BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to deco...BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),respectively.Clinically Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these patients.However,due to its invasiveness and costs,CSPH is almost never evaluated in clinical practice.Therefore,recognizing noninvasively predicting tools still have more appeal across healthcare systems.The red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been explored.AIM In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD patients.METHODS Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 years.At baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were collected.During FUP,DEs(timing and modaities)were recorded.CSPH was assessed at the baseline and on DE occurrence according to the available Clinical Practice Guidelines.RESULTS Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve analysis revealed RPR>0.472 and>0.894 as the best cut-offs in the prediction respectively of 3-year first DE,as well as its superiority compared to the other non-invasive tools examined.RPR(P:0.02)and the presence of baseline-CSPH(P:0.04)were significantly and independently associated with the DE.Patients presenting baseline-CSPH and RPR>0.472 showed higher risk of decompensation(P:0.0023).CONCLUSION Altogether these findings suggest the RPR as a valid and potentially applicable non-invasive tool in the prediction of timing and modalities of decompensation in MASLD-related cACLD patients.展开更多
BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular events.AIM To explore the value of...BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular events.AIM To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December 2021.The NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were recorded.The receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of HF.The correlation between NLR and RDW with the presence or absence of cardiac events was also investigated.RESULTS Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of HF.Furthermore,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac events.CONCLUSION NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic efficiency.Additionally,NLR and RDW values were directly proportional to patient outcomes.展开更多
This study conducts both numerical and empirical assessments of thermal transfer and fluid flow characteristics in a Solar Air Collector(SAC)using a Delta Wing Vortex Generator(DWVG),and the effects of different heigh...This study conducts both numerical and empirical assessments of thermal transfer and fluid flow characteristics in a Solar Air Collector(SAC)using a Delta Wing Vortex Generator(DWVG),and the effects of different height ratios(Rh=0.6,0.8,1,1.2 and 1.4)in delta wing vortex generators,which were not considered in the earlier studies,are investigated.Energy and exergy analyses are performed to gain maximum efficiency.The Reynolds number based on the outlet velocity and hydraulic diameter falls between 4400 and 22000,corresponding to the volume flow rate of 5.21–26.07 m^(3)/h.It is observed that the delta wing vortex generators with a higher height ratio yield maximum heat transfer enhancement and overall enhancement ratio.The empirical and numerical findings demonstrate that the exergy and thermal efficiencies decline in a specific range.TheNusselt number,pressure drop,energy,and exergy efficiencies enhance with rising Reynolds number,although the friction coefficient diminishes.The maximum heat transfer enhancement is 57%.According to the evaluation of exergy efficiency,the greatest efficiency of 31.2%is obtained at Rh=1.4 and Reynolds number 22000.展开更多
Bumps in coal mines have been recognized as a major hazard for many years. These sudden and violent failures around mine openings have compromised safety, ventilation and access to mine workings.Previous studies showe...Bumps in coal mines have been recognized as a major hazard for many years. These sudden and violent failures around mine openings have compromised safety, ventilation and access to mine workings.Previous studies showed that the violence of coal specimen failure depends on both the interface friction and width-to-height（W/H） ratio of coal specimen. The mode of failure for a uniaxially loaded coal specimen or a coal pillar is a combination of both shear failure along the interface and compressive failure in the coal. The shear failure along the interface triggered the compressive failure in coal. The compressive failure of a coal specimen or a coal pillar can be controlled by changing its W/H ratio. As the W/H ratio increases, the ultimate strength increases. Hence, with a proper combination of interface friction and the W/H ratio of pillar or coal specimen, the mode of failure will change from sudden violent failure which is brittle failure to non-violent failure which is ductile failure. The main objective of this paper is to determine at what W/H ratio and interface friction the mode of failure changes from violent to non-violent. In this research, coal specimens of W/H ratio ranging from 1 to 10 were uniaxially tested under two interface frictions of 0.1 and 0.25, and the results are presented and discussed.展开更多
The size and shape of rice grains influence their yield and commercial value.We investigated the role of OsDA1,a rice homolog of the Arabidopsis DA1 gene,in regulating grain size and shape.OsDA1 was highly expressed i...The size and shape of rice grains influence their yield and commercial value.We investigated the role of OsDA1,a rice homolog of the Arabidopsis DA1 gene,in regulating grain size and shape.OsDA1 was highly expressed in young spikelets and glumes.Its overexpression led to enlarged seeds with increased width and decreased length/width ratio(LWR)and knocking out OsDA1 reduced grain width and increased grain length and LWR.A R310K point mutation in the DA1-like domain is a potential target for breeding for increased grain width and length.OsDA1 interacted with TCP gene-family proteins to regulate grain size and shape.Our findings deepen our understanding of the molecular mechanisms underlying grain size regulation and provide useful information for improving grain yield.展开更多
The existing research on dynamics and slip ratio of wheeled mobile robot （WMR） are derived without considering the effect of height, and the existing models can not be used to analyze the dynamics performance of the...The existing research on dynamics and slip ratio of wheeled mobile robot （WMR） are derived without considering the effect of height, and the existing models can not be used to analyze the dynamics performance of the robot with variable height while moving such as NOROS- Ⅱ. The existing method of dynamics modeling is improved by adding the constraint equation between perpendicular displacement of body and horizontal displacement of wheel into the constraint conditions. The dynamic model of NOROS- Ⅱ in wheel motion is built by the Lagrange method under nonholonomic constraints. The inverse dynamics is calculated in three different paths based on this model, and the results demonstrate that torques of hip pitching joints are inversely proportional to the height of robot. The relative error of calculated torques is less than 2% compared with that of ADAMS simulation, by which the validity of dynamic model is verified, Moreover, the relative horizontal motion between fore/hind wheels and body is produced when the height is changed, and thus the accurate slip ratio can not be obtained by the traditional equation. The improved slip ratio equations with the parameter of the vertical velocity of body are introduced for fore wheels and hind wheels respectively. Numerical simulations of slip ratios are conducted to reveal the effect of varied height on slip ratios of different wheels. The result shows that the slip ratios of fore/hind wheels become larger/smaller respectively as the height increases, and as the height is reduced, the reverse applies. The proposed research of dynamic model and slip ratio based on the robot height provides the effective method to analyze the dynamics of WMRs with varying height.展开更多
AIM: To evaluate the accuracy of red cell distribution width (RDW) to platelet ratio (RPR) to predict in-hospital mortality in acute pancreatitis (AP).
