BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower limbs.RLS typically affects the legs.However,it can also affect several other body regions,such as th...BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower limbs.RLS typically affects the legs.However,it can also affect several other body regions,such as the arms,abdomen,face,neck,head,and genital area.There are only a few reports of the RLS variant affecting the head.AIM To assess the epidemiological,clinical,and other aspects of the RLS variant affecting the head.METHODS We conducted a retrospective study of 17 adult patients(>18 years)who met the RLS criteria and simultaneously experienced RLS-like symptoms in the head.RESULTS The median age at which symptoms appeared was 41.6 years.Males and females were equally affected(1.1:1).All 17 patients had uncomfortable sensations in the lower legs.Insomnia or disturbed sleep was the most common comorbidity(n=16,88.2%).However,headache was the most common presenting or primary symptom(n=10,70.5%).Dizziness or an abnormal sensation in the head was the second most common presenting symptom(5 patients,29.4%).Other presenting features were leg pain,backache,and generalized body pain.All patients responded favorably to dopaminergic medications.CONCLUSION If RLS-related unpleasant sensations and pain are felt in the head,they may be misinterpreted as headache,dizziness,or psychosomatic symptoms.RLS and headaches in a subset of patients may be two phenotypic manifestations of the same disorder.展开更多
Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells ...Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological recovery.However,the mechanism of CXCR4 upregulation in induced neural stem cells remains unclear.In this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 expression.However,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial activation.In agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury mice.Notably,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head injury.In conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neural stem cells on microglial activation via upregulation of CXCR4 and Crry,thereby promoting induced neural stem cell–mediated improvement of neuronal injury,cerebral edema,and neurological disorders following closed head injury.展开更多
Purpose: In super-aging societies, prosthodontists will have a growing role and will need to improve their nutrition knowledge. This study aimed to evaluate the effectiveness of a workshop-based model for increasing d...Purpose: In super-aging societies, prosthodontists will have a growing role and will need to improve their nutrition knowledge. This study aimed to evaluate the effectiveness of a workshop-based model for increasing dysphagia diet awareness among prosthodontists working with head and neck cancer patients. Methods: The study had a post-intervention design and included 10 maxillofacial prosthetic educators from eight countries who participated in a 120-minute workshop focused on theoretical and practical training in nutrition support for patients with dysphagia. Sessions were held in a specialized restaurant in Tokyo and included lectures, observation of Japanese cooking techniques, hands-on preparation of dysphagia-friendly foods, and cross-cultural comparisons. Knowledge, confidence, and practical application were assessed using a post-workshop questionnaire. Descriptive statistics and thematic analysis were used to evaluate outcomes. Results: Seven of the 10 prosthodontists completed the post-intervention questionnaire. All respondents reported overall satisfaction with the workshop. Session content was regarded as easy to understand by 57.14%, appropriate by 28.57%, and easy by 14.29%. Most respondents (85.71%) were “very satisfied” with the instructors’ explanations, and 100% were “very satisfied” with the workshop’s length and structure;71.42% felt they could apply the knowledge in clinical practice, while 28.58% anticipated challenges. The respondents appreciated the workshop’s focus on dysphagia, particularly in elderly patients, and valued the insights into Japanese dysphagia diets and culture. Conclusions: Workshops on nutrition provide an interactive platform for prosthodontists to enhance their knowledge and improve comprehensive patient care, highlighting the importance for prosthodontists to stay updated on developments in nutrition, particularly in dysphagia.展开更多
Computed tomography is an indispensable X-ray imaging modality used to diagnose numerous pathologies, but it can also involve the delivery of high ionizing radiation doses harmful to the health of patients. This study...Computed tomography is an indispensable X-ray imaging modality used to diagnose numerous pathologies, but it can also involve the delivery of high ionizing radiation doses harmful to the health of patients. This study aims to survey the level of radiation doses delivered to child patients during head exams in CT imaging to set up the Dosimetric Reference Levels (DRLs), a routine dose optimization tool, based on data acquired at the University Hospital of Angré (UHA), the University Hospital of Treichville (UHT) and the Polyclinic Hospital Farah (Farah) for optimizing procedures in Ivorian hospitals. Prospectively performed on 334 CT images of 186 child patients, this study was carried out on CT systems such as Hitachi Scenaria, Sinovision Insitum, and Philips Incisive used respectively at UHA, UHT and Farah. Children’s scan data were classified into four age bands: vol or dose-length product as DLP) value, whatever the hospital, increases with respect to the age of child patients. Based on the 75th percentile of the whole dose distributions, the DRLs of the CTDIvol is 54.37 mGy whatever the age groups and those of the DLP with respect to age bands are 1224.55 mGy∙cm, 1414.06 mGy∙cm, 1632.24 mGy.cm and 1544.57 mGy∙cm, respectively. The averaged values of CTDIvol and DLP smaller than the corresponding DRLs values suggest that practices in our three facilities are optimized. However, comparing our results with those from different international studies, we see that the CTDIvol and DLP values obtained in the present work are higher. These results suggest additional surveys to ensure our DRLs values and efforts from radiologists, imaging technicians and medical physicists to strengthen clinical procedures for the radiation protection of children undergoing CT scans in Côte d’Ivoire.展开更多
