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Hydromassage of macular hole edges for large and persistent full-thickness macular holes
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作者 Yi Cai Wen-Bo Liu +5 位作者 Duo Wei Xun Deng Xiao-Xin Li Ming-Wei Zhao Xuan Shi Jian-Hong Liang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第3期551-557,共7页
●AIM:To introduce the macular hole(MH)hydromassage technique as a potentially beneficial approach for the treatment of large or persistent MH.●METHODS:This retrospective observational case series comprised 16 consec... ●AIM:To introduce the macular hole(MH)hydromassage technique as a potentially beneficial approach for the treatment of large or persistent MH.●METHODS:This retrospective observational case series comprised 16 consecutive patients(17 eyes)diagnosed with MH.Inclusion criteria involved a hole aperture diameter larger than 600μm or the presence of an unclosed MH larger than 600μm following the previous vitrectomy.Standard MH repair procedures were administered in all cases,involving the manipulation and aspiration of the hole margin through the application of water flow with a soft-tip flute needle.A comprehensive assessment was conducted for each case before and after surgery,and optical coherence tomography(OCT)images were captured at every follow-up point.●RESULTS:The mean preoperative aperture diameter was 747±156μm(range 611-1180μm),with a mean base diameter of 1390±435μm(range 578-2220μm).Following surgery,all cases achieved complete anatomical closure of MH,with 13 cases(76.5%)exhibiting type 1 closure and 4 cases(23.5%)demonstrating type 2 closure.No significant differences were observed in the preoperative OCT variables between the two closure types.Eyes with type 1 closure showed a significantly improved visual acuity(0.70±0.10,range 0.50-0.80)compared to those with type 2 closure(0.90±0.12,range 0.80-1.00,P=0.014).●CONCLUSION:The MH hydromassage technique demonstrates promising results,achieving acceptable closure rates in cases of large or persistent MH.This technique may serve as an effective adjunctive maneuver during challenging MH surgery. 展开更多
关键词 macular hole large macular hole persistent macular hole optical coherence tomography surgical technique hydromassage
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Statistical study of magnetic holes in the upstream region of Mercury’s bow shock
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作者 GuoQiang Wang SuDong Xiao +2 位作者 MingYu Wu YuanQiang Chen TieLong Zhang 《Earth and Planetary Physics》 EI CAS CSCD 2024年第2期326-337,共12页
Magnetic holes are magnetic depression structures that exist widely in many plasma environments.The magnetic holes with durations of>1 s in the solar wind at Mercury’s orbit have drawn much attention,but the prope... Magnetic holes are magnetic depression structures that exist widely in many plasma environments.The magnetic holes with durations of>1 s in the solar wind at Mercury’s orbit have drawn much attention,but the properties of the magnetic holes with shorter durations are still unclear.Here,we investigate the magnetic holes with durations of 0.1-100 s in the upstream region of Mercury’s bow shock based on observations by the MESSENGER(MErcury Surface,Space ENvironment,GEochemistry,and Ranging)spacecraft.They can be divided into two groups according to the distribution of their duration:small-duration magnetic holes(SDMHs,<0.6 s)and large-duration magnetic holes(LDMHs,>0.6 s).The duration of each group approximately obeys a log-normal distribution with a median of~0.25 s and 3 s,respectively.Approximately 1.7%(32.6%)of the SDMHs(LDMHs)reduce the magnetic field strength by more than 50%.For both groups,some structures have a linear or quasi-linear polarization,whereas others have an elliptical polarization.The magnetic hole events in both groups tend to have a higher rate of occurrence when the interplanetary magnetic field strength is weaker.Their occurrence rates are also affected by Mercury’s foreshock,which can increase(decrease)the occurrence rate of the SDMHs(LDMHs).This finding suggests that Mercury’s foreshock might be one source of the SDMHs and that the foreshock can destroy some LDMHs.These observations suggest that a new group of magnetic holes with durations of<0.6 s exist in the upstream region of Mercury’s bow shock. 展开更多
关键词 magnetic hole solar wind MERCURY FORESHOCK
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Mechanical properties and energy evolutions of burst-prone coal samples with holes and fillings
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作者 Yukai Fu Yongzheng Wu +3 位作者 Junchen Li Penghe Zhou Zhuoyue Sun Jie He 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第3期176-189,共14页
