Happy Days,one of Samuel Beckett's renowned works,is remarkable for its absurdity.The paper approaches the predominant feature from such aspects as fragmented characters,disconnected language,peculiar structure an...Happy Days,one of Samuel Beckett's renowned works,is remarkable for its absurdity.The paper approaches the predominant feature from such aspects as fragmented characters,disconnected language,peculiar structure and grotesque stagecraft.展开更多
It analyses an excerpt from the post-modern novel Slaughterhouse-Five from the perspective of systemic functional linguistics.Through transitivity analysis and cohesion analysis,it finds that the novelist Kurt Vonnegu...It analyses an excerpt from the post-modern novel Slaughterhouse-Five from the perspective of systemic functional linguistics.Through transitivity analysis and cohesion analysis,it finds that the novelist Kurt Vonnegut uses passive voice and the image of the moon to enhance the passivity and insanity of the anti-hero Bill Pilgrim respectively.Moreover,the fact that there is only one conjunction helps to form the feature of fragmentedness of the postmodern novel.展开更多
Objective To describe the clinical characteristics of idiopathic ventricular fibrillation （IVF） with fragmented QRS complex （f-QRS） and J wave in resting electrocardiogram. Methods We reviewed data from 21 case su...Objective To describe the clinical characteristics of idiopathic ventricular fibrillation （IVF） with fragmented QRS complex （f-QRS） and J wave in resting electrocardiogram. Methods We reviewed data from 21 case subjects in our hospital who were resuscitated after cardiac arrest due to IVF and assessed the prevalence of f-QRS and J wave in resting electrocardiogram （ECG）. All the case subjects were classified among three groups based on the electrocardiographic morphology： group I, both f-QRS and J wave were observed （n = 6）, group II, only J wave was observed （n = 9）, group III, neither f-QRS nor J wave was observed （n = 6）. Population characteristics, history of syncope or sudden cardiac arrest, incidence of ventricular fibrillation （VF）, and circumstance of VF were evaluated among the three groups. Results The incidence of index events （syncope, survived cardiac arrest and VF episodes recorded in implantable cardioverter defibrillator （ICD） or pacemakers） was 13.4 ~ 5.6 per-year in group I, 10.8 ~ 3.9 per-year in group II, and 9.8 -4- 4.2 per-year in group HI. There were significant differences in incidences among the three groups, the most frequent index events were observed in group I. The hazard ratio for incidence was 3.2 （95%CI, 1.1-7.9; P = 0.01）. The history and circumstance of the index events were different among the groups. In group I, all the index events occurred during sleep in early morning. In group II, four subjects suffered VF during strenuous physical activities or agitation state, two during sleep in early morning, three in usual activity. In group III, one subject suffered VF during sleep in early morning, one in agitation state, four in usual activity. Conclusions This study suggests that the IVF patients with the combined appearance of f-QRS and J wave in the resting ECG suffer an increased risk of VF, this subgroup of IVF patients has a unique clinical feature.展开更多
The road effect on small rodent population is investigated at 8 fragmented forest areas in the Baekdudaegan mountain range, South Korea in September 2001. We especially focused on the distribution and body condition o...The road effect on small rodent population is investigated at 8 fragmented forest areas in the Baekdudaegan mountain range, South Korea in September 2001. We especially focused on the distribution and body condition of small rodents near the roads. Korean field mouse (Apodemus peninsulae) seems to be more sensitive to the existence of a road than striped field mouse (Apodemus agrarius). Korean field mouse prefers interior forest area to around road. Striped field mouse is a habitat generalist and has wide distributional range around road, but Korean field mouse is forest-inhabiting species and their distribution is limited in forest area. These results suggest the effect of road is different on each small rodent species and their habitat preferences.展开更多
The development of information technology has changed people's learning methods. Fragmented learning,as an informal learning method,has become an important way to accept new knowledge and learn new technologies. T...The development of information technology has changed people's learning methods. Fragmented learning,as an informal learning method,has become an important way to accept new knowledge and learn new technologies. Through analyzing the connotation,characteristics,and advantages and disadvantages of fragmented learning,this paper came up with reasonable recommendations for fragmented learning. To truly become systematic and holistic knowledge,fragmented knowledge must be explored,understood,integrated and internalized. This paper is expected to play an important guiding role in building a lifelong learning society.展开更多
