A mathematical optimal model is developed to address the problem of logistics hubs location.The method integrates nonlinear programming models and fuzzy comprehensive evaluation,and handles both quantitative and quali...A mathematical optimal model is developed to address the problem of logistics hubs location.The method integrates nonlinear programming models and fuzzy comprehensive evaluation,and handles both quantitative and qualitative factors that influence the location of logistics hubs.A mathematical programming model is used to find the optimal candidate sites of the logistics hub based on profit-maximizing criteria.Then a fuzzy comprehensive evaluation method is adopted to determine the final optimal location of those candidate sites by taking account of criteria including stability of policy environment,convenience of transportation(e.g.,easy access to highways/expressways,etc.),rationality of economy,competition and sustainability.Finally,the methodology is demonstrated by a case study of the Transfar Logistics Base in Zhejiang Province.The results verify the method application for logistics hub locations and show how to locate a logistics hub in practice from the case of Transfar Logistics Base.展开更多
Size distribution characteristics of intercity bus hubs in China from 1997 to 2（104 were analyzed regarding highway passenger volume as a size index of intercity bus hubs. Yearly fractal dimensions of intercity bus h...Size distribution characteristics of intercity bus hubs in China from 1997 to 2（104 were analyzed regarding highway passenger volume as a size index of intercity bus hubs. Yearly fractal dimensions of intercity bus hub sizes were exactly calculated by a novel model. Fractal dimensions of the 200 biggest intercity bus hubs from 2000 to 2004 were 1. 486 2 to 1. 511 8, and that is consistent with fractal dimensions of Chinese urban system sizes. It showed that the size distribution of intercity bus hubs had fractal structure. Fractal dimensions from 1997 to 2004 indicated that intercity bus hub size distribution grew from bi-fractal to single fractal. It is concluded that the intercity bus hub system is in evolutionary progress, and the Central Government should support large intercity bus hubs more to optimize system structure.展开更多
This article examines the approaches that are adopted by both Singapore and Hong Kong in developing themselves as ＂regional hubs of higher education＂ through different strategies on the development of their higher e...This article examines the approaches that are adopted by both Singapore and Hong Kong in developing themselves as ＂regional hubs of higher education＂ through different strategies on the development of their higher education systems, and via developing transnational higher education. The article starts off with a delineation on how the process of globalization has structurally altered the landscape of the global higher education market, upon which these changes drive both Singapore and Hong Kong to become more competitive in the global education marketplace. By examining and evaluating the recent education reforms in the two Asian city-states, the author argues that the two places have significant differences and are using rather different strategies in developing their higher education sectors, which can then reflect upon their fundamental differences in terms of the basic mindsets, underlying philosophies and style of governance of higher education by the two governments.展开更多
The route optimization problem for road networks was applied to pedestrian flow.Evacuation path networks with nodes and arcs considering the traffic capacities of facilities were built in metro hubs,and a path impedan...The route optimization problem for road networks was applied to pedestrian flow.Evacuation path networks with nodes and arcs considering the traffic capacities of facilities were built in metro hubs,and a path impedance function for metro hubs which used the relationships among circulation speed,density and flow rate for pedestrians was defined.Then,a route optimization model which minimizes the movement time of the last evacuee was constructed to optimize evacuation performance.Solutions to the proposed mathematical model were obtained through an iterative optimization process.The route optimization model was applied to Xidan Station of Beijing Metro Line 4 based on the actual situations,and the calculation results of the model were tested using buildingExodus microscopic evacuation simulation software.The simulation result shows that the proposed model shortens the evacuation time by 16.05%,3.15% and 2.78% compared with all or none method,equally split method and Logit model,respectively.Furthermore,when the population gets larger,evacuation efficiency in the proposed model has a greater advantage.展开更多