FinFET technologies are becoming the mainstream process as technology scales down. Based on a 28-nm bulk p- FinFET device, we have investigated the fin width and height dependence of bipolar amplification for heavy-io...FinFET technologies are becoming the mainstream process as technology scales down. Based on a 28-nm bulk p- FinFET device, we have investigated the fin width and height dependence of bipolar amplification for heavy-ion-irradiated FinFETs by 3D TCAD numerical simulation. Simulation results show that due to a well bipolar conduction mechanism rather than a channel （fin） conduction path, the transistors with narrower fins exhibit a diminished bipolar amplification effect, while the fin height presents a trivial effect on the bipolar amplification and charge collection. The results also indicate that the single event transient （SET） pulse width can be mitigated about 35% at least by optimizing the ratio of fin width and height, which can provide guidance for radiation-hardened applications in bulk FinFET technology.展开更多
Residual coal pillars play an important role in mining the adjacent coal seam safely,managing the gobs and maintaining the stability of abandoned coal mines.The height to diameter ratio(H/D)affects the stability of re...Residual coal pillars play an important role in mining the adjacent coal seam safely,managing the gobs and maintaining the stability of abandoned coal mines.The height to diameter ratio(H/D)affects the stability of residual coal pillars.In this study,uniaxial compressive tests of coal specimens with five H/D(2.0,1.5,1.0,0.8 and 0.6)were performed,and the stress,strain and acoustic emission(AE)were monitored.Results show that the uniaxial compressive strength(UCS)and peak strain increase with H/D decreasing.An empirical equation is proposed to calculate the UCS based on the H/D.The AE activities during coal failure process can be separated into four periods.The span of quiet period and rapid decline period shorten with H/D decreasing.The smaller the H/D is,the more complicated the failure characteristics of coal will be.The failure form of coal with H/D of 2.0,1.5,and 1.0 is primarily shear failure,while splitting failure along the axial direction is the mainly mode when H/D is 0.8 or 0.6.The initiation,expansion,aggregation and connection of micro-cracks can be reflected by the real-time spatial evolution of AE event points.展开更多
The aim was to explore the linear regression prediction models between sowing time and plant height, leaf stem ratio and DW/FW ratio of forage sorghum in autumn idle land. [Method] The relationships between sowing tim...The aim was to explore the linear regression prediction models between sowing time and plant height, leaf stem ratio and DW/FW ratio of forage sorghum in autumn idle land. [Method] The relationships between sowing time and plant height, leaf stem ratio and DW/FW ratio of forage sorghum were simulated and compared by employing field plot experiment and linear regression analysis. [Result] The sowing time had a great impact on plant height, leaf stem ratio and DW/FW ratio of forage sorghum in autumn idle land. With the delay of sowing time, the plant height and DW/FW ratio of forage sorghum decreased, while the leaf stem ratio increased. The regression models between sowing time and plant height, leaf stem ratio and DW/FW ratio of forage sorghum were established： plant height and sowing time, yheight = 234.725- 5.005X; leaf stem ratio and sowing time,ylcaf= 0.096 ＋ 0,019x; DW/FW ratio and sowing time, ydry= 0.305-0.002X. From July 23rd to August 30th, the plant height of forage sorghum was reduced by 5.005 cm, the leaf stem ratio was increased by 0.019 and the DW/FW ratio was reduced by 0.002 in average when hhe sowing time was delayed by one day. [Conclusion] This study provides a theoretical support for the production of forage sorghum in autumn idle land.展开更多
The squeeze cast technology is only applicable, at present, to the castings with a ratio of height to thickness less than 3.5. Researching the squeeze cast technology for castings with a large ratio of height to thick...The squeeze cast technology is only applicable, at present, to the castings with a ratio of height to thickness less than 3.5. Researching the squeeze cast technology for castings with a large ratio of height to thickness will broaden the applicable range of the advanced casting technology. This paper describes a study of the temperature distribution during solidification for castings with a ratio of height to thickness of 7 by the methods of experiment and computer simulation. The shrinkage porosity distribution in the castings and the mechanical properties of the castings were also researched. The experimental and simulated results show that increasing squeeze force, or enhancing mold temperature, cannot reduce the shrinkage porosities in the castings. When castings solidify in a sequential manner and the squeeze force effectively acts on the surface of the liquid metal, the shrinkage porosities in the castings are eliminated and mechanical properties are clearly improved.展开更多
BACKGROUND In spite of developing medical technologies to discover the etiopathogenesis of diseases and developments in the treatment of coronary artery disease, acute coronary syndromes(ACS) continue to be the main c...BACKGROUND In spite of developing medical technologies to discover the etiopathogenesis of diseases and developments in the treatment of coronary artery disease, acute coronary syndromes(ACS) continue to be the main cause of mortality and morbidity worldwide. New cardiac biomarkers and techniques are needed to help provide rapid diagnosis in order to evaluate risk in coronary artery patients.AIM To evaluate the effects of R to S ratio(RSR) in the electrocardiograph of patients with ACS, from the point of the arising complication after myocardial infarction(MI), to three-vessel disease(TVD) and mortality.METHODS The data of 1,296 patients with ACS, who presented to the emergency department of our hospital with chest pain between