BACKGROUND Pancreatic tuberculosis(PTB)is a rare disease,even in immunocompetent hosts.Abdominal tuberculosis involving the pancreatic head and peripancreatic areas may simulate pancreatic head carcinoma.CASE SUMMARY ...BACKGROUND Pancreatic tuberculosis(PTB)is a rare disease,even in immunocompetent hosts.Abdominal tuberculosis involving the pancreatic head and peripancreatic areas may simulate pancreatic head carcinoma.CASE SUMMARY We present the case of a 32-year-old man who was admitted to our hospital for intermittent epigastric pain and weight loss.A computed tomography scan and magnetic resonance imaging revealed a mass in the head of the pancreas.The lesion was initially diagnosed as pancreatic head carcinoma on abdominal imaging.Laparotomy confirmed the diagnosis of PTB and the patient received antituberculosis therapy.CONCLUSION The present case is reported to emphasize the importance of including PTB in the differential diagnosis of pancreatic lesions.展开更多
Obtaining accurate ship positions and headings in remote sensing images plays a crucial role in various applications.However,current deep learning-based methods primarily focus on ship position detection,while the det...Obtaining accurate ship positions and headings in remote sensing images plays a crucial role in various applications.However,current deep learning-based methods primarily focus on ship position detection,while the detection of ship wakes relies on traditional non-deep learning approaches,which often underperform in complex marine environments.We proposed a novel,simple,and efficient method called Point-Vector Net.The proposed method leverages convolutional neural networks(CNN)for feature extraction and subsequently integrates multi-scale features to generate high-resolution feature maps.In the final stage,ship positions and headings are represented using a combination of points and vectors.Comparative experiments with results from automatic identification system(AIS)reports demonstrate that our method achieved impressive performance in two-class ship target detection,with an average precision of 96.4%,recall rate of 94.3%,and an F 1 score of 95.2%.Notably,the average heading error was 3.3°.The proposed model achieved a practical inference speed(FPS>30),and the average processing time for inferring a large-scale Sentinel-2 remote sensing image was 11.4 s.展开更多
This research investigates the design and optimization of a photovoltaic(PV)water pumping system to address seasonal water demands across five locations with varying elevation heads.The systemdraws water froma deep we...This research investigates the design and optimization of a photovoltaic(PV)water pumping system to address seasonal water demands across five locations with varying elevation heads.The systemdraws water froma deep well with a static water level of 30mand a dynamic level of 50m,serving agricultural and livestock needs.The objective of this study is to accurately size a PV system that balances energy generation and demand while minimizing grid dependency.Meanwhile,the study presents a comprehensivemethodology to calculate flowrates,pumping power,daily energy consumption,and system capacity.Therefore,the PV system rating,energy output,and economic performance were evaluated using metrics such as discounted payback period(DPP),net present value(NPV),and sensitivity analysis.The results show that a 2.74 kWp PV system is optimal,producing 4767 kWh/year to meet the system’s annual energy demand of 4686 kWh.In summer,energy demand peaks at 1532.7 kWh,while in winter,it drops to 692.1 kWh.Meanwhile,flow rates range from 11.71 m^(3)/h at 57 m head to 10.49 m^(3)/h at 70 m head,demonstrating the system’s adaptability to diverse hydraulic conditions.Economic analysis reveals that at a 5%interest rate and an electricity price of$0.15/kWh,the NPV is$6981.82 with a DPP of 3.76 years.However,a 30%increase in electricity prices improves the NPV to$10,005.18 and shortens the DPP to 2.76 years,whereas a 20%interest rate reduces the NPV to$1038.79 and extends the DPP to 6.08 years.Nevertheless,the annual PV energy generation exceeds total energy demand by 81 kWh,reducing grid dependency and lowering electricity costs.Additionally,the PV system avoids approximately 3956.6 kg of CO_(2) emissions annually,underscoring its environmental benefits over traditional pumping systems.As a result,this study highlights the economic and environmental viability of PV-powered water pumping systems,offering actionable insights for sustainable energy solutions in agriculture.展开更多
The performance degradation of vehicle engine cylinder heads is a complex phenomenon,and the accurate prediction of their remaining useful life is essential for maintenance planning.To address the problem of low predi...The performance degradation of vehicle engine cylinder heads is a complex phenomenon,and the accurate prediction of their remaining useful life is essential for maintenance planning.To address the problem of low prediction accuracy caused by insufficient data mining depth in current prediction models for the remaining service life of engine cylinder heads,a prediction method of dualchannel model is proposed.Firstly,the driving status data of multiple vehicles is summarized and analyzed,and the on-board network common variables related to cylinder head life are screened.Secondly,driving segments are defined,the driving state features of each driving segment are extracted,and feature correlation analysis and principal component analysis are performed.All driving state profiles of the vehicle are divided using the clustering algorithm,and the cumulative degradation factors for driving state profiles are defined and calculated.Furthermore,the mileage of each driving segment is classified into intervals by applying fuzzy set theory,and the state transfer probability matrices of driving state profiles and driving segment mileage are calculated.A new engine head life prediction model based on dual channel Markov chain(DCMC)is established.Finally,the proposed method is applied to the residual life prediction of cylinder head of seven actual vehicles,and the comparison with actual life statistics results proved the validity of the proposed method.展开更多