This paper is engaged in the research of urban rail transit hub integration and transfer.Firstly,this paper focuses on the space division,the aggregation form of hub subsystems,the spatial layout of hub subsystems,and...This paper is engaged in the research of urban rail transit hub integration and transfer.Firstly,this paper focuses on the space division,the aggregation form of hub subsystems,the spatial layout of hub subsystems,and the design of integrated functions to achieve an integrated layout.In addition,this study also conducted a selection of transfer classification and transfer station layout of urban rail transit hubs,with the aims to promote the improvement of the functions of urban rail transit hubs,the rationality of transfers,and to improve the service quality of the hub system which meet the demand of the public travel.展开更多
Coordinated scheduling of multimode plays a pivotal role in the rapid gathering and dissipating of passengers in transport hubs. Based on the survey data, the whole-day reaching time distribution at transfer points of...Coordinated scheduling of multimode plays a pivotal role in the rapid gathering and dissipating of passengers in transport hubs. Based on the survey data, the whole-day reaching time distribution at transfer points of passengers from the dominant mode to the connecting mode was achieved. A GI/M K/1 bulk service queuing system was constituted by putting the passengers' reaching time distribution as the input and the connecting mode as the service institution. Through queuing theory, the relationship between average queuing length under steady-state and headway of the connecting mode was achieved. By putting the minimum total cost of system as optimization objective, the headway as decision variable, a coordinated scheduling model of multimode in intermodal transit hubs was established. At last, a dynamic scheduling strategy was generated to cope with the unexpected changes of the dominant mode. The instance analysis indicates that this model can significantly reduce passengers' queuing time by approximately 17% with no apparently increase in departure frequency, which provides a useful solution for the coordinated scheduling of different transport modes in hubs.展开更多
To increase the passenger transferring efficiency, the bus coordination holding control for transit hubs, which is as an important dynamic dispatching method for improving the service level of transit hubs, was studie...To increase the passenger transferring efficiency, the bus coordination holding control for transit hubs, which is as an important dynamic dispatching method for improving the service level of transit hubs, was studied in the framework of bus coordination dispatching mode. Firstly, the bus coordination holding control flow was studied based on Advanced Public Transportation Systems (APTS) environment. Then a control model was presented to optimize the bus vehicle holding time, and a genetic algorithm was designed as the solving method. In the end, an example was given to illustrate the effectiveness of the control strategy and the algorithm.展开更多
Multi-energy systems are one of the key technologies to tackle energy crisis and environmental pollution.An energy hub(EH)is a minimum multi-energy system.Interconnection of multiple EHs through energy routers(ERs)can...Multi-energy systems are one of the key technologies to tackle energy crisis and environmental pollution.An energy hub(EH)is a minimum multi-energy system.Interconnection of multiple EHs through energy routers(ERs)can realize mutual energy assistance.This paper proposes a peer-to-peer(P2P)energy sharing strategy between EHs including ERs in an interconnected system,which is divided into two levels.In the lower level,a method of determining the charging/discharging constraints of energy storage devices is proposed.Based on the Lyapunov optimization method,virtual queues are used to model the energy storage devices and flexible loads in the system.The objective is to minimize the overall operating cost of the interconnected system.In the upper level,a non-cooperative game model is introduced to minimize the cost of purchasing power from other EHs for each EH.A best response-based method is adapted to find the Nash equilibrium.The simulation outcomes demonstrate that application of the proposed strategy can reduce operating costs of an interconnected system and each EH.On basis of a real-world dataset of interconnected EHs,both analytical and numerical results show the effectiveness of the proposed strategy.展开更多
Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer types.However,its potential therapeu...Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer types.However,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear yet.Methods:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were identified.Enrichment analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene set.Among the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration assays.Therefore,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by qPCR.Result s:Four active ingredients of saffron and 184 of their target genes were identified.Further,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC cells.Molecular docking experiments indicated that ESR1 and CCND1 were the target genes of crocetin.These results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu cells.Conclusion:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating medications.However,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.展开更多
BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unkn...BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unknown.AIM To explore potential molecular connections between H.pylori infection and T2DM.METHODS We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with H.pylori infection and T2DM were identified.Hub genes were validated using human gastric biopsy samples.Correlations between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further analyzed.RESULTS A total of 67 DEGs were commonly presented in patients with H.pylori infection and T2DM.Five significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell infiltration.The gene-miRNA analysis detected 13 miRNAs with at least two gene cross-links.TF-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub genes.CONCLUSION We identified five hub genes that may have molecular connections between H.pylori infection and T2DM.This study provides new insights into the pathogenesis of H.pylori-induced onset of T2DM.展开更多
Multimodal transportation hubs serve as transfer points with the function of collecting,transferring,and distributing passengers and play a significant role in the entire multimodal transportation network.In an emerge...Multimodal transportation hubs serve as transfer points with the function of collecting,transferring,and distributing passengers and play a significant role in the entire multimodal transportation network.In an emergency,the development of an effective and efficient emergency evacuation strategy to evacuate passengers from multimodal transportation hubs is very important.This paper aims to conduct a comprehensive review on passenger emergency evacuations from multimodal transportation hubs,summarize the achievements,identify gaps in existing literature,thus to lay a solid foundation for future studies.This paper first reviewed studies on evacuee behavior characteristics in emergency evacuations,including pedestrian characteristics,pedestrian behavior characteristics,and pedestrian flow characteristics.Then evacuation models,including pedestrian evacuation models and multimodal transportation evacuation models,were investigated.In addition,a retrospective analysis was carried out for evacuation simulation.It is found that while many studies have been conducted on passenger emergency evacuations from multimodal transportation hubs,most of them focus more on evacuating pedestrians from inside to outside of hub buildings;the studies on evacuation at multimodal transfer points are limited.It is also found that most existing studies tried to establish a general model to handle all types of emergency evacuations;in fact,a model would be more efficient if it is just established for a specific emergency and for a specific type of hubs.Also,existing data collection methods may collect biased data;new data collection methods need to be explored to increase the accuracy of data collection.Future study directions include the evacuation at multimodal transfer points,interactive effects between individual pedestrian behavior and pedestrian group behavior,more specific types of emergency evacuations,more accurate data collection methods,and tradeoffs between cost and benefit in emergency evacuations.展开更多
The issue of "missing baryons” is always an unsolved mystery in galaxy cosmology, and an important reason for the great uncertainty of the galaxies' formation and evolution. To find the "missing" b...The issue of "missing baryons” is always an unsolved mystery in galaxy cosmology, and an important reason for the great uncertainty of the galaxies' formation and evolution. To find the "missing" baryons, extra high-resolution spectral observation and imaging of the soft X-ray band (<1 kev) is required. However, the existing observation methods cannot meet this requirement. Therefore, Tsinghua University leads and proposes the Chinese "Hot Universe Baryon Surveyor (HUBS)" satellite program.展开更多
The accuracy of the simulation model has a pro-found impact on the optimal operation of the energy hubs(EHs).However,in many articles,the constant model of the efficiency of equipment is adopted to formulate the opera...The accuracy of the simulation model has a pro-found impact on the optimal operation of the energy hubs(EHs).However,in many articles,the constant model of the efficiency of equipment is adopted to formulate the operation system,which would probably lead to a simplification of the simulation models.But,EHs are typically operated under off-design condition due to the fluctuations in cooling,heating,electricity requirement.More-over,even though the off-design characteristics are considered,few studies have suggested comparing the differences between those two models by considering the operation cost.In order to assess the effect of the off-design characteristics of EH on the optimal operation accuracy in this paper,two test cases are performed on the fixed and variable load conditions,respectively.In addition,the individual effect of off-design characteristics of each equipment on the optimal operation cost of the EH is also investigated through four optimization runs.It is worth mentioning that the optimal operation