Drilling fluids with complicated compositions are becoming more common as the oil and gas industry develops. The production of hazardous cuttings is increasing, which not only stifles the oil and gas industry’s devel...Drilling fluids with complicated compositions are becoming more common as the oil and gas industry develops. The production of hazardous cuttings is increasing, which not only stifles the oil and gas industry’s development but also poses a severe environmental threat. Deep underground re-injection is a cost-effective and efficient method for dealing with hazardous cuttings. Numerous experiments and numerical studies on cuttings re-injection have been conducted in the past thirty years. However, there is still a divergence of views on the fracture development in the process of cuttings re-injection. A comprehensive review of existing studies is necessary to help researchers advance this technology. This paper provides a review of the fundamental studies on fracture behaviors during the deep underground re-injection of drilling cuttings. The limitations of the existing studies are also discussed to inspire new research endeavors.展开更多
Heterogeneity is an inherent component of rock and may be present in different forms including mineral heterogeneity,geometrical heterogeneity,weak grain boundaries and micro-defects.Microcracks are usually observed i...Heterogeneity is an inherent component of rock and may be present in different forms including mineral heterogeneity,geometrical heterogeneity,weak grain boundaries and micro-defects.Microcracks are usually observed in crystalline rocks in two forms:natural and stress-induced;the amount of stressinduced microcracking increases with depth and in-situ stress.Laboratory results indicate that the physical properties of rocks such as strength,deformability,P-wave velocity and permeability are influenced by increase in miciocrack intensity.In this study,the finite-discrete element method(FDEM)is used to model microcrack heterogeneity by introducing into a model sample sets of microcracks using the proposed micro discrete fracture network(μDFN) approach.The characteristics of the microcracks required to create μDFN models are obtained through image analyses of thin sections of Lac du Bonnet granite adopted from published literature.A suite of two-dimensional laboratory tests including uniaxial,triaxial compression and Brazilian tests is simulated and the results are compared with laboratory data.The FDEM-μDFN models indicate that micro-heterogeneity has a profound influence on both the mechanical behavior and resultant fracture pattern.An increase in the microcrack intensity leads to a reduction in the strength of the sample and changes the character of the rock strength envelope.Spalling and axial splitting dominate the failure mode at low confinement while shear failure is the dominant failure mode at high confinement.Numerical results from simulated compression tests show that microcracking reduces the cohesive component of strength alone,and the frictional strength component remains unaffected.Results from simulated Brazilian tests show that the tensile strength is influenced by the presence of microcracks,with a reduction in tensile strength as microcrack intensity increases.The importance of microcrack heterogeneity in reproducing a bi-linear or S-shape failure envelope and its effects on the mechanisms leading to spalling damage near an underground opening are also discussed.展开更多
Over the past twenty years, there has been a growing interest in the development of numerical models that can realistically capture the progressive failure of rock masses. In particular, the investigation of damage de...Over the past twenty years, there has been a growing interest in the development of numerical models that can realistically capture the progressive failure of rock masses. In particular, the investigation of damage development around underground excavations represents a key issue in several rock engineering applications, including tunnelling, mining, drilling, hydroelectric power generation, and the deep geological disposal of nuclear waste. The goal of this paper is to show the effectiveness of a hybrid finitediscrete element method(FDEM) code to simulate the fracturing mechanisms associated with the excavation of underground openings in brittle rock formations. A brief review of the current state-of-theart modelling approaches is initially provided, including the description of selecting continuum- and discontinuum-based techniques. Then, the influence of a number of factors, including mechanical and in situ stress anisotropy, as well as excavation geometry, on the simulated damage is analysed for three different geomechanical scenarios. Firstly, the fracture nucleation and growth process under isotropic rock mass conditions is simulated for a circular shaft. Secondly, the influence of mechanical anisotropy on the development of an excavation damaged zone(EDZ) around a tunnel excavated in a layered rock formation is considered. Finally, the interaction mechanisms between two large caverns of an underground hydroelectric power station are investigated, with particular emphasis on the rock mass response sensitivity to the pillar width and excavation sequence. Overall, the numerical results indicate that FDEM simulations can provide unique geomechanical insights in cases where an explicit consideration of fracture and fragmentation processes is of paramount importance.展开更多
Mineral contents and fractures of shale from well Yuye-1 and outcrops were examined mainly based on systematic description of the cores and outcrops, and data from experimental analyses. The data enabled us to thoroug...Mineral contents and fractures of shale from well Yuye-1 and outcrops were examined mainly based on systematic description of the cores and outcrops, and data from experimental analyses. The data enabled us to thoroughly explore the mineralogy and developmental features of shale of the Lower Silurian Longmaxi Formation in the study area. The results show that,the Lower Silurian Longmaxi Shale(SLS) in the southeastern margin of Sichuan Basin, China, is primarily characterized by a high content of brittle minerals and a relatively low content of clay minerals. The total content of brittle minerals is approximately 57%,including 27% quartz, 12.2% feldspar, 11.2% carbonate and 2.4% pyrite. The total content of clay minerals reaches 41.6%,composed of illite(23.8%), mixed-layer of illite and smectite(I/S)(10.8%) and chlorite(7.0%). The SLS accommodates the widespread development of various types of fractures, including tectonic fractures, diagenetic fractures, inter-layer fractures and slip fractures. The developmental level of the fracture in the SLS is mainly influenced by faults, lithology, mineral contents and total organic carbon content(TOC) in study area.展开更多
By using thin section identification, cathodoluminescence, major and trace elements and fluid inclusion tests and authigenic illite dating, based on observation of core cracks, combined with the microscopic characteri...By using thin section identification, cathodoluminescence, major and trace elements and fluid inclusion tests and authigenic illite dating, based on observation of core cracks, combined with the microscopic characteristics and imaging logging characteristics of fractures, the stages of the fractures in the Huagang Formation of the central reversal tectonic belt of the Xihu Sag in the East China Sea, and the matching relationship between the fracture development stages and the oil and gas charging stages are clarified. There are diagenetic fractures and tectonic fractures in the reservoirs of the Huagang Formation in the study area. The diagenetic fractures developed during the diagenetic stage of the reservoirs and have less effect on oil and gas migration and transport. The tectonic fractures are divided into three stages based on tectonic movements controlling the fractures and their relationships with hydrocarbon charging: The first stage of fractures was generated in the early stage of the Himalayan Movement–Longjing Movement(12–13 Ma ago), when the tectonic stress caused the sutures and shale strips to twist, deform, and break. Tectonic microfractures generated in this period had short extension, narrow width, and poor effectiveness, and had little effect on oil and gas migration and transport. The second stage of fractures came up during the middle-late period of Himalayan Movement–Longjing Movement(9–12 Ma ago), when tectonic movements caused the development of tectonic fractures in the central reversal tectonic belt, these fractures are of large scale, long extension, and good effectiveness, and matched with the first stage of large scale oil and gas charging(9–12 Ma ago), so they play an important role in oil and gas migration, transportation, and accumulation. The third stage of fractures were created from Himalayan Movement–Okinawa Trough movement to the present day(0–3 Ma ago), the fractures are tectonic ones developing successively;matching with the second stage(0–3 Ma ago) of large-scale oil and gas charging, they created conditions for continuous natural gas migration and transportation. All these prove that the development of reservoir fractures in the Huagang Formation of Xihu Sag can provide seepage space and continuous and effective channels for efficient migration and accumulation of oil and gas.展开更多
Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated amputations.However,the mechanisms behind blast-induced HO remain unclea...Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated amputations.However,the mechanisms behind blast-induced HO remain unclear.Animal models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an amputation.Several studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact loading.However,these models are limited by the survivability of the animal and repeatability of the model.In this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast only.The platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's body.We obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and weight.Importantly,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled injury.We further conducted parametric studies by varying the features of the design of the platform.These factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting injury.This platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast injury.In addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.展开更多
BACKGROUND Spinal osteoporosis is a prevalent health condition characterized by the thinning of bone tissues in the spine,increasing the risk of fractures.Given its high incidence,especially among older populations,it...BACKGROUND Spinal osteoporosis is a prevalent health condition characterized by the thinning of bone tissues in the spine,increasing the risk of fractures.Given its high incidence,especially among older populations,it is critical to have accurate and effective predictive models for fracture risk.Traditionally,clinicians have relied on a combination of factors such as demographics,clinical attributes,and radiological characteristics to predict fracture risk in these patients.However,these models often lack precision and fail to include all potential risk factors.There is a need for a more comprehensive,statistically robust prediction model that can better identify high-risk individuals for early intervention.AIM To construct and validate a model for forecasting fracture risk in patients with spinal osteoporosis.METHODS The medical records of 80 patients with spinal osteoporosis who were diagnosed and treated between 2019 and 2022 were retrospectively examined.The patients were selected according to strict criteria and categorized into two groups:Those with fractures(n=40)and those without fractures(n=40).Demographics,clinical attributes,biochemical indicators,bone mineral density(BMD),and radiological characteristics were collected and compared.A logistic regression analysis was employed to create an osteoporotic fracture risk-prediction model.The area under the receiver operating characteristic curve(AUROC)was used to evaluate the model’s performance.RESULTS Factors significantly associated with fracture risk included age,sex,body mass index(BMI),smoking history,BMD,vertebral trabecular alterations,and prior vertebral fractures.The final risk-prediction model was developed using the formula:(logit[P]=-3.75+0.04×age-1.15×sex+0.02×BMI+0.83×smoking history+2.25×BMD-1.12×vertebral trabecular alterations+1.83×previous vertebral fractures).The AUROC of the model was 0.93(95%CI:0.88-0.96,P<0.001),indicating strong discriminatory capabilities.CONCLUSION The fracture risk-prediction model,utilizing accessible clinical,biochemical,and radiological information,offered a precise tool for the evaluation of fracture risk in patients with spinal osteoporosis.The model has potential in the identification of high-risk individuals for early intervention and the guidance of appropriate preventive actions to reduce the impact of osteoporosis-related fractures.展开更多
Structure plane is one of the important factors affecting the stability and failure mode of rock mass engineering.Rock mass structure characterization is the basic work of rock mechanics research and the important con...Structure plane is one of the important factors affecting the stability and failure mode of rock mass engineering.Rock mass structure characterization is the basic work of rock mechanics research and the important content of numerical simulation.A new 3-dimensional rough discrete fracture network(RDFN3D)model and its modeling method based on the Weierstrass-Mandelbrot(W-M)function were presented in this paper.The RDFN3D model,which improves and unifies the modelling methods for the complex structural planes,has been realized.The influence of fractal dimension,amplitude,and surface precision on the modeling parameters of RDFN3D was discussed.The reasonable W-M parameters suitable for the roughness coefficient of JRC were proposed,and the relationship between the mathematical model and the joint characterization was established.The RDFN3D together with the smooth 3-dimensional discrete fracture network(DFN3D)models were successfully exported to the drawing exchange format,which will provide a wide application in numerous numerical simulation codes including both the continuous and discontinuous methods.The numerical models were discussed using the COMSOL Multiphysics code and the 3-dimensional particle flow code,respectively.The reliability of the RDFN3D model was preliminarily discussed and analyzed.The roughness and spatial connectivity of the fracture networks have a dominant effect on the fluid flow patterns.The research results can provide a new geological model and analysis model for numerical simulation and engineering analysis of jointed rock mass.展开更多
Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not...Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well understood.Type-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is absent.Immunofluorescence was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory columns.Parenchymal and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,CD34/CD39.LIF immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/CD118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,cytoarchitecture.These neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent precursors.Dissociated cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage cells.Fluorescence-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in culture.This is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal cords.Our data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterized by surface BMPRⅡ^(+)hNPCs.Our study has provided a new methodology for an in vitro model capable of amplifying human fetal spinal cord cell numbers for>10 passages.Investigations of the role BMPRⅡplays in spinal cord development have primarily relied upon mouse and rat models,with interpolations to human development being derived through inference.Because of significant species differences between murine biology and human,including anatomical dissimilarities in central nervous system(CNS)structure,the findings made in murine models cannot be presumed to apply to human spinal cord development.For these reasons,our human in vitro model offers a novel tool to better understand neurodevelopmental pathways,including BMP signaling,as well as spinal cord injury research and testing drug therapies.展开更多
