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Interpersonal Perception in Virtual Groups: Examining Homophily, Identification and Individual Attraction Using Social Relations Model in Network
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作者 Zuoming Wang 《Social Networking》 2023年第2期45-56,共12页
With the penetration of the Internet, virtual groups have become more and more popular. The reliability and accuracy of interpersonal perception in the virtual environment is an intriguing issue. Using the Social rela... With the penetration of the Internet, virtual groups have become more and more popular. The reliability and accuracy of interpersonal perception in the virtual environment is an intriguing issue. Using the Social relations model (SRM) [1], this paper investigates interpersonal perception in virtual groups from a multilevel perspective. In particular, it examines the following three areas: homophily, identification, and individual attraction, and explores how much of these directional and dyadic relational evaluations can be attributed to the effect of the actor, the partner, and the relationship. 展开更多
关键词 Virtual groups Interpersonal Perception Social relations Model HOMOPHILY IDENTIFICATION Individual Attraction
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Multi-Criteria Group Decision-Making Method Based on an Improved Single-Valued Neutrosophic Hamacher Weighted Average Operator and Grey Relational Analysis
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作者 Ye Mei Junjie Yang Bo Chen 《Journal of Computer and Communications》 2023年第3期167-188,共22页
This paper proposes a multi-criteria decision-making (MCGDM) method based on the improved single-valued neutrosophic Hamacher weighted averaging (ISNHWA) operator and grey relational analysis (GRA) to overcome the lim... This paper proposes a multi-criteria decision-making (MCGDM) method based on the improved single-valued neutrosophic Hamacher weighted averaging (ISNHWA) operator and grey relational analysis (GRA) to overcome the limitations of present methods based on aggregation operators. First, the limitations of several existing single-valued neutrosophic weighted averaging aggregation operators (i.e. , the single-valued neutrosophic weighted averaging, single-valued neutrosophic weighted algebraic averaging, single-valued neutrosophic weighted Einstein averaging, single-valued neutrosophic Frank weighted averaging, and single-valued neutrosophic Hamacher weighted averaging operators), which can produce some indeterminate terms in the aggregation process, are discussed. Second, an ISNHWA operator was developed to overcome the limitations of existing operators. Third, the properties of the proposed operator, including idempotency, boundedness, monotonicity, and commutativity, were analyzed. Application examples confirmed that the ISNHWA operator and the proposed MCGDM method are rational and effective. The proposed improved ISNHWA operator and MCGDM method can overcome the indeterminate results in some special cases in existing single-valued neutrosophic weighted averaging aggregation operators and MCGDM methods. 展开更多
关键词 Single-Valued Neutrosophic Numbers Single-Valued Neutrosophic Hamacher Weighted Averaging Operator Grey relational Analysis Multi-Criteria Decision-Making Multi-Criteria group Decision-Making
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Determinants of loan repayment among agricultural microcredit finance group members in Delta state, Nigeria 被引量:3