Background: Era of contraception, abortions, [20th, 21st centuries] implemented as family welfare schemes, witnessed increased global incidence of Type 2 diabetes mellitus, systemic hypertension. Objectives: Altruisti...Background: Era of contraception, abortions, [20th, 21st centuries] implemented as family welfare schemes, witnessed increased global incidence of Type 2 diabetes mellitus, systemic hypertension. Objectives: Altruistic association of contraception [if any], with increasing diabetes mellitus, systemic hypertension, was sought after. Methods: In 2012, retrospective analysis of, prevalence of diabetes mellitus, systemic hypertension, in 350 patients of 20 - 35 years, 35 - 50 years, >50 years, age groups, data collected by convenient, stratified random sampling, from different geographical locations, between 2003-2012 and its association with presence, absence of contraception, abortion was undertaken;simultaneously, serum estrogen levels obtained from 105 patients, were also analysed. Results: 10 - 45 fold increase in Type 2 diabetes mellitus was seen in contraceptive users of >20 years to >50 years;15 - 50 fold increase in incidence of systemic hypertension was seen in contraceptive users of >20 years to >50 years. Endogenous estrogen was reduced below normal in 75% of contraceptive users, and 25% of contraceptive users had low normal serum estrogen. Cholesterol deprived diet, due to decreased synthesis of endogenous estrogen, androgen also was associated with 50% increase in diabetes mellitus, systemic hypertension. Conclusion: Concept is acquired contraception, abortion status, with smashed fragmentation of germ cells, reduced endogenous estrogen, androgen, results in defaulted genomic repertoire, deranged cell metabolism, increased incidence of diabetes mellitus, systemic hypertension as part of metabolic syndrome. Contraception reversal declined the diseases as a cause and effective phenomenon.展开更多
Background:Remnant microhabitats are important for bird habitat selection and plant regeneration in the fragmented habitat.However,empirical information on the consequences of how microhabitat use by birds affects the...Background:Remnant microhabitats are important for bird habitat selection and plant regeneration in the fragmented habitat.However,empirical information on the consequences of how microhabitat use by birds affects the early recruitment of plants is lacking.Methods:In this study,we evaluated whether microhabitat selection by the Black Bulbul(Hypsipetes leucocephalus)(J.F.Gmelin,1789)impacts the early recruitment of the endangered tree species,the Chinese Yew(Taxus chinensis(Pilger)Rehd),in a fragmented forest over a 4-year period(2011–2012,2018–2019).Results:Our results showed the main factors affecting H.leucocephalus microhabitat selection were distance to the nearest T.chinensis mature tree,herb cover and density,leaf litter cover,and vegetation type.Moreover,the results of logistic regression also highlighted the importance of elevation,distance to light gap and roads,tree cover in bird microhabitat selection.Furthermore,the seed emergence rate in microhabitats used by birds did not differ from the natural forest,which was related to five factors of bird microhabitat.The Random Forest model showed that seedling emergence rate was increased with leaf litter cover and distance to fallen dead trees,but decreased in relation to herb cover,slope,and elevation.Conclusion:Our results highlight the importance of remnant microhabitats in fragmented forests for sustaining forest ecology and optimal management.The contribution of microhabitats used by birds to plant recruitment provides insights into how frugivore species contribute to plant regeneration,which should be incorporated in future conservation and management practices of fragmented forests.展开更多
Background: Patients requiring valve replacement at a younger age, for rheumatic heart disease was apparently increasing after the new age practice of contraception. Methods: In 2012, data of patients referred to tert...Background: Patients requiring valve replacement at a younger age, for rheumatic heart disease was apparently increasing after the new age practice of contraception. Methods: In 2012, data of patients referred to tertiary care hospital from two cardiology screening camps conducted in the community, were analyzed for the severity of presentation of rheumatic heart disease and associated contraception status by dividing into the three age groups—20 - 35 years, 36 - 50 years, >51 years;~400 patients attended the camps;31 female and 2 male patients were referred to the tertiary care hospital for further evaluation and categorized treatment, including valve replacement surgeries;among the 33 referred patients, belonging to the three age groups, the data were analyzed for [if any] correlation of contraception status with severe rheumatic heart disease. 8 randomly chosen males, of the 3 age groups, from a different community, whose life partners had undergone sterilization, were assessed for their serum testosterone levels. Results: Among 20 - 35 years, 7 female patients with contraception required valve replacement surgeries [p 51 years, 3 female and 2 male patients without contraception received medical treatment only展开更多
Many bird species are specialized to live in the broadleaved,evergreen forests in the mountain regions in Southeast Asia.These mountain habitats are not continuously distributed as the different mountain areas are sep...Many bird species are specialized to live in the broadleaved,evergreen forests in the mountain regions in Southeast Asia.These mountain habitats are not continuously distributed as the different mountain areas are separated by lowlands,which has restricted gene flow and thus contributed to the high biological diversity in this region.The degree of connectivity between mountain areas has fluctuated with the Pleistocene glacial cycles,being largest during the glaciations when the mountain forests spread to lower elevations.Here we study how the intermittent periods of restricted gene flow and connectivity between the populations of five montane species of babblers(Aves,Timaliidae)in Vietnam may be traced in their genomes.The results suggest that the babbler species in the Central Highlands have been isolated from their sister-populations in northern Vietnam for between ca.585 and 380 ky.For two species with populations in both the Central Highlands and the Da Lat region,we found that these split at more or less the same time(440–340 kya).We also found a significant statistical correlation between the time of the splits of these populations and the lowest altitude at which they are known to occur(no similar correlation was found with the geographic distances between populations).The populations in northern Vietnam show higher genetic variation than their counterparts in South-Central Vietnam,supporting the postulate that smaller populations may have lower genetic variation than larger.In accordance with this,we found the lowest genetic variation in the two species with the smallest populations in the Central Highlands.These two populations also show low levels of genomic heterozygosity.Our results show that the south-central populations of the studied babbler species are genetically distinct from their sister-populations in northern Vietnam,providing additional argument for the long-term protection of the evergreen mountain forests in Southeast Asia.展开更多
