Objective:To study the effect of immune-enhancing enteral nutrition application before radical resection of rectal carcinoma on postoperative immune response level and trauma endurance capacity.Methods:A total of 94 p...Objective:To study the effect of immune-enhancing enteral nutrition application before radical resection of rectal carcinoma on postoperative immune response level and trauma endurance capacity.Methods:A total of 94 patients who received radical resection of rectal carcinoma in our hospital between May 2013 and October 2015 were selected and randomly divided into EN group and control group, the EN group received preoperative immune-enhancing enteral nutrition preparations, and the control group received routine preoperative nutrition intervention. The same day after operation, peripheral blood mononuclear cells were collected to determine CD69 and HLA-DR levels, and serum was collected to determine the levels of IgM, IgG, inflammatory response indexes and stress response indexes.Results:CD69 and HLA-DR levels in peripheral blood mononuclear cells as well as IgM, IgG, TP, ALB, PA and TF levels in serum of EN group were significantly higher than those of control group, and serum CRP, YKL-40, IL-1β, TNF-α, IL-6, HSP70, ACTH, Cor and HO-1 levels of EN group were significantly lower than those of control group.Conclusion:Immune-enhancing enteral nutrition application before radical resection of rectal carcinoma can improve the immune function and nutritional status, strengthen trauma endurance capacity and relieve postoperative inflammatory response and stress response.展开更多
Objective:To investigate the effect of immune-enhanced enteral nutrition on inflammatory response and immune function in elderly patients with severe septic shock.Methods:From September 2016 to October 2018,58 cases o...Objective:To investigate the effect of immune-enhanced enteral nutrition on inflammatory response and immune function in elderly patients with severe septic shock.Methods:From September 2016 to October 2018,58 cases of serious septic shock patients treated in our hospital,were randomly assigned to two groups.A group-enteral nutrition emulsion group(n=29);B group-enteral nutrition mixed suspension group(n=29);The admission day,one week,two week after admission,the index data of patients',inflammation and immune were collected.Results:With the increase of admission time,CD4 and CD4/CD8 levels in the two groups were gradually increased and CD8 levels were gradually decreased.At 1 and 2 weeks after admission,CD4 and CD4/CD8 levels in the observation group were higher than those in the control group(P<0.05),and CD8 levels were lower than those in the control group(P<0.05).Each immunoglobulin index of subjects in both groups increased with the increase of admission time.The IgG and IgM levels of subjects in the observation group were higher than those in the control group(P<0.05).IgA levels of subjects in the observation group were higher than those in the control group at 1 and 2 weeks after admission(P<0.05).With the increase of admission time,the c-reactive protein concentration of subjects in the two groups decreased gradually(P<0.05).One week after admission,there was no significant difference in c-reactive protein between the observation group and the control group(P>0.05).C-reactive protein of subjects in the observation group was higher than that in the control group at 2 weeks after admission(P<0.05).With the increase of admission time,the concentration of plasma diamine oxidase(DAO)in the two groups decreased gradually,and the DAO at different time points in each group showed statistical difference(P<0.05).1 week after admission,there was no significant difference in DAO between the observation group and the control group(P>0.05).At 2 weeks after admission,the DAO of subjects in the observation group was higher than that in the control group(P<0.05).Conclusions:Immune-enhancing enteral nutrition is more helpful to control the inflammatory response in patients of serious septic shock,and it's also can modulate the immune function.展开更多
The objective of this study is to investigate the immune-enhancing ability of viable and heat-killed Weissella cibaria JW15(JW15)isolated from Kimchi in RAW 264.7 macrophages.The immune effects were evaluated by measu...The objective of this study is to investigate the immune-enhancing ability of viable and heat-killed Weissella cibaria JW15(JW15)isolated from Kimchi in RAW 264.7 macrophages.The immune effects were evaluated by measuring the production of NO,cytokines,inflammatory enzyme,and activation of NF-κB.Viable JW15 executed higher activity on stimulating the release of TNF-αas well as activating NF-κB compared to that of heatkilled JW15.Additionally,viable and heat-killed JW15 significantly increased the production of NO,IL-6 and TNF-αmore than that of Lactobacillus rhamnosus GG(LGG).Furthermore,viable JW15 induced higher production of i NOS compared with that of viable LGG.Collectively,our finding indicates that viable JW15 had similar,if not more,immune-enhancing activities as heat-killed JW15.In addition,viable JW15 had higher immune-enhancing activity than commercial strain LGG.Therefore,viable JW15 has the potential to be used as a functional food to improve the host immune response.展开更多
Objective The aim of this study was to investigate changes in nutritional status and related indexes in patients with Nutritional Risk Score(NRS)≥3 gastric cancer after nutritional support treatment.Methods A total o...Objective The aim of this study was to investigate changes in nutritional status and related indexes in patients with Nutritional Risk Score(NRS)≥3 gastric cancer after nutritional support treatment.Methods A total of 50 patients with gastric cancer were divided into two groups according to the different nutritional support treatment they received during postoperative chemotherapy:immune-enhanced enteral nutrition group(n=25)and conventional enteral nutrition group(n=25).Changes in patient’body mass index(BMI),hemoglobin(HB),serum total protein(TP),serum albumin(ALB),and immune indexes(CD3+,CD4+/CD8+,CD3+/CD8+)were monitored before and after chemotherapy.At the same time,the incidence and classification of gastrointestinal adverse reactions after chemotherapy were assessed.Results Compared with the conventional enteral nutrition group,the nutritional and immune indexes in the immune-enhanced enteral nutrition group were significantly improved.After chemotherapy,the incidence of adverse reactions in the digestive tract was relatively lower and the grade was reduced.Conclusion Immune-enhanced enteral nutrition support can significantly improve the nutritional status of patients,improve immune function,increase the susceptibility of cancer patients to chemotherapy,reduce toxicity and adverse effects,and improve the quality of life of tumor patients compared with conventional enteral nutrition support.展开更多
文摘Objective:To study the effect of immune-enhancing enteral nutrition application before radical resection of rectal carcinoma on postoperative immune response level and trauma endurance capacity.Methods:A total of 94 patients who received radical resection of rectal carcinoma in our hospital between May 2013 and October 2015 were selected and randomly divided into EN group and control group, the EN group received preoperative immune-enhancing enteral nutrition preparations, and the control group received routine preoperative nutrition intervention. The same day after operation, peripheral blood mononuclear cells were collected to determine CD69 and HLA-DR levels, and serum was collected to determine the levels of IgM, IgG, inflammatory response indexes and stress response indexes.Results:CD69 and HLA-DR levels in peripheral blood mononuclear cells as well as IgM, IgG, TP, ALB, PA and TF levels in serum of EN group were significantly higher than those of control group, and serum CRP, YKL-40, IL-1β, TNF-α, IL-6, HSP70, ACTH, Cor and HO-1 levels of EN group were significantly lower than those of control group.Conclusion:Immune-enhancing enteral nutrition application before radical resection of rectal carcinoma can improve the immune function and nutritional status, strengthen trauma endurance capacity and relieve postoperative inflammatory response and stress response.