This paper describes numerical simulation of hydraulic fracturing using fracture-based continuum modeling(FBCM)of coupled geomechanical-hydrological processes to evaluate a technique for high-density fracturing and fr...This paper describes numerical simulation of hydraulic fracturing using fracture-based continuum modeling(FBCM)of coupled geomechanical-hydrological processes to evaluate a technique for high-density fracturing and fracture caging.The simulations are innovative because of modeling discrete fractures explicitly in continuum analysis.A key advantage of FBCM is that fracture initiation and propagation are modeled explicitly without changing the domain grid(i.e.no re-meshing).Further,multiple realizations of a preexisting fracture distribution can be analyzed using the same domain grid.The simulated hydraulic fracturing technique consists of pressurizing multiple wells simultaneously:initially without permeating fluids into the rock,to seed fractures uniformly and at high density in the wall rock of the wells;followed by fluid injection to propagate the seeded fracture density hydraulically.FBCM combines the ease of continuum modeling with the potential accuracy of modeling discrete fractures and fracturing explicitly.Fractures are modeled as piecewise planar based on intersections with domain elements;fracture geometry stored as continuum properties is used to calculate parameters needed to model individual fractures;and rock behavior is modeled through tensorial aggregation of the behavior of discrete fractures and unfractured rock.Simulations are presented for previously unfractured rock and for rock with preexisting fractures of horizontal,shallow-dipping,steeply dipping,or vertical orientation.Simulations of a single-well model are used to determine the pattern and spacing for a multiple-well design.The results illustrate high-density fracturing and fracture caging through simultaneous fluid injection in multiple wells:for previously unfractured rock or rock with preexisting shallow-dipping or horizontal fractures,and in situ vertical compressive stress greater than horizontal.If preexisting fractures are steeply dipping or vertical,and considering the same in situ stress condition,well pressurization without fluid permeation appears to be the only practical way to induce new fractures and contain fracturing within the target domain.展开更多
Borehole instability in naturally fractured rocks poses significant challenges to drilling.Drilling mud invades the surrounding formations through natural fractures under the difference between the wellbore pressure(P...Borehole instability in naturally fractured rocks poses significant challenges to drilling.Drilling mud invades the surrounding formations through natural fractures under the difference between the wellbore pressure(P w)and pore pressure(P p)during drilling,which may cause wellbore instability.However,the weakening of fracture strength due to mud intrusion is not considered in most existing borehole stability analyses,which may yield significant errors and misleading predictions.In addition,only limited factors were analyzed,and the fracture distribution was oversimplified.In this paper,the impacts of mud intrusion and associated fracture strength weakening on borehole stability in fractured rocks under both isotropic and anisotropic stress states are investigated using a coupled DEM(distinct element method)and DFN(discrete fracture network)method.It provides estimates of the effect of fracture strength weakening,wellbore pressure,in situ stresses,and sealing efficiency on borehole stability.The results show that mud intrusion and weakening of fracture strength can damage the borehole.This is demonstrated by the large displacement around the borehole,shear displacement on natural fractures,and the generation of fracture at shear limit.Mud intrusion reduces the shear strength of the fracture surface and leads to shear failure,which explains that the increase in mud weight may worsen borehole stability during overbalanced drilling in fractured formations.A higher in situ stress anisotropy exerts a significant influence on the mechanism of shear failure distribution around the wellbore.Moreover,the effect of sealing natural fractures on maintaining borehole stability is verified in this study,and the increase in sealing efficiency reduces the radial invasion distance of drilling mud.This study provides a directly quantitative prediction method of borehole instability in naturally fractured formations,which can consider the discrete fracture network,mud intrusion,and associated weakening of fracture strength.The information provided by the numerical approach(e.g.displacement around the borehole,shear displacement on fracture,and fracture at shear limit)is helpful for managing wellbore stability and designing wellbore-strengthening operations.展开更多
Karst fracture-cavity carbonate reservoirs,in which natural cavities are connected by natural fractures to form cavity clusters in many circumstances,have become significant fields of oil and gas exploration and explo...Karst fracture-cavity carbonate reservoirs,in which natural cavities are connected by natural fractures to form cavity clusters in many circumstances,have become significant fields of oil and gas exploration and exploitation.Proppant fracturing is considered as the best method for exploiting carbonate reservoirs;however,previous studies primarily focused on the effects of individual types of geological formations,such as natural fractures or cavities,on fracture propagation.In this study,true-triaxial physical simulation experiments were systematically performed under four types of stress difference conditions after the accurate prefabrication of four types of different fracture-cavity distributions in artificial samples.Subsequently,the interaction mechanism between the hydraulic fractures and fracture-cavity structures was systematically analyzed in combination with the stress distribution,cross-sectional morphology of the main propagation path,and three-dimensional visualization of the overall fracture network.It was found that the propagation of hydraulic fractures near the cavity was inhibited by the stress concentration surrounding the cavity.In contrast,a natural fracture with a smaller approach angle(0°and 30°)around the cavity can alleviate the stress concentration and significantly facilitate the connection with the cavity.In addition,the hydraulic fracture crossed the natural fracture at the 45°approach angle and bypassed the cavity under higher stress difference conditions.A new stimulation effectiveness evaluation index was established based on the stimulated reservoir area(SRA),tortuosity of the hydraulic fractures(T),and connectivity index(CI)of the cavities.These findings provide new insights into the fracturing design of carbonate reservoirs.展开更多
Radial borehole fracturing that combines radial boreholes with hydraulic fracturing is anticipated to improve the output of tight oil and gas reservoirs.This paper aims to investigate fracture propagation and pressure...Radial borehole fracturing that combines radial boreholes with hydraulic fracturing is anticipated to improve the output of tight oil and gas reservoirs.This paper aims to investigate fracture propagation and pressure characteristics of radial borehole fracturing in multiple layers.A series of laboratory experiments with artificial rock samples(395 mm×395 mm×395 mm)was conducted using a true triaxial fracturing device.Three crucial factors corresponding to the vertical distance of adjacent radial borehole layers(vertical distance),the azimuth and diameter of the radial borehole are examined.Experimental results show that radial borehole fracturing in multiple layers generates diverse fracture geometries.Four types of fractures are identified based on the connectivity between hydraulic fractures and radial boreholes.The vertical distance significantly influences fracture propagation perpendicular to the radial borehole axis.An increase in the vertical distance impedes fracture connection across multiple radial borehole layers and reduces the fracture propagation distance along the radial borehole axis.The azimuth also influences fracture propagation along the radial borehole axis.Increasing the azimuth reduces the guiding ability of radial boreholes,which makes the fracture quickly curve to the maximum horizontal stress direction.The breakdown pressure correlates with diverse fracture geometries observed.When the fractures connect multi-layer radial boreholes,increasing the vertical distance decreases the breakdown pressure.Decreasing the azimuth and increasing the diameter also decrease the breakdown pressure.The extrusion force exists between the adjacent fractures generated in radial boreholes in multiple rows,which plays a crucial role in enhancing the guiding ability of radial boreholes and results in higher breakdown pressure.The research provides valuable theoretical insights for the field application of radial borehole fracturing technology in tight oil and gas reservoirs.展开更多