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作者 Solomon Enimu Emmanuel O.Eyo Eucharia A.Ajah 《Financial Innovation》 2017年第1期303-314,共12页
Background:This study examined the determinants of loan repayment among microcredit finance group members in Delta State,Nigeria.Methods:To capture the determinants of loan repayment in the study area,a total of 48 mi... Background:This study examined the determinants of loan repayment among microcredit finance group members in Delta State,Nigeria.Methods:To capture the determinants of loan repayment in the study area,a total of 48 microcredit groups and 300 microcredit group members were randomly selected through a multi-stage random sampling technique.The study data was collected by questionnaire.Statistical tools such as simple descriptive statistics(table,frequency,percentage and mean)and a multiple regression analysis were used to examine the data.Results:The results indicate that females form a greater proportion of the study area microcredit group members at 70%,moreover 73%of the respondents have a household size of between 6 to 10 persons.These findings revealed that the groups had a mean 8 years of existence with a mean membership size of 13 persons.Further,an average interest rate of 40 percent per annum was charged on loans,with mean loan duration of 6 months.The regression’s result demonstrated that the determinants of the group member’s loan repayment included the group member’s age,household size,house income,and educational level,the amount of credit received,length of stay in their locality,distance to the credit source,supervision and disbursement lag.Conclusion:Therefore it was suggested that the various agricultural microcredit finance groups should carefully examine the significant determinants of loan repayment for the approach’s viability and sustainability and for optimum repayment performance. 展开更多
关键词 Determinants Loan repayment MICROCREDIT groups memberS Delta state
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Group Decision Making With Consistency of Intuitionistic Fuzzy Preference Relations Under Uncertainty 被引量:1
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作者 Yang Lin Yingming Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第3期741-748,共8页
Intuitionistic fuzzy preference relation(IFPR) is a suitable technique to express fuzzy preference information by decision makers(DMs). This paper aims to provide a group decision making method where DMs use the IFPRs... Intuitionistic fuzzy preference relation(IFPR) is a suitable technique to express fuzzy preference information by decision makers(DMs). This paper aims to provide a group decision making method where DMs use the IFPRs to indicate their preferences with uncertain weights. To begin with, a model to derive weight vectors of alternatives from IFPRs based on multiplicative consistency is presented. Specifically, for any IFPR,by minimizing its absolute deviation from the corresponding consistent IFPR, the weight vectors are generated. Secondly,a method to determine relative weights of DMs depending on preference information is developed. After that we prioritize alternatives based on the obtained weights considering the risk preference of DMs. Finally, this approach is applied to the problem of technical risks assessment of armored equipment to illustrate the applicability and superiority of the proposed method. 展开更多
关键词 group decision making(GDM) intuitionistic fuzzy preference relation(IFPR) intuitionistic fuzzy set(IFS) multiplicative consistency risk preference uncertain weights