During the mining process of impact-prone coal seams,drilling pressure relief can reduce the impact propensity of the coal seam,but it also reduces the integrity and strength of the coal mass at the side of the roadwa... During the mining process of impact-prone coal seams,drilling pressure relief can reduce the impact propensity of the coal seam,but it also reduces the integrity and strength of the coal mass at the side of the roadway.Therefore,studying the mechanical properties and energy evolution rules of coal samples containing holes and filled structures has certain practical significance for achieving coordinated control of coal mine rockburst disasters and the stability of roadway surrounding rocks.To achieve this aim,seven types of burst-prone coal samples were prepared and subject to uniaxial compression experiments with the aid of a TAW-3000 electro-hydraulic servo testing machine.Besides,the stress–strain curves,acoustic emission signals,DIC strain fields and other data were collected during the experiments.Furthermore,the failure modes and energy evolutions of samples with varying drilled hole sizes and filling materials were analyzed.The results show that the indexes related to burst propensity of the drilled coal samples decline to some extent compared with those of the intact one,and the decline is positively corelated to the diameter of the drilled hole.After hole filling,the strain concentration degree around the drilled hole is lowered to a certain degree,and polyurethane filling has a more remarkable effect than cement filling.Meanwhile,hole filling can enhance the strength and deformation resistance of coal.Hole drilling can accelerate the release of accumulated elastic strain energy,turning the acoustic emission events from low-frequency and high-energy ones to high-frequency and low-energy ones,whereas hole filling can reduce the intensity of energy release.The experimental results and theoretical derivation demonstrate that hole filling promotes coal deformability and strength mainly by weakening stress concentration surrounding the drilled holes.Moreover,the fillings can achieve a better filling effect if their elastic modulus and Poisson’s ratio are closer to those of the coal body. 展开更多
关键词 Rock mechanics Coal Mechanical properties hole filling Energy evolution
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Triple points and phase transitions of D-dimensional dyonic Ad S black holes with quasitopological electromagnetism in Einstein–Gauss–Bonnet gravity
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作者 牟平辉 蒋青权 +1 位作者 何柯腱 李国平 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期272-287,共16页
By considering the negative cosmological constant Λ as a thermodynamic pressure, we study the thermodynamics and phase transitions of the D-dimensional dyonic Ad S black holes(BHs) with quasitopological electromagnet... By considering the negative cosmological constant Λ as a thermodynamic pressure, we study the thermodynamics and phase transitions of the D-dimensional dyonic Ad S black holes(BHs) with quasitopological electromagnetism in Einstein–Gauss–Bonnet(EGB) gravity. The results indicate that the small/large BH phase transition that is similar to the van der Waals(vdW) liquid/gas phase transition always exists for any spacetime dimensions. Interestingly, we then find that this BH system exhibits a more complex phase structure in 6-dimensional case that is missed in other dimensions.Specifically, it shows for D = 6 that we observed the small/intermediate/large BH phase transitions in a specific parameter region with the triple point naturally appeared. Moreover, when the magnetic charge turned off, we still observed the small/intermediate/large BH phase transitions and triple point only in 6-dimensional spacetime, which is consistent with the previous results. However, for the dyonic Ad S BHs with quasitopological electromagnetism in Einstein–Born–Infeld(EBI) gravity, the novel phase structure composed of two separate coexistence curves observed by Li et al. [Phys. Rev. D105 104048(2022)] disappeared in EGB gravity. This implies that this novel phase structure is closely related to gravity theories, and seems to have nothing to do with the effect of quasitopological electromagnetism. In addition, it is also true that the critical exponents calculated near the critical points possess identical values as mean field theory. Finally, we conclude that these findings shall provide some deep insights into the intriguing thermodynamic properties of the dyonic Ad S BHs with quasitopological electromagnetism in EGB gravity. 展开更多
关键词 AdS black hole phase transition triple point
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Generalized Newton’s Theory of Universal Gravitation and Black Holes
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作者 Lenser Aghalovyan 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第1期126-137,共12页
The Newton’s theory of universal gravitation is generalized. Significantly strong at short distances central interaction of bodies and particles is established in comparison with Newtonian. A connection is found with... The Newton’s theory of universal gravitation is generalized. Significantly strong at short distances central interaction of bodies and particles is established in comparison with Newtonian. A connection is found with Black Holes, with the horizon of events. Possibility of systematization of all Black Holes is shown. An illustration is given on the example of Black Hole S<sub>gr</sub>A*. 展开更多
关键词 GRAVITATION Central Interaction Escape Velocity Black hole Horizon of Events
