In this paper,characteristics of spatial and temporal variation of linear fitting goodness before some moderately strong earthquakes(Ms≥5.0)in the eastern part of China(east of longitude 180)are studied according to ...In this paper,characteristics of spatial and temporal variation of linear fitting goodness before some moderately strong earthquakes(Ms≥5.0)in the eastern part of China(east of longitude 180)are studied according to the famous Gutenberg-Richter’s relation expressed as lgN=a-bM,by using the moderate and small events that occurred in and around the source area.The results show that the linear goodness of fitting varies abnormally prior to these moderately strong earthquakes.In the early stage of the earthquake preparatory process,distribution of the energy released through small events in and around the source area is isostatic and the fitting goodness approximates 1,while the distribution of the energy turns to be isostatic before moderately strong earthquakes,leading to the obvious decrease of the linear goodness of fitting.This phenomenon could be a medium term anomaly and a medium term criterion for moderately strong earthquake prediction.展开更多
Focus on cultivating students’mathematical thinking and ability to solve problems in life,guide students to form a scientific attitude of seeking truth from facts,and make students feel the charm of mathematics.
In cognitive radio networks,spectrum sensing under circumstances of dynamically varying noise and lacking prior information is a key challenge to the conventional spectrum sensing algorithms.Since the necessary inform...In cognitive radio networks,spectrum sensing under circumstances of dynamically varying noise and lacking prior information is a key challenge to the conventional spectrum sensing algorithms.Since the necessary information is rather difficult to obtain practically,most existing spectrum sensing methods are fettered in applications.Motivated by these,in this paper,a Frequency domain Goodness of Fit Test(FGoF)based spectrum sensing method is proposed.The FGoF makes full use of underlying information in Guard-Bands and the advantages of GoF test works for any distribution.Analytical and simulated results show that the FGoF is a robust spectrum sensing method in cognitive radio with the inherent advantages of invulnerability to dynamically varying noise.展开更多
A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function an...A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function and cumulative distribution function is presented. The statistical features of the Generalized Kumaraswamy Generalized Power Gompertz distribution are systematically derived and adequately studied. The estimation of the model parameters in the absence of censoring and under-right censoring is performed using the method of maximum likelihood. The test statistic for right-censored data, criteria test for GKGPG distribution, estimated matrix Ŵ, Ĉ, and Ĝ, criteria test Y<sup>2</sup>n</sub>, alongside the quadratic form of the test statistic is derived. Mean simulated values of maximum likelihood estimates and their corresponding square mean errors are presented and confirmed to agree closely with the true parameter values. Simulated levels of significance for Y<sup>2</sup>n</sub> (γ) test for the GKGPG model against their theoretical values were recorded. We conclude that the null hypothesis for which simulated samples are fitted by GKGPG distribution is widely validated for the different levels of significance considered. From the summary of the results of the strength of a specific type of braided cord dataset on the GKGPG model, it is observed that the proposed GKGPG model fits the data set for a significance level ε = 0.05.展开更多
The error distribution testing plays an important role in linear regression as distribution misspecification seriously affects the validity and efficiency of regression analysis. The least squares (OLS) residuals are ...The error distribution testing plays an important role in linear regression as distribution misspecification seriously affects the validity and efficiency of regression analysis. The least squares (OLS) residuals are often used to construct test statistics;in order to overcome the non-independent and identically residuals, the best linear unbiased scale (BLUS) residuals are applied in this paper, which, unlike OLS residuals, the residuals vector is identically and independently distributed. Based on the BLUS residuals, a new test statistic is constructed by using the sample random distance between sample quantile and quasi sample quantile derived from the null distribution, and the goodness-of-fit test of error distribution in the linear model is studied. The powers of the new tests under certain alternatives are examined. They are more powerful tests for the hypotheses concerned.展开更多
