenetic analysis.Results:A total of 87 out of 192(45.3%)of the K.pneumoniae isolates collected were ESBL producers.However,only 8.3%(16/192)and 10.9%(21/192)of the total isolates were detected to carry K1-and K2-serotype associated genes,respectively.Statistical analysis showed that K1 and K2 capsular serotypes were not significantly associated with ESBL phenotype(P=0.196).However,they were significantly associated with hypervirulent,as demonstrated by the positive string test(P<0.001).MLST analysis revealed that ST23 as the predominant sequence type(ST)in the K1 serotype,while the ST in the K2 serotype is more diverse.Conclusions:Although the occurrence of ESBL-producing isolates among the hypervirulent strains was low,their coexistence warrants the need for continuous surveillance.MLST showed that these isolates were genetically heterogeneous. 展开更多
关键词 Extended spectrumβ-lactamases Klebsiella pneumoniae Capsular serotypes GENOTYPIC
下载PDF
THE ABSENCE OF SINGULAR CONTINUOUS SPECTRUM FOR PERTURBED JACOBI OPERATORS
11
作者 傅钲淇 黎雄 《Acta Mathematica Scientia》 SCIE CSCD 2024年第2期515-531,共17页
This paper is mainly about the spectral properties of a class of Jacobi operators(H_(c,b)u)(n)=c_(n)u(n+1)+c_(n-1)u(n-1)+b_(n)u(n),.where∣c_(n)−1∣=O(n^(−α))and b_(n)=O(n^(−1)).We will show that,forα≥1,the singula... This paper is mainly about the spectral properties of a class of Jacobi operators(H_(c,b)u)(n)=c_(n)u(n+1)+c_(n-1)u(n-1)+b_(n)u(n),.where∣c_(n)−1∣=O(n^(−α))and b_(n)=O(n^(−1)).We will show that,forα≥1,the singular continuous spectrum of the operator is empty. 展开更多
关键词 Jacobi operator singular continuous spectrum Prüfer variables
下载PDF
Wideband spectrum sensing using step-sampling based on the multipath nyquist folding receiver
12
作者 Kai-lun Tian Kai-li Jiang +5 位作者 Sen Cao Jian Gao Ying Xiong Bin Tang Xu-ying Zhang Yan-fei Li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期523-536,共14页
Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spec... Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated outputs.In this case,a multipath NYFR architecture with a step-sampling rate for the different paths is proposed.The different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these grids.Thus,high-precision parameter estimation is performed by utilizing the NYFR characteristics.Compared with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm probability.Comparative simulation experiments verify the effectiveness of the proposed architecture in this paper. 展开更多
关键词 Wideband spectrum sensing Sub-Nyquist sampling Step-sampling Nyquist folding receiver(NYFR) Multisignal processing
下载PDF
Uphill or downhill?Cropland use change and its drivers from the perspective of slope spectrum
13
作者 PAN Sipei LIANG Jiale +1 位作者 CHEN Wanxu PENG Yelin 《Journal of Mountain Science》 SCIE CSCD 2024年第2期484-499,共16页
The continuous decrease of low-slope cropland resources caused by construction land crowding poses huge threat to regional sustainable development and food security.Slope spectrum analysis of topographic and geomorphi... The continuous decrease of low-slope cropland resources caused by construction land crowding poses huge threat to regional sustainable development and food security.Slope spectrum analysis of topographic and geomorphic features is considered as a digital terrain analysis method which reflects the macro-topographic features by using micro-topographic factors.However,pieces of studies have extended the concept of slope spectrum in the field of geoscience to construction land to explore its expansion law,while research on the slope trend of cropland from that perspective remains rare.To address the gap,in virtue of spatial analysis and geographically weighted regression(GWR)model,the cropland use change in the Yangtze River Basin(YRB)from 2000 to 2020 was analyzed and the driving factors were explored from the perspective of slope spectrum.Results showed that the slope spectrum curves of cropland area-frequency in the YRB showed a first upward then a downward trend.The change curve of the slope spectrum of cropland in each province(municipality)exhibited various distribution patterns.Quantitative analysis of morphological parameters of cropland slope spectrum revealed that the further down the YRB,the stronger the flattening characteristics,the more obvious the concentration.The province experienced the greatest downhill cropland climbing(CLC)was Shannxi,while province experienced the highest uphill CLC was Zhejiang.The most common cropland use change type in the YRB was horizontal expansion type.The factors affecting average cropland climbing index(ACCI)were quite stable in different periods,while population density(POP)changed from negative to positive during the study period.This research is of practical significance for the rational utilization of cropland at the watershed scale. 展开更多
