A series of Au/Co_(x)Fe_(3-x)O_(4) catalysts was synthesized using the sol-deposition method by depositing 2–5 nm Au particles on Fe-doped Co_(3)O_(4).Co_(2)FeO_(4),with a Co/Fe molar ratio of 2:1,exhibited higher sp...A series of Au/Co_(x)Fe_(3-x)O_(4) catalysts was synthesized using the sol-deposition method by depositing 2–5 nm Au particles on Fe-doped Co_(3)O_(4).Co_(2)FeO_(4),with a Co/Fe molar ratio of 2:1,exhibited higher specific surface area,Co^(3+)/Co^(2+)ratio,and oxygen vacancy content compared to Co_(3)O_(4).As a result,it displayed better performance in CO oxidation,achieving a total conversion temperature(T100)of 96℃.Au greatly improved the catalytic efficiency of all Co_(x)Fe_(3-x)O_(4) samples,with the 0.2%Au/Co_(2)FeO_(4) catalyst achieving a further decrease in T100 to 73℃.Stability tests conducted at room temperature on the 1%Au/Co_(x)Fe_(3-x)O_(4) catalysts demonstrated a slowed deactivation rate after Fe-doping.The reaction pathway for CO oxidation catalyzed by Au/Co_(2)FeO_(4) followed the Mars-van Krevelen mechanism.展开更多
Cyanide is the most widely used reagent in gold production processes. However, cyanide is highly toxic and poses safety haz-ards during transportation and use. Therefore, it is necessary to develop gold leaching reage...Cyanide is the most widely used reagent in gold production processes. However, cyanide is highly toxic and poses safety haz-ards during transportation and use. Therefore, it is necessary to develop gold leaching reagents that can replace cyanide. This paper intro-duces a method for synthesizing a gold leaching reagent. Sodium cyanate is used as the main raw material, with sodium hydroxide and so-dium ferrocyanide used as additives. The gold leaching reagent can be obtained under the conditions of a mass ratio of sodium cyanate,sodium hydroxide, and sodium ferrocyanide of 15:3:1, synthesis temperature of 600℃, and synthesis time of 1 h. This reagent has a goodrecovery effect on gold concentrate and gold-containing electronic waste. The gold leaching rate of roasted desulfurized gold concentratecan reach 87.56%. For the extraction experiments of three types of gold-containing electronic waste, the gold leaching rate can reach over90% after 2 h. Furthermore, the reagent exhibits good selectivity towards gold. Component analysis indicates that the effective compon-ent in the reagent could be sodium isocyanate.展开更多
In October 2024,the Ministry of Natural Resources of PRC released the 2024 China Mineral Resources Report,which focuses on new progress since 2023 in the geological and mineral survey and evaluation,mineral resource e...In October 2024,the Ministry of Natural Resources of PRC released the 2024 China Mineral Resources Report,which focuses on new progress since 2023 in the geological and mineral survey and evaluation,mineral resource exploration and development,mine ecological restoration,green mine construction,new changes in mineral resource policies and regulations,new measures in mineral resource management,new situations in scientific and technological innovation,as well as the new achievements of the international geological and mineral cooperation.展开更多
This study comprises the relationship between organic matter(OM)and gold occurrence using two distinctive ore deposits of the Bakyrchik gold-sulfide deposit(Kazakhstan)and Western Mecsek uranium ore deposit(Hungary).T...This study comprises the relationship between organic matter(OM)and gold occurrence using two distinctive ore deposits of the Bakyrchik gold-sulfide deposit(Kazakhstan)and Western Mecsek uranium ore deposit(Hungary).The two ore deposits are identified as organicrich sedimentary formations linked to the Variscan gold cycle globally.Characterizing OM is essential because it can act as a carrier for gold,influencing its distribution and behavior within the deposit.Understanding the nature and distribution of OM can provide insights into the processes of gold deposition and help optimize exploration and extraction strategies in mining operations.The primary objective is to characterize OM by identifying its elemental composition,thermal maturity,functional groups,and soluble fractions;and extract gold from OM using a two-step sequential extraction method(hydrogen peroxide and aqua regia)combined with geochemical techniques.Analytical and experimental results from samples of both ore deposits indicate the presence of finely disseminated solid bitumen and reworked vitrinite,originating from thermally matured(RmcRo%—3.76 in Bakyrchik;Ro%—2.25 in W-Mecsek)terrigenous high plants.Both deposits exhibit extremely low extractable bitumen yield and TOC(0.34%in Bakyrchik;0.25 wt%in W-Mecsek),characterized by an aromatic carboxylic acid organic structure and a composition rich in sulfur-containing(1.17%in Bakyrchik;5.81%in W-Mecsek)aromatic hydrocarbons.Gold occurrence and enrichment within OM were confi rmed through the sequential extraction method