基金Wuhan health and family planning commission research project(No.WZ17B04).
文摘Objective:To investigate the effect of immune-enhanced enteral nutrition on inflammatory response and immune function in elderly patients with severe septic shock.Methods:From September 2016 to October 2018,58 cases of serious septic shock patients treated in our hospital,were randomly assigned to two groups.A group-enteral nutrition emulsion group(n=29);B group-enteral nutrition mixed suspension group(n=29);The admission day,one week,two week after admission,the index data of patients',inflammation and immune were collected.Results:With the increase of admission time,CD4 and CD4/CD8 levels in the two groups were gradually increased and CD8 levels were gradually decreased.At 1 and 2 weeks after admission,CD4 and CD4/CD8 levels in the observation group were higher than those in the control group(P<0.05),and CD8 levels were lower than those in the control group(P<0.05).Each immunoglobulin index of subjects in both groups increased with the increase of admission time.The IgG and IgM levels of subjects in the observation group were higher than those in the control group(P<0.05).IgA levels of subjects in the observation group were higher than those in the control group at 1 and 2 weeks after admission(P<0.05).With the increase of admission time,the c-reactive protein concentration of subjects in the two groups decreased gradually(P<0.05).One week after admission,there was no significant difference in c-reactive protein between the observation group and the control group(P>0.05).C-reactive protein of subjects in the observation group was higher than that in the control group at 2 weeks after admission(P<0.05).With the increase of admission time,the concentration of plasma diamine oxidase(DAO)in the two groups decreased gradually,and the DAO at different time points in each group showed statistical difference(P<0.05).1 week after admission,there was no significant difference in DAO between the observation group and the control group(P>0.05).At 2 weeks after admission,the DAO of subjects in the observation group was higher than that in the control group(P<0.05).Conclusions:Immune-enhancing enteral nutrition is more helpful to control the inflammatory response in patients of serious septic shock,and it's also can modulate the immune function.
基金support of"Cooperative Research Program for Agriculture Science&Technology Development(Project No.PJ01283407)"Rural Development Administration,Republic of Koreasupported by Post-Doctoral Fellowship Program funded by the Ministry of Education of the Republic of Korea through the Chungbuk National University in 2019。
文摘The objective of this study is to investigate the immune-enhancing ability of viable and heat-killed Weissella cibaria JW15(JW15)isolated from Kimchi in RAW 264.7 macrophages.The immune effects were evaluated by measuring the production of NO,cytokines,inflammatory enzyme,and activation of NF-κB.Viable JW15 executed higher activity on stimulating the release of TNF-αas well as activating NF-κB compared to that of heatkilled JW15.Additionally,viable and heat-killed JW15 significantly increased the production of NO,IL-6 and TNF-αmore than that of Lactobacillus rhamnosus GG(LGG).Furthermore,viable JW15 induced higher production of i NOS compared with that of viable LGG.Collectively,our finding indicates that viable JW15 had similar,if not more,immune-enhancing activities as heat-killed JW15.In addition,viable JW15 had higher immune-enhancing activity than commercial strain LGG.Therefore,viable JW15 has the potential to be used as a functional food to improve the host immune response.
文摘Objective The aim of this study was to investigate changes in nutritional status and related indexes in patients with Nutritional Risk Score(NRS)≥3 gastric cancer after nutritional support treatment.Methods A total of 50 patients with gastric cancer were divided into two groups according to the different nutritional support treatment they received during postoperative chemotherapy:immune-enhanced enteral nutrition group(n=25)and conventional enteral nutrition group(n=25).Changes in patient’body mass index(BMI),hemoglobin(HB),serum total protein(TP),serum albumin(ALB),and immune indexes(CD3+,CD4+/CD8+,CD3+/CD8+)were monitored before and after chemotherapy.At the same time,the incidence and classification of gastrointestinal adverse reactions after chemotherapy were assessed.Results Compared with the conventional enteral nutrition group,the nutritional and immune indexes in the immune-enhanced enteral nutrition group were significantly improved.After chemotherapy,the incidence of adverse reactions in the digestive tract was relatively lower and the grade was reduced.Conclusion Immune-enhanced enteral nutrition support can significantly improve the nutritional status of patients,improve immune function,increase the susceptibility of cancer patients to chemotherapy,reduce toxicity and adverse effects,and improve the quality of life of tumor patients compared with conventional enteral nutrition support.