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Modeling and applying credible interval intuitionistic fuzzy reciprocal preference relations in group decision making 被引量:2
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作者 Wei Zhou Zeshui Xu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第2期301-314,共14页
Intuitionistic fuzzy preference relations are powerful techniques used to express uncertain preference information.However, simultaneously providing the exact priority and nonpriority intensities could be difficult in... Intuitionistic fuzzy preference relations are powerful techniques used to express uncertain preference information.However, simultaneously providing the exact priority and nonpriority intensities could be difficult in real applications. A credible interval intuitionistic fuzzy number(CIIFN) is introduced and a credible interval intuitionistic fuzzy reciprocal preference relation(CIIFRPR) is developed to solve this issue. Unlike intuitionistic fuzzy preference relations, the new preference relations use the CIIFNs to express the preference information such that the decision makers simply provide the priority intensity with intervalvalued numbers and calculate the non-preference intensity with the transformed method, which avoids a complex evaluation of non-priority information. Furthermore, some basic operations and comparison laws are investigated, based on which three credible interval intuitionistic fuzzy aggregation operators are proposed.Two models are presented to manage the group decision-making.Finally, a practical case is used to demonstrate the feasibility and reasonability of the proposed preference relations and aggregation operators. 展开更多
关键词 credible INTERVAL intuitionistic FUZZY set credible INTERVAL intuitionistic FUZZY number (CIIFN) credible INTERVAL intuitionistic FUZZY reciprocal PREFERENCE relation (CIIFRPR) AGGREGATION OPERATOR group DECISION making
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Interactive group decision making procedure based on uncertain multiplicative linguistic preference relations 被引量:9
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作者 Zeshui Xu1,2,1.College of Economics and Management,Southeast University,Nanjing 210096,P.R.China 2.Institute of Sciences,University of Science and Technology of the PLA,Nanjing 210007,P.R.China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第3期408-415,共8页
Group decision making problems are investigated with uncertain multiplicative linguistic preference relations.An unbalanced multiplicative linguistic label set is introduced,which can be used by the experts to express... Group decision making problems are investigated with uncertain multiplicative linguistic preference relations.An unbalanced multiplicative linguistic label set is introduced,which can be used by the experts to express their linguistic preference information over alternatives.The uncertain linguistic weighted geometric mean operator is utilized to aggregate all the individual uncertain multiplicative linguistic preference relations into a collective one,and then a simple approach is developed to determine the experts' weights by utilizing the consensus degrees among the individual uncertain multiplicative linguistic preference relations and the collective uncertain multiplicative linguistic preference relations.Furthermore,a practical interactive procedure for group decision making is proposed based on uncertain multiplicative linguistic preference relations,in which a possibility degree formula and a complementary matrix are used to rank the given alternatives.Finally,the proposed procedure is applied to solve the group decision making problem of a manufacturing company searching the best global supplier for one of its most critical parts used in assembling process. 展开更多