Background:Head and neck cancers(HNC)account for a significant global health burden,with increasing incidence rates and complex treatment requirements.Traditional diagnostic and therapeutic approaches,while effective,...Background:Head and neck cancers(HNC)account for a significant global health burden,with increasing incidence rates and complex treatment requirements.Traditional diagnostic and therapeutic approaches,while effective,often result in substantial morbidity and limitations in personalized care.This review provides a comprehensive overview of the latest innovations in diagnostics and therapeutic strategies for HNC from 2015 to 2024.Methods:A review of literature focused on pe-reviewed journals,clinical trial databases,and oncology conference proceedings.Key areas include molecular diagnostics,imaging technologies,minimally invasive surgeries,and innovative therapeutic strategies.Results:Technologies like liquid biopsy next-generation sequencing(NGS)have greatly improved diagnostic accuracy and personalization in HNC care.These advancements have improved survival rates and enhanced patients’quality of life.Personalized therapeutic approaches,including immune checkpoint inhibitors,precision radiation therapy,and surgery,have led to enhanced treatment efficacy while reducing side effects.The integration of AI and machine learning into diagnostics and treatment planning shows promise in optimizing clinical decision-making and predicting treatment outcomes.Conclusion:The current innovations in diagnostics and therapeutics are reshaping the management of head and neck cancer,offering more tailored and effective approaches to care.Overall,the continuous integration of these innovations in clinical practice is reshaping HNC treatment and improving patient outcomes and survival rates.Future research should focus on further refining these technologies,addressing challenges related to accessibility,and exploring their long-term clinical benefits in diverse patient populations.展开更多
The integration of the digital economy with the traditional sales industry has prompted the robust growth of e-commerce.Live-streaming e-commerce,as a novel business model,has gained immense popularity.However,is⁃sues...The integration of the digital economy with the traditional sales industry has prompted the robust growth of e-commerce.Live-streaming e-commerce,as a novel business model,has gained immense popularity.However,is⁃sues of regulatory loopholes and inefficacy continue to surface.In live-streaming e-commerce,the head anchor,as host of the live-streaming rooms,wields significant influence in determining the goods to be showcased and marketed.Such influence expands risks such as infringement of intellectual property rights.Yet the uncertainty in law concerning the identity of head anchors results in a lack of accountability.Current norms are inadequate in constraining the group of head anchors.Drawing on the principles of risk control,the alignment between benefit and risk,and the theory of so⁃cial cost control,this paper argues that it is both justifiable and feasible to impose a duty to exercise reasonable care on head anchors.To effectively enshrine this duty in law,it is of great importance to redefine the mechanism of identifying the duty of care of head anchors in live-streaming e-commerce.In particular,the contents of the duty of care under⁃taken by head anchors and the consequences of breaching such a duty of care should be clarified.展开更多
Intra-tumoral bacteria are pivotal in the initiation and progression of head and neck squamous cell carcinoma(HNSCC),exerting a significant influence on tumor cell biology,immune responses,and the tumor microenvironme...Intra-tumoral bacteria are pivotal in the initiation and progression of head and neck squamous cell carcinoma(HNSCC),exerting a significant influence on tumor cell biology,immune responses,and the tumor microenvironment(TME).Different types and distribution of bacteria threaten the balance of metabolism and the immune environment of tumor cells.Taking advantage of this disrupted homeostasis,intra-tumoral bacteria stimulate the secretion of metabolites or influence specific immune cell types to produce inflammatory or chemokines,thereby influencing the anti-tumor immune response while regulating the level of inflammation and immunosuppression within the TME.Some intra-tumoral bacteria are used as diagnostic and prognostic markers in clinical practice.Based on the unique characteristics of bacteria,the use of engineered bacteria and outer membrane vesicles for drug delivery and biological intervention is a promising new therapeutic strategy.The presence of intra-tumoral bacteria also makes chemoradiotherapy tolerable,resulting in a poor treatment effect.However,due to the immune-related complexity of intra-tumoral bacteria,there may be unexpected effects in immunotherapy.In this review the patterns of intra-tumoral bacteria involvement in HNSCC are discussed,elucidating the dual roles,while exploring the relevance to anti-tumor immune responses in the clinical context and the prospects and limitations of the use of bacteria in targeted therapy.展开更多
This paper reports a case of cerebral stem infarction with quadriplegia and complete dependence on daily life.The course of the disease lasted more than 7 months.Frenchay's improved articulation Disorder Assessmen...This paper reports a case of cerebral stem infarction with quadriplegia and complete dependence on daily life.The course of the disease lasted more than 7 months.Frenchay's improved articulation Disorder Assessment Form has been assessed as severe articulation disorder.The patient has significantly improved his speech function and quality of life after systematic head control training,respiratory function training,articulation motor training,and articulation training.In the course of treatment,emphasis was placed on head postural control training and respiratory function training,and emphasis was placed on the strength and coordination training of articulatory organs,and the results were remarkable.After the patient was discharged from the hospital,the follow-up of basic daily life communication was not limited.展开更多