The journal Truth, Beauty, and Goodness was the main field where ZENG Xu-bai published his literature works; in response to the miscellaneous ＂revolutionary literature＂ at that time, he put forward the idea that lit...The journal Truth, Beauty, and Goodness was the main field where ZENG Xu-bai published his literature works; in response to the miscellaneous ＂revolutionary literature＂ at that time, he put forward the idea that literature should be a combination of unity and artistry, and emphasized self-expression of literature on the basis of popularization of literature. With these literature views, his works also had shown his pursuit for the specialty and artistry of literature, as well as a transition from technique-oriented writing to a balance of emotion expression and technique usage. Anyway, during his translation of French literature and creative practice, the rich literature nutrition he received led to his unclear and complex thoughts which he neutralized with carefulness, and hence his unique literature views.展开更多
Literary works are an important medium for the exploration of truth,goodness and beauty,of which human beings have never stopped the discussion and pursuit.First of all,this paper gives an overview of what are truth,g...Literary works are an important medium for the exploration of truth,goodness and beauty,of which human beings have never stopped the discussion and pursuit.First of all,this paper gives an overview of what are truth,goodness and beauty.Then it summarizes what has been the focus of the unity of truth,goodness and beauty between China and the West.Finally,this paper values the analysis of the truth,goodness and beauty of literary works:the facts of literature should be true,the purpose should be good,and the form should be beautiful.Based on this,the author puts forward the relationship between the three harmonies with the unity of truth,goodness and beauty in literary works,which the author believes is the ultimate pursuit of literature.展开更多
Nowadays,the word globalization has become a most exposed word in contexts of economy,culture and politics.Among the three fields,economic globalization has been paid more attention to.In this article,the author inten...Nowadays,the word globalization has become a most exposed word in contexts of economy,culture and politics.Among the three fields,economic globalization has been paid more attention to.In this article,the author intends to discuss the issue of cultural globalization.In detail,he wants to analyze the impacts of cultural globalization in the making of contemporary Chinese culture.First,the author discussed that the cultural globalization is mostly cultural westernization.Second,he explained that cultural westernization is not a monster to Chinese and the construction of modern Chinese culture.Thirdly and lastly,by discussing some significances of western culture,the author suggested those significances of western culture are valuable to be absorbed in the making of Chinese culture great again.展开更多
Wilhelm is protagonist in Saul Bellow’s novel Seize the Day.He insisted in his virture and goodness,disregarding the bad influence of other people in the cruel materialistic society.He insisted in goodness in his hea...Wilhelm is protagonist in Saul Bellow’s novel Seize the Day.He insisted in his virture and goodness,disregarding the bad influence of other people in the cruel materialistic society.He insisted in goodness in his heart,especially performing in having love in family relationship and having kind will in social relationship.He endured the pain in cold money-oriented society with his good virture.展开更多
This thesis attempts to seek the goodness of human nature,which is core of the moral society,analyzing the "Original Sin"——violence,aggression and greed,etc.In Lear,Edward Bond depicts the sinful character...This thesis attempts to seek the goodness of human nature,which is core of the moral society,analyzing the "Original Sin"——violence,aggression and greed,etc.In Lear,Edward Bond depicts the sinful characters,say,Lear,the two daughters and the victims of violence vividly,however,each one of them cannot persist the temptation of the innate sin,resulting in the eventual self-destruction.Despite the sinful behaviors in the daily life or the political world,the goodness of human nature rather than the inborn sinful nature should play an important role to build the peaceful and harmonious society.展开更多
This paper studies the evolutionary process of cooperative behavior in a public goods game model with heterogeneous investment strategies in square lattices.In the proposed model,players are divided into defectors,coo...This paper studies the evolutionary process of cooperative behavior in a public goods game model with heterogeneous investment strategies in square lattices.In the proposed model,players are divided into defectors,cooperators and discreet investors.Among these,defectors do not participate in investing,discreet investors make heterogeneous investments based on the investment behavior and cooperation value of their neighbors,and cooperators invest equally in each neighbor.In real life,heterogeneous investment is often accompanied by time or economic costs.The discreet investors in this paper pay a certain price to obtain their neighbors'investment behavior and cooperation value,which quantifies the time and economic costs of the heterogeneous investment process.The results of Monte Carlo simulation experiments in this study show that discreet investors can effectively resist the invasion of the defectors,form a stable cooperative group and expand the cooperative advantage in evolution.However,when discreet investors pay too high a price,they lose their strategic advantage.The results in this paper help us understand the role of heterogeneous investment in promoting and maintaining human social cooperation.展开更多