关键词 程序语言 偏好关系 交互式 乘法 群决策 基础 决策问题 专家权重
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Research on Bond-Slip Constitutive Relation for Steel Reinforced Concrete Members 被引量:1
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作者 梁斌 孟凡深 刘俊玲 《Journal of Beijing Institute of Technology》 EI CAS 2009年第2期152-156,共5页
The constitutive relation of bond-slip on steel and concrete interface is proposed for short steel reinforced concrete(SRC)column.Based on the experimental research on bond-slip performance,a mechanical model of short... The constitutive relation of bond-slip on steel and concrete interface is proposed for short steel reinforced concrete(SRC)column.Based on the experimental research on bond-slip performance,a mechanical model of short SRC column in pulling or pushing test is established.By means of the elasto-plasticity theory the explicit formulation of bond-slip constitutive relation τ-s in different anchor-hold place of push and pull member is investigated under the conditions of balance and boundary.The study shows that the constitutive relation is relevant to the embedment length and the thickness of concrete cover.The results are continuous descriptions of bond-slip constitutive relation and can be used to analyze the non-linear performance of SRC members.Results indicate that the principle of the method is correct and it performs well for short SRC column. 展开更多
关键词 粘结滑移本构关系 钢筋混凝土 防滑性能 债券 钢骨混凝土柱 混凝土界面 保护层厚度 力学模型
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Some properties of linguistic preference relation and its ranking in group decision making 被引量:1
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作者 Yejun Xu Qingli Da Xinwang Liu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第2期244-249,共6页
The group decision making problem with linguistic preference relations is studied.The concept of additive consistent linguistic preference relation is defined,and then some properties of the additive consistent lingui... The group decision making problem with linguistic preference relations is studied.The concept of additive consistent linguistic preference relation is defined,and then some properties of the additive consistent linguistic preference relation are studied. In order to rank the alternatives in the group decision making with the linguistic preference relations,the weighted average is first utilized to combine the group linguistic preference relations to one linguistic preference relation,and then the transformation function is proposed to transform the linguistic preference relation to the multiplicative preference relation,and thus the Saaty's eigenvector method(EM) of multiplicative preference relation is utilized to rank the alternatives in group decision making with the linguistic preference relations.Finally,an illustrative numerical example is given to verify the proposed method.A comparative study to the linguistic ordered weighted averaging(LOWA) operator method is also demonstrated. 展开更多
关键词 偏好关系 决策方案 语言 性质 加权平均 职能转变 添加剂 乘法
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The Power of Group Generators and Relations: An Examination of the Concept and Its Applications
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作者 Tiancheng Zhou 《Journal of Applied Mathematics and Physics》 2018年第11期2425-2444,共20页
