Hoi An Ancient Town in Vietnam is not only a UNESCO(United Nations Educational,Scientific,and Cultural Organization)World Heritage Site but also a convergence point of traditional and modern cultures.Throughout its hi...Hoi An Ancient Town in Vietnam is not only a UNESCO(United Nations Educational,Scientific,and Cultural Organization)World Heritage Site but also a convergence point of traditional and modern cultures.Throughout its historical transitions,the cultural heritage of Hoi An Ancient Town has been well preserved and developed,and the worship of Mazu,an essential component of Hoi An’s culture,is no exception.As far as is known,Hoi An in central Vietnam houses the most Mazu temples,including the Chung Wah Hall,the Guangzhou Assembly Hall,the Fujian Assembly Hall,the Teochew Assembly Hall,and the Hainan Assembly Hall,among others,with the Fujian Assembly Hall being the most vibrant center of Mazu worship.This study employs field surveys and literature research to explore the Mazu worship practices at the Fujian Assembly Hall in Hoi An,Quang Nam Province,Vietnam.展开更多
肝脏的低密度脂蛋白受体(LDLR)是清除血浆低密度脂蛋白(LDL)的主要途径,并且是一个非常重要的心血管系统疾病的治疗靶点。LDLR的表达量受到转录和转录后两方面的调控。这里介绍一种新近发现的、通过泛素化作用经转录后途径调控LDLR的蛋...肝脏的低密度脂蛋白受体(LDLR)是清除血浆低密度脂蛋白(LDL)的主要途径,并且是一个非常重要的心血管系统疾病的治疗靶点。LDLR的表达量受到转录和转录后两方面的调控。这里介绍一种新近发现的、通过泛素化作用经转录后途径调控LDLR的蛋白Idol(inducible degrader of the LDLR)。Idol是一个肝脏X受体(LXR)的靶分子,具有E3泛素连接酶活性,可以介导LDLR的泛素化,并在溶酶体降解。Idol还有另外两个LDLR家族的靶蛋白VLDLR和ApoER2。尽管Idol和前蛋白转化酶枯草溶菌素9(PCSK9)存在着很多相似之处,但它们在调控LDLR的途径上是不同的。最近的工作显示Idol与人类的LDL水平有关,Idol可能在人类的血脂代谢有重要作用。展开更多
[目的]综述新近发现的IDOL蛋白(Inducibledegrader of the low-density lipoprotein receptor)对低密度脂蛋白受体(low-densitylipoprotein receptor,LDLR)调节作用及肝X受体(LXR)-IDOL-LDLR轴在脂代谢平衡稳态中作用的研究进展。[方法...[目的]综述新近发现的IDOL蛋白(Inducibledegrader of the low-density lipoprotein receptor)对低密度脂蛋白受体(low-densitylipoprotein receptor,LDLR)调节作用及肝X受体(LXR)-IDOL-LDLR轴在脂代谢平衡稳态中作用的研究进展。[方法]查阅近年来国内外研究IDOL及LXRIDOL通路的相关文献,并归纳总结其在脂代谢中的作用。[结果]IDOL能在转录后水平介导LDLR及其家族其他成员(VLDLR、ApoER2)的泛素化降解,该作用独立于固醇调节元件结合蛋白(SREBP)途径且受LXR的调节。[结论]LXR-IDOL通路能通过IDOL依赖途径泛素化降解LDLR,调节LDLR水平及LDL摄取,从而在脂代谢平衡中发挥重要作用。LXR-IDOL-LDLR轴可能为脂质代谢紊乱及心血管疾病提供新的潜在治疗靶点。展开更多
目的探讨人类诱导型低密度脂蛋白受体降解蛋白(IDOL)基因多态性与成年人肥胖的相关性。方法采用病例对照研究,选择2013年8月—2019年10月期间因心血管疾病在新疆医科大学第一附属医院心脏中心住院治疗的患者1172例,根据肥胖诊断标准分...目的探讨人类诱导型低密度脂蛋白受体降解蛋白(IDOL)基因多态性与成年人肥胖的相关性。方法采用病例对照研究,选择2013年8月—2019年10月期间因心血管疾病在新疆医科大学第一附属医院心脏中心住院治疗的患者1172例,根据肥胖诊断标准分为肥胖组(n=572)和对照组(n=600),采用改进的多重连接检测反应(iMLDR)方法对诱导型低密度脂蛋白受体降解蛋白IDOL基因rs2072783、rs9370867和rs9370867位点进行基因型分型。结果诱导型低密度脂蛋白受体降解蛋白IDOL基因SNP1(rs2072783)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、隐形模型(GG vs AG+AA)的分布频率存在统计学差异。SNP2(rs9370867)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、相加模型(AG vs AA+GG)的分布频率存在统计学差异(P<0.05)。校正混杂因素后,rs2072783位点的隐形模型(GG vs AA+AG)和rs9370867位点的相加模型(AG vs AA+GG)为肥胖患者的危险因素[(rs2072783:OR=1.482,P=0.032,95%CI:1.034-2.121);(rs9370867:OR=1.849,P=0.032,95%CI:1.034-2.121)]。结论诱导型低密度脂蛋白受体降解蛋白IDOL基因多态性与成年人肥胖患病具有相关性。IDOL基因rs9370867和rs2072783位点G等位基因的人群比携带A等位基因的人罹患肥胖的可能性更高,诱导型低密度脂蛋白受体降解蛋白IDOL基因rs9370867位点AG基因型及rs2072783位点的GG基因型是肥胖的易感因素。展开更多