Acetabular fractures in the geriatric population are typically low-energy fractures resulting from a fall from standing height.Compromised bone quality in the elderly,as well as this population’s concomitant medical ...Acetabular fractures in the geriatric population are typically low-energy fractures resulting from a fall from standing height.Compromised bone quality in the elderly,as well as this population’s concomitant medical comorbidities,render the management of such fractures challenging and controversial.Non-operative management remains the mainstay of treatment,although such a choice is associated with numerous and serious complications related to both the hip joint as well as the general condition of the patient.On the other hand,operatively treating acetabular fractures(e.g.,with osteosynthesis or total hip arthroplasty)is gaining popularity.Osteosynthesis can be performed with open reduction and internal fixation or with minimally invasive techniques.Total hip arthroplasty could be performed either in the acute phase combined with osteosynthesis or as a delayed procedure after a period of non-operative management or after failed osteosynthesis of the acetabulum.Regardless of the implemented treatment,orthogeriatric co-management is considered extremely crucial,and it is currently one of the pillars of a successful outcome after an acetabular fracture.展开更多
The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determinati...The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determination based on the HTPF method requires at least six tests or a minimum of 14-15 tests(under different conditions)for reliable results.In this study,we modified the HTPF method by considering the shear stress on each pre-existing fracture,which increased the number of equations for the stress tensor determination and decreased the number of tests required.Different shear stresses were attributed to different fractures by random sampling;therefore,the stress tensors were obtained by searching for the optimal solution using the least squares criterion based on the Monte Carlo method.Thereafter,we constrained the stress tensor based on the tensile strength criterion,compressive strength criterion,and vertical stress constraints.The inverted stress tensors were presented and analyzed based on the tensorial nature of the stress using the Euclidean mean stress tensor.Two stress-measurement campaigns in Weifang(Shandong Province,China)and Mercantour road tunnel(France)were implemented to highlight the validity and efficiency of the modified HTPF(M-HTPF)method.The results showed that the M-HTPF method can be applied for stress tensor inversion using only three to four tests on pre-existing fractures,neglecting the stress gradient.The inversion results were confined to relatively small distribution dispersions and were significantly reliable and stable due to the shear stresses on the fractures and the stress constraints employed.The M-HTPF method is highly feasible and efficient for complete stress tensor determination in a single borehole.展开更多
BACKGROUND Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types:Supracondylar(SC),lateral condyle(LC),and medial epicondyle(ME)fractu...BACKGROUND Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types:Supracondylar(SC),lateral condyle(LC),and medial epicondyle(ME)fractures.AIM To evaluate the epidemiology of pediatric distal humerus fractures(SC,LC,and ME)from an American insurance claims database.METHODS A retrospective review was performed on patients 17 years and younger with the ICD 9 and 10 codes for SC,LC and ME fractures based on the IBM Truven MarketScan®Commercial and IBM Truven MarketScan Medicare Supplemental databases.Patients from 2015 to 2020 were queried for treatments,patient age,sex,length of hospitalization,and comorbidities.RESULTS A total of 1133 SC,154 LC,and 124 ME fractures were identified.SC fractures had the highest percentage of operation at 83%,followed by LC(78%)and ME fractures(41%).Male patients were,on average,older than female patients for both SC and ME fractures.CONCLUSION In the insurance claims databases used,SC fractures were the most reported,followed by LC fractures,and finally ME fractures.Age was identified to be a factor for how a pediatric distal humerus fractures,with patients with SC and LC fractures being younger than those with ME fractures.The peak age per injury per sex was similar to reported historic central tendencies,despite reported trends for younger physiologic development.展开更多
Purpose: This study aims to investigate the predictive value of blood calcium in the prognosis of traumatic fracture. Methods: A retrospective experimental design was employed, 112 cases (52 non-fracture and 60 trauma...Purpose: This study aims to investigate the predictive value of blood calcium in the prognosis of traumatic fracture. Methods: A retrospective experimental design was employed, 112 cases (52 non-fracture and 60 traumatic fracture) were randomly selected. The type of fracture complies with WHO-recommended (2019) diagnostic criteria for osteoporosis combined with fracture. The blood pressure (BP) was measured by OMRON’s HEM-7136 model electronic blood pressure monitor. Blood calcium (Ca<sup>2+</sup>), and blood phosphorus (P) values were measured using Colorimetric Roche kits on a Roche/Hitachi fully automated biochemical analyzer. Data collection and analysis followed. Results: Higher levels of age, systolic and diastolic blood pressures were found in the traumatic fracture group compared to the control group, whereas weight, height, and blood phosphorus did not differ significantly (P adjusting for age, systolic blood pressure, diastolic blood pressure, and blood phosphorus, binary logistic regression analysis revealed that blood calcium was a protective factor against traumatic fracture (β = -26.85, OR = 0.00, 95% CI = 0.00 -0.02, P = 0.022). Conclusion: The findings suggest that high and low blood calcium levels may serve as useful indicators in predicting the prognosis of fractures resulting from trauma.展开更多
FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during development.FE65 belongs to the FE65 protein family.This family is comp...FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during development.FE65 belongs to the FE65 protein family.This family is comprised of three members,FE65,FE65 like-1(FE65L1),and FE65 like-2(FE65L2).展开更多
Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fracture...Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fractured at 30° and 45° angles. The experimental results indicate that the steady creep strain rates of intact and fractured rock present an exponential increase trend with the increase of stress level. A nonlinear creep model is developed based on the experimental results, in which the initial damage caused by fracture together with the damage caused by constant load have been taken into consideration. The fitting analysis results indicated that the model proposed is more accurate at identifying the full creep regions in fractured granite, especially the accelerated stage of creep deformation. The least-square fit error of the proposed creep model is significantly lower than that of Nishihara model by almost an order of magnitude. An analysis of the effects of elastic modulus, viscosity coefficient, and damage factors on fractured rock strain rate and creep strain is conducted. If no consideration is given to the effects of the damage, the proposed nonlinear creep model can degenerate into to the classical Nishihara model.展开更多
基金financially supported by National Natural Science Foundation of China(Grant Nos.52074312 and 52004298)。
文摘Drilling fluids with complicated compositions are becoming more common as the oil and gas industry develops. The production of hazardous cuttings is increasing, which not only stifles the oil and gas industry’s development but also poses a severe environmental threat. Deep underground re-injection is a cost-effective and efficient method for dealing with hazardous cuttings. Numerous experiments and numerical studies on cuttings re-injection have been conducted in the past thirty years. However, there is still a divergence of views on the fracture development in the process of cuttings re-injection. A comprehensive review of existing studies is necessary to help researchers advance this technology. This paper provides a review of the fundamental studies on fracture behaviors during the deep underground re-injection of drilling cuttings. The limitations of the existing studies are also discussed to inspire new research endeavors.