problem of the EH considering the off-design characteristics and on-off status of the equipment is a mixed integer non-linear programming problem(MINLP).By testing the design and off-design models on the two cases,the results of simulation demonstrate that the optimal operation cost for the off-design model is larger than that for the design model.Nonetheless,in the aspect of the authenticity of the system operation strategy,the off-design model performs better than the design model.Furthermore,a larger relative error of the system operation cost between the two models can be observed when the EH is operated under a relatively lower load condition,revealing that the influence of off-design characteristic on the optimal operation of EHs is too significant to be neglected.展开更多
Excessive abdominal fat deposition reduces the feed efficiency and increase the cost of production in broilers.Therefore,it is an important task for poultry breeders to breed broilers with low abdominal fat.Abdominal ...Excessive abdominal fat deposition reduces the feed efficiency and increase the cost of production in broilers.Therefore,it is an important task for poultry breeders to breed broilers with low abdominal fat.Abdominal fat deposition is a highly complex biological process,and its molecular basis remains elusive.In this study,we performed transcriptome analysis to compare gene expression profiles at different stages of abdominal fat deposition to identify the key genes and pathways involved in abdominal fat accumulation.We found that abdominal fat weight(AFW)increased gradually from day 35(D35)to 91(D91),and then decreased at day 119(D119).Accordingly,after detecting differentially expressed genes(DEGs)by comparing gene expression profiles at D35 vs.D63 and D35 vs.D91,and identifying gene modules associated with fat deposition by weighted gene co-expression network analysis(WGCNA),we performed intersection analysis of the detected DEGs and WGCNA gene modules and identified 394 and 435 intersecting genes,respectively.The results of the Gene Ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses showed that the steroid hormone biosynthesis and insulin signaling pathways were co-enriched in all intersecting genes,steroid hormones have been shown that regulated insulin signaling pathway,indicating the importance of the steroid hormone biosynthesis pathway in the development of broiler abdominal fat.We then identified 6 hub genes(ACTB,SOX9,RHOBTB2,PDLIM3,NEDD9,and DOCK4)related to abdominal fat deposition.Further analysis also revealed that there were direct interactions between 6 hub genes.SOX9 has been shown to bind to proteins required for steroid hormone receptor binding,and RHOBTB2 indirectly regulates the steroid hormones biosynthesis through cyclin factor,and ultimately affect fat deposition.Our results suggest that the genes RHOBTB2 and SOX9 play an important role in fat deposition in broilers,by regulating steroid hormone synthesis.These findings provide new targets and directions for further studies on the mechanisms of fat deposition in chicken.展开更多
基金The National Key Technology R&D Program of China during the 11th Five-Year Plan Period(No.2006BAH02A06)Program for New Century Excellent Talents in China(No.NCET-05-0529)
文摘A mathematical optimal model is developed to address the problem of logistics hubs location.The method integrates nonlinear programming models and fuzzy comprehensive evaluation,and handles both quantitative and qualitative factors that influence the location of logistics hubs.A mathematical programming model is used to find the optimal candidate sites of the logistics hub based on profit-maximizing criteria.Then a fuzzy comprehensive evaluation method is adopted to determine the final optimal location of those candidate sites by taking account of criteria including stability of policy environment,convenience of transportation(e.g.,easy access to highways/expressways,etc.),rationality of economy,competition and sustainability.Finally,the methodology is demonstrated by a case study of the Transfar Logistics Base in Zhejiang Province.The results verify the method application for logistics hub locations and show how to locate a logistics hub in practice from the case of Transfar Logistics Base.
基金The Ph.D.Programs Foundation of Ministry of Edu-cation of China(No20050710006)
文摘Size distribution characteristics of intercity bus hubs in China from 1997 to 2（104 were analyzed regarding highway passenger volume as a size index of intercity bus hubs. Yearly fractal dimensions of intercity bus hub sizes were exactly calculated by a novel model. Fractal dimensions of the 200 biggest intercity bus hubs from 2000 to 2004 were 1. 486 2 to 1. 511 8, and that is consistent with fractal dimensions of Chinese urban system sizes. It showed that the size distribution of intercity bus hubs had fractal structure. Fractal dimensions from 1997 to 2004 indicated that intercity bus hub size distribution grew from bi-fractal to single fractal. It is concluded that the intercity bus hub system is in evolutionary progress, and the Central Government should support large intercity bus hubs more to optimize system structure.