In recent years,studies have shown that there is a correlation between sleep disorders and cancer,but at the present stage,the research on sleep disorders and tumor related animal models is relatively insufficient.Our...In recent years,studies have shown that there is a correlation between sleep disorders and cancer,but at the present stage,the research on sleep disorders and tumor related animal models is relatively insufficient.Our research will focus on mice bearing B16F10-luc-G5 melanoma tumor with sleep fragmentation,detecting promoting effect of sleep fragmentation(SF)on the metastasis of melanoma.At the same time,we used Ganoderma lucidum poly⁃saccharides peptide(GL-pp,80 mg·kg-1),a component of traditional Chinese medicine Ganoderma lucidum,which has long enjoyed a good reputation at home and abroad,to observe its anti-tumor metastasis effects on B16F10-luc-G5 mice with SF.Then we used whole proteomics to analyze the difference proteins expressed in lung tissue and compared between groups,includes mice bearing B16F10-luc-G5,mice bearing B16F10-luc-G5 with SF and GL-pp administered mice bearing B16F10-luc-G5 with SF.With the analysis using bioinformatics,we found several key proteins,their genes name are Adcy9,ptk2,Yap1 and Lpin2,Per1 and Tim.And several important clusters,they are,immune system,platelet aggres⁃sion,energy metabolism,cell cytoskeleton,cell adhesion and circadian rhythms.Moreover,we detected the TLR4 signal pathway and macrophage differentiation to reconfirm the results of proteomics and trying to elucidate the mechanism of SF on tumor growth and metastasis and the effects of GL-pp.展开更多
Patients with chronic obstructive pulmonary disease(COPD)have an increased risk for cardiovascular events,and electrocardiography has an important role in detecting cardiac side effects of COPD-related hypoxia.
Anthropogenic activities are increasing habitat fragmentation, as well as the number of threatened and endangered species. Thus, isolated fragments with natural remnant stands, or in situ or ex situ endangered species...Anthropogenic activities are increasing habitat fragmentation, as well as the number of threatened and endangered species. Thus, isolated fragments with natural remnant stands, or in situ or ex situ endangered species rescue populations, are on the rise. The most common method for assessing the “conservation health” of such populations is to determine or estimate the census size. However, while it is known that the census size of a population does not always correlate with its genetic diversity, methods for modeling how different factors can drive variation in the relationship of census size to genetic diversity in plant populations are needed. Here we use the computer program NEWGARDEN to investigate how the relationship of stand size versus genetic diversity (measured as both the percent of the founding alleles retained and FIT) can be extremely variable depending on founder number, founder density, and gene dispersal distances. Populations of endangered species that appear to have the same conservation health in terms of similar population numbers may differ greatly in their conservation health as indicated by the genetic diversity they retain. NEWGARDEN can be used to explore how different founding and intra- or interspecific life history characteristics can affect genetic diversity relative to census size. If proper historical data exist, NEWGARDEN can also be used to estimate the percent of founding genetic diversity remaining in a given stand.展开更多
Background-Rationale of the Study: Among several invasive and non-invasive tests for risk stratification of acute coronary syndromes (ACS), fewer markers can be utilized in clinical practice. Our rationale is to valid...Background-Rationale of the Study: Among several invasive and non-invasive tests for risk stratification of acute coronary syndromes (ACS), fewer markers can be utilized in clinical practice. Our rationale is to validate use of QRS-fragmentation as a promising bed-side test for assessment of prognosis in those patients. Methods and Results: Collection of two-hundred and twenty patients with ACS was done during two years (from January 2011 till January 2013). Significant organic vaLVe disease and QRS duration ≥ 120 ms as well as patients with permanent pacemakers were excluded. Patients were subjected to full clinical examination, ECG and Echocardiography in the first day of admission followed by diagnostic coronary angiography before discharge and a nuclear study was done for Randomized sample from each group. 12-leads ECG revealed fragmentation of QRS in 74 patients and 146 patients with no QRS fragmentation. Localization of the infarct site revealed NS difference between percentages in both groups. Echocardiography revealed a significant deterioration of LV functions in group-A than group-B. Also, MR jet area was significantly higher in group-A. Coronary angiography revealed severer lesions in group-A more than group-B. Nuclear study revealed higher percentages of irreversible scars in group-A (30%) and higher reversibility in group-B (80%). In-hospital Occurrence of complications from ACS revealed a significant higher incidence of MACE in group-A. Conclusion: Presence of fragmented QRS in surface ECG during ACS represents myocardial scar or fibrosis and reflects the severity of coronary lesions and a correlation between fQRS and depression of LVfunction is established. Indeed, occurrence of MACE is suspected.展开更多