employing ICP-OES and LA-ICP-MS techniques.The sequentially extracted gold content from OM reached up to 3 ppm in Bakyrchik and up to 3.28 ppm in Western Mecsek,accompanied by Ag(ranging from 0.01 to 0.32 ppm).Higher concentrations of Au(4 ppm)and Ag(27 ppm)were extracted from residue materials,which are likely associated with sulfide minerals.The presence of gold in OM was further validated using LA-ICP-MS.Gold bonding within OM structure,gold is preserved in the form of lattice gold or structurally bonded metal most likely within the aromatic hydrocarbon fractions of the OM in both the W-Mecsek and Bakyrchik deposits.These findings underscore the profound potential of ongoing exploration endeavors,off ering pivotal revelations regarding the extraction and practical application of Au and Ag derived from OM within the geochemical framework of both ore deposits.展开更多
Objective Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer t...Objective Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer treatment through combining the benefits of various mechanisms.Methods In this study, we developed a synergistic strategy for chemo-photothermal therapy by constructing nanocomposites using gold nanorods(GNRs) and tetrahedral framework nucleic acids(tFNA) loaded with the anti-tumor drug doxorubicin(DOX).Results Our in vitro studies have systematically clarified the anti-cancer behaviors of tFNA-DOX@GNR nanocomposites, characterized by their enhanced cellular uptake and proficient lysosomal escape capabilities. It was found that the key role of tFNA-DOX@GNR nanocomposites in tumor ablation is primarily due to their capacity to induce cytotoxicity in tumor cells via a photothermal effect, which generates instantaneous high temperatures. This mechanism introduces various responses in tumor cells, facilitated by the thermal effect and the integrated chemotherapeutic action of DOX. These reactions include the induction of endoplasmic reticulum stress, characterized by elevated reactive oxygen species levels, the promotion of apoptotic cell death, and the suppression of tumor cell proliferation.Conclusion This work exhibits the potential of synergistic therapy utilizing nanocomposites for cancer treatment and offers a promising avenue for future therapeutic strategies.展开更多
Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and bio...Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.展开更多
The adsorption behaviors and mechanisms of gold from thiosulfate solution on strong-base anion exchange resin were systematically investigated.The comparison experiment of adsorption ability and selectivity for gold s...The adsorption behaviors and mechanisms of gold from thiosulfate solution on strong-base anion exchange resin were systematically investigated.The comparison experiment of adsorption ability and selectivity for gold showed that gel Amberlite IRA-400 resin with Type Ⅰ quaternary ammonium functional group had better adsorption performance.The increases of resin dosage,ammonia concentration and solution pH were favorable to gold adsorption,whereas the rises of cupric and thiosulfate concentrations were disadvantageous to gold loading.Microscopic characterization results indicated that gold was adsorbed in the form of [Au(S_(2)O_(3))_(2)]^(3–) complex anion by exchanging with the counter ion Cl^(–) in the functional group of the resin.Density functional theory calculation result manifested that gold adsorption was mainly depended on the hydrogen bond and van der Waals force generated between O atom in [Au(S_(2)O_(3))_(2)]^(3–) and H atom in the quaternary ammonium functional group of the resin.展开更多
Ultrasmall gold nanoparticles(AuNPs)typically includes atomically precise gold nanoclusters(AuNCs)and AuNPs with a core size below 3 nm.Serving as a bridge between small molecules and traditional inorganic nanoparticl...Ultrasmall gold nanoparticles(AuNPs)typically includes atomically precise gold nanoclusters(AuNCs)and AuNPs with a core size below 3 nm.Serving as a bridge between small molecules and traditional inorganic nanoparticles,the ultrasmall AuNPs show the unique advantages of both small molecules(e.g.,rapid distribution,renal clearance,low non-specific organ accumulation)and nanoparticles(e.g.,long blood circulation and enhanced permeability and retention effect).The emergence of ultrasmall AuNPs creates significant opportunities to address many challenges in the health field including disease diagnosis,monitoring and treatment.Since the nano–bio interaction dictates the overall biological applications of the ultrasmall AuNPs,this review elucidates the recent advances in the biological interactions and imaging of ultrasmall AuNPs.We begin with the introduction of the factors that influence the cellular interactions of ultrasmall AuNPs.We then discuss the organ interactions,especially focus on the interactions of the liver and kidneys.We further present the recent advances in the tumor interactions of ultrasmall AuNPs.In addition,the imaging performance of the ultrasmall AuNPs is summarized and discussed.Finally,we summarize this review and provide some perspective on the future research direction of the ultrasmall AuNPs,aiming to accelerate their clinical translation.展开更多