This paper investigates the approach of presenting groups by generators and relations from an original angle. It starts by interpreting this familiar concept with the novel notion of “formal words” created by juxtap... This paper investigates the approach of presenting groups by generators and relations from an original angle. It starts by interpreting this familiar concept with the novel notion of “formal words” created by juxtaposing letters in a set. Taking that as basis, several fundamental results related to free groups, such as Dyck’s Theorem, are proven. Then, the paper highlights three creative applications of the concept in classifying finite groups of a fixed order, representing all dihedral groups geometrically, and analyzing knots topologically. All three applications are of considerable significance in their respective topic areas and serve to illustrate the advantages and certain limitations of the approach flexibly and comprehensively. 展开更多
关键词 Generators and relationS Free group Dyck’s Theorem Dihedral group Presentation Classification of Finite groupS (Application) Realizing Dihedral groupS Geometrically (Application) KNOT group (Application)
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THE PROXIMAL RELATION,REGIONALLY PROXIMAL RELATION AND BANACH PROXIMAL RELATION FOR AMENABLE GROUP ACTIONS
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作者 连媛 黄小军 李智强 《Acta Mathematica Scientia》 SCIE CSCD 2021年第3期729-752,共24页
In this paper,we study the proximal relation,regionally proximal relation and Banach proximal relation of a topological dynamical system for amenable group actions.A useful tool is the support of a topological dynamic... In this paper,we study the proximal relation,regionally proximal relation and Banach proximal relation of a topological dynamical system for amenable group actions.A useful tool is the support of a topological dynamical system which is used to study the structure of the Banach proximal relation,and we prove that above three relations all coincide on a Banach mean equicontinuous system generated by an amenable group action. 展开更多
关键词 Proximal relation amenable group mean equicontinuity
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Group Decision-Making Method with Incomplete Intuitionistic Fuzzy Preference Relations Based on a Generalized Multiplicative Consistent Concept
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作者 Xiaoyun Lu Jiuying Dong +1 位作者 Hecheng Li Shuping Wan 《Computer Modeling in Engineering & Sciences》 SCIE EI 2022年第9期881-907,共27页
Based on the analyses of existing preference group decision-making(PGDM)methods with intuitionistic fuzzy preference relations(IFPRs),we present a new PGDM framework with incomplete IFPRs.A generalized multiplicative ... Based on the analyses of existing preference group decision-making(PGDM)methods with intuitionistic fuzzy preference relations(IFPRs),we present a new PGDM framework with incomplete IFPRs.A generalized multiplicative consistent for IFPRs is defined,and a mathematical programming model is constructed to supplement the missing values in incomplete IFPRs.Moreover,in this study,another mathematical programming model is constructed to improve the consistency level of unacceptably multiplicative consistent IFPRs.For group decisionmaking(GDM)with incomplete IFPRs,three reliable sources influencing the weights of experts are identified.Subsequently,a method for determining the weights of experts is developed by simultaneously considering three reliable sources.Furthermore,a targeted consensus process(CPR)is developed in this study with reference to the actual situation of the consensus level of each IFPR.Meanwhile,in response to the proposed multiplicative consistency definition,a novel method for determining the optimal priority weights of alternatives is redefined.Lastly,based on the above theory,a novel GDM method with incomplete IFPRs is developed,and the comparative and sensitivity analysis results demonstrate the utility and superiority of this work. 展开更多