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Investigation on photonic crystal nanobeam cavity based on mixed diamond–circular holes
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作者 Jingtong Bin Kerui Feng +4 位作者 Shang Ma Ke Liu Yong Cheng Jing Chen Qifa Liu 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2024年第1期63-70,共8页
A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is pro-posed.The performance of the cavity is simulated and studied theoretically.Using thefin... A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is pro-posed.The performance of the cavity is simulated and studied theoretically.Using thefinite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance indicators.Mutual modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding performance.The optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength range.Light can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole structure.Thereby,the energy can be confined within a small mode volume to achieve an ultra-high Q/Vm ratio. 展开更多
关键词 Photonic crystal nanobeam cavity Mixed diamond–circular holes Slots and anti-slots FDTD simulation Quality factor Mode volume
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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve
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作者 Carina Hromada Patrick Heimel +10 位作者 Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher 《Neural Regeneration Research》 SCIE CAS 2025年第6期1789-1800,共12页
Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the ... Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimization of the macroscopic holes silk^(+) tNGC approach containing macroscopic holes might result in improved grafting technology suitable for future clinical use. 展开更多
关键词 axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit VASCULARIZATION
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Supermassive Primordial Black Holes for Nano-Hertz Gravitational Waves and High-redshift JWST Galaxies
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作者 Hai-Long Huang Yong Cai +2 位作者 Jun-Qian Jiang Jun Zhang Yun-Song Piao 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第9期1-6,共6页
Recently,observational hints for supermassive black holes have been accumulating,prompting the question:Can primordial black holes(PBHs)be supermassive,particularly with masses M■10^(9)M_(⊙)?A supercritical bubble,c... Recently,observational hints for supermassive black holes have been accumulating,prompting the question:Can primordial black holes(PBHs)be supermassive,particularly with masses M■10^(9)M_(⊙)?A supercritical bubble,containing an inflating baby universe,that nucleated during inflation can evolve into a PBH in our observable universe.We find that when the inflaton slowly transitions past a neighboring vacuum,the nucleation rate of supercritical bubbles inevitably peaks,leading to a mass distribution of multiverse PBHs with a peak mass up to M■10^(11)M_(⊙).Thus,our mechanism naturally provides a primordial origin for supermassive black holes. 展开更多
关键词 (cosmology:)early universe (cosmology:)inflation (galaxies:)quasars:supermassive black holes
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Quantum Unruh Effect on Radiation of Black Holes
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作者 Tianxi Zhang 《Journal of Modern Physics》 2024年第6期938-949,共12页
The quantum Unruh effect on radiation of a gravitational object including a black hole is analyzed and calculated. It is surprisingly found that the well-known Hawking radiation of a black hole is not physical. Applyi... The quantum Unruh effect on radiation of a gravitational object including a black hole is analyzed and calculated. It is surprisingly found that the well-known Hawking radiation of a black hole is not physical. Applying the Stephan-Boltzmann law with the use of the Unruh radiation temperature at the surface of a black hole to calculate the power of radiation of the black hole is conceptually unphysical. This is because the Unruh radiation temperature results from the gravitational field of the object rather than from the thermal motion of matter of the object, so that the Stephan-Boltzmann law is not applicable. This paper shows that the emission power of Unruh radiation from a gravitational object should be calculated in terms of the rate of increase of the total Unruh radiation energy outside the object. The result obtained from this study indicates that a gravitational object can emit Unruh radiation when the variation of its mass and radius satisfies an inequality of dM/M > 1.25dR/R. For a black hole, the emission of Unruh radiation does not occur unless it can loose its mass (dM < 0). The emission power of Unruh radiation is only an extremely tiny part of the rate of mass-energy loss if the black hole is not extremely micro-sized. This study turns down our traditional understanding of the Hawking radiation and thermodynamics of black holes. 展开更多
关键词 Black hole GRAVITATION Quantum Field Theory Blackbody Radiation
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Active-passive radial-additive friction stir repairing of mechanical hole out of dimension tolerance of AZ31 magnesium alloy