The Birimian Baguiomo formations are located in the northern part of the Boromo greenstone belt. In this belt, the volcanic rocks (tholeiitic basalt, calcalkaline basalt, andesite) hosting the gold mineralization are ...The Birimian Baguiomo formations are located in the northern part of the Boromo greenstone belt. In this belt, the volcanic rocks (tholeiitic basalt, calcalkaline basalt, andesite) hosting the gold mineralization are located in the Kwademen-Baguiomo shear zone. This mineralization, located only a few kilometers from the Kwademen gold deposit, is uncharacterized and, together with the latter, could constitute a gold potential capable of being economically exploitable. It is in this sense that this work is carried out with a view to characterizing the gold mineralization of the Baguiomo gold panning site. To carry out this work, we have made direct field measurements, combined with microstructures, and combined all this with data from geochemical rock analysis of the basalts that are the main host formations. Geochemical data show that tholeitic basalts formed from a mantle plume that was emplaced in an oceanic plateau context. Calc-alkaline basalts and andesites are comparable to Paleoproterozoic tholeitic basalts (PTH3), which are slightly enriched in light rare earths. Fertility tests show that these basalts concentrate between 3 and 6 ppb of gold at the time of accretion, which is sufficient for remobilization of this primary gold during the Eburnian orogeny to yield a deposit of around 4 - 5 Moz. Gold mineralization is associated with pyrite crystals when the latter are disseminated in the rock mass, whereas it is associated with hematite in quartz veins concordant with S1 shear deformation. It is mainly the pyrite crystals in the pressure shadows that contain the gold grains, whose development would be synchronous with micro-shear zone reactivation during the first phase of D1<sub>B</sub> deformation. The second phase of D2<sub>B</sub> deformation, which is a crenulation or fracture schistosity, does not significantly affect the shear deformation that controls mineralization.展开更多
The Hatu gold deposit is the largest historical gold producer of the West Junggar,western China,with an Au reserve of about 62 t.The orebodies were controlled by NE-,EW-,and NW-trending subsidiary faults associated wi...The Hatu gold deposit is the largest historical gold producer of the West Junggar,western China,with an Au reserve of about 62 t.The orebodies were controlled by NE-,EW-,and NW-trending subsidiary faults associated with the Anqi fault.This deposit exhibits characteristics typical of a fault-controlled lode system,and the orebodies consist of auriferous quartz veins and altered wall rocks within Early Carboniferous volcano-sedimentary rocks.Three stages of mineralization have been identified in the Hatu gold deposit:the early pyrite-albite-quartz stage,the middle polymetallic sulfides-ankerite-quartz stage,and late quartz-calcite stage.The sulfur isotopic values of pyrite and arsenopyrite vary in a narrow range from-0.8‰to1.3‰and an average of 0.4‰,the near-zeroδ~(34)S values implicate the thorough homogenization of the sulfur isotopes during the metamorphic dehydration of the Early Carboniferous volcano-sedimentary rocks.Lead isotopic results of pyrite and arsenopyrite(^(206)Pb/^(204)Pb=17.889-18.447,^(207)Pb/^(204)Pb=15.492-15.571,^(208)Pb/^(204)Pb=37.802-38.113)are clustered between orogenic and mantle/upper crust lines,indicating that the lead was mainly sourced from the hostrocks within the Early Carboniferous Tailegula Formation.The characteristics of S and Pb isotopes suggest that the ore-forming metals of the Hatu orogenic gold deposit are of metamorphogenic origin,associated with the continental collision between the Yili-Kazakhstan and Siberian plates during the Late Carboniferous.展开更多
1.Objective The West Qinling Orogen extends east-west over 1500 km and is endowed with dozens of large-super large scale gold deposits.The Zaozigou gold deposit has a proven reserve of 134 t with an average grade of 3...1.Objective The West Qinling Orogen extends east-west over 1500 km and is endowed with dozens of large-super large scale gold deposits.The Zaozigou gold deposit has a proven reserve of 134 t with an average grade of 3.08 g/t thus is one of the largest deposits in the West Qinling Orogen.However,whether the fluid type is metamorphic or magmatichydrothermal and ore-formation processes of the Zaozigou gold deposit are equivocal.Scheelite is a ubiquitous accessory mineral in geologically diverse ore-deposit types and attested to be a strong indicator of ore-forming conditions and oredeposit genesis.展开更多