In the realm of public goods game,punishment,as a potent tool,stands out for fostering cooperation.While it effectively addresses the first-order free-rider problem,the associated costs can be substantial.Punishers in...In the realm of public goods game,punishment,as a potent tool,stands out for fostering cooperation.While it effectively addresses the first-order free-rider problem,the associated costs can be substantial.Punishers incur expenses in imposing sanctions,while defectors face fines.Unfortunately,these monetary elements seemingly vanish into thin air,representing a loss to the system itself.However,by virtue of the redistribution of fines to cooperators and punishers,not only can we mitigate this loss,but the rewards for these cooperative individuals can be enhanced.Based upon this premise,this paper introduces a fine distribution mechanism to the traditional pool punishment model.Under identical parameter settings,by conducting a comparative experiment with the conventional punishment model,the paper aims to investigate the impact of fine distribution on the evolution of cooperation in spatial public goods game.The experimental results clearly demonstrate that,in instances where the punishment cost is prohibitively high,the cooperative strategies of the traditional pool punishment model may completely collapse.However,the model enriched with fine distribution manages to sustain a considerable number of cooperative strategies,thus highlighting its effectiveness in promoting and preserving cooperation,even in the face of substantial punishment cost.展开更多
A multi-strategy hybrid whale optimization algorithm(MSHWOA)for complex constrained optimization problems is proposed to overcome the drawbacks of easily trapping into local optimum,slow convergence speed and low opti...A multi-strategy hybrid whale optimization algorithm(MSHWOA)for complex constrained optimization problems is proposed to overcome the drawbacks of easily trapping into local optimum,slow convergence speed and low optimization precision.Firstly,the population is initialized by introducing the theory of good point set,which increases the randomness and diversity of the population and lays the foundation for the global optimization of the algorithm.Then,a novel linearly update equation of convergence factor is designed to coordinate the abilities of exploration and exploitation.At the same time,the global exploration and local exploitation capabilities are improved through the siege mechanism of Harris Hawks optimization algorithm.Finally,the simulation experiments are conducted on the 6 benchmark functions and Wilcoxon rank sum test to evaluate the optimization performance of the improved algorithm.The experimental results show that the proposed algorithm has more significant improvement in optimization accuracy,convergence speed and robustness than the comparison algorithm.展开更多
Objective:To evaluate relationship between changes in the beneficial bacteria in intensive care unit(ICU)patients and nutritional therapy type.Methods:Ten patients aged≥18 years admitted to the ICU between January an...Objective:To evaluate relationship between changes in the beneficial bacteria in intensive care unit(ICU)patients and nutritional therapy type.Methods:Ten patients aged≥18 years admitted to the ICU between January and December 2020,were included.Good enteral nutrition was defined as early achievement of target calorie intake through enteral feeding.The ratio of beneficial bacteria at the first and second bowel movements after each patient’s admission was calculated and the patients were classified into the increase or decrease group.Among all patients,five each were in the increase and decrease groups.We investigated patient background,changes in sequential organ failure assessment(SOFA)and acute physiology and chronic health evaluation(APACHE)Ⅱscores,nutritional doses or methods,and clinical outcomes.Results:No relationship was found between changes in the ratio of beneficial bacteria and changes in SOFA/APACHEⅡscores at the time of admission.The rate of good enteral nutrition was significantly higher in the increase group than in the decrease group(4/5 vs.0/5,P=0.01).Conclusions:An increase in beneficial bacteria may be significantly related to the early establishment of enteral nutrition.In the future,accumulating cases may make it possible to establish a new nutritional strategy for critically ill patients from an intestinal microbiota perspective.展开更多