January 2014 and December2018 and were admitted to the cardiology clinic, were retrospectively included in this cross-sectional cohort study. Patients with an RSR value less than I were assigned to group Ⅰ, while those with an RSR value greater than Ⅰ were assigned to group Ⅱ.RESULTS In our study, 466(35.9%) of the 1,296 patients, 357(38.3%) in group 1 and 109(29.9%) in group 2, were female, with a mean age of 61.56 ± 9.42. ST-elevation MI 573(44.2%), unstable angina(UA) 502(38.7%) and non ST-elevation MI 220(17%)were more prevalent in group Ⅰ. Acute anterior MI 263(20.3) in group Ⅰ, and acute inferior MI 184(14.2) in group Ⅱ was higher. Ischemic heart failure was the most common complication. In group Ⅱ, the red cell distribution width(RDW) was 15.42 ± 1.82, the gensini score was 48.39 ± 36.44, the left ventricular ejection fraction was 41.17 ± 10.41, the TVD was 111(8.5), and the mortality rate was 72(5.6), which was significantly higher than group Ⅰ RDW; in MI with ST and nonST-elevation, in TVD, mortality and complications were high and low in UA. In single and multivariate regression analyses, the variables were associated with ACS risk.CONCLUSION RSR levels may be an auxiliary predictive value in ACS in terms of complications developing after MI, TVD, and mortality.展开更多
In this paper experimental wind wave data are analyzed. It is found that differences in spectral width will give rise to differences in wave height distribution. The effect of spectral width on the distribution is mai...In this paper experimental wind wave data are analyzed. It is found that differences in spectral width will give rise to differences in wave height distribution. The effect of spectral width on the distribution is mainly in the high wave range. The effect of wave steepness is in low, medium and high wave ranges. In the high wave range the effect of spectral width is comparable to that of wave steepness. Differences in spectral width in the observations may give rise to discrepancies in the result when wave steepness is the only parameter in the distribution.展开更多
Large cutting height fully mechanized top-coal caving is a new mining method that improves recovery ratio and single-pass production. It also allows safe and efficient mining. A rational cutting height is one key para...Large cutting height fully mechanized top-coal caving is a new mining method that improves recovery ratio and single-pass production. It also allows safe and efficient mining. A rational cutting height is one key parameter of this technique. Numerical simulation and a granular-media model experiment were used to analyze the effect of cutting height on the rock pressure of a fully mechanized top-coal caving work face. The recovery ratio was also studied. As the cutting height increases the top-coal thickness is reduced. Changing the ratio of cutting to drawing height intensifies the face pressure and the top-coal shattering. A maximum cutting height exists under a given set of conditions due to issues with surrounding rock-mass control. An increase in cutting height makes the top-coal cave better and the recovery ratio when drawing top-coal is then improved. A method of adjusting the face rock pressure is presented. Changing the cutting to drawing height ratio is the technique used to control face rock pressure. The recovery ratio when cutting coal exceeds that when caving top-coal so the face recovery ratio may be improved by over sizing the cutting height and increasing the top-coal drawing ratio. An optimum ratio of cutting to drawing height exists that maximizes the face recovery ratio. A rational cutting height is determined by comprehensively considering the surrounding rock-mass control and the recovery ratio. At the same time increasing the cutting height can improve single pass mining during fully mechanized top-coal caving.展开更多
The effects of process parameters on the depth-to-width ratio （D/W） of flux-cored wire underwater wet welding with a certain type of homemade .flux-cored wire are studied. It is found that the welding .speed, wire f...The effects of process parameters on the depth-to-width ratio （D/W） of flux-cored wire underwater wet welding with a certain type of homemade .flux-cored wire are studied. It is found that the welding .speed, wire feeding speed and torch oscillating amplitude hare significant effects on the dopth-to-width ratio （D/W） of welds. The D/W ratio of welds increases significantly with the increase of welding speed without the oscillating of welding torch. It increased （from 0. 14 to 0. 26 ） with the increase of wire feeding speed while the torch oscillating. And it decreased linearly with the increase of torch oscillating amplitude. However, the influelwe of oscillating speed, wire extension and welding voltage on the D/W ratio of welds was not obvious.展开更多
Bed morphology is the result of a dynamic response to a complex meandering river system. It is an important factor for the further development of river. Based on the meandering river characterized by a large depth-to-...Bed morphology is the result of a dynamic response to a complex meandering river system. It is an important factor for the further development of river. Based on the meandering river characterized by a large depth-to-width ratio, a theoretical model is established with the coupling of Navier-Stokes （N-S）~ sediment transport, and bed deformation equations. The flow characteristics and bed response of river are obtained with the perturbation method. The research results show that, under the effect of two- dimensional flow disturbance, the bars and pools present the regular response. For a given sinuousness, the amplitude of the bed response can be used as a criterion to judge the bedform stability. The effects of the Reynolds number, disturbance wavenumber, sinuousness, and bed morphology gradient on the bed response development are described.展开更多
