The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological pro...The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix.展开更多
The introduction of functionalized magnetizable particles and high-gradient magnetic separation represents a time and money saving alternative to conventional purification and separation unit operations in the biotech...The introduction of functionalized magnetizable particles and high-gradient magnetic separation represents a time and money saving alternative to conventional purification and separation unit operations in the biotechnical sector. This technique has some advantages especially for the recycling of immobilized enzymes. A new magnetic filter with sight glasses was constructed and produced to study the performance of high-gradient magnetic separation at varied parameters. By optical analysis the buildup of a clogging was identified as the major parameter which affected the separation performance. For the cleaning procedure, a two-phase flow of water with highly dispersed air bubbles was tested which led to a nearly complete cleaning of the filter chamber.展开更多
We present a review of the principal developments in the evolution and synergism of solute and particle migration in a liquid melt in high-gradient magnetic fields and we also describe their effects on the solidificat...We present a review of the principal developments in the evolution and synergism of solute and particle migration in a liquid melt in high-gradient magnetic fields and we also describe their effects on the solidification microstructure of alloys.Diverse areas relevant to various aspects of theory and applications of high-gradient magnetic field-controlled migration of solutes and particles are surveyed. They include introduction, high-gradient magnetic field effects, migration behavior of solute and particles in high-gradient magnetic fields, microstructure evolution induced by high-gradient magnetic fieldcontrolled migrations of solute and particles, and properties of materials modified by high-gradient magnetic field-tailored microstructure. Selected examples of binary and multiphase alloy systems are presented and examined, with the main focus on the correlation between the high-gradient magnetic field-modified migration and the related solidification microstructure evolution. Particular attention is given to the mechanisms responsible for the microstructure evolution induced by highgradient magnetic fields.展开更多
文摘The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix.
文摘The introduction of functionalized magnetizable particles and high-gradient magnetic separation represents a time and money saving alternative to conventional purification and separation unit operations in the biotechnical sector. This technique has some advantages especially for the recycling of immobilized enzymes. A new magnetic filter with sight glasses was constructed and produced to study the performance of high-gradient magnetic separation at varied parameters. By optical analysis the buildup of a clogging was identified as the major parameter which affected the separation performance. For the cleaning procedure, a two-phase flow of water with highly dispersed air bubbles was tested which led to a nearly complete cleaning of the filter chamber.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51425401,51690161,51574073,and 51774086)Fundamental Research Funds for the Central Universities,China(Grant Nos.N170902002 and N170908001)Liaoning Innovative Research Team in University,China(Grant No.LT2017011)
文摘We present a review of the principal developments in the evolution and synergism of solute and particle migration in a liquid melt in high-gradient magnetic fields and we also describe their effects on the solidification microstructure of alloys.Diverse areas relevant to various aspects of theory and applications of high-gradient magnetic field-controlled migration of solutes and particles are surveyed. They include introduction, high-gradient magnetic field effects, migration behavior of solute and particles in high-gradient magnetic fields, microstructure evolution induced by high-gradient magnetic fieldcontrolled migrations of solute and particles, and properties of materials modified by high-gradient magnetic field-tailored microstructure. Selected examples of binary and multiphase alloy systems are presented and examined, with the main focus on the correlation between the high-gradient magnetic field-modified migration and the related solidification microstructure evolution. Particular attention is given to the mechanisms responsible for the microstructure evolution induced by highgradient magnetic fields.