文摘This article examines the approaches that are adopted by both Singapore and Hong Kong in developing themselves as ＂regional hubs of higher education＂ through different strategies on the development of their higher education systems, and via developing transnational higher education. The article starts off with a delineation on how the process of globalization has structurally altered the landscape of the global higher education market, upon which these changes drive both Singapore and Hong Kong to become more competitive in the global education marketplace. By examining and evaluating the recent education reforms in the two Asian city-states, the author argues that the two places have significant differences and are using rather different strategies in developing their higher education sectors, which can then reflect upon their fundamental differences in terms of the basic mindsets, underlying philosophies and style of governance of higher education by the two governments.
基金Project(51078086)supported by the National Natural Science Foundation of China
文摘The route optimization problem for road networks was applied to pedestrian flow.Evacuation path networks with nodes and arcs considering the traffic capacities of facilities were built in metro hubs,and a path impedance function for metro hubs which used the relationships among circulation speed,density and flow rate for pedestrians was defined.Then,a route optimization model which minimizes the movement time of the last evacuee was constructed to optimize evacuation performance.Solutions to the proposed mathematical model were obtained through an iterative optimization process.The route optimization model was applied to Xidan Station of Beijing Metro Line 4 based on the actual situations,and the calculation results of the model were tested using buildingExodus microscopic evacuation simulation software.The simulation result shows that the proposed model shortens the evacuation time by 16.05%,3.15% and 2.78% compared with all or none method,equally split method and Logit model,respectively.Furthermore,when the population gets larger,evacuation efficiency in the proposed model has a greater advantage.
文摘This paper is engaged in the research of urban rail transit hub integration and transfer.Firstly,this paper focuses on the space division,the aggregation form of hub subsystems,the spatial layout of hub subsystems,and the design of integrated functions to achieve an integrated layout.In addition,this study also conducted a selection of transfer classification and transfer station layout of urban rail transit hubs,with the aims to promote the improvement of the functions of urban rail transit hubs,the rationality of transfers,and to improve the service quality of the hub system which meet the demand of the public travel.
基金Projects(51278221,51378076)supported by the National Natural Science Foundation of China
文摘Coordinated scheduling of multimode plays a pivotal role in the rapid gathering and dissipating of passengers in transport hubs. Based on the survey data, the whole-day reaching time distribution at transfer points of passengers from the dominant mode to the connecting mode was achieved. A GI/M K/1 bulk service queuing system was constituted by putting the passengers' reaching time distribution as the input and the connecting mode as the service institution. Through queuing theory, the relationship between average queuing length under steady-state and headway of the connecting mode was achieved. By putting the minimum total cost of system as optimization objective, the headway as decision variable, a coordinated scheduling model of multimode in intermodal transit hubs was established. At last, a dynamic scheduling strategy was generated to cope with the unexpected changes of the dominant mode. The instance analysis indicates that this model can significantly reduce passengers' queuing time by approximately 17% with no apparently increase in departure frequency, which provides a useful solution for the coordinated scheduling of different transport modes in hubs.
基金Sponsored by the National Natural Science Foundation of China (Grant No. 70601022)the National Basic Research Program of China (Grant No.2006CB705505)
文摘To increase the passenger transferring efficiency, the bus coordination holding control for transit hubs, which is as an important dynamic dispatching method for improving the service level of transit hubs, was studied in the framework of bus coordination dispatching mode. Firstly, the bus coordination holding control flow was studied based on Advanced Public Transportation Systems (APTS) environment. Then a control model was presented to optimize the bus vehicle holding time, and a genetic algorithm was designed as the solving method. In the end, an example was given to illustrate the effectiveness of the control strategy and the algorithm.
基金supported by National Natural Science Foundation of China under Grant 52061635104.