The probability distribution of wave heights under the assumption of narrowband linear wave theory follows the Rayleigh distribution and the statistical relationships between some characteristic wave heights, derived ...The probability distribution of wave heights under the assumption of narrowband linear wave theory follows the Rayleigh distribution and the statistical relationships between some characteristic wave heights, derived from this distribution, are widely used for the treatment of realistic wind waves. However, the bandwidth of wave frequency influences the probability distribution of wave heights. In this paper, a wave-spectrum-width parameter B was introduced into the JONSWAP spectrum. This facilitated the construction of a wind-wave spectrum and the reconstruction of wind-wave time series for various growth stages, based on which the probability density distributions of the wind-wave heights were studied statistically. The distribution curves deviated slightly from the theoretical Rayleigh distribution with increasing B. The probability that a wave height exceeded a certain value was clearly smaller than the theoretical value for B≥0.3, and the difference between them increased with the threshold value. The relation between the Hs/σ ratio and B was investigated statistically, which revealed that the Hs/σ ratio deviated from 4.005 and declined with B. When B reached 0.698 1, the Hs/σ ratio was 3.825, which is about 95.5% of its original value. This indicates an overestimation in the a potential method for improving the accuracy of the Hs extremely large waves under severe sea states. prediction of Hs from Hs=4.005σ, and provides remote sensing retrieval algorithm, critical for展开更多
The use of the Unmanned Aerial System (UAS) has attracted scientific attention because of its potential to generate high-throughput phenotyping data. The application of UAS to guar phenotyping remains limited. Guar is...The use of the Unmanned Aerial System (UAS) has attracted scientific attention because of its potential to generate high-throughput phenotyping data. The application of UAS to guar phenotyping remains limited. Guar is multi-purpose legume species. India and Pakistan are the world’s top guar producers. The U.S. is the world guar largest market with an import value of >$1 billion annually. The objective of this study was to test the feasibility of UAS phenotyping of plant height and canopy width in guar. The UAS data were collected from a field plot of 10 guar accessions on July 7, 2021, and September 27, 2021. The study was organized in a Randomized Complete Block Design (RCBD) with 3 blocks. A total of 23 Vegetation Indices (VIs) were computed. The analysis of variance showed significant genotypic effects on plant weight (p < 0.05) and canopy width (p on plant height (p most VIs were significant for both flights (p Vegetation Index (NDVI) and Red Edge Normalized Difference Vegetation Index (NDRE) were significantly and highly correlated with plant height (r = 0.74) and canopy width (r = 0.68). The results will be of interest in developing high throughput phenotyping approach for guar breeding.展开更多
The air-turbo-rocket(ATR)engine is a promising propulsion plant for achieving numerous surface and air launched missile missions.The application of lobed mixer in the ATR combustor can promote the mixing of the fuelri...The air-turbo-rocket(ATR)engine is a promising propulsion plant for achieving numerous surface and air launched missile missions.The application of lobed mixer in the ATR combustor can promote the mixing of the fuelrich gas and the air,thus improving the engine performance significantly.The numerical simulation method was conducted to explore the effects of lobe peak-to-trough width ratio on mixing and combustion performance in ATR combustors.Results show that:For a given peak lobe width b1,the combustion efficiency and total pressure loss decrease with the increase of trough lobe width b2;For a given b2,the combustion efficiency and total pressure loss decrease with the increase of b1;The fan-type lobed mixer with smaller b2has a better effect on promoting the combustion efficiency in the region near the ATR combustor center line than that with a pair of parallel side walls.The total pressure recovery coefficient reaches more than 0.99 at the exit of combustor in nonreactive combustion while the total pressure loss reaches more than 4%in the reacting combustion.Compared with the mixing process,more than80%of the total pressure loss is caused during combustion.展开更多
We demonstrate here that global-scale determination of a key ionospheric parameter,the peak height of the F_(2)region(h_(m)F_(2)),can be obtained by making a simple ratio measurement of the atomic oxygen 130.4 and 135...We demonstrate here that global-scale determination of a key ionospheric parameter,the peak height of the F_(2)region(h_(m)F_(2)),can be obtained by making a simple ratio measurement of the atomic oxygen 130.4 and 135.6 nm emissions in the far-ultraviolet nightglow with a nadir-viewing system such as a pair of photometers suitable for flight on a CubeSat.We further demonstrate that measurements from an altitude that is within the typical range of nighttime h_(m)F_(2)250−450 km can provide the ratios that are needed for retrieval of the h_(m)F_(2).Our study is conducted mostly through numerical simulations by using radiative transfer models of the two emissions coupled with empirical models of the atmosphere and ionosphere.Modeling results show that the relationship between the h_(m)F_(2)and the intensity ratio is sensitive to the altitude from which the emissions are observed,primarily because of the distinctly different degrees of resonant scattering of the two emissions in the atmosphere.A roughly quadratic relationship can be established for observations from an orbit of~400 km,which enables h_(m)F_(2)retrieval.Parametric analysis indicates that the relationship can be affected by the ambient atmospheric conditions through resonant scattering and O2 absorption.For typical nighttime conditions with h_(m)F_(2)250−450 km,retrieval of the h_(m)F_(2)from synthetic observations shows that the typical errors are only a few kilometers(up to~20 km),depending on the accuracy of the ambient conditions predicted by the empirical models.Our findings pave the way for use of the 130.4/135.6 nm intensity ratios for global-scale monitoring of the nighttime ionosphere at mid to low latitudes.展开更多