With the deepening of Internet technology in international trade,cross-border e-commerce has become the main incremental contributor in the import and export trade of goods,and its transaction volume has gradually inc...With the deepening of Internet technology in international trade,cross-border e-commerce has become the main incremental contributor in the import and export trade of goods,and its transaction volume has gradually increased from 16%of China’s total import and export of goods in 2014 to 42%in 2023.展开更多
Exerting the leading role of standards is very important for achieving the high-quality development. In recent years, China has unceasingly improved the mandatory national standards for energy efficiency and safety of...Exerting the leading role of standards is very important for achieving the high-quality development. In recent years, China has unceasingly improved the mandatory national standards for energy efficiency and safety of products, expedited the development and revision of standards in the areas of digital, intelligent, green and low-carbon development, and led the continuous technological upgrading of industrial and consumer goods.展开更多
BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the dif...BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of chemoresistance.METHODS In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA sequencing.RESULTS Exosome hsa-miR-483-5p was up-regulated in good responders post-nCRT.Bioinformatics analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling pathway.Further analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor stage.In addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 values.Accordingly,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was constructed.CONCLUSION This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs.However,further research is required within the framework of our established miRNA-mRNA network.展开更多
Recently released economic data reflecting China’s brisk economic activities and vibrant foreign trade attest to a steady acceleration in the country’s economic growth.The National Bureau of Statistics(NBS)reported ...Recently released economic data reflecting China’s brisk economic activities and vibrant foreign trade attest to a steady acceleration in the country’s economic growth.The National Bureau of Statistics(NBS)reported 5.5 percent year-on-year growth during the first two months of 2024 for retail sales of consumer goods,4.2 percent for fixed-asset investment,and 7 percent for value-added of the industrial enterprises above the designated size.The country’s total import and export of goods,meanwhile,expanded 8.7 percent year-on-year,and its volume for this period achieved a historical high of RMB 6.61 trillion.展开更多
Flannery O’Connor is one of the representative figures of American Southern writers.Being recognized as the most outstanding writer of the American South after Faulkner,she has great influence in the literary world.H...Flannery O’Connor is one of the representative figures of American Southern writers.Being recognized as the most outstanding writer of the American South after Faulkner,she has great influence in the literary world.Her works are always shrouded in a strange and grotesque atmosphere and full of death as well as religious metaphors.The protagonists are a series of American Southern freaks struggling with the crisis of spiritual belief.The protagonists of her novel A Good Man is Hard to Find are a hypocritical believer in the world of sinners and a lost man suffering in the midst of real sin,thus O’Connor uses the highest form of violence-death to bring ultimate redemption to them.In people’s conception,violence and redemption are often opposite to each other,but O’Connor uses bloody and violent plots to explore the theme of religious salvation,integrating and unifying the two contrary concepts to form her unique and profound violent redemption writing.展开更多
文摘In this paper,characteristics of spatial and temporal variation of linear fitting goodness before some moderately strong earthquakes(Ms≥5.0)in the eastern part of China(east of longitude 180)are studied according to the famous Gutenberg-Richter’s relation expressed as lgN=a-bM,by using the moderate and small events that occurred in and around the source area.The results show that the linear goodness of fitting varies abnormally prior to these moderately strong earthquakes.In the early stage of the earthquake preparatory process,distribution of the energy released through small events in and around the source area is isostatic and the fitting goodness approximates 1,while the distribution of the energy turns to be isostatic before moderately strong earthquakes,leading to the obvious decrease of the linear goodness of fitting.This phenomenon could be a medium term anomaly and a medium term criterion for moderately strong earthquake prediction.
基金Educational Planning Project in Changde City,Hunan Province——“Research on Primary School Mathematical Creative Work from the Perspective of Core Literacy”:Research on Primary School Mathematical Creative Work from the Perspective of Core Literacy(Project No.:CDJYKY201835).