Despite its often illegal nature, artisanal gold mining in Burkina Faso contributes to the economic and social development of the country. However, the rudimentary techniques used in gold panning have a significant im...Despite its often illegal nature, artisanal gold mining in Burkina Faso contributes to the economic and social development of the country. However, the rudimentary techniques used in gold panning have a significant impact on the environment due to inappropriate practices and the use of various chemical substances. This study aims to assess the impact of artisanal gold mining on the quality of water resources in a rural community at Méguet, Burkina Faso. To this end, surface and groundwater samples were collected and analyzed at the BUMIGEB laboratory. Field results show that the waters are slightly alkaline (6.97 < pH < 8.1), weakly mineralized and conductive (124 < EC < 543 μS/cm), with temperatures ranging from 24.6˚C to 31.6˚C. In addition, trace metals (TMEs) analyzed from surface and subsurface waters show very high levels, generally deviating from the levels recommended by WHO guidelines for Burkina Faso. Trace metals contamination of water resources in the commune of Méguet is mainly due to Fe (3.78 - 11.12 mg/kg), Hg (0.03 - 0.29 mg/kg), As (0.01- 6.31 mg/kg) and Pb (0.01 - 3.8 mg/kg). This study can serve as a basis for guiding national environmental policies to protect the water resources of the Méguet mine.展开更多
The Yueguang gold deposit is located in Fengjia,Xinhua County,Hunan Province,South China.It represents a recently discovered small-scale gold deposit situated in the southwestern region of the Jiangnan Orogenic Belt,w...The Yueguang gold deposit is located in Fengjia,Xinhua County,Hunan Province,South China.It represents a recently discovered small-scale gold deposit situated in the southwestern region of the Jiangnan Orogenic Belt,west of the Baimashan granitic batholith.In order to discern the characteristics of the ore-formingfluids,the underlying mineralization processes,and establish a foundation for the origin of the Yueguang gold depositfluid inclusion micro-thermometry,as well as quartz hydrogen and oxygen isotope analysis,have been carried out on samples obtained from various stages of mineralization.The hydrothermal miner-alization stages within the Yueguang gold deposit can be categorized into three stages:(i)the barren,pre-ore quartz-pyrite stage(Stage Ⅰ),the quartz-pyrite-gold stage(Stage Ⅱ),and the post-ore quartz-carbonate stage(Stage Ⅲ),with the second stage being the main mineralization stage.Thefluid inclusions identified in samples from the main min-eralization stage can predominantly be described with the NaCl–H_(2)O and CO_(2)–NaCl–H_(2)O systems.These inclusions display homogenization temperatures ranging from 158.8 to 334.9℃,and thefluid salinity ranges from 0.3%to 4.0%(wt.%NaCl equiv.).Laser Raman spectroscopy analysis of individual inclusions further reveals the presence of gas-phases such as CO_(2),CH_(4),and N_(2).Isotopic analysis indicatesδ^(18)Ofluid values ranging from 3.95 to 6.7‰ and δDH_(2)O values ranging from-71.9 to-55.7‰.These results indi-cate that the ore-formingfluid of the Yueguang gold deposit belongs to metamorphic hydrothermalfluids of middle-low temperature and low salinity.In the process of ore formation,gold is transported in the form of Au(HS)2-complexes,with gold deposition being driven byfluid immiscibility.Therefore,the Yueguang gold deposit is categorized as an orogenic gold deposit dominated by metamorphic hydrother-malfluid.It may become a new target for gold exploration in the Baimashan region,central Hunan Province.展开更多
The finite deformation structures recorded in the Essakane area, located in the northeast corner of Burkina Faso, highlight three major compressive deformation phases, successively named D1, D2, and D3. The D1 event p...The finite deformation structures recorded in the Essakane area, located in the northeast corner of Burkina Faso, highlight three major compressive deformation phases, successively named D1, D2, and D3. The D1 event phase, trending NE-SW, is characterised by P1 folds and S1 axial plane schistosity. The D2 phase trending NW-SE is characterised by folds P2, schistosity (S2) and shear (C) planes. And the D3 phase trending NNE-SSW to N-S is characterised by P3 folds, crenulation microfolds and S3 spaced schistosity. It has also been noted that gold mineralizations are mainly hosted in quartz, carbonate, pyrite, and arsenopyrite veins. Structural interpretation indicates that these veins are organized into lenticular bodies that were formed during the first two deformation phases (D1 and D2). This suggests a strong structural control typical of orogenic gold concentrations.展开更多
基金supported by the Fundamental Research Program of Shanxi Province of China(202203021211103,202303021212172,202403021211196).