Background: In spite of advanced technologies and drug discoveries, morbidity and mortality were undoubtedly increasing in the era of contraception and abortion. Aims: Altruistic correlation of increasing morbidity, m...Background: In spite of advanced technologies and drug discoveries, morbidity and mortality were undoubtedly increasing in the era of contraception and abortion. Aims: Altruistic correlation of increasing morbidity, mortality, with contraception, abortion was planned for. Methods: In 2012, a retrospective analysis of prevalence of mortality in 350 patients of 20 - 35 years, 35 - 50 years and >50 years from data collected between 2003 and 2012 by convenient, stratified random sampling, from community, hospital, and its association with contraception and abortion status was undertaken;simultaneously, serum estrogen levels obtained from 105 patients were analyzed. In 2014, randomly chosen 8 males, of the 3 age groups, from a different community, whose life partners had undergone sterilization, were assessed for their serum testosterone levels. Results: Contraception users exhibited 3 - 4 fold increased mortality [p 50 years [p < 0.0005]. Endogenous estrogen was reduced in 75% [p < 0.0005] of contraceptive users. Plasma testosterone was reduced in males observing contraception, to less than 50% of normal, e.g. 1.3 ng/ml;66.6% contraception users aged 20 - 35 years had reduced [p < 0.0005] testosterone;100% of male contraception users aged 36 - 70 years showed reduced testosterone [p < 0.0005]. Conclusion: The “withered tree akin host” concept is contraception, abortion, with smashed fragmentation of germ cells. Reduced endogenous estrogen, androgen [dried up, destroyed life factors] result in deranged cell metabolism, cell cycle, and defaulted genomic repertoire, leading to failure of all established pharmacological therapeutics, including advanced technologies which yield gratifying results in non contracepted people today and in every one, before the era of contraception;subsets of people, host with contraception, with destroyed life factors, behave helplessly, concerning therapeutic applications, compared with subsets of people, host without contraception, with intact genomic repertoire, God ordained Life factors, make a remarkable recovery. Contraception reversal replants the germ cells [germ cells destruction stops], hormones rejuvenate to 79.9% of age normal, and diseases abate with recovery.展开更多
In the era of new media,people’s lifestyle,education and the like are inseparable from the Internet.At the same time,due to the emergence of smart devices such as mobile phones and tablet computers,people’s reading ...In the era of new media,people’s lifestyle,education and the like are inseparable from the Internet.At the same time,due to the emergence of smart devices such as mobile phones and tablet computers,people’s reading habits have changed.Fragmented reading has become an important form of reading for college students.College students themselves have the strong ability to accept change,so fragmented reading has gradually become an important form of student learning.This paper mainly analyses fragmented reading by college students and its impact on society in the era of new media.展开更多
This paper attempts to investigate the feasibility and learning effects of English fragmented learning via mobile devices.Questionnaires and interviews were employed to do the survey on 157 undergraduates from 24 univ...This paper attempts to investigate the feasibility and learning effects of English fragmented learning via mobile devices.Questionnaires and interviews were employed to do the survey on 157 undergraduates from 24 universities in China.The research findings reveal that English fragmented learning via mobile devices has some positive effects on the improvement of learners’knowledge and learning ability.In addition,there have been a certain number of useful learning resources and platforms with diversified features.The study has the implications that fragmented mobile learning is feasible and can be popularized in English learning.展开更多
Objective: To study the correlation of QRS complex after percutaneous coronary intervention (PCI) with myocardial ischemia reperfusion injury and apoptosis molecule contents. Methods:Patients with non-ST-segment eleva...Objective: To study the correlation of QRS complex after percutaneous coronary intervention (PCI) with myocardial ischemia reperfusion injury and apoptosis molecule contents. Methods:Patients with non-ST-segment elevation myocardial infarction who were treated in Nanchong Central Hospital between June 2014 and August 2016 were selected and divided into the PCI group who received emergency PCI surgery and the control group who accepted selective PCI or refused emergency PCI after the medical data were retrospectively analyzed. The fQRS as well as the contents of ischemia reperfusion injury indexes and apoptosis molecules was determined after 1 week of treatment. Results: The incidence of fQRS in PCI group was significantly lower than that in control group;serum MDA, cTnI, H-FABP, sTWEAK, sFas, sTRAIL and Caspase-3 contents as well as peripheral blood Nrf-2 and HO-1 expression of PCI group were greatly lower than those of control group;serum MDA, cTnI, H-FABP, sTWEAK, sFas, sTRAIL and Caspase-3 contents as well as peripheral blood Nrf-2 and HO-1 expression of PCI group of patients with fQRS complex (+) were greatly higher than those of patients with fQRS complex (-). Conclusion: The occurrence of fQRS after PCI is closely related to myocardial ischemia reperfusion injury and apoptosis.展开更多
OCTOBER 25 is Central African Regional Integration Day. Few people know or observe this holiday because the citizens of Africa＇s poorest and most conflict-prone region have little to celebrate.