文摘Heterogeneity is an inherent component of rock and may be present in different forms including mineral heterogeneity,geometrical heterogeneity,weak grain boundaries and micro-defects.Microcracks are usually observed in crystalline rocks in two forms:natural and stress-induced;the amount of stressinduced microcracking increases with depth and in-situ stress.Laboratory results indicate that the physical properties of rocks such as strength,deformability,P-wave velocity and permeability are influenced by increase in miciocrack intensity.In this study,the finite-discrete element method(FDEM)is used to model microcrack heterogeneity by introducing into a model sample sets of microcracks using the proposed micro discrete fracture network(μDFN) approach.The characteristics of the microcracks required to create μDFN models are obtained through image analyses of thin sections of Lac du Bonnet granite adopted from published literature.A suite of two-dimensional laboratory tests including uniaxial,triaxial compression and Brazilian tests is simulated and the results are compared with laboratory data.The FDEM-μDFN models indicate that micro-heterogeneity has a profound influence on both the mechanical behavior and resultant fracture pattern.An increase in the microcrack intensity leads to a reduction in the strength of the sample and changes the character of the rock strength envelope.Spalling and axial splitting dominate the failure mode at low confinement while shear failure is the dominant failure mode at high confinement.Numerical results from simulated compression tests show that microcracking reduces the cohesive component of strength alone,and the frictional strength component remains unaffected.Results from simulated Brazilian tests show that the tensile strength is influenced by the presence of microcracks,with a reduction in tensile strength as microcrack intensity increases.The importance of microcrack heterogeneity in reproducing a bi-linear or S-shape failure envelope and its effects on the mechanisms leading to spalling damage near an underground opening are also discussed.
基金supported by the Natural Science and Engineering Research Council (NSERC) of Canada in the form of discovery grant No. 341275the Swiss National Cooperative for the Disposal of Radioactive Waste (NAGRA)
文摘Over the past twenty years, there has been a growing interest in the development of numerical models that can realistically capture the progressive failure of rock masses. In particular, the investigation of damage development around underground excavations represents a key issue in several rock engineering applications, including tunnelling, mining, drilling, hydroelectric power generation, and the deep geological disposal of nuclear waste. The goal of this paper is to show the effectiveness of a hybrid finitediscrete element method(FDEM) code to simulate the fracturing mechanisms associated with the excavation of underground openings in brittle rock formations. A brief review of the current state-of-theart modelling approaches is initially provided, including the description of selecting continuum- and discontinuum-based techniques. Then, the influence of a number of factors, including mechanical and in situ stress anisotropy, as well as excavation geometry, on the simulated damage is analysed for three different geomechanical scenarios. Firstly, the fracture nucleation and growth process under isotropic rock mass conditions is simulated for a circular shaft. Secondly, the influence of mechanical anisotropy on the development of an excavation damaged zone(EDZ) around a tunnel excavated in a layered rock formation is considered. Finally, the interaction mechanisms between two large caverns of an underground hydroelectric power station are investigated, with particular emphasis on the rock mass response sensitivity to the pillar width and excavation sequence. Overall, the numerical results indicate that FDEM simulations can provide unique geomechanical insights in cases where an explicit consideration of fracture and fragmentation processes is of paramount importance.
基金Project(41302076)supported by the National Natural Science Foundation of ChinaProject(BJ14266)supported by Special Fund of Ministry of Science and Technology from the State Key Laboratory of Continental Dynamics(Northwest University),China
文摘Mineral contents and fractures of shale from well Yuye-1 and outcrops were examined mainly based on systematic description of the cores and outcrops, and data from experimental analyses. The data enabled us to thoroughly explore the mineralogy and developmental features of shale of the Lower Silurian Longmaxi Formation in the study area. The results show that,the Lower Silurian Longmaxi Shale(SLS) in the southeastern margin of Sichuan Basin, China, is primarily characterized by a high content of brittle minerals and a relatively low content of clay minerals. The total content of brittle minerals is approximately 57%,including 27% quartz, 12.2% feldspar, 11.2% carbonate and 2.4% pyrite. The total content of clay minerals reaches 41.6%,composed of illite(23.8%), mixed-layer of illite and smectite(I/S)(10.8%) and chlorite(7.0%). The SLS accommodates the widespread development of various types of fractures, including tectonic fractures, diagenetic fractures, inter-layer fractures and slip fractures. The developmental level of the fracture in the SLS is mainly influenced by faults, lithology, mineral contents and total organic carbon content(TOC) in study area.
基金sponsored jointly by the National Natural Science Foundation Project(41072098,41002072)National Special Proiect of Investigation and Evaluation on Strategic Screening for National Oil & Gas Resources-"Potentials of Shale Gas Resources in Kev Chinese Areas and Optimization of Favorable Areas"(No.2009GYXQ-15)+2 种基金Major Special Project for National Science and Technology(2008ZX05031-001-005HZ)"973"Project of Development Plan for National Key Fundamental Studies(2006CB202302)CNPC Science & Technology Innovation Foundation Project(2008D-5006-01-06)
基金Supported by the China National Science and Technology Major Project(2016ZX05027,2016ZX05027-002-006)
文摘By using thin section identification, cathodoluminescence, major and trace elements and fluid inclusion tests and authigenic illite dating, based on observation of core cracks, combined with the microscopic characteristics and imaging logging characteristics of fractures, the stages of the fractures in the Huagang Formation of the central reversal tectonic belt of the Xihu Sag in the East China Sea, and the matching relationship between the fracture development stages and the oil and gas charging stages are clarified. There are diagenetic fractures and tectonic fractures in the reservoirs of the Huagang Formation in the study area. The diagenetic fractures developed during the diagenetic stage of the reservoirs and have less effect on oil and gas migration and transport. The tectonic fractures are divided into three stages based on tectonic movements controlling the fractures and their relationships with hydrocarbon charging: The first stage of fractures was generated in the early stage of the Himalayan Movement–Longjing Movement(12–13 Ma ago), when the tectonic stress caused the sutures and shale strips to twist, deform, and break. Tectonic microfractures generated in this period had short extension, narrow width, and poor effectiveness, and had little effect on oil and gas migration and transport. The second stage of fractures came up during the middle-late period of Himalayan Movement–Longjing Movement(9–12 Ma ago), when tectonic movements caused the development of tectonic fractures in the central reversal tectonic belt, these fractures are of large scale, long extension, and good effectiveness, and matched with the first stage of large scale oil and gas charging(9–12 Ma ago), so they play an important role in oil and gas migration, transportation, and accumulation. The third stage of fractures were created from Himalayan Movement–Okinawa Trough movement to the present day(0–3 Ma ago), the fractures are tectonic ones developing successively;matching with the second stage(0–3 Ma ago) of large-scale oil and gas charging, they created conditions for continuous natural gas migration and transportation. All these prove that the development of reservoir fractures in the Huagang Formation of Xihu Sag can provide seepage space and continuous and effective channels for efficient migration and accumulation of oil and gas.