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作者 Hua Liu Zhenlei Liu +3 位作者 Shude Ji Yumei Yue Zhibo Dong Changlong Chen 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第9期3186-3199,共14页
In order to avoid the depth increasing of repaired hole and eliminate the super-fine grain band in stir zone by radial-additive friction stir repairing(R-AFSR), a solid-state repairing technique of active-passive radi... In order to avoid the depth increasing of repaired hole and eliminate the super-fine grain band in stir zone by radial-additive friction stir repairing(R-AFSR), a solid-state repairing technique of active-passive radial-additive friction stir repairing(AP-RAFSR) assisted by the truncated cone-shaped filling material was proposed in this study. The mechanical hole out of dimension tolerance of AZ31 magnesium alloy was chosen as the repaired object. The results indicated that the AP-RAFSR process rather than the R-AFSR process avoided the kissing bond in the bottom of the repairing interface under the condition of the tool pin length equal to the height of the standard mechanical hole.The continuously-distributed and large-length super-fine grain bands were eliminated in the stir zone by AP-RAFSR. The maximum tensile and compressive-shear strengths of repaired hole by AP-RAFSR reached 190.6 MPa and 138.9 MPa at 1200 rpm respectively, which were equivalent to 97.7% and 89.6% of those of the standard mechanical hole. This AP-RAFSR process assisted by the truncated cone-shaped filling material provides a new technique to obtain a no-depth-increasing, defect-free and high-strength repaired mechanical hole. 展开更多
关键词 Active-passive radial-additive friction stir repairing Mechanical hole out of dimension tolerance Numerical simulation Microstructure Mechanical properties
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Repairing of exit-hole in friction-stir-spot welded joints for 2024-T4 aluminum alloy by resistance welding
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作者 Lipeng Deng Pengliang Niu +2 位作者 Liming Ke Jinhe Liu Jidong Kang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2023年第4期660-669,共10页
The exit-hole in friction stir spot welded(FSSWed) 2024-T4 aluminum alloy joints was successfully repaired by using a three-phase secondary rectification resistance spot welding machine, which is termed as filling exi... The exit-hole in friction stir spot welded(FSSWed) 2024-T4 aluminum alloy joints was successfully repaired by using a three-phase secondary rectification resistance spot welding machine, which is termed as filling exit-hole based on resistance welding(FEBRW). The filling dynamic behavior of force was recorded by a device monitoring. Optical microscope(OM), electron backscatter diffraction(EBSD), and tensile shear tests and finite element modelling were conducted to investigate the repairing stages and bonding mechanisms of the repaired joints in detail. Results showed that exit-hole was completely filled and repaired experiencing three stages. Metallurgical bonding was achieved between plug and exit-hole wall in two forms, including melting bonding in the middle of the joints and partial diffusion bonding on both the upper and bottom of the joints. The highest tensile shear strength of the repaired joints was 7.43 kN, which was 36.3% higher than that of the as welded joints. Resistance welding paves an efficient way to repair the exit-hole in FSSWed joints. 展开更多
关键词 resistance welding exit-hole repairing bonding mechanisms
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Vibration Reduction by a Partitioned Dynamic Vibration Absorber with Acoustic Black Hole Features 被引量:1
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作者 Xiaoning Zhao Chaoyan Wang +2 位作者 Hongli Ji Jinhao Qiu Li Cheng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第4期120-134,共15页
Vibration quality is a vital indicator for assessing the progress of modern equipment.The dynamic vibration absorber(DVA)based on the acoustic black hole(ABH)feature is a new passive control method that manipulates wa... Vibration quality is a vital indicator for assessing the progress of modern equipment.The dynamic vibration absorber(DVA)based on the acoustic black hole(ABH)feature is a new passive control method that manipulates waves.It offers efficient energy focalization and broad-spectrum vibration suppression,making it highly promising for applications in large equipment such as aircraft,trains,and ships.Despite previous advancements in ABH-DVA development,certain challenges remain,particularly in ensuring effective coupling with host structures during control.To address these issues,this study proposes a partitioned ABH-featured dynamic vibration absorber(PABH-DVA)with partitions in the radial direction of the disc.By employing a plate as the host structure,simulations and experiments were conducted,demonstrating that the PABH-DVA outperforms the original symmetric ABH-DVA in terms of damping performance.The study also calculated and compared the coupling coefficients of the two ABH-DVAs to uncover the mechanism behind the enhanced damping.Simulation results revealed that the PABH-DVA exhibits more coupled modes,occasionally with lower coupling coefficients than the symmetric ABH-DVA.The influence of frequency ratio and modal mass was further analyzed to explain the reasons behind the PABH-DVA's superior damping performance.Additionally,the study discussed the impact of the number of slits and their orientation.This research further explains the coupling mechanism between the ABH-DVA and the controlled structure,and provides new ideas for the further application of ABH in engineering. 展开更多
