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Timing impact on the initiation of pirfenidone therapy on idiopathic pulmonary fibrosis disease progression
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作者 Basma M E Mohamed Mohamed E A Abdelrahim 《World Journal of Clinical Cases》 SCIE 2024年第32期6538-6542,共5页
In this editorial,we comment on the article by Lei et al,with a specific focus on the timing of the initiation of the antifibrotic agent pirfenidone(PFD)in the management of idiopathic pulmonary fibrosis(IPF)and its i... In this editorial,we comment on the article by Lei et al,with a specific focus on the timing of the initiation of the antifibrotic agent pirfenidone(PFD)in the management of idiopathic pulmonary fibrosis(IPF)and its impact on lung function of IPF patients.PFD is an antifibrotic agent that is widely used in the management of IPF in both early and advanced stages.It inhibits various pathways and has antifibrotic,anti-inflammatory,and antioxidant properties.Despite dosage lowering,PFD slowed IPF progression and maintained functional capacity.The 6-min walk distance test indicated that patients tolerated adverse events well,and PFD significantly reduced the incidence of progression episodes and death.Even when a single disease-progression event occurred,continuing PFD treatment had benefits. 展开更多
关键词 Idiopathic pulmonary fibrosis Pirfenidone Pirfenidone anti-inflammatory mechanism Pirfenidone antifibrotic activity Timing impact
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Impact factors and citation times of Chinese scientific journals covered by ISI JCR(2000-2003)
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《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第13期F003-F003,共1页
关键词 impact factors and citation times of Chinese scientific journals covered by ISI JCR 2003 ISI
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Missile guidance law design based on free-time convergent error dynamics
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作者 LIU Yuanhe XIE Nianhao +1 位作者 LI Kebo LIANG Yan’gang 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第5期1315-1325,共11页
To solve the finite-time error-tracking problem in mis-sile guidance,this paper presents a unified design approach through error dynamics and free-time convergence theory.The proposed approach is initiated by establis... To solve the finite-time error-tracking problem in mis-sile guidance,this paper presents a unified design approach through error dynamics and free-time convergence theory.The proposed approach is initiated by establishing a desired model for free-time convergent error dynamics,characterized by its independence from initial conditions and guidance parameters,and adjustable convergence time.This foundation facilitates the derivation of specific guidance laws that integrate constraints such as leading angle,impact angle,and impact time.The theoretical framework of this study elucidates the nuances and synergies between the proposed guidance laws and existing methodologies.Empirical evaluations through simulation comparisons underscore the enhanced accuracy and adaptability of the proposed laws. 展开更多
关键词 guidance design free-time convergence error dynamics approach impact angle constraint impact time constraint
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Sliding mode control and Lyapunov based guidance law with impact time constraints 被引量:5
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作者 Xiaojian Zhang Mingyong Liu Yang Li 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第6期1186-1192,共7页
This paper analyses the issue of impact time control of super-cavitation weapons impact fixed targets which mainly refer to the ships or submarines who lost power, but still have combat capability. Control over impact... This paper analyses the issue of impact time control of super-cavitation weapons impact fixed targets which mainly refer to the ships or submarines who lost power, but still have combat capability. Control over impact time constraints of guidance law(ITCG) is derived by using sliding mode control(SMC) and Lyapunov stability theorem. The expected impact time is realized by using the notion of attack process and estimated time-to-go to design sliding mode surface(SMS). ITCG contains equivalent and discontinuous guidance laws, once state variables arrive at SMS,the equivalent guidance law keeps the state variables on SMS,then the discontinuous guidance law enforces state variables to move and reach SMS. The singularity problem of ITCG is also analyzed. Theoretical analysis and numerical simulation results are given to test the effectiveness of ITCG designed in this paper. 展开更多
关键词 Lyapunov stability sliding mode control impact time salvo attack TIME-TO-GO guidance law
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A hybrid proportional navigation based two-stage impact time control guidance law 被引量:1
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作者 HUANG Jia CHANG Sijiang CHEN Shengfu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2022年第2期461-473,共13页
To improve applicability and adaptability of the impact time control guidance(ITCG) in practical engineering, a twostage ITCG law with simple but effective structure is proposed based on the hybrid proportional naviga... To improve applicability and adaptability of the impact time control guidance(ITCG) in practical engineering, a twostage ITCG law with simple but effective structure is proposed based on the hybrid proportional navigation, namely, the pureproportional-navigation and the retro-proportional-navigation.For the case with the impact time error less than zero, the first stage of the guided trajectory is driven by the retro-proportionalnavigation and the second one is driven by the pure-proportionalnavigation. When the impact time error is greater than zero, both of the stages are generated by the pure-proportional-navigation but using different navigation gains. It is demonstrated by twoand three-dimensional numerical simulations that the proposed guidance law at least has comparable results to existing proportional-navigation-based ITCG laws and is shown to be advantageous in certain circumstances in that the proposed guidance law alleviates its dependence on the time-to-go estimation, consumes less control energy, and adapts itself to more boundary conditions and constraints. The results of this research are expected to be supplementary to the current research literature. 展开更多
关键词 missile guidance law impact time control pure-proportional-navigation retro-proportional-navigation time-to-go estimation