基金the auspices of the Royal British Legion Centre for Blast Injury Studies at Imperial College Londonthe financial support of the Royal British Legion。
文摘Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated amputations.However,the mechanisms behind blast-induced HO remain unclear.Animal models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an amputation.Several studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact loading.However,these models are limited by the survivability of the animal and repeatability of the model.In this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast only.The platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's body.We obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and weight.Importantly,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled injury.We further conducted parametric studies by varying the features of the design of the platform.These factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting injury.This platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast injury.In addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.
文摘BACKGROUND Spinal osteoporosis is a prevalent health condition characterized by the thinning of bone tissues in the spine,increasing the risk of fractures.Given its high incidence,especially among older populations,it is critical to have accurate and effective predictive models for fracture risk.Traditionally,clinicians have relied on a combination of factors such as demographics,clinical attributes,and radiological characteristics to predict fracture risk in these patients.However,these models often lack precision and fail to include all potential risk factors.There is a need for a more comprehensive,statistically robust prediction model that can better identify high-risk individuals for early intervention.AIM To construct and validate a model for forecasting fracture risk in patients with spinal osteoporosis.METHODS The medical records of 80 patients with spinal osteoporosis who were diagnosed and treated between 2019 and 2022 were retrospectively examined.The patients were selected according to strict criteria and categorized into two groups:Those with fractures(n=40)and those without fractures(n=40).Demographics,clinical attributes,biochemical indicators,bone mineral density(BMD),and radiological characteristics were collected and compared.A logistic regression analysis was employed to create an osteoporotic fracture risk-prediction model.The area under the receiver operating characteristic curve(AUROC)was used to evaluate the model’s performance.RESULTS Factors significantly associated with fracture risk included age,sex,body mass index(BMI),smoking history,BMD,vertebral trabecular alterations,and prior vertebral fractures.The final risk-prediction model was developed using the formula:(logit[P]=-3.75+0.04×age-1.15×sex+0.02×BMI+0.83×smoking history+2.25×BMD-1.12×vertebral trabecular alterations+1.83×previous vertebral fractures).The AUROC of the model was 0.93(95%CI:0.88-0.96,P<0.001),indicating strong discriminatory capabilities.CONCLUSION The fracture risk-prediction model,utilizing accessible clinical,biochemical,and radiological information,offered a precise tool for the evaluation of fracture risk in patients with spinal osteoporosis.The model has potential in the identification of high-risk individuals for early intervention and the guidance of appropriate preventive actions to reduce the impact of osteoporosis-related fractures.
基金This work was financially supported by the National Key R&D Program of China(No.2021YFC2900500)the National Natural Science Foundation of China(Nos.52074020 and 42202306)+2 种基金the Open Fund of State Key Laboratory of Water Resource Protection and Utilization in Coal Mining(No.WPUKFJJ2019-06)the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities)(No.FRF-IDRY-21001)the Natural Science Foundation of Jiangsu Province,China(No.BK20200993).
文摘Structure plane is one of the important factors affecting the stability and failure mode of rock mass engineering.Rock mass structure characterization is the basic work of rock mechanics research and the important content of numerical simulation.A new 3-dimensional rough discrete fracture network(RDFN3D)model and its modeling method based on the Weierstrass-Mandelbrot(W-M)function were presented in this paper.The RDFN3D model,which improves and unifies the modelling methods for the complex structural planes,has been realized.The influence of fractal dimension,amplitude,and surface precision on the modeling parameters of RDFN3D was discussed.The reasonable W-M parameters suitable for the roughness coefficient of JRC were proposed,and the relationship between the mathematical model and the joint characterization was established.The RDFN3D together with the smooth 3-dimensional discrete fracture network(DFN3D)models were successfully exported to the drawing exchange format,which will provide a wide application in numerous numerical simulation codes including both the continuous and discontinuous methods.The numerical models were discussed using the COMSOL Multiphysics code and the 3-dimensional particle flow code,respectively.The reliability of the RDFN3D model was preliminarily discussed and analyzed.The roughness and spatial connectivity of the fracture networks have a dominant effect on the fluid flow patterns.The research results can provide a new geological model and analysis model for numerical simulation and engineering analysis of jointed rock mass.
基金supported by grants from the National Health and Medical Research Council(NHMRC)of Australia(Nos.571100 and 1048082)the Baxter Charitable Foundation(to TCL)+1 种基金Medical Research grants from the Rebecca L.Cooper Medical Research Foundation(to MWW,TCL,and MDL)supported by a Charles D.Kelman,M.D.Postdoctoral Award(2010)from the International Retinal Research Foundation(USA)。
文摘Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well understood.Type-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is absent.Immunofluorescence was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory columns.Parenchymal and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,CD34/CD39.LIF immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/CD118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,cytoarchitecture.These neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent precursors.Dissociated cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage cells.Fluorescence-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in culture.This is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal cords.Our data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterized by surface BMPRⅡ^(+)hNPCs.Our study has provided a new methodology for an in vitro model capable of amplifying human fetal spinal cord cell numbers for>10 passages.Investigations of the role BMPRⅡplays in spinal cord development have primarily relied upon mouse and rat models,with interpolations to human development being derived through inference.Because of significant species differences between murine biology and human,including anatomical dissimilarities in central nervous system(CNS)structure,the findings made in murine models cannot be presumed to apply to human spinal cord development.For these reasons,our human in vitro model offers a novel tool to better understand neurodevelopmental pathways,including BMP signaling,as well as spinal cord injury research and testing drug therapies.