文摘Focus on cultivating students’mathematical thinking and ability to solve problems in life,guide students to form a scientific attitude of seeking truth from facts,and make students feel the charm of mathematics.
基金This work was supported in part by the National Natural Science Foundation of China(No.61901408)in part by Natural Science Foundation of Jiangsu Province(No.BK20170512)in part by Universities Natural Science Research Project of Jiangsu Province(No.17KJB413003).
文摘In cognitive radio networks,spectrum sensing under circumstances of dynamically varying noise and lacking prior information is a key challenge to the conventional spectrum sensing algorithms.Since the necessary information is rather difficult to obtain practically,most existing spectrum sensing methods are fettered in applications.Motivated by these,in this paper,a Frequency domain Goodness of Fit Test(FGoF)based spectrum sensing method is proposed.The FGoF makes full use of underlying information in Guard-Bands and the advantages of GoF test works for any distribution.Analytical and simulated results show that the FGoF is a robust spectrum sensing method in cognitive radio with the inherent advantages of invulnerability to dynamically varying noise.
文摘A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function and cumulative distribution function is presented. The statistical features of the Generalized Kumaraswamy Generalized Power Gompertz distribution are systematically derived and adequately studied. The estimation of the model parameters in the absence of censoring and under-right censoring is performed using the method of maximum likelihood. The test statistic for right-censored data, criteria test for GKGPG distribution, estimated matrix Ŵ, Ĉ, and Ĝ, criteria test Y<sup>2</sup>n</sub>, alongside the quadratic form of the test statistic is derived. Mean simulated values of maximum likelihood estimates and their corresponding square mean errors are presented and confirmed to agree closely with the true parameter values. Simulated levels of significance for Y<sup>2</sup>n</sub> (γ) test for the GKGPG model against their theoretical values were recorded. We conclude that the null hypothesis for which simulated samples are fitted by GKGPG distribution is widely validated for the different levels of significance considered. From the summary of the results of the strength of a specific type of braided cord dataset on the GKGPG model, it is observed that the proposed GKGPG model fits the data set for a significance level ε = 0.05.
文摘The error distribution testing plays an important role in linear regression as distribution misspecification seriously affects the validity and efficiency of regression analysis. The least squares (OLS) residuals are often used to construct test statistics;in order to overcome the non-independent and identically residuals, the best linear unbiased scale (BLUS) residuals are applied in this paper, which, unlike OLS residuals, the residuals vector is identically and independently distributed. Based on the BLUS residuals, a new test statistic is constructed by using the sample random distance between sample quantile and quasi sample quantile derived from the null distribution, and the goodness-of-fit test of error distribution in the linear model is studied. The powers of the new tests under certain alternatives are examined. They are more powerful tests for the hypotheses concerned.
文摘The journal Truth, Beauty, and Goodness was the main field where ZENG Xu-bai published his literature works; in response to the miscellaneous ＂revolutionary literature＂ at that time, he put forward the idea that literature should be a combination of unity and artistry, and emphasized self-expression of literature on the basis of popularization of literature. With these literature views, his works also had shown his pursuit for the specialty and artistry of literature, as well as a transition from technique-oriented writing to a balance of emotion expression and technique usage. Anyway, during his translation of French literature and creative practice, the rich literature nutrition he received led to his unclear and complex thoughts which he neutralized with carefulness, and hence his unique literature views.
文摘Literary works are an important medium for the exploration of truth,goodness and beauty,of which human beings have never stopped the discussion and pursuit.First of all,this paper gives an overview of what are truth,goodness and beauty.Then it summarizes what has been the focus of the unity of truth,goodness and beauty between China and the West.Finally,this paper values the analysis of the truth,goodness and beauty of literary works:the facts of literature should be true,the purpose should be good,and the form should be beautiful.Based on this,the author puts forward the relationship between the three harmonies with the unity of truth,goodness and beauty in literary works,which the author believes is the ultimate pursuit of literature.