The cult of Mazu is a common folk belief in China and Vietnam.Originating from the Song and Yuan Dynasties,particularly during the Ming and Qing Dynasties,the cult of Mazu spread to Vietnam through maritime trade and ...The cult of Mazu is a common folk belief in China and Vietnam.Originating from the Song and Yuan Dynasties,particularly during the Ming and Qing Dynasties,the cult of Mazu spread to Vietnam through maritime trade and migration from coastal regions of China.After centuries of integration and development,it evolved into its own cultural system of Mazu worship,becoming an important component of Vietnamese folk culture.Hainan,China,as a crucial supply station on the Maritime Silk Road,has close connections with the transmission of Mazu culture to Vietnam.This paper adopts field investigations and literature research methods to explore the Mazu worship and culture in Hainan,China,and the Qiongfu Assembly Halls in Vietnam.展开更多
Recently,American talent shows with its unique glamour and huge profit have attracted many Chinese TV stations to imitate.The process of imitation is essentially a collision of American and Chinese cultures.This study...Recently,American talent shows with its unique glamour and huge profit have attracted many Chinese TV stations to imitate.The process of imitation is essentially a collision of American and Chinese cultures.This study focuses on American Idol and Super Girls,discusses their different manifestations of individualism and analyzes the reasons behind it.The analysis shows that the differences of the two countries'cultural background contribute to the different manifestations of individualism.In a word,during the process of imitating American talent shows,the problems of Chinese talent shows indicate that American individualism has its positive as well as negative effects.Consequently,Chinese people should hold a critical attitude toward American individualism.展开更多
基金sponsored by the 2021 Research Project of Hainan Research Center for Applied Foreign Languages(HNWYJD21-05)by the Scientific Research Project of Hainan Higher Education Institutions(Hnky2023-20).
文摘Hoi An Ancient Town in Vietnam is not only a UNESCO(United Nations Educational,Scientific,and Cultural Organization)World Heritage Site but also a convergence point of traditional and modern cultures.Throughout its historical transitions,the cultural heritage of Hoi An Ancient Town has been well preserved and developed,and the worship of Mazu,an essential component of Hoi An’s culture,is no exception.As far as is known,Hoi An in central Vietnam houses the most Mazu temples,including the Chung Wah Hall,the Guangzhou Assembly Hall,the Fujian Assembly Hall,the Teochew Assembly Hall,and the Hainan Assembly Hall,among others,with the Fujian Assembly Hall being the most vibrant center of Mazu worship.This study employs field surveys and literature research to explore the Mazu worship practices at the Fujian Assembly Hall in Hoi An,Quang Nam Province,Vietnam.
