Local field potential(LFP) signals of the rat hippocampus were recorded under noninvasive focused ultrasound stimulation(FUS) with different ultrasonic powers. The LFP mean absolute power was calculated with the Welch...Local field potential(LFP) signals of the rat hippocampus were recorded under noninvasive focused ultrasound stimulation(FUS) with different ultrasonic powers. The LFP mean absolute power was calculated with the Welch algorithm at the delta, theta, alpha, beta, and gamma frequency bands. The experimental results demonstrate that the LFP mean absolute power at different frequency bands increases as the ultrasound power increases.展开更多
Low-intensity focused ultrasound stimulation(FUS), which possesses high spatial resolution and penetration depth, has been developing rapidly for noninvasive brain neuromodulation in recent years. In this letter, a lo...Low-intensity focused ultrasound stimulation(FUS), which possesses high spatial resolution and penetration depth, has been developing rapidly for noninvasive brain neuromodulation in recent years. In this letter, a low-intensity FUS system was developed for noninvasive brain neuromodulation in vivo. The radius of ultrasonic focal spot was quantitatively calculated in theory to evaluate the spatial resolution. The local field potential(LFP) of rat hippocompus were recorded before and after FUS. The effect of FUS on LFP power spectrum was investigated by computing the LFP mean absolute power and relative power with Welch algorithm. The experiment results show that noninvasive FUS can enhance LFP mean absolute power and alter the LFP relative power at different frequency bands. The results indicate that FUS can modulate brain rhythms and has significant potential in the modulation of neuronal and psychiatric diseases.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.61273063)China Postdoctoral Science Foundation(Grant No.2013M540215)the Natural Science Foundation of Hebei Province,China(Grant No.F2014203161)
文摘Local field potential(LFP) signals of the rat hippocampus were recorded under noninvasive focused ultrasound stimulation(FUS) with different ultrasonic powers. The LFP mean absolute power was calculated with the Welch algorithm at the delta, theta, alpha, beta, and gamma frequency bands. The experimental results demonstrate that the LFP mean absolute power at different frequency bands increases as the ultrasound power increases.
基金National Natural Science Foundation of Chinagrant number:61503321+1 种基金Natural Science Foundation of Hebei Provincegrant number:F2014203161
文摘Low-intensity focused ultrasound stimulation(FUS), which possesses high spatial resolution and penetration depth, has been developing rapidly for noninvasive brain neuromodulation in recent years. In this letter, a low-intensity FUS system was developed for noninvasive brain neuromodulation in vivo. The radius of ultrasonic focal spot was quantitatively calculated in theory to evaluate the spatial resolution. The local field potential(LFP) of rat hippocompus were recorded before and after FUS. The effect of FUS on LFP power spectrum was investigated by computing the LFP mean absolute power and relative power with Welch algorithm. The experiment results show that noninvasive FUS can enhance LFP mean absolute power and alter the LFP relative power at different frequency bands. The results indicate that FUS can modulate brain rhythms and has significant potential in the modulation of neuronal and psychiatric diseases.