关键词 Cropland climbing Land use change Slope spectrum Driving factors Geographically weighted regression Yangtze River Basin
原文传递
Robust Space-Time Adaptive Track-Before-Detect Algorithm Based on Persymmetry and Symmetric Spectrum
14
作者 Xiaojing Su Da Xu +1 位作者 Dongsheng Zhu Zhixun Ma 《Journal of Beijing Institute of Technology》 EI CAS 2024年第1期65-74,共10页
Underwater monopulse space-time adaptive track-before-detect method,which combines space-time adaptive detector(STAD)and the track-before-detect algorithm based on dynamic programming(DP-TBD),denoted as STAD-DP-TBD,ca... Underwater monopulse space-time adaptive track-before-detect method,which combines space-time adaptive detector(STAD)and the track-before-detect algorithm based on dynamic programming(DP-TBD),denoted as STAD-DP-TBD,can effectively detect low-speed weak targets.However,due to the complexity and variability of the underwater environment,it is difficult to obtain sufficient secondary data,resulting in a serious decline in the detection and tracking performance,and leading to poor robustness of the algorithm.In this paper,based on the adaptive matched filter(AMF)test and the RAO test,underwater monopulse AMF-DP-TBD algorithm and RAO-DP-TBD algorithm which incorporate persymmetry and symmetric spectrum,denoted as PSAMF-DP-TBD and PS-RAO-DP-TBD,are proposed and compared with the AMF-DP-TBD algorithm and RAO-DP-TBD algorithm based on persymmetry array,denoted as P-AMF-DP-TBD and P-RAO-DP-TBD.The simulation results show that the four methods can work normally with sufficient secondary data and slightly insufficient secondary data,but when the secondary data is severely insufficient,the P-AMF-DP-TBD and P-RAO-DP-TBD algorithms has failed while the PSAMF-DP-TBD and PS-RAO-DP-TBD algorithms still have good detection and tracking capabilities. 展开更多
关键词 space-time adaptive detection track before detect ROBUSTNESS persymmetric property symmetric spectrum AMF test RAO test
下载PDF
Modified Black Widow Optimization-Based Enhanced Threshold Energy Detection Technique for Spectrum Sensing in Cognitive Radio Networks
15
作者 R.Saravanan R.Muthaiah A.Rajesh 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2339-2356,共18页
This study develops an Enhanced Threshold Based Energy Detection approach(ETBED)for spectrum sensing in a cognitive radio network.The threshold identification method is implemented in the received signal at the second... This study develops an Enhanced Threshold Based Energy Detection approach(ETBED)for spectrum sensing in a cognitive radio network.The threshold identification method is implemented in the received signal at the secondary user based on the square law.The proposed method is implemented with the signal transmission of multiple outputs-orthogonal frequency division multiplexing.Additionally,the proposed method is considered the dynamic detection threshold adjustments and energy identification spectrum sensing technique in cognitive radio systems.In the dynamic threshold,the signal ratio-based threshold is fixed.The threshold is computed by considering the Modified Black Widow Optimization Algorithm(MBWO).So,the proposed methodology is a combination of dynamic threshold detection and MBWO.The general threshold-based detection technique has different limitations such as the inability optimal signal threshold for determining the presence of the primary user signal.These limitations undermine the sensing accuracy of the energy identification technique.Hence,the ETBED technique is developed to enhance the energy efficiency of cognitive radio networks.The projected approach is executed and analyzed with performance and comparison analysis.The proposed method is contrasted with the conventional techniques of theWhale Optimization Algorithm(WOA)and GreyWolf Optimization(GWO).It indicated superior results,achieving a high average throughput of 2.2 Mbps and an energy efficiency of 3.8,outperforming conventional techniques. 展开更多
关键词 Cognitive radio network spectrum sensing noise uncertainty modified black widow optimization algorithm energy detection technique
下载PDF
Clinical characteristics of patients with early-and late-onset optic neuromyelitis optica spectrum disease
16