关键词 Acoustic black hole Vibration control Dynamic vibration absorber Coupling analysis
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Construction and Weight Distributions of Binary Linear Codes Based on Deep Holes
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作者 Yong Yang Wenwei Qiu 《Applied Mathematics》 2023年第10期684-695,共12页
Deep holes are very important in the decoding of generalized RS codes, and deep holes of RS codes have been widely studied, but there are few works on constructing general linear codes based on deep holes. Therefore, ... Deep holes are very important in the decoding of generalized RS codes, and deep holes of RS codes have been widely studied, but there are few works on constructing general linear codes based on deep holes. Therefore, we consider constructing binary linear codes by combining deep holes with binary BCH codes. In this article, we consider the 2-error-correcting binary primitive BCH codes and the extended codes to construct new binary linear codes by combining them with deep holes, respectively. Furthermore, three classes of binary linear codes are constructed, and then we determine the parameters and the weight distributions of these new binary linear codes. 展开更多
关键词 Linear Codes MacWilliams Equations Weight Distribution Dual Codes Deep holes Covering Radius
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Black Holes and the Third Law of Thermodynamics Revisited
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作者 Miguel Socolovsky 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2023年第2期499-505,共7页
Black holes contradict the Nernst-Planck (N/P) version of the 3rd law of thermodynamics, but agree with its unattainability (U) version. This happens without contradiction, because the N/P and U versions are not equiv... Black holes contradict the Nernst-Planck (N/P) version of the 3rd law of thermodynamics, but agree with its unattainability (U) version. This happens without contradiction, because the N/P and U versions are not equivalent, namely, N/P implies U but U does not imply N/P. So, black holes obey the weaker version of the 3rd law, but not the stronger one. 展开更多
关键词 THERMODYNAMICS Third Law Black holes
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A New Proposal for Black Holes
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作者 John R. Klauder 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2023年第1期55-59,共5页
The understanding of what a black hole is like is not easy and may not yet be well understood. The introduction of canonical quantization into the issue has not been significant to our understanding. However, introduc... The understanding of what a black hole is like is not easy and may not yet be well understood. The introduction of canonical quantization into the issue has not been significant to our understanding. However, introducing affine quantization, a new procedure, offers a very unusual expression that seems to be plausible, and quite profound as well. 展开更多
关键词 Black holes Canonical Quantization Affine Quantization
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Adiabaticity Violated Not Enough: Presume Primordial Black Holes to Generate Gravitons for Cosmological Constant, as Candidate for DE Initially
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作者 Andrew Walcott Beckwith 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2023年第1期100-107,共8页
Instant preheating as given in terms of window where adiabaticity is violated is a completely inefficient form of particle production if we use Padmandabhan scalar potentials. This necessitates using a very different ... Instant preheating as given in terms of window where adiabaticity is violated is a completely inefficient form of particle production if we use Padmandabhan scalar potentials. This necessitates using a very different mechanism for early universe gravition production as an example which is to break up the initial “mass” formed about 10<sup>60</sup> times Planck mass into graviton emitting 10<sup>5</sup> gram sized micro black holes. The mechanism is to assume that we have a different condition than the usual adiabaticity idea which is connected with reheating of the universe. Hence, we will be looking at an earlier primordial black hole generation for generation of gravitons. 展开更多
关键词 Black holes Cosmological Constant Universe Gravition
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Trials to Resolve Black Holes Instabilities in Brane World Cosmology Models
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作者 Poula Tadros Mohamed Assaad Abdel-Raouf 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2023年第2期411-413,共3页