文摘This paper describes numerical simulation of hydraulic fracturing using fracture-based continuum modeling(FBCM)of coupled geomechanical-hydrological processes to evaluate a technique for high-density fracturing and fracture caging.The simulations are innovative because of modeling discrete fractures explicitly in continuum analysis.A key advantage of FBCM is that fracture initiation and propagation are modeled explicitly without changing the domain grid(i.e.no re-meshing).Further,multiple realizations of a preexisting fracture distribution can be analyzed using the same domain grid.The simulated hydraulic fracturing technique consists of pressurizing multiple wells simultaneously:initially without permeating fluids into the rock,to seed fractures uniformly and at high density in the wall rock of the wells;followed by fluid injection to propagate the seeded fracture density hydraulically.FBCM combines the ease of continuum modeling with the potential accuracy of modeling discrete fractures and fracturing explicitly.Fractures are modeled as piecewise planar based on intersections with domain elements;fracture geometry stored as continuum properties is used to calculate parameters needed to model individual fractures;and rock behavior is modeled through tensorial aggregation of the behavior of discrete fractures and unfractured rock.Simulations are presented for previously unfractured rock and for rock with preexisting fractures of horizontal,shallow-dipping,steeply dipping,or vertical orientation.Simulations of a single-well model are used to determine the pattern and spacing for a multiple-well design.The results illustrate high-density fracturing and fracture caging through simultaneous fluid injection in multiple wells:for previously unfractured rock or rock with preexisting shallow-dipping or horizontal fractures,and in situ vertical compressive stress greater than horizontal.If preexisting fractures are steeply dipping or vertical,and considering the same in situ stress condition,well pressurization without fluid permeation appears to be the only practical way to induce new fractures and contain fracturing within the target domain.
基金financially supported by National Natural Science Foundation of China(Grant Nos.52074312 and 52211530097)CNPC Science and Technology Innovation Foundation(Grant No.2021DQ02-0505).
文摘Borehole instability in naturally fractured rocks poses significant challenges to drilling.Drilling mud invades the surrounding formations through natural fractures under the difference between the wellbore pressure(P w)and pore pressure(P p)during drilling,which may cause wellbore instability.However,the weakening of fracture strength due to mud intrusion is not considered in most existing borehole stability analyses,which may yield significant errors and misleading predictions.In addition,only limited factors were analyzed,and the fracture distribution was oversimplified.In this paper,the impacts of mud intrusion and associated fracture strength weakening on borehole stability in fractured rocks under both isotropic and anisotropic stress states are investigated using a coupled DEM(distinct element method)and DFN(discrete fracture network)method.It provides estimates of the effect of fracture strength weakening,wellbore pressure,in situ stresses,and sealing efficiency on borehole stability.The results show that mud intrusion and weakening of fracture strength can damage the borehole.This is demonstrated by the large displacement around the borehole,shear displacement on natural fractures,and the generation of fracture at shear limit.Mud intrusion reduces the shear strength of the fracture surface and leads to shear failure,which explains that the increase in mud weight may worsen borehole stability during overbalanced drilling in fractured formations.A higher in situ stress anisotropy exerts a significant influence on the mechanism of shear failure distribution around the wellbore.Moreover,the effect of sealing natural fractures on maintaining borehole stability is verified in this study,and the increase in sealing efficiency reduces the radial invasion distance of drilling mud.This study provides a directly quantitative prediction method of borehole instability in naturally fractured formations,which can consider the discrete fracture network,mud intrusion,and associated weakening of fracture strength.The information provided by the numerical approach(e.g.displacement around the borehole,shear displacement on fracture,and fracture at shear limit)is helpful for managing wellbore stability and designing wellbore-strengthening operations.
基金sponsored by the National Natural Science Foundation of China(Grants Nos.52104046 and 52104010).
文摘Karst fracture-cavity carbonate reservoirs,in which natural cavities are connected by natural fractures to form cavity clusters in many circumstances,have become significant fields of oil and gas exploration and exploitation.Proppant fracturing is considered as the best method for exploiting carbonate reservoirs;however,previous studies primarily focused on the effects of individual types of geological formations,such as natural fractures or cavities,on fracture propagation.In this study,true-triaxial physical simulation experiments were systematically performed under four types of stress difference conditions after the accurate prefabrication of four types of different fracture-cavity distributions in artificial samples.Subsequently,the interaction mechanism between the hydraulic fractures and fracture-cavity structures was systematically analyzed in combination with the stress distribution,cross-sectional morphology of the main propagation path,and three-dimensional visualization of the overall fracture network.It was found that the propagation of hydraulic fractures near the cavity was inhibited by the stress concentration surrounding the cavity.In contrast,a natural fracture with a smaller approach angle(0°and 30°)around the cavity can alleviate the stress concentration and significantly facilitate the connection with the cavity.In addition,the hydraulic fracture crossed the natural fracture at the 45°approach angle and bypassed the cavity under higher stress difference conditions.A new stimulation effectiveness evaluation index was established based on the stimulated reservoir area(SRA),tortuosity of the hydraulic fractures(T),and connectivity index(CI)of the cavities.These findings provide new insights into the fracturing design of carbonate reservoirs.
基金The authors gratefully acknowledge the financial support received from the Strategic Cooperation Technology Projects of CNPC and CUPB(No.ZLZX2020-01)the National Key Scientific Research Instrument Research Project of NSFC(No.51827804).
文摘Radial borehole fracturing that combines radial boreholes with hydraulic fracturing is anticipated to improve the output of tight oil and gas reservoirs.This paper aims to investigate fracture propagation and pressure characteristics of radial borehole fracturing in multiple layers.A series of laboratory experiments with artificial rock samples(395 mm×395 mm×395 mm)was conducted using a true triaxial fracturing device.Three crucial factors corresponding to the vertical distance of adjacent radial borehole layers(vertical distance),the azimuth and diameter of the radial borehole are examined.Experimental results show that radial borehole fracturing in multiple layers generates diverse fracture geometries.Four types of fractures are identified based on the connectivity between hydraulic fractures and radial boreholes.The vertical distance significantly influences fracture propagation perpendicular to the radial borehole axis.An increase in the vertical distance impedes fracture connection across multiple radial borehole layers and reduces the fracture propagation distance along the radial borehole axis.The azimuth also influences fracture propagation along the radial borehole axis.Increasing the azimuth reduces the guiding ability of radial boreholes,which makes the fracture quickly curve to the maximum horizontal stress direction.The breakdown pressure correlates with diverse fracture geometries observed.When the fractures connect multi-layer radial boreholes,increasing the vertical distance decreases the breakdown pressure.Decreasing the azimuth and increasing the diameter also decrease the breakdown pressure.The extrusion force exists between the adjacent fractures generated in radial boreholes in multiple rows,which plays a crucial role in enhancing the guiding ability of radial boreholes and results in higher breakdown pressure.The research provides valuable theoretical insights for the field application of radial borehole fracturing technology in tight oil and gas reservoirs.