作者 LI Fei LIU Ting +5 位作者 Yang Yi-hao LIN Hui-xia TONG jing-yi LI Zong-jun LIANG Bin-ji LI Qi-fu 《Journal of Hainan Medical University》 CAS 2024年第2期14-19,共6页
Objective:To analyze the different clinical features of patients with early-onset(EO-NMOSDs)and late-onset neuromyelitis optica spectrum diseases(LO-NMOSDs).Methods:A total of 51patients with neuromyelitis optica spec... Objective:To analyze the different clinical features of patients with early-onset(EO-NMOSDs)and late-onset neuromyelitis optica spectrum diseases(LO-NMOSDs).Methods:A total of 51patients with neuromyelitis optica spectrum disease who were diagnosed in our hospital for the first time from January 2015 to December 2022 were included in the First Affiliated Hospital of Hainan Medical College and divided into 22 cases in the EO-NMOSDs group and 29 cases in the LO-NMOSDs group according to whether the age of onset was 50 years old.The basic data,Extended Disability Status Scale(EDSS)score,blood and cerebrospinal fluid test indicators of the two groups were statistically analyzed.Results:There were no significant differences in demographic characteristics,clinical features and serum AQP-4 antibody positivity rate between the two groups(all P>0.05),and there were significant differences in triglycerides(TG),low-density lipoprotein(LDL),apolipoprotein A(APOA),apolipoprotein B(APOB)and lipoprotein a(P=0.010,P=0.048,P=0.014,P=0.061,P=0.001,respectively),and cerebrospinal fluid LDH,There were significant differences between microprotein quantification and EDSS score(P=0.018,P=0.034,P=0.025,respectively),and the level of microprotein quantification in cerebrospinal fluid of LO-NMOSDs had a certain correlation with the degree of disability(r=0.52,P<0.03).Conclusion:LO-NMOSDs and EO-NMOSDs group patients have similar demographic characteristics,serum AQP-4 antibody positive rate and clinical features,but compared with EO-NMOSDs,patients in LO-NMOSDs group are prone to abnormal lipid metabolism,higher trace proteins in cerebrospinal fluid and more likely to be disabled,and among LO-NMOSDs,the higher the trace protein in the cerebrospinal fluid,the more severe the disability status of patients. 展开更多
关键词 Optic neuromyelitis optica spectrum DISORDERS Late onset Cerebrospinal fluid microprotein quantification EDSS score
下载PDF
Des-Arg(9)bradykinin as a causal metabolite for autism spectrum disorder
17
作者 Zhong-Yu Huang Zi-Pan Lyu +3 位作者 Hong-Gui Li Hua-Zhi You Xiang-Na Yang Cai-Hui Cha 《World Journal of Psychiatry》 SCIE 2024年第1期88-101,共14页
BACKGROUND Early diagnosis and therapeutic interventions can greatly enhance the developmental trajectory of children with autism spectrum disorder(ASD).However,the etiology of ASD is not completely understood.The pre... BACKGROUND Early diagnosis and therapeutic interventions can greatly enhance the developmental trajectory of children with autism spectrum disorder(ASD).However,the etiology of ASD is not completely understood.The presence of confounding factors from environment and genetics has increased the difficulty of the identification of diagnostic biomarkers for ASD.AIM To estimate and interpret the causal relationship between ASD and metabolite profile,taking into consideration both genetic and environmental influences.METHODS A two-sample Mendelian randomization(MR)analysis was conducted using summarized data from large-scale genome-wide association studies(GWAS)including a metabolite GWAS dataset covering 453 metabolites from 7824 European and an ASD GWAS dataset comprising 18381 ASD cases and 27969 healthy controls.Metabolites in plasma were set as exposures with ASD as the main outcome.The causal relationships were estimated using the inverse variant weight(IVW)algorithm.We also performed leave-one-out sensitivity tests to validate the robustness of the results.Based on the drafted metabolites,enrichment analysis was conducted to interpret the association via constructing a protein-protein interaction network with multi-scale evidence from databases including Infinome,SwissTargetPrediction,STRING,and Metascape.RESULTS Des-Arg(9)-bradykinin was identified as a causal metabolite that increases the risk of ASD(β=0.262,SE=0.064,P_(IVW)=4.64×10^(-5)).The association was robust,with no significant heterogeneity among instrument variables(P_(MR Egger)=0.663,P_(IVW)=0.906)and no evidence of pleiotropy(P=0.949).Neuroinflammation and the response to stimulus were suggested as potential biological processes mediating the association between Des-Arg(9)bradykinin and ASD.CONCLUSION Through the application of MR,this study provides practical insights into the potential causal association between plasma metabolites and ASD.These findings offer perspectives for the discovery of diagnostic or predictive biomarkers to support clinical practice in treating ASD. 展开更多