文摘BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),respectively.Clinically Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these patients.However,due to its invasiveness and costs,CSPH is almost never evaluated in clinical practice.Therefore,recognizing noninvasively predicting tools still have more appeal across healthcare systems.The red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been explored.AIM In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD patients.METHODS Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 years.At baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were collected.During FUP,DEs(timing and modaities)were recorded.CSPH was assessed at the baseline and on DE occurrence according to the available Clinical Practice Guidelines.RESULTS Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve analysis revealed RPR>0.472 and>0.894 as the best cut-offs in the prediction respectively of 3-year first DE,as well as its superiority compared to the other non-invasive tools examined.RPR(P:0.02)and the presence of baseline-CSPH(P:0.04)were significantly and independently associated with the DE.Patients presenting baseline-CSPH and RPR>0.472 showed higher risk of decompensation(P:0.0023).CONCLUSION Altogether these findings suggest the RPR as a valid and potentially applicable non-invasive tool in the prediction of timing and modalities of decompensation in MASLD-related cACLD patients.
基金Supported by Zhejiang Province Traditional Chinese Medicine Science and 158 Technology Project,No.2023ZL008.
文摘BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular events.AIM To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December 2021.The NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were recorded.The receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of HF.The correlation between NLR and RDW with the presence or absence of cardiac events was also investigated.RESULTS Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of HF.Furthermore,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac events.CONCLUSION NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic efficiency.Additionally,NLR and RDW values were directly proportional to patient outcomes.
文摘This study conducts both numerical and empirical assessments of thermal transfer and fluid flow characteristics in a Solar Air Collector(SAC)using a Delta Wing Vortex Generator(DWVG),and the effects of different height ratios(Rh=0.6,0.8,1,1.2 and 1.4)in delta wing vortex generators,which were not considered in the earlier studies,are investigated.Energy and exergy analyses are performed to gain maximum efficiency.The Reynolds number based on the outlet velocity and hydraulic diameter falls between 4400 and 22000,corresponding to the volume flow rate of 5.21–26.07 m^(3)/h.It is observed that the delta wing vortex generators with a higher height ratio yield maximum heat transfer enhancement and overall enhancement ratio.The empirical and numerical findings demonstrate that the exergy and thermal efficiencies decline in a specific range.TheNusselt number,pressure drop,energy,and exergy efficiencies enhance with rising Reynolds number,although the friction coefficient diminishes.The maximum heat transfer enhancement is 57%.According to the evaluation of exergy efficiency,the greatest efficiency of 31.2%is obtained at Rh=1.4 and Reynolds number 22000.
基金sponsored by Coal and Energy Research Bureau and CDC-NIOSH under Grant No.R01OH009532
文摘Bumps in coal mines have been recognized as a major hazard for many years. These sudden and violent failures around mine openings have compromised safety, ventilation and access to mine workings.Previous studies showed that the violence of coal specimen failure depends on both the interface friction and width-to-height（W/H） ratio of coal specimen. The mode of failure for a uniaxially loaded coal specimen or a coal pillar is a combination of both shear failure along the interface and compressive failure in the coal. The shear failure along the interface triggered the compressive failure in coal. The compressive failure of a coal specimen or a coal pillar can be controlled by changing its W/H ratio. As the W/H ratio increases, the ultimate strength increases. Hence, with a proper combination of interface friction and the W/H ratio of pillar or coal specimen, the mode of failure will change from sudden violent failure which is brittle failure to non-violent failure which is ductile failure. The main objective of this paper is to determine at what W/H ratio and interface friction the mode of failure changes from violent to non-violent. In this research, coal specimens of W/H ratio ranging from 1 to 10 were uniaxially tested under two interface frictions of 0.1 and 0.25, and the results are presented and discussed.
基金This work is supported in part by the National Transgenic Science and Technology Program(2016ZX08010-002)National Natural Science Foundation of China(157101834)Agricultural Science and Technology Innovation Program of CAAS.
文摘The size and shape of rice grains influence their yield and commercial value.We investigated the role of OsDA1,a rice homolog of the Arabidopsis DA1 gene,in regulating grain size and shape.OsDA1 was highly expressed in young spikelets and glumes.Its overexpression led to enlarged seeds with increased width and decreased length/width ratio(LWR)and knocking out OsDA1 reduced grain width and increased grain length and LWR.A R310K point mutation in the DA1-like domain is a potential target for breeding for increased grain width and length.OsDA1 interacted with TCP gene-family proteins to regulate grain size and shape.Our findings deepen our understanding of the molecular mechanisms underlying grain size regulation and provide useful information for improving grain yield.