文摘肝脏的低密度脂蛋白受体(LDLR)是清除血浆低密度脂蛋白(LDL)的主要途径,并且是一个非常重要的心血管系统疾病的治疗靶点。LDLR的表达量受到转录和转录后两方面的调控。这里介绍一种新近发现的、通过泛素化作用经转录后途径调控LDLR的蛋白Idol(inducible degrader of the LDLR)。Idol是一个肝脏X受体(LXR)的靶分子,具有E3泛素连接酶活性,可以介导LDLR的泛素化,并在溶酶体降解。Idol还有另外两个LDLR家族的靶蛋白VLDLR和ApoER2。尽管Idol和前蛋白转化酶枯草溶菌素9(PCSK9)存在着很多相似之处,但它们在调控LDLR的途径上是不同的。最近的工作显示Idol与人类的LDL水平有关,Idol可能在人类的血脂代谢有重要作用。
文摘[目的]综述新近发现的IDOL蛋白(Inducibledegrader of the low-density lipoprotein receptor)对低密度脂蛋白受体(low-densitylipoprotein receptor,LDLR)调节作用及肝X受体(LXR)-IDOL-LDLR轴在脂代谢平衡稳态中作用的研究进展。[方法]查阅近年来国内外研究IDOL及LXRIDOL通路的相关文献,并归纳总结其在脂代谢中的作用。[结果]IDOL能在转录后水平介导LDLR及其家族其他成员(VLDLR、ApoER2)的泛素化降解,该作用独立于固醇调节元件结合蛋白(SREBP)途径且受LXR的调节。[结论]LXR-IDOL通路能通过IDOL依赖途径泛素化降解LDLR,调节LDLR水平及LDL摄取,从而在脂代谢平衡中发挥重要作用。LXR-IDOL-LDLR轴可能为脂质代谢紊乱及心血管疾病提供新的潜在治疗靶点。
文摘目的探讨人类诱导型低密度脂蛋白受体降解蛋白(IDOL)基因多态性与成年人肥胖的相关性。方法采用病例对照研究,选择2013年8月—2019年10月期间因心血管疾病在新疆医科大学第一附属医院心脏中心住院治疗的患者1172例,根据肥胖诊断标准分为肥胖组(n=572)和对照组(n=600),采用改进的多重连接检测反应(iMLDR)方法对诱导型低密度脂蛋白受体降解蛋白IDOL基因rs2072783、rs9370867和rs9370867位点进行基因型分型。结果诱导型低密度脂蛋白受体降解蛋白IDOL基因SNP1(rs2072783)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、隐形模型(GG vs AG+AA)的分布频率存在统计学差异。SNP2(rs9370867)在肥胖组及对照组中基因型分布频率、等位基因频率、显性模型(AA vs AG+GG)、相加模型(AG vs AA+GG)的分布频率存在统计学差异(P<0.05)。校正混杂因素后,rs2072783位点的隐形模型(GG vs AA+AG)和rs9370867位点的相加模型(AG vs AA+GG)为肥胖患者的危险因素[(rs2072783:OR=1.482,P=0.032,95%CI:1.034-2.121);(rs9370867:OR=1.849,P=0.032,95%CI:1.034-2.121)]。结论诱导型低密度脂蛋白受体降解蛋白IDOL基因多态性与成年人肥胖患病具有相关性。IDOL基因rs9370867和rs2072783位点G等位基因的人群比携带A等位基因的人罹患肥胖的可能性更高,诱导型低密度脂蛋白受体降解蛋白IDOL基因rs9370867位点AG基因型及rs2072783位点的GG基因型是肥胖的易感因素。
基金sponsored by the 2021 Research Project of Hainan Research Center for Applied Foreign Languages(HNWYJD21-05)by the Scientific Research Project of Hainan Higher Education Institutions(Hnky2023-20).
文摘The cult of Mazu is a common folk belief in China and Vietnam.Originating from the Song and Yuan Dynasties,particularly during the Ming and Qing Dynasties,the cult of Mazu spread to Vietnam through maritime trade and migration from coastal regions of China.After centuries of integration and development,it evolved into its own cultural system of Mazu worship,becoming an important component of Vietnamese folk culture.Hainan,China,as a crucial supply station on the Maritime Silk Road,has close connections with the transmission of Mazu culture to Vietnam.This paper adopts field investigations and literature research methods to explore the Mazu worship and culture in Hainan,China,and the Qiongfu Assembly Halls in Vietnam.
文摘Recently,American talent shows with its unique glamour and huge profit have attracted many Chinese TV stations to imitate.The process of imitation is essentially a collision of American and Chinese cultures.This study focuses on American Idol and Super Girls,discusses their different manifestations of individualism and analyzes the reasons behind it.The analysis shows that the differences of the two countries'cultural background contribute to the different manifestations of individualism.In a word,during the process of imitating American talent shows,the problems of Chinese talent shows indicate that American individualism has its positive as well as negative effects.Consequently,Chinese people should hold a critical attitude toward American individualism.