关键词 Des-Arg(9)bradykinin Autism spectrum disorder Mendelian randomization METABOLITE Enrichment analysis
下载PDF
The significance of metabolic fingerprinting in carcinogenesis
18
作者 Ayodele Ademola Adelakun Princess Adekunbi Owokalade 《Cancer Advances》 2024年第1期1-6,共6页
Carcinogenesis describes the process through which normal cells transform into malignant cells(cancer).There were an estimated 18.1 million new cases of cancer(all cancers combined excluding non-melanoma skin cancer)w... Carcinogenesis describes the process through which normal cells transform into malignant cells(cancer).There were an estimated 18.1 million new cases of cancer(all cancers combined excluding non-melanoma skin cancer)worldwide in 2020:8.8 million(48%)in females and 9.3 million(52%)in males,giving a male:female ratio of 10:9.5.It may be initiated by the action of biological,physical,or chemical agents that cause a non-lethal,permanent,DNA error on the cell with a consequence of altered cell metabolism.This altered cell metabolism include the Warburg effect,altered lipid and amino acid metabolism and production of various metabolites.It also results in unique metabolic dependencies that,in some cases,can be targeted with precision medicine and nutrition,including drugs that selectively target metabolic enzymes.Metabolic fingerprinting has been applied to the study of carcinogenesis and is particularly helpful in early diagnosis,staging and choice of treatment,thus improving health outcomes.This technology could therefore be harnessed effectively while combining with other omics technologies. 展开更多
关键词 CANCER metabolomics PROGNOSIS DIAGNOSIS fingerprint
下载PDF
Spectrum-Effect Relationship Between High Performance Liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine 被引量:5
19
作者 XIAO Sui FEI Chen-zhong +3 位作者 ZHANG Li-fang ZHENG Wen-li ZHANG Ke-yu XUE Fei-qun 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2014年第5期1082-1089,共8页
Quality control and screening of active substances in traditional Chinese medicines have been performed using fi ngerprint analysis. The spectrum-effect relationship between chromatography fi ngerprints and effi cacy ... Quality control and screening of active substances in traditional Chinese medicines have been performed using fi ngerprint analysis. The spectrum-effect relationship between chromatography fi ngerprints and effi cacy of herbal drugs is considered as a potentially useful method for determining active ingredients in complex mixtures. The study was designed to develop a method for determining the bioactive components of a compound Chinese medicine called Tiefeng based on spectrum-effect relationships between high-performance liquid chromatography(HPLC) fi ngerprints and anticoccidial activities. Four peaks of the established HPLC fi ngerprint indicate the main bioactive components of this medicine. In addition, pharmacodynamic atlas was defi ned and used to assess the anticoccidial activity of Tiefeng from different sources for the fi rst time. We found that the level of anticoccidial activity of Tiefeng was consistent with the degree of similarity between the pharmacodynamic atlas and chromatogram of any sample. Furthermore, effect of this medicine was related with the main active constituents, along with the origin and the harvesting time. 展开更多
关键词 色谱指纹图谱 高效液相色谱法 活性物质 中国医药 抗球虫 光谱效应 HPLC指纹图谱 生物活性成分
下载PDF
HPLC Fingerprinting and Spectrum-antitumor Effect Relationship for Discrimination between Mylabris phalerata Pallas and Mylabris cichorii Linnaeus
20
作者 Jian-Yong Zhang Qi-Hong Chen +4 位作者 Xian Pei Rong Yan Can-Can Duan Yun Liu Xiao-Fei Li 《TMR Modern Herbal Medicine》 2018年第1期11-18,共8页
目的:基于高效液相指纹图谱和光谱-抗肿瘤作用的关系来区别两种斑蝥.方法:在本研究中,开发了一种简单有效的高效液相色谱法整合化学计量学分析与光谱-抗肿瘤作用关系的方法来区别两种斑蝥:南方大斑蝥(MP)和黄黑小斑蝥(MC).结... 目的:基于高效液相指纹图谱和光谱-抗肿瘤作用的关系来区别两种斑蝥.方法:在本研究中,开发了一种简单有效的高效液相色谱法整合化学计量学分析与光谱-抗肿瘤作用关系的方法来区别两种斑蝥:南方大斑蝥(MP)和黄黑小斑蝥(MC).结果:在指纹图谱分析中,我们通过PCA和OPLS一DA用相似性和模式识别分析的选择了14个特征峰来评估MP与MC的差异.来自中国10个地区样本的HPLC色谱图表明了MP和MC之间的差异,另外,发现了7个化学标志物.在光谱-抗肿瘤作用关系分析中,通过灰度相关分析和多元线性回归分析,发现了4个活性标志物能够降低IC50,可能是斑蝥中的抗肿瘤成分.化学计量分析法联合光谱-效应关系的结果表明峰2(胞嘧啶),4(未知)和14(未知)是区分2种斑蝥的重要区分标志物.结论:这种方法可行,可信并且能有效的区分MP和MC,并能提供一种对昆虫药物的质量控制的新方法. 展开更多
关键词 高效液相色谱法 指纹图谱 光谱-肿瘤作用 斑蝥 差别
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部