关键词 Intuitionistic fuzzy preference relations multiplicative consistency CONSENSUS optimization model group decision-making
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RELATIVE ENTROPY DIMENSION FOR COUNTABLE AMENABLE GROUP ACTIONS
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作者 肖祖彪 殷正宇 《Acta Mathematica Scientia》 SCIE CSCD 2023年第6期2430-2448,共19页
We study the topological complexities of relative entropy zero extensions acted upon by countable-infinite amenable groups.First,for a given Følner sequence,we define the relative entropy dimensions and the dimen... We study the topological complexities of relative entropy zero extensions acted upon by countable-infinite amenable groups.First,for a given Følner sequence,we define the relative entropy dimensions and the dimensions of the relative entropy generating sets to characterize the sub-exponential growth of the relative topological complexity.we also investigate the relations among these.Second,we introduce the notion of a relative dimension set.Moreover,using the method,we discuss the disjointness between the relative entropy zero extensions via the relative dimension sets of two extensions,which says that if the relative dimension sets of two extensions are different,then the extensions are disjoint. 展开更多
关键词 amenable groups relative entropy dimensions relative dimension sets
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BSI Group Chairman Sir David John in China to Meet Customers and Consolidate Relations with the Chinese Standards Community
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作者 Mandy Shi 《China Standardization》 2005年第1期15-15,共1页
On 29th November 2004, BSI Group Chairman Sir David John and senior colleagues were in Beijing to meet with Management Systems’ clients of the BSI Group and to consolidate already established relationships with the C... On 29th November 2004, BSI Group Chairman Sir David John and senior colleagues were in Beijing to meet with Management Systems’ clients of the BSI Group and to consolidate already established relationships with the Chinese standards community. This trip came in the wake of last year’s visit of the Group Chairman to Beijing and Shanghai, which paved the way for the signing of a cooperation agreement between BSI and the Standardization Adminis- 展开更多
关键词 BSI group Chairman Sir David John in China to Meet Customers and Consolidate relations with the Chinese Standards Community John
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Effect of cognitive behavioral group therapy on rehabilitation of community patients with schizophrenia:A short-term randomized control trial
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作者 Xue-Lian Chen Xiao-Ting Deng +1 位作者 Fu-Gang Sun Qing-Jun Huang 《World Journal of Psychiatry》 SCIE 2023年第8期583-592,共10页