基金supported by National Outstanding Youth Science Foundation of China (Grant No. 51125020)National Hi-tech Research and Development Program of China (863 Program, Grant No. 2006AA04Z207)Program for New Century Excellent Talents in University, China
文摘The existing research on dynamics and slip ratio of wheeled mobile robot （WMR） are derived without considering the effect of height, and the existing models can not be used to analyze the dynamics performance of the robot with variable height while moving such as NOROS- Ⅱ. The existing method of dynamics modeling is improved by adding the constraint equation between perpendicular displacement of body and horizontal displacement of wheel into the constraint conditions. The dynamic model of NOROS- Ⅱ in wheel motion is built by the Lagrange method under nonholonomic constraints. The inverse dynamics is calculated in three different paths based on this model, and the results demonstrate that torques of hip pitching joints are inversely proportional to the height of robot. The relative error of calculated torques is less than 2% compared with that of ADAMS simulation, by which the validity of dynamic model is verified, Moreover, the relative horizontal motion between fore/hind wheels and body is produced when the height is changed, and thus the accurate slip ratio can not be obtained by the traditional equation. The improved slip ratio equations with the parameter of the vertical velocity of body are introduced for fore wheels and hind wheels respectively. Numerical simulations of slip ratios are conducted to reveal the effect of varied height on slip ratios of different wheels. The result shows that the slip ratios of fore/hind wheels become larger/smaller respectively as the height increases, and as the height is reduced, the reverse applies. The proposed research of dynamic model and slip ratio based on the robot height provides the effective method to analyze the dynamics of WMRs with varying height.
基金Supported by Ankara Numune Education and Research Hospital
文摘AIM: To evaluate the accuracy of red cell distribution width (RDW) to platelet ratio (RPR) to predict in-hospital mortality in acute pancreatitis (AP).
基金supported by the National Natural Science of China(Grant No.61376109)
文摘FinFET technologies are becoming the mainstream process as technology scales down. Based on a 28-nm bulk p- FinFET device, we have investigated the fin width and height dependence of bipolar amplification for heavy-ion-irradiated FinFETs by 3D TCAD numerical simulation. Simulation results show that due to a well bipolar conduction mechanism rather than a channel （fin） conduction path, the transistors with narrower fins exhibit a diminished bipolar amplification effect, while the fin height presents a trivial effect on the bipolar amplification and charge collection. The results also indicate that the single event transient （SET） pulse width can be mitigated about 35% at least by optimizing the ratio of fin width and height, which can provide guidance for radiation-hardened applications in bulk FinFET technology.
基金Projects(51974192,52004172)supported by the National Natural Science Foundation of ChinaProject(51925402)supported by the Distinguished Youth Funds of National Natural Science Foundation of ChinaProject(U1710258)supported by the Joint Funds of National Natural Science Foundation of China and Shanxi Province,China。
文摘Residual coal pillars play an important role in mining the adjacent coal seam safely,managing the gobs and maintaining the stability of abandoned coal mines.The height to diameter ratio(H/D)affects the stability of residual coal pillars.In this study,uniaxial compressive tests of coal specimens with five H/D(2.0,1.5,1.0,0.8 and 0.6)were performed,and the stress,strain and acoustic emission(AE)were monitored.Results show that the uniaxial compressive strength(UCS)and peak strain increase with H/D decreasing.An empirical equation is proposed to calculate the UCS based on the H/D.The AE activities during coal failure process can be separated into four periods.The span of quiet period and rapid decline period shorten with H/D decreasing.The smaller the H/D is,the more complicated the failure characteristics of coal will be.The failure form of coal with H/D of 2.0,1.5,and 1.0 is primarily shear failure,while splitting failure along the axial direction is the mainly mode when H/D is 0.8 or 0.6.The initiation,expansion,aggregation and connection of micro-cracks can be reflected by the real-time spatial evolution of AE event points.
文摘The aim was to explore the linear regression prediction models between sowing time and plant height, leaf stem ratio and DW/FW ratio of forage sorghum in autumn idle land. [Method] The relationships between sowing time and plant height, leaf stem ratio and DW/FW ratio of forage sorghum were simulated and compared by employing field plot experiment and linear regression analysis. [Result] The sowing time had a great impact on plant height, leaf stem ratio and DW/FW ratio of forage sorghum in autumn idle land. With the delay of sowing time, the plant height and DW/FW ratio of forage sorghum decreased, while the leaf stem ratio increased. The regression models between sowing time and plant height, leaf stem ratio and DW/FW ratio of forage sorghum were established： plant height and sowing time, yheight = 234.725- 5.005X; leaf stem ratio and sowing time,ylcaf= 0.096 ＋ 0,019x; DW/FW ratio and sowing time, ydry= 0.305-0.002X. From July 23rd to August 30th, the plant height of forage sorghum was reduced by 5.005 cm, the leaf stem ratio was increased by 0.019 and the DW/FW ratio was reduced by 0.002 in average when hhe sowing time was delayed by one day. [Conclusion] This study provides a theoretical support for the production of forage sorghum in autumn idle land.