文摘A series of Au/Co_(x)Fe_(3-x)O_(4) catalysts was synthesized using the sol-deposition method by depositing 2–5 nm Au particles on Fe-doped Co_(3)O_(4).Co_(2)FeO_(4),with a Co/Fe molar ratio of 2:1,exhibited higher specific surface area,Co^(3+)/Co^(2+)ratio,and oxygen vacancy content compared to Co_(3)O_(4).As a result,it displayed better performance in CO oxidation,achieving a total conversion temperature(T100)of 96℃.Au greatly improved the catalytic efficiency of all Co_(x)Fe_(3-x)O_(4) samples,with the 0.2%Au/Co_(2)FeO_(4) catalyst achieving a further decrease in T100 to 73℃.Stability tests conducted at room temperature on the 1%Au/Co_(x)Fe_(3-x)O_(4) catalysts demonstrated a slowed deactivation rate after Fe-doping.The reaction pathway for CO oxidation catalyzed by Au/Co_(2)FeO_(4) followed the Mars-van Krevelen mechanism.
基金financially supported by the National Natural Science Foundation of China (No.51974016)。
文摘Cyanide is the most widely used reagent in gold production processes. However, cyanide is highly toxic and poses safety haz-ards during transportation and use. Therefore, it is necessary to develop gold leaching reagents that can replace cyanide. This paper intro-duces a method for synthesizing a gold leaching reagent. Sodium cyanate is used as the main raw material, with sodium hydroxide and so-dium ferrocyanide used as additives. The gold leaching reagent can be obtained under the conditions of a mass ratio of sodium cyanate,sodium hydroxide, and sodium ferrocyanide of 15:3:1, synthesis temperature of 600℃, and synthesis time of 1 h. This reagent has a goodrecovery effect on gold concentrate and gold-containing electronic waste. The gold leaching rate of roasted desulfurized gold concentratecan reach 87.56%. For the extraction experiments of three types of gold-containing electronic waste, the gold leaching rate can reach over90% after 2 h. Furthermore, the reagent exhibits good selectivity towards gold. Component analysis indicates that the effective compon-ent in the reagent could be sodium isocyanate.
文摘In October 2024,the Ministry of Natural Resources of PRC released the 2024 China Mineral Resources Report,which focuses on new progress since 2023 in the geological and mineral survey and evaluation,mineral resource exploration and development,mine ecological restoration,green mine construction,new changes in mineral resource policies and regulations,new measures in mineral resource management,new situations in scientific and technological innovation,as well as the new achievements of the international geological and mineral cooperation.
基金Social Policy Grant(064.01.00 SPG)financed by Nazarbayev University,Kazakhstan。
文摘This study comprises the relationship between organic matter(OM)and gold occurrence using two distinctive ore deposits of the Bakyrchik gold-sulfide deposit(Kazakhstan)and Western Mecsek uranium ore deposit(Hungary).The two ore deposits are identified as organicrich sedimentary formations linked to the Variscan gold cycle globally.Characterizing OM is essential because it can act as a carrier for gold,influencing its distribution and behavior within the deposit.Understanding the nature and distribution of OM can provide insights into the processes of gold deposition and help optimize exploration and extraction strategies in mining operations.The primary objective is to characterize OM by identifying its elemental composition,thermal maturity,functional groups,and soluble fractions;and extract gold from OM using a two-step sequential extraction method(hydrogen peroxide and aqua regia)combined with geochemical techniques.Analytical and experimental results from samples of both ore deposits indicate the presence of finely disseminated solid bitumen and reworked vitrinite,originating from thermally matured(RmcRo%—3.76 in Bakyrchik;Ro%—2.25 in W-Mecsek)terrigenous high plants.Both deposits exhibit extremely low extractable bitumen yield and TOC(0.34%in Bakyrchik;0.25 wt%in W-Mecsek),characterized by an aromatic carboxylic acid organic structure and a composition rich in sulfur-containing(1.17%in Bakyrchik;5.81%in W-Mecsek)aromatic hydrocarbons.Gold occurrence and enrichment within OM were confi rmed through the sequential extraction method employing ICP-OES and LA-ICP-MS techniques.The sequentially extracted gold content from OM reached up to 3 ppm in Bakyrchik and up to 3.28 ppm in Western Mecsek,accompanied by Ag(ranging from 0.01 to 0.32 ppm).Higher concentrations of Au(4 ppm)and Ag(27 ppm)were extracted from residue materials,which are likely associated with sulfide minerals.The presence of gold in OM was further validated using LA-ICP-MS.Gold bonding within OM structure,gold is preserved in the form of lattice gold or structurally bonded metal most likely within the aromatic hydrocarbon fractions of the OM in both the W-Mecsek and Bakyrchik deposits.These findings underscore the profound potential of ongoing exploration endeavors,off ering pivotal revelations regarding the extraction and practical application of Au and Ag derived from OM within the geochemical framework of both ore deposits.