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is characterized by the accumulation of fat in the liver in individuals who do not consume alcohol.Several risk factors influencing the onset of NAFLD after laparosco...BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is characterized by the accumulation of fat in the liver in individuals who do not consume alcohol.Several risk factors influencing the onset of NAFLD after laparoscopic pancreaticoduodenectomy(LPD)have been identified.This study investigated the risk factors associated with the development of fatty liver after laparoscopic duodenum-preserving pancreatic total head resection(LDPPHRt)and LPD.AIM To compare the effects of LDPPHRt and LPD on the development of postoperative NAFLD.METHODS This retrospective cohort study included 59 patients who were histologically diagnosed with benign or low-grade malignant pancreatic tumors and who underwent laparoscopic pancreatic surgery(LDPPHRt or LPD)between May 2020 and April 2023.Patient data on perioperative and postoperative variables were analyzed and compared.Multivariate logistic regression was used to identify pre-,peri-,and postoperative risk factors for NAFLD,with statistical significance set at P<0.05.RESULTS Of the 59 patients included in the study,17(28.8%)developed NAFLD within 6-12 months post-surgery.The incidence of NAFLD was significantly higher in the LPD group compared to the LDPPHRt group(40.0%vs 12.5%,P=0.022).Multivariable analysis identified the LDPPHRt surgical approach(compared to LPD)as an independent protective factor against the development of postoperative NAFLD,with an odds ratio of 0.208(95%confidence interval:0.046-0.931;P=0.040).CONCLUSION Our findings indicate that LDPPHRt is more effective than LPD in reducing the incidence of postoperative NAFLD,which may inform surgical decision-making and optimize patient outcomes after laparoscopic pancreatic surgery.展开更多
Yellow rust(Puccinia striiformis f.sp.Tritici,YR)and fusarium head blight(Fusarium graminearum,FHB)are the two main diseases affecting wheat in the main grain-producing areas of East China,which is common for the two ...Yellow rust(Puccinia striiformis f.sp.Tritici,YR)and fusarium head blight(Fusarium graminearum,FHB)are the two main diseases affecting wheat in the main grain-producing areas of East China,which is common for the two diseases to appear simultaneously in some main production areas.It is necessary to discriminate wheat YR and FHB at the regional scale to accurately locate the disease in space,conduct detailed disease severity monitoring,and scientific control.Four images on different dates were acquired from Sentinel-2,Landsat-8,and Gaofen-1 during the critical period of winter wheat,and 22 remote sensing features that characterize the wheat growth status were then calculated.Meanwhile,6 meteorological parameters that reflect the wheat phenological information were also obtained by combining the site meteorological data and spatial interpolation technology.Then,the principal components(PCs)of comprehensive remote sensing and meteorological features were extracted with principal component analysis(PCA).The PCs-based discrimination models were established to map YR and FHB damage using the random forest(RF)and backpropagation neural network(BPNN).The models’performance was verified based on the disease field truth data(57 plots during the filling period)and 5-fold cross-validation.The results revealed that the PCs obtained after PCA dimensionality reduction outperformed the initial features(IFs)from remote sensing and meteorology in discriminating between the two diseases.Compared to the IFs,the average area under the curve for both micro-average and macro-average ROC curves increased by 0.07 in the PCs-based RF models and increased by 0.16 and 0.13,respectively,in the PCs-based BPNN models.Notably,the PCs-based BPNN discrimination model emerged as the most effective,achieving an overall accuracy of 83.9%.Our proposed discrimination model for wheat YR and FHB,coupled with multi-source remote sensing images and meteorological data,overcomes the limitations of a single-sensor and single-phase remote sensing information in multiple stress discrimination in cloudy and rainy areas.It performs well in revealing the damage spatial distribution of the two diseases at a regional scale,providing a basis for detailed disease severity monitoring,and scientific prevention and control.展开更多
Objectives: The primary objective was to characterize the range of Knowledge, Attitude, and Practice (KAP) of Helmet use in children amongst parents to prevent head injuries and death. Methods: This is a cross-section...Objectives: The primary objective was to characterize the range of Knowledge, Attitude, and Practice (KAP) of Helmet use in children amongst parents to prevent head injuries and death. Methods: This is a cross-sectional study, done by online survey using a snowball sampling technique, the number of included responses were 386 parents (Male and female) living in Riyadh Aged 21 - 60 years old or above. Results: The study showed that there is a difference in Parents’ belief in the importance of helmet use while riding a Bicycle vs Motorcycle/Quad bike and that was affected by parents’ education level, almost all the people who answered the survey (76.7%) agree that it is important for their children to wear a helmet when riding both a Bicycle and a Motorcycle or Quadbike with a cumulative percentage of (93.8%). And almost all agreed on multiple approaches to help increase helmet use be it by forcing rental shops to give out helmets, forcing sellers to recommend the use of helmets, increasing awareness campaigns, and imposing fines for not wearing helmets. Conclusions: This study is the first to explore Family helmet use while riding Bicycles and Motorcycles/Quad bikes. Although Parent’s belief in the importance of helmet use for their children was high, it is clear that the level of practice is low. With that the risk of head injuries might be high, our findings suggest that safety interventions for increasing pediatric helmet use are needed to increase helmet use and reduce the risk of head injury and hospitalization.展开更多
Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regen...Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.展开更多
AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-thre...AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-three healthy subjects were enrolled.The ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning protocol.Images of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were measured.The repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman plots.RESULTS:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel density.CONCLUSION:OCTA ONH parameters demonstrate good repeatability in healthy subjects.The interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.展开更多
文摘BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower limbs.RLS typically affects the legs.However,it can also affect several other body regions,such as the arms,abdomen,face,neck,head,and genital area.There are only a few reports of the RLS variant affecting the head.AIM To assess the epidemiological,clinical,and other aspects of the RLS variant affecting the head.METHODS We conducted a retrospective study of 17 adult patients(>18 years)who met the RLS criteria and simultaneously experienced RLS-like symptoms in the head.RESULTS The median age at which symptoms appeared was 41.6 years.Males and females were equally affected(1.1:1).All 17 patients had uncomfortable sensations in the lower legs.Insomnia or disturbed sleep was the most common comorbidity(n=16,88.2%).However,headache was the most common presenting or primary symptom(n=10,70.5%).Dizziness or an abnormal sensation in the head was the second most common presenting symptom(5 patients,29.4%).Other presenting features were leg pain,backache,and generalized body pain.All patients responded favorably to dopaminergic medications.CONCLUSION If RLS-related unpleasant sensations and pain are felt in the head,they may be misinterpreted as headache,dizziness,or psychosomatic symptoms.RLS and headaches in a subset of patients may be two phenotypic manifestations of the same disorder.
基金supported by the National Natural Science Foundation of China,Nos.82271397(to MG),82001293(to MG),82171355(to RX),81971295(to RX),and 81671189(to RX)。
文摘Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological recovery.However,the mechanism of CXCR4 upregulation in induced neural stem cells remains unclear.In this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 expression.However,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial activation.In agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury mice.Notably,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head injury.In conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neural stem cells on microglial activation via upregulation of CXCR4 and Crry,thereby promoting induced neural stem cell–mediated improvement of neuronal injury,cerebral edema,and neurological disorders following closed head injury.
文摘Purpose: In super-aging societies, prosthodontists will have a growing role and will need to improve their nutrition knowledge. This study aimed to evaluate the effectiveness of a workshop-based model for increasing dysphagia diet awareness among prosthodontists working with head and neck cancer patients. Methods: The study had a post-intervention design and included 10 maxillofacial prosthetic educators from eight countries who participated in a 120-minute workshop focused on theoretical and practical training in nutrition support for patients with dysphagia. Sessions were held in a specialized restaurant in Tokyo and included lectures, observation of Japanese cooking techniques, hands-on preparation of dysphagia-friendly foods, and cross-cultural comparisons. Knowledge, confidence, and practical application were assessed using a post-workshop questionnaire. Descriptive statistics and thematic analysis were used to evaluate outcomes. Results: Seven of the 10 prosthodontists completed the post-intervention questionnaire. All respondents reported overall satisfaction with the workshop. Session content was regarded as easy to understand by 57.14%, appropriate by 28.57%, and easy by 14.29%. Most respondents (85.71%) were “very satisfied” with the instructors’ explanations, and 100% were “very satisfied” with the workshop’s length and structure;71.42% felt they could apply the knowledge in clinical practice, while 28.58% anticipated challenges. The respondents appreciated the workshop’s focus on dysphagia, particularly in elderly patients, and valued the insights into Japanese dysphagia diets and culture. Conclusions: Workshops on nutrition provide an interactive platform for prosthodontists to enhance their knowledge and improve comprehensive patient care, highlighting the importance for prosthodontists to stay updated on developments in nutrition, particularly in dysphagia.
文摘Computed tomography is an indispensable X-ray imaging modality used to diagnose numerous pathologies, but it can also involve the delivery of high ionizing radiation doses harmful to the health of patients. This study aims to survey the level of radiation doses delivered to child patients during head exams in CT imaging to set up the Dosimetric Reference Levels (DRLs), a routine dose optimization tool, based on data acquired at the University Hospital of Angré (UHA), the University Hospital of Treichville (UHT) and the Polyclinic Hospital Farah (Farah) for optimizing procedures in Ivorian hospitals. Prospectively performed on 334 CT images of 186 child patients, this study was carried out on CT systems such as Hitachi Scenaria, Sinovision Insitum, and Philips Incisive used respectively at UHA, UHT and Farah. Children’s scan data were classified into four age bands: vol or dose-length product as DLP) value, whatever the hospital, increases with respect to the age of child patients. Based on the 75th percentile of the whole dose distributions, the DRLs of the CTDIvol is 54.37 mGy whatever the age groups and those of the DLP with respect to age bands are 1224.55 mGy∙cm, 1414.06 mGy∙cm, 1632.24 mGy.cm and 1544.57 mGy∙cm, respectively. The averaged values of CTDIvol and DLP smaller than the corresponding DRLs values suggest that practices in our three facilities are optimized. However, comparing our results with those from different international studies, we see that the CTDIvol and DLP values obtained in the present work are higher. These results suggest additional surveys to ensure our DRLs values and efforts from radiologists, imaging technicians and medical physicists to strengthen clinical procedures for the radiation protection of children undergoing CT scans in Côte d’Ivoire.