基金The research is supported by Nature Science Foundation ofChina, No.: 50275098
文摘The squeeze cast technology is only applicable, at present, to the castings with a ratio of height to thickness less than 3.5. Researching the squeeze cast technology for castings with a large ratio of height to thickness will broaden the applicable range of the advanced casting technology. This paper describes a study of the temperature distribution during solidification for castings with a ratio of height to thickness of 7 by the methods of experiment and computer simulation. The shrinkage porosity distribution in the castings and the mechanical properties of the castings were also researched. The experimental and simulated results show that increasing squeeze force, or enhancing mold temperature, cannot reduce the shrinkage porosities in the castings. When castings solidify in a sequential manner and the squeeze force effectively acts on the surface of the liquid metal, the shrinkage porosities in the castings are eliminated and mechanical properties are clearly improved.
文摘BACKGROUND In spite of developing medical technologies to discover the etiopathogenesis of diseases and developments in the treatment of coronary artery disease, acute coronary syndromes(ACS) continue to be the main cause of mortality and morbidity worldwide. New cardiac biomarkers and techniques are needed to help provide rapid diagnosis in order to evaluate risk in coronary artery patients.AIM To evaluate the effects of R to S ratio(RSR) in the electrocardiograph of patients with ACS, from the point of the arising complication after myocardial infarction(MI), to three-vessel disease(TVD) and mortality.METHODS The data of 1,296 patients with ACS, who presented to the emergency department of our hospital with chest pain between January 2014 and December2018 and were admitted to the cardiology clinic, were retrospectively included in this cross-sectional cohort study. Patients with an RSR value less than I were assigned to group Ⅰ, while those with an RSR value greater than Ⅰ were assigned to group Ⅱ.RESULTS In our study, 466(35.9%) of the 1,296 patients, 357(38.3%) in group 1 and 109(29.9%) in group 2, were female, with a mean age of 61.56 ± 9.42. ST-elevation MI 573(44.2%), unstable angina(UA) 502(38.7%) and non ST-elevation MI 220(17%)were more prevalent in group Ⅰ. Acute anterior MI 263(20.3) in group Ⅰ, and acute inferior MI 184(14.2) in group Ⅱ was higher. Ischemic heart failure was the most common complication. In group Ⅱ, the red cell distribution width(RDW) was 15.42 ± 1.82, the gensini score was 48.39 ± 36.44, the left ventricular ejection fraction was 41.17 ± 10.41, the TVD was 111(8.5), and the mortality rate was 72(5.6), which was significantly higher than group Ⅰ RDW; in MI with ST and nonST-elevation, in TVD, mortality and complications were high and low in UA. In single and multivariate regression analyses, the variables were associated with ACS risk.CONCLUSION RSR levels may be an auxiliary predictive value in ACS in terms of complications developing after MI, TVD, and mortality.
文摘In this paper experimental wind wave data are analyzed. It is found that differences in spectral width will give rise to differences in wave height distribution. The effect of spectral width on the distribution is mainly in the high wave range. The effect of wave steepness is in low, medium and high wave ranges. In the high wave range the effect of spectral width is comparable to that of wave steepness. Differences in spectral width in the observations may give rise to discrepancies in the result when wave steepness is the only parameter in the distribution.
基金Financial support for this work, provided by the National Basic Research Program of China (No.2007CB209400)the National Natural Science Foundation of China (No.51004104)
文摘Large cutting height fully mechanized top-coal caving is a new mining method that improves recovery ratio and single-pass production. It also allows safe and efficient mining. A rational cutting height is one key parameter of this technique. Numerical simulation and a granular-media model experiment were used to analyze the effect of cutting height on the rock pressure of a fully mechanized top-coal caving work face. The recovery ratio was also studied. As the cutting height increases the top-coal thickness is reduced. Changing the ratio of cutting to drawing height intensifies the face pressure and the top-coal shattering. A maximum cutting height exists under a given set of conditions due to issues with surrounding rock-mass control. An increase in cutting height makes the top-coal cave better and the recovery ratio when drawing top-coal is then improved. A method of adjusting the face rock pressure is presented. Changing the cutting to drawing height ratio is the technique used to control face rock pressure. The recovery ratio when cutting coal exceeds that when caving top-coal so the face recovery ratio may be improved by over sizing the cutting height and increasing the top-coal drawing ratio. An optimum ratio of cutting to drawing height exists that maximizes the face recovery ratio. A rational cutting height is determined by comprehensively considering the surrounding rock-mass control and the recovery ratio. At the same time increasing the cutting height can improve single pass mining during fully mechanized top-coal caving.
文摘The effects of process parameters on the depth-to-width ratio （D/W） of flux-cored wire underwater wet welding with a certain type of homemade .flux-cored wire are studied. It is found that the welding .speed, wire feeding speed and torch oscillating amplitude hare significant effects on the dopth-to-width ratio （D/W） of welds. The D/W ratio of welds increases significantly with the increase of welding speed without the oscillating of welding torch. It increased （from 0. 14 to 0. 26 ） with the increase of wire feeding speed while the torch oscillating. And it decreased linearly with the increase of torch oscillating amplitude. However, the influelwe of oscillating speed, wire extension and welding voltage on the D/W ratio of welds was not obvious.
文摘Bed morphology is the result of a dynamic response to a complex meandering river system. It is an important factor for the further development of river. Based on the meandering river characterized by a large depth-to-width ratio, a theoretical model is established with the coupling of Navier-Stokes （N-S）~ sediment transport, and bed deformation equations. The flow characteristics and bed response of river are obtained with the perturbation method. The research results show that, under the effect of two- dimensional flow disturbance, the bars and pools present the regular response. For a given sinuousness, the amplitude of the bed response can be used as a criterion to judge the bedform stability. The effects of the Reynolds number, disturbance wavenumber, sinuousness, and bed morphology gradient on the bed response development are described.