BACKGROUND The efficacy of cognitive behavioral group therapy(CBGT)for cognitive dysfunction and negative symptoms of schizophrenia is established,but more evidence is required.AIM To assess the effectiveness of CBGT ... BACKGROUND The efficacy of cognitive behavioral group therapy(CBGT)for cognitive dysfunction and negative symptoms of schizophrenia is established,but more evidence is required.AIM To assess the effectiveness of CBGT combined with mental health education as a treatment for schizophrenia compared with mental health education alone.METHODS In all,120 schizophrenia out-patients were randomized into CBGT combined with mental health education or single mental health education.The primary outcomes were positive and negative symptoms,cognitive function,excitatory factor,anxiety and depression symptom improvements on the positive and negative syndrome scale score.Secondary outcome measures included social function and drug compliance.RESULTS There were significant differences between CBGT combined with mental health education and single mental health education on measures of positive and negative symptoms,cognitive functions,excitatory factor,anxiety and depression symptoms,and social functions.No other significant difference in outcomes was observed.CONCLUSION CBGT combined with mental health education may be relevant beneficial treatment method in reducing symptoms,cognitive and social functions of patients with schizophrenia. 展开更多
关键词 SCHIZOPHRENIA Cognitive behavioral group therapy Family members Social functions Mental health COMMUNITY Psychological intervention
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DRG支付背景下某公立医院专科建设思考及实施效果分析
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作者 路璐 刘雨辰 +2 位作者 韩媛媛 宫红岩 王明刚 《中国医院》 北大核心 2024年第4期92-95,共4页
近年来,随着医改的持续深化,按疾病诊断相关分组(DRG)支付逐渐成为新医改的焦点。DRG支付制度不仅是医保结付的方式,同时也是公立医院规范医生诊疗行为、衡量医疗服务质量的管理工具,促使医院由粗放管理转向精细管理转型,对公立医院的... 近年来,随着医改的持续深化,按疾病诊断相关分组(DRG)支付逐渐成为新医改的焦点。DRG支付制度不仅是医保结付的方式,同时也是公立医院规范医生诊疗行为、衡量医疗服务质量的管理工具,促使医院由粗放管理转向精细管理转型,对公立医院的运营管理理念提出一系列挑战。因此,分析DRG支付方式改革给公立医院带来的影响以及相关运营情况意义重大。笔者选取某公立医院推进DRG支付方式改革以来的22 791例病案资料进行分析,探讨在DRG支付背景下医院运营的应对策略及主要问题,为公立医院更好地落实DRG支付政策及高质量发展转型提供建议。 展开更多
关键词 疾病诊断相关分组 公立医院 医疗质量 医疗成本
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基于决策树模型HC25病组DRGs细分组及住院费用的影响因素研究
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作者 闫晓婷 任洁 +3 位作者 李红霞 张欣欣 朱绮霞 张文 《安徽医学》 2024年第4期505-510,共6页
目的构建基于决策树模型HC25病组患者DRGs细分组的研究及住院费用的影响因素。方法收集西安交通大学第一附属医院2020年1月至2022年6月依据CHS-DRG分组方案进入HC25(胆囊切除术,不伴并发症或合并症)病组患者的病案首页数据(n=3844),通... 目的构建基于决策树模型HC25病组患者DRGs细分组的研究及住院费用的影响因素。方法收集西安交通大学第一附属医院2020年1月至2022年6月依据CHS-DRG分组方案进入HC25(胆囊切除术,不伴并发症或合并症)病组患者的病案首页数据(n=3844),通过单因素和多因素分析了解影响住院费用的主要因素,通过建立决策树模型进行病例组合,分析分组效果及不同分组的费用标准。结果正态性检验结果显示:住院费用呈偏态分布(χ2=0.197,P<0.001);单因素方差分析结果显示:住院费用在不同年龄、性别、手术方式、患者来源、医疗付费方式、入院病情危重情况、术前时间、住院时间、是否有再住院计划之间,差异有统计学意义(P均<0.05);多重线性逐步回归分析结果显示,影响住院费用显著性差异的因素从大到小依次为:住院时间、手术方式、入院病情危重情况、性别、术前时间、患者来源、再住院计划(P均<0.05);采用CHAID共生成了7个DRGs分组,第一层分类节点变量是手术方式,第二层是术前时间、住院时间,第三层是入院时病情危重情况;不同DRGs组合的住院费用比较,差异有统计学意义(χ2=2474.595,P<0.001),组合DRGs(1)的住院费用最高,权重最高;DRGs(7)的住院费用最低,权重最小;所有DRGs病组中超标费用患者共170例(4.42%),各组超标费用比例均<10%。结论基于决策树模型对HC25病组的细分组效果合理有效,能较客观反映医疗资源消耗水平。 展开更多
关键词 胆囊切除术 决策树 疾病诊断相关分组 住院费用
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中外创新药物医保支付的比较研究
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作者 于飞 卢静 +1 位作者 高辰旭 李敬伟 《医药导报》 CAS 北大核心 2024年第3期470-476,共7页
按疾病诊断相关分组(DRG)付费是当前我国医保支付改革的重要研究方向,但在一定程度上限制了创新药物的临床推广使用。许多国家已对创新药物的额外支付进行了深入研究。该文以美国、法国、德国为例,分析总结DRG付费体系下创新药物额外支... 按疾病诊断相关分组(DRG)付费是当前我国医保支付改革的重要研究方向,但在一定程度上限制了创新药物的临床推广使用。许多国家已对创新药物的额外支付进行了深入研究。该文以美国、法国、德国为例,分析总结DRG付费体系下创新药物额外支付的国际经验,并结合我国创新药物医保支付现状及DRG付费对创新药物发展的影响,提出了明确的纳入标准、选择合适支付模式、建立动态调整机制、完善支付方式等政策建议,以期在全面推进DRG付费改革中,为进一步建立和完善我国创新药物医保支付机制提供参考。 展开更多
关键词 创新药物 医保支付 按疾病诊断相关分组 政策建议