In this letter, we report on our trials to remove the instability of black holes in brane world cosmological models consisting of two branes and a bulk. In order to resolve this problem, general types of interaction p... In this letter, we report on our trials to remove the instability of black holes in brane world cosmological models consisting of two branes and a bulk. In order to resolve this problem, general types of interaction potentials were employed. Careful analyses have shown that although the black holes instabilities were removed, a sort of arbitrariness adherent to the motion of the two branes towards each other has taken place leading to an unstable system. Thus, the models seem to us rather paradoxical. 展开更多
关键词 Brane World Cosmology String Cosmology Black holes
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High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells 被引量:1
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作者 Yu-Su Wang Wen-Hui Chu +4 位作者 Jing-Jie Zhai Wen-Ying Wang Zhong-Mei He Quan-Min Zhao Chun-Yi Li 《World Journal of Stem Cells》 SCIE 2024年第2期176-190,共15页
BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown... BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral integrity.AIM To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral defects.METHODS We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM deposition.Decellularized sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the controls.Three weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee joints.RESULTS The defects were successfully repaired by applying the ECM-sheets.The highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem cells.CONCLUSION Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship. 展开更多
关键词 Osteochondral defect repair Mesenchymal stem cells Extracellular matrix DECELLULARIZATION Antler stem cells Reserve mesenchymal cells Xenogeneic
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From Black Holes to Information Erasure: Uniting Bekenstein’s Bound and Landauer’s Principle
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作者 Boris Menin 《Journal of Applied Mathematics and Physics》 2023年第8期2185-2194,共10页
This research aims to integrate Bekenstein’s bound and Landauer’s principle, providing a unified framework to understand the limits of information and energy in physical systems. By combining these principles, we ex... This research aims to integrate Bekenstein’s bound and Landauer’s principle, providing a unified framework to understand the limits of information and energy in physical systems. By combining these principles, we explore the implications for black hole thermodynamics, astrophysics, astronomy, information theory, and the search for new laws of nature. The result includes an estimation of the number of bits stored in a black hole (less than 1.4 × 10<sup>30</sup> bits/m<sup>3</sup>), enhancing our understanding of information storage in extreme gravitational environments. This integration offers valuable insights into the fundamental nature of information and energy, impacting scientific advancements in multiple disciplines. 展开更多
关键词 Astrophysics and Astronomy Bekenstein Bound Black hole Thermodynamics Information and Energy Limits Information Theory and Quantum Mechanics Landauer’s Principle
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How Dark Energy Might Be Produced by Black Holes
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作者 Eugene Terry Tatum 《Journal of Modern Physics》 CAS 2023年第5期573-582,共10页
If confirmed, the new galactic observations in support of rapidly growing supermassive black holes in association with their production of dark energy may provide for a quantum leap forward in our understanding of bla... If confirmed, the new galactic observations in support of rapidly growing supermassive black holes in association with their production of dark energy may provide for a quantum leap forward in our understanding of black holes, dark energy, and universal expansion. The primary implication of these observations is that growth of black holes may well be coupled with universal expansion (“cosmological coupling”). Study of the Flat Space Cosmology (FSC) model, in conjunction with these new observations, suggests a novel mechanism of “black hole dark energy radiation”. This brief note gives a rationale for how the high gravitational energy density vacuum within or adjacent to a black hole horizon could be sufficiently energetic to pull entangled pairs of positive matter energy particles and negative dark energy “particles” of equal magnitude out of the horizon vacuum and send them off in opposite directions (i.e., gravitationally-attractive matter inward and gravitationally-repelling dark energy outward). One effect would be that a black hole can rapidly grow in mass-energy without mergers or the usual accretion of pre-existing matter. A second effect would be continual production of dark energy within the cosmic vacuum, fueling a continuous and finely-tuned light-speed expansion of the universe. 展开更多
关键词 Astrophysics: Galaxies Black holes Dark Energy Vacuum Energy Cosmological Coupling Flat Space Cosmology ER = EPR Gravitized Vacuum Dark Matter Hawking Radiation
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