文摘Multi-energy systems are one of the key technologies to tackle energy crisis and environmental pollution.An energy hub(EH)is a minimum multi-energy system.Interconnection of multiple EHs through energy routers(ERs)can realize mutual energy assistance.This paper proposes a peer-to-peer(P2P)energy sharing strategy between EHs including ERs in an interconnected system,which is divided into two levels.In the lower level,a method of determining the charging/discharging constraints of energy storage devices is proposed.Based on the Lyapunov optimization method,virtual queues are used to model the energy storage devices and flexible loads in the system.The objective is to minimize the overall operating cost of the interconnected system.In the upper level,a non-cooperative game model is introduced to minimize the cost of purchasing power from other EHs for each EH.A best response-based method is adapted to find the Nash equilibrium.The simulation outcomes demonstrate that application of the proposed strategy can reduce operating costs of an interconnected system and each EH.On basis of a real-world dataset of interconnected EHs,both analytical and numerical results show the effectiveness of the proposed strategy.
基金the Taishan Scholar Project(No.ts20190991)the Key R&D Project of Shandong Province(2022CXPT023)。
文摘Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer types.However,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear yet.Methods:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were identified.Enrichment analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene set.Among the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration assays.Therefore,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by qPCR.Result s:Four active ingredients of saffron and 184 of their target genes were identified.Further,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC cells.Molecular docking experiments indicated that ESR1 and CCND1 were the target genes of crocetin.These results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu cells.Conclusion:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating medications.However,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.
基金Supported by National Natural Science Foundation of China,No.82100594.
文摘BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unknown.AIM To explore potential molecular connections between H.pylori infection and T2DM.METHODS We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with H.pylori infection and T2DM were identified.Hub genes were validated using human gastric biopsy samples.Correlations between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further analyzed.RESULTS A total of 67 DEGs were commonly presented in patients with H.pylori infection and T2DM.Five significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell infiltration.The gene-miRNA analysis detected 13 miRNAs with at least two gene cross-links.TF-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub genes.CONCLUSION We identified five hub genes that may have molecular connections between H.pylori infection and T2DM.This study provides new insights into the pathogenesis of H.pylori-induced onset of T2DM.
基金supported by The National Key Research and Development Program of China(No.2018YFB1601200)
文摘Multimodal transportation hubs serve as transfer points with the function of collecting,transferring,and distributing passengers and play a significant role in the entire multimodal transportation network.In an emergency,the development of an effective and efficient emergency evacuation strategy to evacuate passengers from multimodal transportation hubs is very important.This paper aims to conduct a comprehensive review on passenger emergency evacuations from multimodal transportation hubs,summarize the achievements,identify gaps in existing literature,thus to lay a solid foundation for future studies.This paper first reviewed studies on evacuee behavior characteristics in emergency evacuations,including pedestrian characteristics,pedestrian behavior characteristics,and pedestrian flow characteristics.Then evacuation models,including pedestrian evacuation models and multimodal transportation evacuation models,were investigated.In addition,a retrospective analysis was carried out for evacuation simulation.It is found that while many studies have been conducted on passenger emergency evacuations from multimodal transportation hubs,most of them focus more on evacuating pedestrians from inside to outside of hub buildings;the studies on evacuation at multimodal transfer points are limited.It is also found that most existing studies tried to establish a general model to handle all types of emergency evacuations;in fact,a model would be more efficient if it is just established for a specific emergency and for a specific type of hubs.Also,existing data collection methods may collect biased data;new data collection methods need to be explored to increase the accuracy of data collection.Future study directions include the evacuation at multimodal transfer points,interactive effects between individual pedestrian behavior and pedestrian group behavior,more specific types of emergency evacuations,more accurate data collection methods,and tradeoffs between cost and benefit in emergency evacuations.
基金supported by the National Natural Science Foundation of China (51706233, U1831203, 51427806)Strategic Pilot Projects in Space Science of China (XDA15010400)Key Research Program of Frontier Sciences, CAS (QYZDYSSW-JSC028)
文摘The issue of "missing baryons” is always an unsolved mystery in galaxy cosmology, and an important reason for the great uncertainty of the galaxies' formation and evolution. To find the "missing" baryons, extra high-resolution spectral observation and imaging of the soft X-ray band (<1 kev) is required. However, the existing observation methods cannot meet this requirement. Therefore, Tsinghua University leads and proposes the Chinese "Hot Universe Baryon Surveyor (HUBS)" satellite program.