This study is aimed to investigate the clinical significance and the short-term prognostic value of frag- mented QRS （fQRS） for patients with acute myocardial infarction （AMI）. Three hundred patients with AMI were...This study is aimed to investigate the clinical significance and the short-term prognostic value of frag- mented QRS （fQRS） for patients with acute myocardial infarction （AMI）. Three hundred patients with AMI were tested with retrospective analysis on the patients＇ clinical information, hospitalized treatment, fQRS onset time, location of lesions, and other relevant data, in order to assess the relationship between the presence of fQRS and its prognosis. The rates of malignant cardiac arrhythmia, left ventricular systolic dysfunction （LVSD）, and mortality in the positive fQRS group were 13.6%, 29.2%, and 23.7%, respectively, with all showing a p value 〈0.05. For the ST segment elevation myocardial infarction （STEMI） subgroup, all the rates showed significant differences with a p value 〈0.01, while for the non-STEMI （NSTEMI） subgroup showed no significant differences. In patients with a positive fQRS, there were no differences in malignant cardiac arrhythmia between patients with and without percutaneous coronary in- tervention （PCI） （p〉0.05）. As for the LVSD and mortality, the p values between patients with and without PCI were 0.031 and 0.000, respectively, suggesting statistical significance. The results imply that AMI patients with positive fQRS especially for the patients with STEMI had higher rates of malignant cardiac arrhythmia, LVSD, and mortality than the non-fQRS group. Patients of AMI with positive fQRS, who underwent early revascularization, could lower the incidence of the cardiovascular event. In addition, the presence of fQRS could be used as an indication of early in- tervention treatment for patients.展开更多
文摘Happy Days,one of Samuel Beckett's renowned works,is remarkable for its absurdity.The paper approaches the predominant feature from such aspects as fragmented characters,disconnected language,peculiar structure and grotesque stagecraft.
文摘It analyses an excerpt from the post-modern novel Slaughterhouse-Five from the perspective of systemic functional linguistics.Through transitivity analysis and cohesion analysis,it finds that the novelist Kurt Vonnegut uses passive voice and the image of the moon to enhance the passivity and insanity of the anti-hero Bill Pilgrim respectively.Moreover,the fact that there is only one conjunction helps to form the feature of fragmentedness of the postmodern novel.
文摘Objective To describe the clinical characteristics of idiopathic ventricular fibrillation （IVF） with fragmented QRS complex （f-QRS） and J wave in resting electrocardiogram. Methods We reviewed data from 21 case subjects in our hospital who were resuscitated after cardiac arrest due to IVF and assessed the prevalence of f-QRS and J wave in resting electrocardiogram （ECG）. All the case subjects were classified among three groups based on the electrocardiographic morphology： group I, both f-QRS and J wave were observed （n = 6）, group II, only J wave was observed （n = 9）, group III, neither f-QRS nor J wave was observed （n = 6）. Population characteristics, history of syncope or sudden cardiac arrest, incidence of ventricular fibrillation （VF）, and circumstance of VF were evaluated among the three groups. Results The incidence of index events （syncope, survived cardiac arrest and VF episodes recorded in implantable cardioverter defibrillator （ICD） or pacemakers） was 13.4 ~ 5.6 per-year in group I, 10.8 ~ 3.9 per-year in group II, and 9.8 -4- 4.2 per-year in group HI. There were significant differences in incidences among the three groups, the most frequent index events were observed in group I. The hazard ratio for incidence was 3.2 （95%CI, 1.1-7.9; P = 0.01）. The history and circumstance of the index events were different among the groups. In group I, all the index events occurred during sleep in early morning. In group II, four subjects suffered VF during strenuous physical activities or agitation state, two during sleep in early morning, three in usual activity. In group III, one subject suffered VF during sleep in early morning, one in agitation state, four in usual activity. Conclusions This study suggests that the IVF patients with the combined appearance of f-QRS and J wave in the resting ECG suffer an increased risk of VF, this subgroup of IVF patients has a unique clinical feature.
文摘The road effect on small rodent population is investigated at 8 fragmented forest areas in the Baekdudaegan mountain range, South Korea in September 2001. We especially focused on the distribution and body condition of small rodents near the roads. Korean field mouse (Apodemus peninsulae) seems to be more sensitive to the existence of a road than striped field mouse (Apodemus agrarius). Korean field mouse prefers interior forest area to around road. Striped field mouse is a habitat generalist and has wide distributional range around road, but Korean field mouse is forest-inhabiting species and their distribution is limited in forest area. These results suggest the effect of road is different on each small rodent species and their habitat preferences.
基金Supported by Research Project on Education and Teaching Reform of Higher Education Institutions in Hainan Province(Hnjg2016-12)Education and Teaching Reform Research Project of Hainan University(hdjy1604)
文摘The development of information technology has changed people's learning methods. Fragmented learning,as an informal learning method,has become an important way to accept new knowledge and learn new technologies. Through analyzing the connotation,characteristics,and advantages and disadvantages of fragmented learning,this paper came up with reasonable recommendations for fragmented learning. To truly become systematic and holistic knowledge,fragmented knowledge must be explored,understood,integrated and internalized. This paper is expected to play an important guiding role in building a lifelong learning society.
