Objective To compare the results of a novel regimen of human menopausal gonadotrophin （hMG） in combination with clomiphene citrate （CC） in mid-to-late follicular phase with those of a short protocol of GnRH agoni...Objective To compare the results of a novel regimen of human menopausal gonadotrophin （hMG） in combination with clomiphene citrate （CC） in mid-to-late follicular phase with those of a short protocol of GnRH agonist （GnRHa） and hMG used for IVF. Methods In the retrospective study, 842 patients undergoing IVF were collected and classified into two groups： hMG in combination with CC in mid-to-late follicular phase （group A, n=319） and short protocol of GnRHa-hMG （group B, n=523）. The main outcome measures were ovarian responses in stimulation cycles and pregnancy outcomes in subsequent frozen-thawed embryo transfer （FET） cycles. Results In group A, the serum LH concentration on day 8 -10 was similar with that on the day of hCG administration （2.43 ± 1.92 IU vs 2.51 ±2.05 IU）. The number of mature follicles and oocytes retrieved was significantly lower in group A than in group B while the fertilization rate and the cleavage rate were comparable. The clinical pregnancy rate （47. 79% vs 48.04%）, the implantation rate （32.49% vs 33.11%） and the cumulative pregnancy rate （58.09% vs 60.22%） were respectively similar in group A and group B. Conclusion hMG in combination with CC in mid-to-late follicular phase results in the same pregnancy outcome as short protocol. The novel protocol may take the advantage of eliminating the occurrehce of a premature endogenous LH Surge.展开更多
目的：探讨卵巢储备正常者在促排卵不同阶段添加高纯度人绝经期促性腺激素（highly purified human menopausal gonadotrophin，HP-hMO）对体外受精．胚胎移植（WF-ET）结局的影响。方法：收集接受IVF或单精子胞质内显微注射技术（ICSl...目的：探讨卵巢储备正常者在促排卵不同阶段添加高纯度人绝经期促性腺激素（highly purified human menopausal gonadotrophin，HP-hMO）对体外受精．胚胎移植（WF-ET）结局的影响。方法：收集接受IVF或单精子胞质内显微注射技术（ICSll治疗的25～35岁卵巢储备功能正常的患者（n=153），根据是否添加HP-hMG及添加时机分为A组（未添加HP—hMG），B组（Gn第1日添加HP—hMG）和C组（Gn第6～8日添加HP．hMG），分析三组妊娠结局。结果：A组hCG注射日LH、E2水平低于B组及C组（P〈0．05），A组hCG注射目P水平高于B组及C组（P〈0．05），获卵数及MII卵子数A组及C组高于B组（P〈0．05），优质胚胎率B组高于A组及C组（P〈0．05），累积妊娠率，C组（85％）高于A组（59．3％）及B组（67．6％），差异有统计学意义（P〈0．05），3组受精率、成熟卵率、种植率差异无统计学意义（P〈0．05）。结论：卵巢储备功能正常者在采用标准长方案促排卵时，中晚期添加HP．hMG可改善累积妊娠结局；卵泡发育不同阶段添加HP—hMG，可能适用于不同的人群。展开更多
基金supported by National Natural Science Foundation of China (No. 31071275, No. 81270749 and No. 31101070)
文摘Objective To compare the results of a novel regimen of human menopausal gonadotrophin （hMG） in combination with clomiphene citrate （CC） in mid-to-late follicular phase with those of a short protocol of GnRH agonist （GnRHa） and hMG used for IVF. Methods In the retrospective study, 842 patients undergoing IVF were collected and classified into two groups： hMG in combination with CC in mid-to-late follicular phase （group A, n=319） and short protocol of GnRHa-hMG （group B, n=523）. The main outcome measures were ovarian responses in stimulation cycles and pregnancy outcomes in subsequent frozen-thawed embryo transfer （FET） cycles. Results In group A, the serum LH concentration on day 8 -10 was similar with that on the day of hCG administration （2.43 ± 1.92 IU vs 2.51 ±2.05 IU）. The number of mature follicles and oocytes retrieved was significantly lower in group A than in group B while the fertilization rate and the cleavage rate were comparable. The clinical pregnancy rate （47. 79% vs 48.04%）, the implantation rate （32.49% vs 33.11%） and the cumulative pregnancy rate （58.09% vs 60.22%） were respectively similar in group A and group B. Conclusion hMG in combination with CC in mid-to-late follicular phase results in the same pregnancy outcome as short protocol. The novel protocol may take the advantage of eliminating the occurrehce of a premature endogenous LH Surge.
文摘目的：探讨卵巢储备正常者在促排卵不同阶段添加高纯度人绝经期促性腺激素（highly purified human menopausal gonadotrophin，HP-hMO）对体外受精．胚胎移植（WF-ET）结局的影响。方法：收集接受IVF或单精子胞质内显微注射技术（ICSll治疗的25～35岁卵巢储备功能正常的患者（n=153），根据是否添加HP-hMG及添加时机分为A组（未添加HP—hMG），B组（Gn第1日添加HP—hMG）和C组（Gn第6～8日添加HP．hMG），分析三组妊娠结局。结果：A组hCG注射日LH、E2水平低于B组及C组（P〈0．05），A组hCG注射目P水平高于B组及C组（P〈0．05），获卵数及MII卵子数A组及C组高于B组（P〈0．05），优质胚胎率B组高于A组及C组（P〈0．05），累积妊娠率，C组（85％）高于A组（59．3％）及B组（67．6％），差异有统计学意义（P〈0．05），3组受精率、成熟卵率、种植率差异无统计学意义（P〈0．05）。结论：卵巢储备功能正常者在采用标准长方案促排卵时，中晚期添加HP．hMG可改善累积妊娠结局；卵泡发育不同阶段添加HP—hMG，可能适用于不同的人群。