基金The work was supported by the State Key Program of National Natural Science Foundation of China(Grant No.51437006)the Natural Science Foundation of Guangdong Province,China(2018A030313799).
文摘The accuracy of the simulation model has a pro-found impact on the optimal operation of the energy hubs(EHs).However,in many articles,the constant model of the efficiency of equipment is adopted to formulate the operation system,which would probably lead to a simplification of the simulation models.But,EHs are typically operated under off-design condition due to the fluctuations in cooling,heating,electricity requirement.More-over,even though the off-design characteristics are considered,few studies have suggested comparing the differences between those two models by considering the operation cost.In order to assess the effect of the off-design characteristics of EH on the optimal operation accuracy in this paper,two test cases are performed on the fixed and variable load conditions,respectively.In addition,the individual effect of off-design characteristics of each equipment on the optimal operation cost of the EH is also investigated through four optimization runs.It is worth mentioning that the optimal operation problem of the EH considering the off-design characteristics and on-off status of the equipment is a mixed integer non-linear programming problem(MINLP).By testing the design and off-design models on the two cases,the results of simulation demonstrate that the optimal operation cost for the off-design model is larger than that for the design model.Nonetheless,in the aspect of the authenticity of the system operation strategy,the off-design model performs better than the design model.Furthermore,a larger relative error of the system operation cost between the two models can be observed when the EH is operated under a relatively lower load condition,revealing that the influence of off-design characteristic on the optimal operation of EHs is too significant to be neglected.
基金funded by the grants from the Beijing Natural Science Foundation,China(6202028)the National Natural Science Foundation of China(32172723)+2 种基金the State Key Laboratory of Animal Nutrition,China(2004DA125184G2109)the Agricultural Science and Technology Innovation Program,China(ASTIP-IAS04)the China Agriculture Research System of MOF and MARA(CARS-41).
文摘Excessive abdominal fat deposition reduces the feed efficiency and increase the cost of production in broilers.Therefore,it is an important task for poultry breeders to breed broilers with low abdominal fat.Abdominal fat deposition is a highly complex biological process,and its molecular basis remains elusive.In this study,we performed transcriptome analysis to compare gene expression profiles at different stages of abdominal fat deposition to identify the key genes and pathways involved in abdominal fat accumulation.We found that abdominal fat weight(AFW)increased gradually from day 35(D35)to 91(D91),and then decreased at day 119(D119).Accordingly,after detecting differentially expressed genes(DEGs)by comparing gene expression profiles at D35 vs.D63 and D35 vs.D91,and identifying gene modules associated with fat deposition by weighted gene co-expression network analysis(WGCNA),we performed intersection analysis of the detected DEGs and WGCNA gene modules and identified 394 and 435 intersecting genes,respectively.The results of the Gene Ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses showed that the steroid hormone biosynthesis and insulin signaling pathways were co-enriched in all intersecting genes,steroid hormones have been shown that regulated insulin signaling pathway,indicating the importance of the steroid hormone biosynthesis pathway in the development of broiler abdominal fat.We then identified 6 hub genes(ACTB,SOX9,RHOBTB2,PDLIM3,NEDD9,and DOCK4)related to abdominal fat deposition.Further analysis also revealed that there were direct interactions between 6 hub genes.SOX9 has been shown to bind to proteins required for steroid hormone receptor binding,and RHOBTB2 indirectly regulates the steroid hormones biosynthesis through cyclin factor,and ultimately affect fat deposition.Our results suggest that the genes RHOBTB2 and SOX9 play an important role in fat deposition in broilers,by regulating steroid hormone synthesis.These findings provide new targets and directions for further studies on the mechanisms of fat deposition in chicken.