文摘Background: Era of contraception, abortions, [20th, 21st centuries] implemented as family welfare schemes, witnessed increased global incidence of Type 2 diabetes mellitus, systemic hypertension. Objectives: Altruistic association of contraception [if any], with increasing diabetes mellitus, systemic hypertension, was sought after. Methods: In 2012, retrospective analysis of, prevalence of diabetes mellitus, systemic hypertension, in 350 patients of 20 - 35 years, 35 - 50 years, >50 years, age groups, data collected by convenient, stratified random sampling, from different geographical locations, between 2003-2012 and its association with presence, absence of contraception, abortion was undertaken;simultaneously, serum estrogen levels obtained from 105 patients, were also analysed. Results: 10 - 45 fold increase in Type 2 diabetes mellitus was seen in contraceptive users of >20 years to >50 years;15 - 50 fold increase in incidence of systemic hypertension was seen in contraceptive users of >20 years to >50 years. Endogenous estrogen was reduced below normal in 75% of contraceptive users, and 25% of contraceptive users had low normal serum estrogen. Cholesterol deprived diet, due to decreased synthesis of endogenous estrogen, androgen also was associated with 50% increase in diabetes mellitus, systemic hypertension. Conclusion: Concept is acquired contraception, abortion status, with smashed fragmentation of germ cells, reduced endogenous estrogen, androgen, results in defaulted genomic repertoire, deranged cell metabolism, increased incidence of diabetes mellitus, systemic hypertension as part of metabolic syndrome. Contraception reversal declined the diseases as a cause and effective phenomenon.
基金This study was supported by the National Natural Science Foundation of China(Grant No.31700468)the Natural Science Foundation of Jiangsu Province(Grant No.BK2017636).
文摘Background:Remnant microhabitats are important for bird habitat selection and plant regeneration in the fragmented habitat.However,empirical information on the consequences of how microhabitat use by birds affects the early recruitment of plants is lacking.Methods:In this study,we evaluated whether microhabitat selection by the Black Bulbul(Hypsipetes leucocephalus)(J.F.Gmelin,1789)impacts the early recruitment of the endangered tree species,the Chinese Yew(Taxus chinensis(Pilger)Rehd),in a fragmented forest over a 4-year period(2011–2012,2018–2019).Results:Our results showed the main factors affecting H.leucocephalus microhabitat selection were distance to the nearest T.chinensis mature tree,herb cover and density,leaf litter cover,and vegetation type.Moreover,the results of logistic regression also highlighted the importance of elevation,distance to light gap and roads,tree cover in bird microhabitat selection.Furthermore,the seed emergence rate in microhabitats used by birds did not differ from the natural forest,which was related to five factors of bird microhabitat.The Random Forest model showed that seedling emergence rate was increased with leaf litter cover and distance to fallen dead trees,but decreased in relation to herb cover,slope,and elevation.Conclusion:Our results highlight the importance of remnant microhabitats in fragmented forests for sustaining forest ecology and optimal management.The contribution of microhabitats used by birds to plant recruitment provides insights into how frugivore species contribute to plant regeneration,which should be incorporated in future conservation and management practices of fragmented forests.
文摘Background: Patients requiring valve replacement at a younger age, for rheumatic heart disease was apparently increasing after the new age practice of contraception. Methods: In 2012, data of patients referred to tertiary care hospital from two cardiology screening camps conducted in the community, were analyzed for the severity of presentation of rheumatic heart disease and associated contraception status by dividing into the three age groups—20 - 35 years, 36 - 50 years, >51 years;~400 patients attended the camps;31 female and 2 male patients were referred to the tertiary care hospital for further evaluation and categorized treatment, including valve replacement surgeries;among the 33 referred patients, belonging to the three age groups, the data were analyzed for [if any] correlation of contraception status with severe rheumatic heart disease. 8 randomly chosen males, of the 3 age groups, from a different community, whose life partners had undergone sterilization, were assessed for their serum testosterone levels. Results: Among 20 - 35 years, 7 female patients with contraception required valve replacement surgeries [p 51 years, 3 female and 2 male patients without contraception received medical treatment only
基金This work was supported by the Swedish Research Council(grant no.621-2017-3693 to PE).
文摘Many bird species are specialized to live in the broadleaved,evergreen forests in the mountain regions in Southeast Asia.These mountain habitats are not continuously distributed as the different mountain areas are separated by lowlands,which has restricted gene flow and thus contributed to the high biological diversity in this region.The degree of connectivity between mountain areas has fluctuated with the Pleistocene glacial cycles,being largest during the glaciations when the mountain forests spread to lower elevations.Here we study how the intermittent periods of restricted gene flow and connectivity between the populations of five montane species of babblers(Aves,Timaliidae)in Vietnam may be traced in their genomes.The results suggest that the babbler species in the Central Highlands have been isolated from their sister-populations in northern Vietnam for between ca.585 and 380 ky.For two species with populations in both the Central Highlands and the Da Lat region,we found that these split at more or less the same time(440–340 kya).We also found a significant statistical correlation between the time of the splits of these populations and the lowest altitude at which they are known to occur(no similar correlation was found with the geographic distances between populations).The populations in northern Vietnam show higher genetic variation than their counterparts in South-Central Vietnam,supporting the postulate that smaller populations may have lower genetic variation than larger.In accordance with this,we found the lowest genetic variation in the two species with the smallest populations in the Central Highlands.These two populations also show low levels of genomic heterozygosity.Our results show that the south-central populations of the studied babbler species are genetically distinct from their sister-populations in northern Vietnam,providing additional argument for the long-term protection of the evergreen mountain forests in Southeast Asia.