基金supported by the PLAGH Innovation Funds,(Grant No.22QNFC080)the Sichuan Science and Technology Program(Grant No.2023ZYD0064 and 2023YFG0220)+2 种基金the Fundamental Research Funds for the Central Universities(Grant No.YJ202242)the Research Funding from West China School/Hospital of Stomatology, Sichuan University(Grant No.QDJF2022-2)National Undergraduate Training Program for Innovation(Grant No.C2024129736)。
文摘Objective Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer treatment through combining the benefits of various mechanisms.Methods In this study, we developed a synergistic strategy for chemo-photothermal therapy by constructing nanocomposites using gold nanorods(GNRs) and tetrahedral framework nucleic acids(tFNA) loaded with the anti-tumor drug doxorubicin(DOX).Results Our in vitro studies have systematically clarified the anti-cancer behaviors of tFNA-DOX@GNR nanocomposites, characterized by their enhanced cellular uptake and proficient lysosomal escape capabilities. It was found that the key role of tFNA-DOX@GNR nanocomposites in tumor ablation is primarily due to their capacity to induce cytotoxicity in tumor cells via a photothermal effect, which generates instantaneous high temperatures. This mechanism introduces various responses in tumor cells, facilitated by the thermal effect and the integrated chemotherapeutic action of DOX. These reactions include the induction of endoplasmic reticulum stress, characterized by elevated reactive oxygen species levels, the promotion of apoptotic cell death, and the suppression of tumor cell proliferation.Conclusion This work exhibits the potential of synergistic therapy utilizing nanocomposites for cancer treatment and offers a promising avenue for future therapeutic strategies.
基金supported by the National Natural Science Foundation of China(Grant Nos.82073439 and 82373475)。
文摘Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.
基金the financial support from the Natural Science Foundation of Hunan Province, China (No. 2023JJ40723)China Postdoctoral Science Foundation (No. 2022M723549)the National Natural Science Foundation of China (Nos. 52174271, 51504293)。
文摘The adsorption behaviors and mechanisms of gold from thiosulfate solution on strong-base anion exchange resin were systematically investigated.The comparison experiment of adsorption ability and selectivity for gold showed that gel Amberlite IRA-400 resin with Type Ⅰ quaternary ammonium functional group had better adsorption performance.The increases of resin dosage,ammonia concentration and solution pH were favorable to gold adsorption,whereas the rises of cupric and thiosulfate concentrations were disadvantageous to gold loading.Microscopic characterization results indicated that gold was adsorbed in the form of [Au(S_(2)O_(3))_(2)]^(3–) complex anion by exchanging with the counter ion Cl^(–) in the functional group of the resin.Density functional theory calculation result manifested that gold adsorption was mainly depended on the hydrogen bond and van der Waals force generated between O atom in [Au(S_(2)O_(3))_(2)]^(3–) and H atom in the quaternary ammonium functional group of the resin.
基金the National Natural Science Foundation of China(Grant 22022403 and 22274058)Fundamental Research Funds for the Central Universities.
文摘Ultrasmall gold nanoparticles(AuNPs)typically includes atomically precise gold nanoclusters(AuNCs)and AuNPs with a core size below 3 nm.Serving as a bridge between small molecules and traditional inorganic nanoparticles,the ultrasmall AuNPs show the unique advantages of both small molecules(e.g.,rapid distribution,renal clearance,low non-specific organ accumulation)and nanoparticles(e.g.,long blood circulation and enhanced permeability and retention effect).The emergence of ultrasmall AuNPs creates significant opportunities to address many challenges in the health field including disease diagnosis,monitoring and treatment.Since the nano–bio interaction dictates the overall biological applications of the ultrasmall AuNPs,this review elucidates the recent advances in the biological interactions and imaging of ultrasmall AuNPs.We begin with the introduction of the factors that influence the cellular interactions of ultrasmall AuNPs.We then discuss the organ interactions,especially focus on the interactions of the liver and kidneys.We further present the recent advances in the tumor interactions of ultrasmall AuNPs.In addition,the imaging performance of the ultrasmall AuNPs is summarized and discussed.Finally,we summarize this review and provide some perspective on the future research direction of the ultrasmall AuNPs,aiming to accelerate their clinical translation.