文摘BACKGROUND Pancreatic tuberculosis(PTB)is a rare disease,even in immunocompetent hosts.Abdominal tuberculosis involving the pancreatic head and peripancreatic areas may simulate pancreatic head carcinoma.CASE SUMMARY We present the case of a 32-year-old man who was admitted to our hospital for intermittent epigastric pain and weight loss.A computed tomography scan and magnetic resonance imaging revealed a mass in the head of the pancreas.The lesion was initially diagnosed as pancreatic head carcinoma on abdominal imaging.Laparotomy confirmed the diagnosis of PTB and the patient received antituberculosis therapy.CONCLUSION The present case is reported to emphasize the importance of including PTB in the differential diagnosis of pancreatic lesions.
基金Supported by the National Key R&D Program of China(No.2022YFB3902400)the China High Resolution Earth Observation System Program(No.41-Y30F07-9001-20/22)。
文摘Obtaining accurate ship positions and headings in remote sensing images plays a crucial role in various applications.However,current deep learning-based methods primarily focus on ship position detection,while the detection of ship wakes relies on traditional non-deep learning approaches,which often underperform in complex marine environments.We proposed a novel,simple,and efficient method called Point-Vector Net.The proposed method leverages convolutional neural networks(CNN)for feature extraction and subsequently integrates multi-scale features to generate high-resolution feature maps.In the final stage,ship positions and headings are represented using a combination of points and vectors.Comparative experiments with results from automatic identification system(AIS)reports demonstrate that our method achieved impressive performance in two-class ship target detection,with an average precision of 96.4%,recall rate of 94.3%,and an F 1 score of 95.2%.Notably,the average heading error was 3.3°.The proposed model achieved a practical inference speed(FPS>30),and the average processing time for inferring a large-scale Sentinel-2 remote sensing image was 11.4 s.
文摘This research investigates the design and optimization of a photovoltaic(PV)water pumping system to address seasonal water demands across five locations with varying elevation heads.The systemdraws water froma deep well with a static water level of 30mand a dynamic level of 50m,serving agricultural and livestock needs.The objective of this study is to accurately size a PV system that balances energy generation and demand while minimizing grid dependency.Meanwhile,the study presents a comprehensivemethodology to calculate flowrates,pumping power,daily energy consumption,and system capacity.Therefore,the PV system rating,energy output,and economic performance were evaluated using metrics such as discounted payback period(DPP),net present value(NPV),and sensitivity analysis.The results show that a 2.74 kWp PV system is optimal,producing 4767 kWh/year to meet the system’s annual energy demand of 4686 kWh.In summer,energy demand peaks at 1532.7 kWh,while in winter,it drops to 692.1 kWh.Meanwhile,flow rates range from 11.71 m^(3)/h at 57 m head to 10.49 m^(3)/h at 70 m head,demonstrating the system’s adaptability to diverse hydraulic conditions.Economic analysis reveals that at a 5%interest rate and an electricity price of$0.15/kWh,the NPV is$6981.82 with a DPP of 3.76 years.However,a 30%increase in electricity prices improves the NPV to$10,005.18 and shortens the DPP to 2.76 years,whereas a 20%interest rate reduces the NPV to$1038.79 and extends the DPP to 6.08 years.Nevertheless,the annual PV energy generation exceeds total energy demand by 81 kWh,reducing grid dependency and lowering electricity costs.Additionally,the PV system avoids approximately 3956.6 kg of CO_(2) emissions annually,underscoring its environmental benefits over traditional pumping systems.As a result,this study highlights the economic and environmental viability of PV-powered water pumping systems,offering actionable insights for sustainable energy solutions in agriculture.
基金Supported by the Open Project Fund of the National Key Laboratory of Internal Combustion Engine and Power System(No.skler-202102).
文摘The performance degradation of vehicle engine cylinder heads is a complex phenomenon,and the accurate prediction of their remaining useful life is essential for maintenance planning.To address the problem of low prediction accuracy caused by insufficient data mining depth in current prediction models for the remaining service life of engine cylinder heads,a prediction method of dualchannel model is proposed.Firstly,the driving status data of multiple vehicles is summarized and analyzed,and the on-board network common variables related to cylinder head life are screened.Secondly,driving segments are defined,the driving state features of each driving segment are extracted,and feature correlation analysis and principal component analysis are performed.All driving state profiles of the vehicle are divided using the clustering algorithm,and the cumulative degradation factors for driving state profiles are defined and calculated.Furthermore,the mileage of each driving segment is classified into intervals by applying fuzzy set theory,and the state transfer probability matrices of driving state profiles and driving segment mileage are calculated.A new engine head life prediction model based on dual channel Markov chain(DCMC)is established.Finally,the proposed method is applied to the residual life prediction of cylinder head of seven actual vehicles,and the comparison with actual life statistics results proved the validity of the proposed method.