文摘In recent years,studies have shown that there is a correlation between sleep disorders and cancer,but at the present stage,the research on sleep disorders and tumor related animal models is relatively insufficient.Our research will focus on mice bearing B16F10-luc-G5 melanoma tumor with sleep fragmentation,detecting promoting effect of sleep fragmentation(SF)on the metastasis of melanoma.At the same time,we used Ganoderma lucidum poly⁃saccharides peptide(GL-pp,80 mg·kg-1),a component of traditional Chinese medicine Ganoderma lucidum,which has long enjoyed a good reputation at home and abroad,to observe its anti-tumor metastasis effects on B16F10-luc-G5 mice with SF.Then we used whole proteomics to analyze the difference proteins expressed in lung tissue and compared between groups,includes mice bearing B16F10-luc-G5,mice bearing B16F10-luc-G5 with SF and GL-pp administered mice bearing B16F10-luc-G5 with SF.With the analysis using bioinformatics,we found several key proteins,their genes name are Adcy9,ptk2,Yap1 and Lpin2,Per1 and Tim.And several important clusters,they are,immune system,platelet aggres⁃sion,energy metabolism,cell cytoskeleton,cell adhesion and circadian rhythms.Moreover,we detected the TLR4 signal pathway and macrophage differentiation to reconfirm the results of proteomics and trying to elucidate the mechanism of SF on tumor growth and metastasis and the effects of GL-pp.
文摘Patients with chronic obstructive pulmonary disease(COPD)have an increased risk for cardiovascular events,and electrocardiography has an important role in detecting cardiac side effects of COPD-related hypoxia.
文摘Anthropogenic activities are increasing habitat fragmentation, as well as the number of threatened and endangered species. Thus, isolated fragments with natural remnant stands, or in situ or ex situ endangered species rescue populations, are on the rise. The most common method for assessing the “conservation health” of such populations is to determine or estimate the census size. However, while it is known that the census size of a population does not always correlate with its genetic diversity, methods for modeling how different factors can drive variation in the relationship of census size to genetic diversity in plant populations are needed. Here we use the computer program NEWGARDEN to investigate how the relationship of stand size versus genetic diversity (measured as both the percent of the founding alleles retained and FIT) can be extremely variable depending on founder number, founder density, and gene dispersal distances. Populations of endangered species that appear to have the same conservation health in terms of similar population numbers may differ greatly in their conservation health as indicated by the genetic diversity they retain. NEWGARDEN can be used to explore how different founding and intra- or interspecific life history characteristics can affect genetic diversity relative to census size. If proper historical data exist, NEWGARDEN can also be used to estimate the percent of founding genetic diversity remaining in a given stand.
文摘Background-Rationale of the Study: Among several invasive and non-invasive tests for risk stratification of acute coronary syndromes (ACS), fewer markers can be utilized in clinical practice. Our rationale is to validate use of QRS-fragmentation as a promising bed-side test for assessment of prognosis in those patients. Methods and Results: Collection of two-hundred and twenty patients with ACS was done during two years (from January 2011 till January 2013). Significant organic vaLVe disease and QRS duration ≥ 120 ms as well as patients with permanent pacemakers were excluded. Patients were subjected to full clinical examination, ECG and Echocardiography in the first day of admission followed by diagnostic coronary angiography before discharge and a nuclear study was done for Randomized sample from each group. 12-leads ECG revealed fragmentation of QRS in 74 patients and 146 patients with no QRS fragmentation. Localization of the infarct site revealed NS difference between percentages in both groups. Echocardiography revealed a significant deterioration of LV functions in group-A than group-B. Also, MR jet area was significantly higher in group-A. Coronary angiography revealed severer lesions in group-A more than group-B. Nuclear study revealed higher percentages of irreversible scars in group-A (30%) and higher reversibility in group-B (80%). In-hospital Occurrence of complications from ACS revealed a significant higher incidence of MACE in group-A. Conclusion: Presence of fragmented QRS in surface ECG during ACS represents myocardial scar or fibrosis and reflects the severity of coronary lesions and a correlation between fQRS and depression of LVfunction is established. Indeed, occurrence of MACE is suspected.