基金Supported by the National High Technology Research and Development Program of China(863 Program)(No.2013AA09A505)the National Natural Science Foundation of China(Nos.U1133001,41376027,41406017)the NSFC-Shandong Joint Fund for Marine Science Research Centers(No.U1406401)
文摘The probability distribution of wave heights under the assumption of narrowband linear wave theory follows the Rayleigh distribution and the statistical relationships between some characteristic wave heights, derived from this distribution, are widely used for the treatment of realistic wind waves. However, the bandwidth of wave frequency influences the probability distribution of wave heights. In this paper, a wave-spectrum-width parameter B was introduced into the JONSWAP spectrum. This facilitated the construction of a wind-wave spectrum and the reconstruction of wind-wave time series for various growth stages, based on which the probability density distributions of the wind-wave heights were studied statistically. The distribution curves deviated slightly from the theoretical Rayleigh distribution with increasing B. The probability that a wave height exceeded a certain value was clearly smaller than the theoretical value for B≥0.3, and the difference between them increased with the threshold value. The relation between the Hs/σ ratio and B was investigated statistically, which revealed that the Hs/σ ratio deviated from 4.005 and declined with B. When B reached 0.698 1, the Hs/σ ratio was 3.825, which is about 95.5% of its original value. This indicates an overestimation in the a potential method for improving the accuracy of the Hs extremely large waves under severe sea states. prediction of Hs from Hs=4.005σ, and provides remote sensing retrieval algorithm, critical for
文摘The use of the Unmanned Aerial System (UAS) has attracted scientific attention because of its potential to generate high-throughput phenotyping data. The application of UAS to guar phenotyping remains limited. Guar is multi-purpose legume species. India and Pakistan are the world’s top guar producers. The U.S. is the world guar largest market with an import value of >$1 billion annually. The objective of this study was to test the feasibility of UAS phenotyping of plant height and canopy width in guar. The UAS data were collected from a field plot of 10 guar accessions on July 7, 2021, and September 27, 2021. The study was organized in a Randomized Complete Block Design (RCBD) with 3 blocks. A total of 23 Vegetation Indices (VIs) were computed. The analysis of variance showed significant genotypic effects on plant weight (p < 0.05) and canopy width (p on plant height (p most VIs were significant for both flights (p Vegetation Index (NDVI) and Red Edge Normalized Difference Vegetation Index (NDRE) were significantly and highly correlated with plant height (r = 0.74) and canopy width (r = 0.68). The results will be of interest in developing high throughput phenotyping approach for guar breeding.
基金supported by the National Science and Technology Major Project(No.J2019-Ⅲ-0001-0044)。
文摘The air-turbo-rocket(ATR)engine is a promising propulsion plant for achieving numerous surface and air launched missile missions.The application of lobed mixer in the ATR combustor can promote the mixing of the fuelrich gas and the air,thus improving the engine performance significantly.The numerical simulation method was conducted to explore the effects of lobe peak-to-trough width ratio on mixing and combustion performance in ATR combustors.Results show that:For a given peak lobe width b1,the combustion efficiency and total pressure loss decrease with the increase of trough lobe width b2;For a given b2,the combustion efficiency and total pressure loss decrease with the increase of b1;The fan-type lobed mixer with smaller b2has a better effect on promoting the combustion efficiency in the region near the ATR combustor center line than that with a pair of parallel side walls.The total pressure recovery coefficient reaches more than 0.99 at the exit of combustor in nonreactive combustion while the total pressure loss reaches more than 4%in the reacting combustion.Compared with the mixing process,more than80%of the total pressure loss is caused during combustion.
基金the National Natural Science Foundation of China through Grant 8206100245the Chinese Meteorological Administration through Grant FY-APP-ZX-2022.0222.
文摘We demonstrate here that global-scale determination of a key ionospheric parameter,the peak height of the F_(2)region(h_(m)F_(2)),can be obtained by making a simple ratio measurement of the atomic oxygen 130.4 and 135.6 nm emissions in the far-ultraviolet nightglow with a nadir-viewing system such as a pair of photometers suitable for flight on a CubeSat.We further demonstrate that measurements from an altitude that is within the typical range of nighttime h_(m)F_(2)250−450 km can provide the ratios that are needed for retrieval of the h_(m)F_(2).Our study is conducted mostly through numerical simulations by using radiative transfer models of the two emissions coupled with empirical models of the atmosphere and ionosphere.Modeling results show that the relationship between the h_(m)F_(2)and the intensity ratio is sensitive to the altitude from which the emissions are observed,primarily because of the distinctly different degrees of resonant scattering of the two emissions in the atmosphere.A roughly quadratic relationship can be established for observations from an orbit of~400 km,which enables h_(m)F_(2)retrieval.Parametric analysis indicates that the relationship can be affected by the ambient atmospheric conditions through resonant scattering and O2 absorption.For typical nighttime conditions with h_(m)F_(2)250−450 km,retrieval of the h_(m)F_(2)from synthetic observations shows that the typical errors are only a few kilometers(up to~20 km),depending on the accuracy of the ambient conditions predicted by the empirical models.Our findings pave the way for use of the 130.4/135.6 nm intensity ratios for global-scale monitoring of the nighttime ionosphere at mid to low latitudes.