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自然杀伤细胞2组成员A、程序性死亡因子配体1表达检测对PD-L1阻断免疫治疗肌层浸润性膀胱癌反应性的预测价值
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作者 赵刚刚 张鸿毅 +3 位作者 肖克兵 杨辉 李子峰 赵华才 《陕西医学杂志》 CAS 2024年第2期252-256,共5页
目的:探究自然杀伤细胞2组成员A(NKG2A)及程序性死亡因子配体1(PD-L1)表达检测对PD-L1阻断免疫治疗肌层浸润性膀胱癌反应性的预测价值。方法:选取100例肌层浸润性膀胱癌患者作为研究对象,对其行PD-L1阻断免疫治疗后,根据治疗反应性将其... 目的:探究自然杀伤细胞2组成员A(NKG2A)及程序性死亡因子配体1(PD-L1)表达检测对PD-L1阻断免疫治疗肌层浸润性膀胱癌反应性的预测价值。方法:选取100例肌层浸润性膀胱癌患者作为研究对象,对其行PD-L1阻断免疫治疗后,根据治疗反应性将其分为缓解组和未缓解组;对缓解组患者随访3个月,将其分为复发组和未复发组。比较两组患者NKG2A和PD-L1在CD4^(+)和CD8^(+)上的表达水平,采用ROC曲线分析NKG2A和PD-L1预测膀胱癌患者治疗反应性的价值。结果:100例研究对象中,缓解组患者72例(72.00%),未缓解组患者28例(28.00%),两组性别、年龄比较无统计学差异(均P>0.05),但缓解组患者肿瘤直径小于未缓解组,NKG2A、PD-L1/CD4^(+)和PD-L1/CD8^(+)表达水平均低于未缓解组(均P<0.05)。膀胱癌患者NKG2A、PD-L1/CD4^(+)和PD-L1/CD8^(+)表达预测免疫治疗后缓解的AUC值分别为0.771、0.724、0.710;联合诊断的AUC为0.836。72例缓解患者中,出现复发29例(40.28%),未出现复发43例(59.72%),两组性别、年龄以及肿瘤直径比较无统计学差异(均P>0.05),但复发组NKG2A、PD-L1/CD4^(+)和PD-L1/CD8^(+)表达水平均高于未复发组(均P<0.05)。NKG2A、PD-L1/CD4^(+)和PD-L1/CD8^(+)表达预测膀胱癌患者缓解后复发的AUC值分别为0.775、0.740、0.728;联合诊断的AUC为0.874。结论:NKG2A、PD-L1/CD4^(+)和PD-L1/CD8^(+)在不同治疗反应性肌层浸润性膀胱癌患者外周血中表达水平不同,三者对于膀胱癌患者PD-L1阻断免疫治疗反应性均有一定的预测价值,且三者联合预测效能最佳。 展开更多
关键词 膀胱癌 肿瘤直径 自然杀伤细胞2组成员A 程序性死亡因子配体1 免疫治疗 反应性
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基于合成控制法的DRG改革对住院费用的影响——以北京市三级公立医院为例
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作者 王文娟 梁娟娟 +4 位作者 胡洋溢 蔡媛青 樊荣 尹柏松 张宇薇 《中国卫生政策研究》 CSCD 北大核心 2024年第3期1-9,共9页
目的:分析DRG改革对北京市三级公立医院例均住院总费用及其增速、内部结构的短期效应与长期影响。方法:基于2009—2018年北京市三级公立医院住院费用的年度报表数据,采用合成控制法分析2011年的DRG改革对例均住院总费用及各项费用占比... 目的:分析DRG改革对北京市三级公立医院例均住院总费用及其增速、内部结构的短期效应与长期影响。方法:基于2009—2018年北京市三级公立医院住院费用的年度报表数据,采用合成控制法分析2011年的DRG改革对例均住院总费用及各项费用占比的影响。结果:与未试点的医院相比,短期内试点医院的例均住院总费用有所降低,药占比下降显著,耗材费用占比增速下降明显,手术、治疗、护理费用占比有所下降,检查、化验费用占比略有上升。长期看,试点医院例均住院总费用与增速超过非试点医院,药占比、手术、治疗、护理费用占比低于非试点医院,耗材费用占比大幅提高,检查、化验费用占比呈现较强的个体差异性。结论:DRG改革短期内对控制费用增长具有积极作用,长期效果有待改善,费用结构有待优化;未来应从发挥“双中心”的多元作用、与三级公立医院绩效考核结合、提高体现医生技术劳动价值的收入等方面完善DRG改革。 展开更多
关键词 疾病诊断相关分组 三级公立医院 住院费用 合成控制法
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西藏地区结直肠癌免疫治疗和靶向治疗相关分子标志物的检测及意义
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作者 罗含欢 刘斌云 +7 位作者 霍真 边巴扎西 王倩 多布啦 尼玛卓玛 达珍 王寒 郭平平 《中国医学科学院学报》 CAS CSCD 北大核心 2024年第2期184-192,共9页
目的研究西藏地区结直肠癌中SWI/SNF相关、基质相关、肌动蛋白依赖性染色质调节因子A亚科成员4(SMARCA4)/Brahma相关基因1、V-raf鼠类肉瘤病毒癌基因同源物B(BRAF)、P53、程序性死亡受体1(PD-1)及程序性死亡配体1(PD-L1)免疫组织化学表... 目的研究西藏地区结直肠癌中SWI/SNF相关、基质相关、肌动蛋白依赖性染色质调节因子A亚科成员4(SMARCA4)/Brahma相关基因1、V-raf鼠类肉瘤病毒癌基因同源物B(BRAF)、P53、程序性死亡受体1(PD-1)及程序性死亡配体1(PD-L1)免疫组织化学表达和BRAF、神经营养因子酪氨酸受体激酶(NTRK)基因改变情况,为西藏地区结直肠癌患者的靶向治疗及免疫治疗提供依据。方法收集2015年1月至2021年7月西藏自治区人民医院经手术切除病理确诊为结直肠癌病例64例,全部病例均进行SMARCA4、BRAF、P53、PD-1、PD-L1免疫组织化学染色和NTRK1、NTRK2、NTRK3融合基因荧光原位杂交检测及BRAF V600E基因突变PCR检测。结果64例结直肠癌病例男女比例1.21∶1,平均年龄(56.59±13.27)岁;46例(71.88%)位于结肠,18例(28.12%)位于直肠;60例(93.75%)为腺癌,4例(6.25%)为其他类型;11例(17.19%)为T1或T2期,53例(82.81%)为T3或T4期;24例(37.50%)出现淋巴结转移。免疫组织化学方面,64例中1例(1.56%)SMARCA4部分肿瘤细胞表达减弱或缺失,4例(6.25%)BRAF肿瘤细胞阳性表达,35例(54.69%)P53为突变型表达;45例(70.31%)PD-1肿瘤相关免疫细胞阳性比例分数<10%,19例(29.69%)≥10%;52例(81.25%)PD-L1联合阳性分数<10,12例(18.75%)≥10。64例NTRK1、NTRK2、NTRK3融合基因检测均为阴性;4例(6.25%)检测到BRAF V600E基因突变;1例SMARCA4表达缺失病例未检测到SMARCA4基因改变。PD-L1的表达与错配修复缺陷/高度微卫星不稳定和PD-1的高表达呈显著正相关(χ^(2)=10.223,P=0.001;χ^(2)=11.979,P=0.001)。结论西藏地区结直肠癌中较少出现SMARCA4表达减弱或缺失及NTRK融合基因改变,少数病例有BRAF V600E基因突变,Pan-TRK和BRAF免疫组织化学可作为NTRK融合基因及BRAF基因突变的初筛方法。错配修复缺陷/高度微卫星不稳定的病例中更容易出现PD-L1蛋白高表达,这部分患者有望获益于免疫治疗。P53突变与PD-L1表达无相关性,PD-1的高表达和PD-L1的高表达呈正相关。 展开更多
关键词 西藏地区 结直肠癌 SWI/SNF相关、基质相关、肌动蛋白依赖性染色质调节因子A亚科成员4 程序性死亡受体1 程序性死亡配体1 V-raf鼠类肉瘤病毒癌基因同源物B 神经营养因子酪氨酸受体激酶
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