文摘Background: In spite of advanced technologies and drug discoveries, morbidity and mortality were undoubtedly increasing in the era of contraception and abortion. Aims: Altruistic correlation of increasing morbidity, mortality, with contraception, abortion was planned for. Methods: In 2012, a retrospective analysis of prevalence of mortality in 350 patients of 20 - 35 years, 35 - 50 years and >50 years from data collected between 2003 and 2012 by convenient, stratified random sampling, from community, hospital, and its association with contraception and abortion status was undertaken;simultaneously, serum estrogen levels obtained from 105 patients were analyzed. In 2014, randomly chosen 8 males, of the 3 age groups, from a different community, whose life partners had undergone sterilization, were assessed for their serum testosterone levels. Results: Contraception users exhibited 3 - 4 fold increased mortality [p 50 years [p < 0.0005]. Endogenous estrogen was reduced in 75% [p < 0.0005] of contraceptive users. Plasma testosterone was reduced in males observing contraception, to less than 50% of normal, e.g. 1.3 ng/ml;66.6% contraception users aged 20 - 35 years had reduced [p < 0.0005] testosterone;100% of male contraception users aged 36 - 70 years showed reduced testosterone [p < 0.0005]. Conclusion: The “withered tree akin host” concept is contraception, abortion, with smashed fragmentation of germ cells. Reduced endogenous estrogen, androgen [dried up, destroyed life factors] result in deranged cell metabolism, cell cycle, and defaulted genomic repertoire, leading to failure of all established pharmacological therapeutics, including advanced technologies which yield gratifying results in non contracepted people today and in every one, before the era of contraception;subsets of people, host with contraception, with destroyed life factors, behave helplessly, concerning therapeutic applications, compared with subsets of people, host without contraception, with intact genomic repertoire, God ordained Life factors, make a remarkable recovery. Contraception reversal replants the germ cells [germ cells destruction stops], hormones rejuvenate to 79.9% of age normal, and diseases abate with recovery.
文摘In the era of new media,people’s lifestyle,education and the like are inseparable from the Internet.At the same time,due to the emergence of smart devices such as mobile phones and tablet computers,people’s reading habits have changed.Fragmented reading has become an important form of reading for college students.College students themselves have the strong ability to accept change,so fragmented reading has gradually become an important form of student learning.This paper mainly analyses fragmented reading by college students and its impact on society in the era of new media.
基金This paper was supported by“the National Social Science Fund of China”(Grant Number:17BYY098).
文摘This paper attempts to investigate the feasibility and learning effects of English fragmented learning via mobile devices.Questionnaires and interviews were employed to do the survey on 157 undergraduates from 24 universities in China.The research findings reveal that English fragmented learning via mobile devices has some positive effects on the improvement of learners’knowledge and learning ability.In addition,there have been a certain number of useful learning resources and platforms with diversified features.The study has the implications that fragmented mobile learning is feasible and can be popularized in English learning.
文摘Objective: To study the correlation of QRS complex after percutaneous coronary intervention (PCI) with myocardial ischemia reperfusion injury and apoptosis molecule contents. Methods:Patients with non-ST-segment elevation myocardial infarction who were treated in Nanchong Central Hospital between June 2014 and August 2016 were selected and divided into the PCI group who received emergency PCI surgery and the control group who accepted selective PCI or refused emergency PCI after the medical data were retrospectively analyzed. The fQRS as well as the contents of ischemia reperfusion injury indexes and apoptosis molecules was determined after 1 week of treatment. Results: The incidence of fQRS in PCI group was significantly lower than that in control group;serum MDA, cTnI, H-FABP, sTWEAK, sFas, sTRAIL and Caspase-3 contents as well as peripheral blood Nrf-2 and HO-1 expression of PCI group were greatly lower than those of control group;serum MDA, cTnI, H-FABP, sTWEAK, sFas, sTRAIL and Caspase-3 contents as well as peripheral blood Nrf-2 and HO-1 expression of PCI group of patients with fQRS complex (+) were greatly higher than those of patients with fQRS complex (-). Conclusion: The occurrence of fQRS after PCI is closely related to myocardial ischemia reperfusion injury and apoptosis.
文摘OCTOBER 25 is Central African Regional Integration Day. Few people know or observe this holiday because the citizens of Africa＇s poorest and most conflict-prone region have little to celebrate.
基金Project supported by the National Science & Technology Pillar Program during the 12th Five-Year Plan Period(No.2011BAI11B06),China
文摘This study is aimed to investigate the clinical significance and the short-term prognostic value of frag- mented QRS （fQRS） for patients with acute myocardial infarction （AMI）. Three hundred patients with AMI were tested with retrospective analysis on the patients＇ clinical information, hospitalized treatment, fQRS onset time, location of lesions, and other relevant data, in order to assess the relationship between the presence of fQRS and its prognosis. The rates of malignant cardiac arrhythmia, left ventricular systolic dysfunction （LVSD）, and mortality in the positive fQRS group were 13.6%, 29.2%, and 23.7%, respectively, with all showing a p value 〈0.05. For the ST segment elevation myocardial infarction （STEMI） subgroup, all the rates showed significant differences with a p value 〈0.01, while for the non-STEMI （NSTEMI） subgroup showed no significant differences. In patients with a positive fQRS, there were no differences in malignant cardiac arrhythmia between patients with and without percutaneous coronary in- tervention （PCI） （p〉0.05）. As for the LVSD and mortality, the p values between patients with and without PCI were 0.031 and 0.000, respectively, suggesting statistical significance. The results imply that AMI patients with positive fQRS especially for the patients with STEMI had higher rates of malignant cardiac arrhythmia, LVSD, and mortality than the non-fQRS group. Patients of AMI with positive fQRS, who underwent early revascularization, could lower the incidence of the cardiovascular event. In addition, the presence of fQRS could be used as an indication of early in- tervention treatment for patients.