文摘Background:Head and neck cancers(HNC)account for a significant global health burden,with increasing incidence rates and complex treatment requirements.Traditional diagnostic and therapeutic approaches,while effective,often result in substantial morbidity and limitations in personalized care.This review provides a comprehensive overview of the latest innovations in diagnostics and therapeutic strategies for HNC from 2015 to 2024.Methods:A review of literature focused on pe-reviewed journals,clinical trial databases,and oncology conference proceedings.Key areas include molecular diagnostics,imaging technologies,minimally invasive surgeries,and innovative therapeutic strategies.Results:Technologies like liquid biopsy next-generation sequencing(NGS)have greatly improved diagnostic accuracy and personalization in HNC care.These advancements have improved survival rates and enhanced patients’quality of life.Personalized therapeutic approaches,including immune checkpoint inhibitors,precision radiation therapy,and surgery,have led to enhanced treatment efficacy while reducing side effects.The integration of AI and machine learning into diagnostics and treatment planning shows promise in optimizing clinical decision-making and predicting treatment outcomes.Conclusion:The current innovations in diagnostics and therapeutics are reshaping the management of head and neck cancer,offering more tailored and effective approaches to care.Overall,the continuous integration of these innovations in clinical practice is reshaping HNC treatment and improving patient outcomes and survival rates.Future research should focus on further refining these technologies,addressing challenges related to accessibility,and exploring their long-term clinical benefits in diverse patient populations.
文摘The integration of the digital economy with the traditional sales industry has prompted the robust growth of e-commerce.Live-streaming e-commerce,as a novel business model,has gained immense popularity.However,is⁃sues of regulatory loopholes and inefficacy continue to surface.In live-streaming e-commerce,the head anchor,as host of the live-streaming rooms,wields significant influence in determining the goods to be showcased and marketed.Such influence expands risks such as infringement of intellectual property rights.Yet the uncertainty in law concerning the identity of head anchors results in a lack of accountability.Current norms are inadequate in constraining the group of head anchors.Drawing on the principles of risk control,the alignment between benefit and risk,and the theory of so⁃cial cost control,this paper argues that it is both justifiable and feasible to impose a duty to exercise reasonable care on head anchors.To effectively enshrine this duty in law,it is of great importance to redefine the mechanism of identifying the duty of care of head anchors in live-streaming e-commerce.In particular,the contents of the duty of care under⁃taken by head anchors and the consequences of breaching such a duty of care should be clarified.
基金supported by grants from the National Natural Science Foundation of China(Grant nos.82472818 and 82103336)the Fundamental Research Funds for the Central Universities(Grant nos.2042024kf0021 and 2042022dx0003)the Natural Science Foundation of Wuhan(Grant no.2023020201020515)。
文摘Intra-tumoral bacteria are pivotal in the initiation and progression of head and neck squamous cell carcinoma(HNSCC),exerting a significant influence on tumor cell biology,immune responses,and the tumor microenvironment(TME).Different types and distribution of bacteria threaten the balance of metabolism and the immune environment of tumor cells.Taking advantage of this disrupted homeostasis,intra-tumoral bacteria stimulate the secretion of metabolites or influence specific immune cell types to produce inflammatory or chemokines,thereby influencing the anti-tumor immune response while regulating the level of inflammation and immunosuppression within the TME.Some intra-tumoral bacteria are used as diagnostic and prognostic markers in clinical practice.Based on the unique characteristics of bacteria,the use of engineered bacteria and outer membrane vesicles for drug delivery and biological intervention is a promising new therapeutic strategy.The presence of intra-tumoral bacteria also makes chemoradiotherapy tolerable,resulting in a poor treatment effect.However,due to the immune-related complexity of intra-tumoral bacteria,there may be unexpected effects in immunotherapy.In this review the patterns of intra-tumoral bacteria involvement in HNSCC are discussed,elucidating the dual roles,while exploring the relevance to anti-tumor immune responses in the clinical context and the prospects and limitations of the use of bacteria in targeted therapy.
基金Teaching and Research Project of Anhui Urban Management Vocational College(Project No.:2024kfkc001)。
文摘This paper reports a case of cerebral stem infarction with quadriplegia and complete dependence on daily life.The course of the disease lasted more than 7 months.Frenchay's improved articulation Disorder Assessment Form has been assessed as severe articulation disorder.The patient has significantly improved his speech function and quality of life after systematic head control training,respiratory function training,articulation motor training,and articulation training.In the course of treatment,emphasis was placed on head postural control training and respiratory function training,and emphasis was placed on the strength and coordination training of articulatory organs,and the results were remarkable.After the patient was discharged from the hospital,the follow-up of basic daily life communication was not limited.
基金Supported by National Natural Science Foundation of China,No.82273442.