文摘Nowadays,the word globalization has become a most exposed word in contexts of economy,culture and politics.Among the three fields,economic globalization has been paid more attention to.In this article,the author intends to discuss the issue of cultural globalization.In detail,he wants to analyze the impacts of cultural globalization in the making of contemporary Chinese culture.First,the author discussed that the cultural globalization is mostly cultural westernization.Second,he explained that cultural westernization is not a monster to Chinese and the construction of modern Chinese culture.Thirdly and lastly,by discussing some significances of western culture,the author suggested those significances of western culture are valuable to be absorbed in the making of Chinese culture great again.
文摘Wilhelm is protagonist in Saul Bellow’s novel Seize the Day.He insisted in his virture and goodness,disregarding the bad influence of other people in the cruel materialistic society.He insisted in goodness in his heart,especially performing in having love in family relationship and having kind will in social relationship.He endured the pain in cold money-oriented society with his good virture.
文摘This thesis attempts to seek the goodness of human nature,which is core of the moral society,analyzing the "Original Sin"——violence,aggression and greed,etc.In Lear,Edward Bond depicts the sinful characters,say,Lear,the two daughters and the victims of violence vividly,however,each one of them cannot persist the temptation of the innate sin,resulting in the eventual self-destruction.Despite the sinful behaviors in the daily life or the political world,the goodness of human nature rather than the inborn sinful nature should play an important role to build the peaceful and harmonious society.
基金Project supported by the Open Foundation of Key Laboratory of Software Engineering of Yunnan Province(Grant Nos.2020SE308 and 2020SE309).
文摘This paper studies the evolutionary process of cooperative behavior in a public goods game model with heterogeneous investment strategies in square lattices.In the proposed model,players are divided into defectors,cooperators and discreet investors.Among these,defectors do not participate in investing,discreet investors make heterogeneous investments based on the investment behavior and cooperation value of their neighbors,and cooperators invest equally in each neighbor.In real life,heterogeneous investment is often accompanied by time or economic costs.The discreet investors in this paper pay a certain price to obtain their neighbors'investment behavior and cooperation value,which quantifies the time and economic costs of the heterogeneous investment process.The results of Monte Carlo simulation experiments in this study show that discreet investors can effectively resist the invasion of the defectors,form a stable cooperative group and expand the cooperative advantage in evolution.However,when discreet investors pay too high a price,they lose their strategic advantage.The results in this paper help us understand the role of heterogeneous investment in promoting and maintaining human social cooperation.
基金the Open Foundation of Key Lab-oratory of Software Engineering of Yunnan Province(Grant Nos.2020SE308 and 2020SE309).
文摘In the realm of public goods game,punishment,as a potent tool,stands out for fostering cooperation.While it effectively addresses the first-order free-rider problem,the associated costs can be substantial.Punishers incur expenses in imposing sanctions,while defectors face fines.Unfortunately,these monetary elements seemingly vanish into thin air,representing a loss to the system itself.However,by virtue of the redistribution of fines to cooperators and punishers,not only can we mitigate this loss,but the rewards for these cooperative individuals can be enhanced.Based upon this premise,this paper introduces a fine distribution mechanism to the traditional pool punishment model.Under identical parameter settings,by conducting a comparative experiment with the conventional punishment model,the paper aims to investigate the impact of fine distribution on the evolution of cooperation in spatial public goods game.The experimental results clearly demonstrate that,in instances where the punishment cost is prohibitively high,the cooperative strategies of the traditional pool punishment model may completely collapse.However,the model enriched with fine distribution manages to sustain a considerable number of cooperative strategies,thus highlighting its effectiveness in promoting and preserving cooperation,even in the face of substantial punishment cost.