文摘The Birimian Baguiomo formations are located in the northern part of the Boromo greenstone belt. In this belt, the volcanic rocks (tholeiitic basalt, calcalkaline basalt, andesite) hosting the gold mineralization are located in the Kwademen-Baguiomo shear zone. This mineralization, located only a few kilometers from the Kwademen gold deposit, is uncharacterized and, together with the latter, could constitute a gold potential capable of being economically exploitable. It is in this sense that this work is carried out with a view to characterizing the gold mineralization of the Baguiomo gold panning site. To carry out this work, we have made direct field measurements, combined with microstructures, and combined all this with data from geochemical rock analysis of the basalts that are the main host formations. Geochemical data show that tholeitic basalts formed from a mantle plume that was emplaced in an oceanic plateau context. Calc-alkaline basalts and andesites are comparable to Paleoproterozoic tholeitic basalts (PTH3), which are slightly enriched in light rare earths. Fertility tests show that these basalts concentrate between 3 and 6 ppb of gold at the time of accretion, which is sufficient for remobilization of this primary gold during the Eburnian orogeny to yield a deposit of around 4 - 5 Moz. Gold mineralization is associated with pyrite crystals when the latter are disseminated in the rock mass, whereas it is associated with hematite in quartz veins concordant with S1 shear deformation. It is mainly the pyrite crystals in the pressure shadows that contain the gold grains, whose development would be synchronous with micro-shear zone reactivation during the first phase of D1<sub>B</sub> deformation. The second phase of D2<sub>B</sub> deformation, which is a crenulation or fracture schistosity, does not significantly affect the shear deformation that controls mineralization.
基金supported by the National Natural Science Foundation of China(Nos.42172093,42202075,and 42302108)the Key Research and Development Project of Xinjiang(No.2023B03015)+1 种基金the Uygur Autonomous Region Tianchi Talent Project,and the Natural Science Foundation of Xinjiang(No.2022D01A344)China Scholarship Council(202304180004)。
文摘The Hatu gold deposit is the largest historical gold producer of the West Junggar,western China,with an Au reserve of about 62 t.The orebodies were controlled by NE-,EW-,and NW-trending subsidiary faults associated with the Anqi fault.This deposit exhibits characteristics typical of a fault-controlled lode system,and the orebodies consist of auriferous quartz veins and altered wall rocks within Early Carboniferous volcano-sedimentary rocks.Three stages of mineralization have been identified in the Hatu gold deposit:the early pyrite-albite-quartz stage,the middle polymetallic sulfides-ankerite-quartz stage,and late quartz-calcite stage.The sulfur isotopic values of pyrite and arsenopyrite vary in a narrow range from-0.8‰to1.3‰and an average of 0.4‰,the near-zeroδ~(34)S values implicate the thorough homogenization of the sulfur isotopes during the metamorphic dehydration of the Early Carboniferous volcano-sedimentary rocks.Lead isotopic results of pyrite and arsenopyrite(^(206)Pb/^(204)Pb=17.889-18.447,^(207)Pb/^(204)Pb=15.492-15.571,^(208)Pb/^(204)Pb=37.802-38.113)are clustered between orogenic and mantle/upper crust lines,indicating that the lead was mainly sourced from the hostrocks within the Early Carboniferous Tailegula Formation.The characteristics of S and Pb isotopes suggest that the ore-forming metals of the Hatu orogenic gold deposit are of metamorphogenic origin,associated with the continental collision between the Yili-Kazakhstan and Siberian plates during the Late Carboniferous.
基金supported by Records of China’s Mineral Geology from the China Geological Survey(DD20190379)the State Key Program of National Natural Science Foundation of China(41730426)the 111 Project of the Ministry of Science and Technology(BP0719021)。
文摘1.Objective The West Qinling Orogen extends east-west over 1500 km and is endowed with dozens of large-super large scale gold deposits.The Zaozigou gold deposit has a proven reserve of 134 t with an average grade of 3.08 g/t thus is one of the largest deposits in the West Qinling Orogen.However,whether the fluid type is metamorphic or magmatichydrothermal and ore-formation processes of the Zaozigou gold deposit are equivocal.Scheelite is a ubiquitous accessory mineral in geologically diverse ore-deposit types and attested to be a strong indicator of ore-forming conditions and oredeposit genesis.