文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is characterized by the accumulation of fat in the liver in individuals who do not consume alcohol.Several risk factors influencing the onset of NAFLD after laparoscopic pancreaticoduodenectomy(LPD)have been identified.This study investigated the risk factors associated with the development of fatty liver after laparoscopic duodenum-preserving pancreatic total head resection(LDPPHRt)and LPD.AIM To compare the effects of LDPPHRt and LPD on the development of postoperative NAFLD.METHODS This retrospective cohort study included 59 patients who were histologically diagnosed with benign or low-grade malignant pancreatic tumors and who underwent laparoscopic pancreatic surgery(LDPPHRt or LPD)between May 2020 and April 2023.Patient data on perioperative and postoperative variables were analyzed and compared.Multivariate logistic regression was used to identify pre-,peri-,and postoperative risk factors for NAFLD,with statistical significance set at P<0.05.RESULTS Of the 59 patients included in the study,17(28.8%)developed NAFLD within 6-12 months post-surgery.The incidence of NAFLD was significantly higher in the LPD group compared to the LDPPHRt group(40.0%vs 12.5%,P=0.022).Multivariable analysis identified the LDPPHRt surgical approach(compared to LPD)as an independent protective factor against the development of postoperative NAFLD,with an odds ratio of 0.208(95%confidence interval:0.046-0.931;P=0.040).CONCLUSION Our findings indicate that LDPPHRt is more effective than LPD in reducing the incidence of postoperative NAFLD,which may inform surgical decision-making and optimize patient outcomes after laparoscopic pancreatic surgery.
基金supported by National Key R&D Program of China(2022YFD2000100)National Natural Science Foundation of China(42401400)Zhejiang Provincial Key Research and Development Program(2023C02018).
文摘Yellow rust(Puccinia striiformis f.sp.Tritici,YR)and fusarium head blight(Fusarium graminearum,FHB)are the two main diseases affecting wheat in the main grain-producing areas of East China,which is common for the two diseases to appear simultaneously in some main production areas.It is necessary to discriminate wheat YR and FHB at the regional scale to accurately locate the disease in space,conduct detailed disease severity monitoring,and scientific control.Four images on different dates were acquired from Sentinel-2,Landsat-8,and Gaofen-1 during the critical period of winter wheat,and 22 remote sensing features that characterize the wheat growth status were then calculated.Meanwhile,6 meteorological parameters that reflect the wheat phenological information were also obtained by combining the site meteorological data and spatial interpolation technology.Then,the principal components(PCs)of comprehensive remote sensing and meteorological features were extracted with principal component analysis(PCA).The PCs-based discrimination models were established to map YR and FHB damage using the random forest(RF)and backpropagation neural network(BPNN).The models’performance was verified based on the disease field truth data(57 plots during the filling period)and 5-fold cross-validation.The results revealed that the PCs obtained after PCA dimensionality reduction outperformed the initial features(IFs)from remote sensing and meteorology in discriminating between the two diseases.Compared to the IFs,the average area under the curve for both micro-average and macro-average ROC curves increased by 0.07 in the PCs-based RF models and increased by 0.16 and 0.13,respectively,in the PCs-based BPNN models.Notably,the PCs-based BPNN discrimination model emerged as the most effective,achieving an overall accuracy of 83.9%.Our proposed discrimination model for wheat YR and FHB,coupled with multi-source remote sensing images and meteorological data,overcomes the limitations of a single-sensor and single-phase remote sensing information in multiple stress discrimination in cloudy and rainy areas.It performs well in revealing the damage spatial distribution of the two diseases at a regional scale,providing a basis for detailed disease severity monitoring,and scientific prevention and control.
文摘Objectives: The primary objective was to characterize the range of Knowledge, Attitude, and Practice (KAP) of Helmet use in children amongst parents to prevent head injuries and death. Methods: This is a cross-sectional study, done by online survey using a snowball sampling technique, the number of included responses were 386 parents (Male and female) living in Riyadh Aged 21 - 60 years old or above. Results: The study showed that there is a difference in Parents’ belief in the importance of helmet use while riding a Bicycle vs Motorcycle/Quad bike and that was affected by parents’ education level, almost all the people who answered the survey (76.7%) agree that it is important for their children to wear a helmet when riding both a Bicycle and a Motorcycle or Quadbike with a cumulative percentage of (93.8%). And almost all agreed on multiple approaches to help increase helmet use be it by forcing rental shops to give out helmets, forcing sellers to recommend the use of helmets, increasing awareness campaigns, and imposing fines for not wearing helmets. Conclusions: This study is the first to explore Family helmet use while riding Bicycles and Motorcycles/Quad bikes. Although Parent’s belief in the importance of helmet use for their children was high, it is clear that the level of practice is low. With that the risk of head injuries might be high, our findings suggest that safety interventions for increasing pediatric helmet use are needed to increase helmet use and reduce the risk of head injury and hospitalization.
基金supported by the National Natural Science Foundation of China,Nos.82271397(to MG),82001293(to MG),82171355(to RX),81971295(to RX)and 81671189(to RX)。
文摘Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.
基金Natural Science Foundation of Guangdong Province(No.2018A0303130306)Shantou Science and Technology Program(No.190917085269835,No.200629165261641).
文摘AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-three healthy subjects were enrolled.The ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning protocol.Images of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were measured.The repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman plots.RESULTS:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel density.CONCLUSION:OCTA ONH parameters demonstrate good repeatability in healthy subjects.The interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.