基金the National Natural Science Foundation of China(No.62176146)。
文摘A multi-strategy hybrid whale optimization algorithm(MSHWOA)for complex constrained optimization problems is proposed to overcome the drawbacks of easily trapping into local optimum,slow convergence speed and low optimization precision.Firstly,the population is initialized by introducing the theory of good point set,which increases the randomness and diversity of the population and lays the foundation for the global optimization of the algorithm.Then,a novel linearly update equation of convergence factor is designed to coordinate the abilities of exploration and exploitation.At the same time,the global exploration and local exploitation capabilities are improved through the siege mechanism of Harris Hawks optimization algorithm.Finally,the simulation experiments are conducted on the 6 benchmark functions and Wilcoxon rank sum test to evaluate the optimization performance of the improved algorithm.The experimental results show that the proposed algorithm has more significant improvement in optimization accuracy,convergence speed and robustness than the comparison algorithm.
文摘Objective:To evaluate relationship between changes in the beneficial bacteria in intensive care unit(ICU)patients and nutritional therapy type.Methods:Ten patients aged≥18 years admitted to the ICU between January and December 2020,were included.Good enteral nutrition was defined as early achievement of target calorie intake through enteral feeding.The ratio of beneficial bacteria at the first and second bowel movements after each patient’s admission was calculated and the patients were classified into the increase or decrease group.Among all patients,five each were in the increase and decrease groups.We investigated patient background,changes in sequential organ failure assessment(SOFA)and acute physiology and chronic health evaluation(APACHE)Ⅱscores,nutritional doses or methods,and clinical outcomes.Results:No relationship was found between changes in the ratio of beneficial bacteria and changes in SOFA/APACHEⅡscores at the time of admission.The rate of good enteral nutrition was significantly higher in the increase group than in the decrease group(4/5 vs.0/5,P=0.01).Conclusions:An increase in beneficial bacteria may be significantly related to the early establishment of enteral nutrition.In the future,accumulating cases may make it possible to establish a new nutritional strategy for critically ill patients from an intestinal microbiota perspective.
文摘With the deepening of Internet technology in international trade,cross-border e-commerce has become the main incremental contributor in the import and export trade of goods,and its transaction volume has gradually increased from 16%of China’s total import and export of goods in 2014 to 42%in 2023.
文摘Exerting the leading role of standards is very important for achieving the high-quality development. In recent years, China has unceasingly improved the mandatory national standards for energy efficiency and safety of products, expedited the development and revision of standards in the areas of digital, intelligent, green and low-carbon development, and led the continuous technological upgrading of industrial and consumer goods.
基金Supported by the National High Level Hospital Clinical Research Funding,No.2022-PUMCH-C-005.
文摘BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of chemoresistance.METHODS In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA sequencing.RESULTS Exosome hsa-miR-483-5p was up-regulated in good responders post-nCRT.Bioinformatics analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling pathway.Further analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor stage.In addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 values.Accordingly,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was constructed.CONCLUSION This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs.However,further research is required within the framework of our established miRNA-mRNA network.
文摘Recently released economic data reflecting China’s brisk economic activities and vibrant foreign trade attest to a steady acceleration in the country’s economic growth.The National Bureau of Statistics(NBS)reported 5.5 percent year-on-year growth during the first two months of 2024 for retail sales of consumer goods,4.2 percent for fixed-asset investment,and 7 percent for value-added of the industrial enterprises above the designated size.The country’s total import and export of goods,meanwhile,expanded 8.7 percent year-on-year,and its volume for this period achieved a historical high of RMB 6.61 trillion.
文摘Flannery O’Connor is one of the representative figures of American Southern writers.Being recognized as the most outstanding writer of the American South after Faulkner,she has great influence in the literary world.Her works are always shrouded in a strange and grotesque atmosphere and full of death as well as religious metaphors.The protagonists are a series of American Southern freaks struggling with the crisis of spiritual belief.The protagonists of her novel A Good Man is Hard to Find are a hypocritical believer in the world of sinners and a lost man suffering in the midst of real sin,thus O’Connor uses the highest form of violence-death to bring ultimate redemption to them.In people’s conception,violence and redemption are often opposite to each other,but O’Connor uses bloody and violent plots to explore the theme of religious salvation,integrating and unifying the two contrary concepts to form her unique and profound violent redemption writing.