文摘Despite its often illegal nature, artisanal gold mining in Burkina Faso contributes to the economic and social development of the country. However, the rudimentary techniques used in gold panning have a significant impact on the environment due to inappropriate practices and the use of various chemical substances. This study aims to assess the impact of artisanal gold mining on the quality of water resources in a rural community at Méguet, Burkina Faso. To this end, surface and groundwater samples were collected and analyzed at the BUMIGEB laboratory. Field results show that the waters are slightly alkaline (6.97 < pH < 8.1), weakly mineralized and conductive (124 < EC < 543 μS/cm), with temperatures ranging from 24.6˚C to 31.6˚C. In addition, trace metals (TMEs) analyzed from surface and subsurface waters show very high levels, generally deviating from the levels recommended by WHO guidelines for Burkina Faso. Trace metals contamination of water resources in the commune of Méguet is mainly due to Fe (3.78 - 11.12 mg/kg), Hg (0.03 - 0.29 mg/kg), As (0.01- 6.31 mg/kg) and Pb (0.01 - 3.8 mg/kg). This study can serve as a basis for guiding national environmental policies to protect the water resources of the Méguet mine.
基金support from several sources,including the Backbone Teacher Training Program(10912-SJGG2021-04233)the Teaching Reform Project of Chengdu University of Technology(JG2130131)+1 种基金the University-Industry Collaborative Education Project,Ministry of Education,China(22097130210756)National Natural Science Foundation of China(42272129).
文摘The Yueguang gold deposit is located in Fengjia,Xinhua County,Hunan Province,South China.It represents a recently discovered small-scale gold deposit situated in the southwestern region of the Jiangnan Orogenic Belt,west of the Baimashan granitic batholith.In order to discern the characteristics of the ore-formingfluids,the underlying mineralization processes,and establish a foundation for the origin of the Yueguang gold depositfluid inclusion micro-thermometry,as well as quartz hydrogen and oxygen isotope analysis,have been carried out on samples obtained from various stages of mineralization.The hydrothermal miner-alization stages within the Yueguang gold deposit can be categorized into three stages:(i)the barren,pre-ore quartz-pyrite stage(Stage Ⅰ),the quartz-pyrite-gold stage(Stage Ⅱ),and the post-ore quartz-carbonate stage(Stage Ⅲ),with the second stage being the main mineralization stage.Thefluid inclusions identified in samples from the main min-eralization stage can predominantly be described with the NaCl–H_(2)O and CO_(2)–NaCl–H_(2)O systems.These inclusions display homogenization temperatures ranging from 158.8 to 334.9℃,and thefluid salinity ranges from 0.3%to 4.0%(wt.%NaCl equiv.).Laser Raman spectroscopy analysis of individual inclusions further reveals the presence of gas-phases such as CO_(2),CH_(4),and N_(2).Isotopic analysis indicatesδ^(18)Ofluid values ranging from 3.95 to 6.7‰ and δDH_(2)O values ranging from-71.9 to-55.7‰.These results indi-cate that the ore-formingfluid of the Yueguang gold deposit belongs to metamorphic hydrothermalfluids of middle-low temperature and low salinity.In the process of ore formation,gold is transported in the form of Au(HS)2-complexes,with gold deposition being driven byfluid immiscibility.Therefore,the Yueguang gold deposit is categorized as an orogenic gold deposit dominated by metamorphic hydrother-malfluid.It may become a new target for gold exploration in the Baimashan region,central Hunan Province.
文摘The finite deformation structures recorded in the Essakane area, located in the northeast corner of Burkina Faso, highlight three major compressive deformation phases, successively named D1, D2, and D3. The D1 event phase, trending NE-SW, is characterised by P1 folds and S1 axial plane schistosity. The D2 phase trending NW-SE is characterised by folds P2, schistosity (S2) and shear (C) planes. And the D3 phase trending NNE-SSW to N-S is characterised by P3 folds, crenulation microfolds and S3 spaced schistosity. It has also been noted that gold mineralizations are mainly hosted in quartz, carbonate, pyrite, and arsenopyrite veins. Structural interpretation indicates that these veins are organized into lenticular bodies that were formed during the first two deformation phases (D1 and D2). This suggests a strong structural control typical of orogenic gold concentrations.