文摘Acetabular fractures in the geriatric population are typically low-energy fractures resulting from a fall from standing height.Compromised bone quality in the elderly,as well as this population’s concomitant medical comorbidities,render the management of such fractures challenging and controversial.Non-operative management remains the mainstay of treatment,although such a choice is associated with numerous and serious complications related to both the hip joint as well as the general condition of the patient.On the other hand,operatively treating acetabular fractures(e.g.,with osteosynthesis or total hip arthroplasty)is gaining popularity.Osteosynthesis can be performed with open reduction and internal fixation or with minimally invasive techniques.Total hip arthroplasty could be performed either in the acute phase combined with osteosynthesis or as a delayed procedure after a period of non-operative management or after failed osteosynthesis of the acetabulum.Regardless of the implemented treatment,orthogeriatric co-management is considered extremely crucial,and it is currently one of the pillars of a successful outcome after an acetabular fracture.
基金supported by the National Natural Science Foundation of China(Grant No.42174118)a research grant(Grant No.ZDJ 2020-7)from the National Institute of Natural Hazards,Ministry of Emergency Management of China.
文摘The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determination based on the HTPF method requires at least six tests or a minimum of 14-15 tests(under different conditions)for reliable results.In this study,we modified the HTPF method by considering the shear stress on each pre-existing fracture,which increased the number of equations for the stress tensor determination and decreased the number of tests required.Different shear stresses were attributed to different fractures by random sampling;therefore,the stress tensors were obtained by searching for the optimal solution using the least squares criterion based on the Monte Carlo method.Thereafter,we constrained the stress tensor based on the tensile strength criterion,compressive strength criterion,and vertical stress constraints.The inverted stress tensors were presented and analyzed based on the tensorial nature of the stress using the Euclidean mean stress tensor.Two stress-measurement campaigns in Weifang(Shandong Province,China)and Mercantour road tunnel(France)were implemented to highlight the validity and efficiency of the modified HTPF(M-HTPF)method.The results showed that the M-HTPF method can be applied for stress tensor inversion using only three to four tests on pre-existing fractures,neglecting the stress gradient.The inversion results were confined to relatively small distribution dispersions and were significantly reliable and stable due to the shear stresses on the fractures and the stress constraints employed.The M-HTPF method is highly feasible and efficient for complete stress tensor determination in a single borehole.
文摘BACKGROUND Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types:Supracondylar(SC),lateral condyle(LC),and medial epicondyle(ME)fractures.AIM To evaluate the epidemiology of pediatric distal humerus fractures(SC,LC,and ME)from an American insurance claims database.METHODS A retrospective review was performed on patients 17 years and younger with the ICD 9 and 10 codes for SC,LC and ME fractures based on the IBM Truven MarketScan®Commercial and IBM Truven MarketScan Medicare Supplemental databases.Patients from 2015 to 2020 were queried for treatments,patient age,sex,length of hospitalization,and comorbidities.RESULTS A total of 1133 SC,154 LC,and 124 ME fractures were identified.SC fractures had the highest percentage of operation at 83%,followed by LC(78%)and ME fractures(41%).Male patients were,on average,older than female patients for both SC and ME fractures.CONCLUSION In the insurance claims databases used,SC fractures were the most reported,followed by LC fractures,and finally ME fractures.Age was identified to be a factor for how a pediatric distal humerus fractures,with patients with SC and LC fractures being younger than those with ME fractures.The peak age per injury per sex was similar to reported historic central tendencies,despite reported trends for younger physiologic development.
文摘Purpose: This study aims to investigate the predictive value of blood calcium in the prognosis of traumatic fracture. Methods: A retrospective experimental design was employed, 112 cases (52 non-fracture and 60 traumatic fracture) were randomly selected. The type of fracture complies with WHO-recommended (2019) diagnostic criteria for osteoporosis combined with fracture. The blood pressure (BP) was measured by OMRON’s HEM-7136 model electronic blood pressure monitor. Blood calcium (Ca<sup>2+</sup>), and blood phosphorus (P) values were measured using Colorimetric Roche kits on a Roche/Hitachi fully automated biochemical analyzer. Data collection and analysis followed. Results: Higher levels of age, systolic and diastolic blood pressures were found in the traumatic fracture group compared to the control group, whereas weight, height, and blood phosphorus did not differ significantly (P adjusting for age, systolic blood pressure, diastolic blood pressure, and blood phosphorus, binary logistic regression analysis revealed that blood calcium was a protective factor against traumatic fracture (β = -26.85, OR = 0.00, 95% CI = 0.00 -0.02, P = 0.022). Conclusion: The findings suggest that high and low blood calcium levels may serve as useful indicators in predicting the prognosis of fractures resulting from trauma.
文摘FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during development.FE65 belongs to the FE65 protein family.This family is comprised of three members,FE65,FE65 like-1(FE65L1),and FE65 like-2(FE65L2).
基金supported by the National Natural Science Foundation of China(No.42307258)the technological research projects in Sichuan Province(No.2022YFSY0007)the China Atomic Energy Authority(CAEA)through the Geological Disposal Program.
文摘Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fractured at 30° and 45° angles. The experimental results indicate that the steady creep strain rates of intact and fractured rock present an exponential increase trend with the increase of stress level. A nonlinear creep model is developed based on the experimental results, in which the initial damage caused by fracture together with the damage caused by constant load have been taken into consideration. The fitting analysis results indicated that the model proposed is more accurate at identifying the full creep regions in fractured granite, especially the accelerated stage of creep deformation. The least-square fit error of the proposed creep model is significantly lower than that of Nishihara model by almost an order of magnitude. An analysis of the effects of elastic modulus, viscosity coefficient, and damage factors on fractured rock strain rate and creep strain is conducted. If no consideration is given to the effects of the damage, the proposed nonlinear creep model can degenerate into to the classical Nishihara model.