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Analysing Delay Impact from Potential Risk Factors on Project Delivery of Oil and Gas Pipeline:A Case Study in IRAQ
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作者 LAYTH KRAIDI RAJ SHAH +1 位作者 WILFRED MATIPA FIONA BORTHWICK 《Journal of Construction Research》 2020年第2期42-55,共14页
The aim of this paper is to present the design and specifications of an integrated Delay Analysis Framework(DAF),which could be used to quantify the delay caused by the Risk Factors(RFs)in Oil and Gas Pipelines(OGPs)p... The aim of this paper is to present the design and specifications of an integrated Delay Analysis Framework(DAF),which could be used to quantify the delay caused by the Risk Factors(RFs)in Oil and Gas Pipelines(OGPs)projects in a simple and systematic way.The main inputs of the DAF are(i)the potential list of RFs in the projects and their impact levels on the projects and the estimated maximum and minimum duration of each task.Monte Carlo Simulation integrated within@Risk simulator was the key process algorithm that used to quantify the impact of delay caused by the associated RFs.The key output of the DAF is the amount of potential delay caused by RFs in the OGP project.The functionalities of the developed DAF were evaluated using a case study of newly developed OGP project,in the south of Iraq.It is found that the case study project might have delayed by 45 days if neglected the consideration of the RFs associated with the project at the construction stage.The paper concludes that identifying the associated RFs and analysing the potential delay in advance will help in reducing the construction delay and improving the effectiveness of the project delivery by taking suitable risk mitigation measures. 展开更多
关键词 Oil and gas pipelines Risk factors Risk analyses Delay analysis framework @Risk Monte carlo simulation Construction delay Time impact
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The impacts of timing and insecticides at early stage of late rice on the population development of brown plant hopper(BPH)
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作者 CHENG Jia’an,ZHU Zengrong,and LOU Tonggen,Dept of Plant Protection and Inst of Applied Entamology,Zhejiang Agri Univ,Hangzhou 310006,China 《Chinese Rice Research Newsletter》 1995年第3期5-6,共2页
Field experiments were carried out in northern Zhejiang Province. Three insecticides (methamidophos,Shachongshuang and triazophos) were used to control the rice leaffolder Cnaphalocrocis medinalis and rice striped ste... Field experiments were carried out in northern Zhejiang Province. Three insecticides (methamidophos,Shachongshuang and triazophos) were used to control the rice leaffolder Cnaphalocrocis medinalis and rice striped stemborer Chilo suppressalis in rice fields during 18—27 days after transplantating. The impacts of timing and insecticides on the population development of brown planthopper Nilaparavata lugens was surveyed by direct counting on the plants or by tapping method. 展开更多
关键词 gene BPH The impacts of timing and insecticides at early stage of late rice on the population development of brown plant hopper
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The impact of operative timing on clinical outcomes in elderly hip fracture
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作者 王晓伟 《外科研究与新技术》 2011年第2期117-118,共2页
Objective To study the effect of operative timing on clinical outcomes in elderly hip fracture.Methods Two hundred sixty-seven patients with hip fracture were treated from July 2006 to May 2008.The patients who had an... Objective To study the effect of operative timing on clinical outcomes in elderly hip fracture.Methods Two hundred sixty-seven patients with hip fracture were treated from July 2006 to May 2008.The patients who had an operation within 展开更多
关键词 The impact of operative timing on clinical outcomes in elderly hip fracture
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Impact time control guidance against maneuvering targets based on a nonlinear virtual relative model 被引量:2
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作者 Yuru BIN Hui WANG +2 位作者 Defu LIN Yaning WANG Xin SUN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第7期444-459,共16页
Aiming at the problem of high-precision interception of air-maneuvering targets with impact time constraints,this paper proposes a novel guidance law based on a nonlinear virtual relative model in which the origin is ... Aiming at the problem of high-precision interception of air-maneuvering targets with impact time constraints,this paper proposes a novel guidance law based on a nonlinear virtual relative model in which the origin is attached to the target.In this way,the original maneuvering target is transformed into a stationary one.A polynomial function of the guidance command in the range domain with two unknown coefficients is introduced into the virtual model,one of the coefficients is determined to achieve the impact time constraint,and the other is determined to satisfy a newly defined virtual look angle constraint.For meeting the terminal constraints simultaneously,the guidance command can finally be obtained.The resulting solution is represented as a combination of proportional navigation guidance-like term which is aimed to meet the zero miss distance constraint,a bias term for impact time control by adjusting the length of the homing trajectory,and an additional term for target maneuvers.Numerous simulations demonstrate that the proposed law achieves an acceptable impact time error for various initial conditions against different types of maneuvering targets and shows more effective performance in comparison with those of other existing guidance laws. 展开更多
关键词 impact time control Maneuvering targets Polynomial guidance Virtual relative model Virtual look angle constraint
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Multiple-stage spatial-temporal cooperative guidance without time-to-go estimation
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作者 Chunyan WANG Weilin WANG +2 位作者 Wei DONG Jianan WANG Fang DENG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第9期399-416,共18页
This paper investigates the spatial-temporal cooperative guidance problem for multiple flight vehicles without relying on time-to-go information.First,a two-stage cooperative guidance strategy,namely the cooperative g... This paper investigates the spatial-temporal cooperative guidance problem for multiple flight vehicles without relying on time-to-go information.First,a two-stage cooperative guidance strategy,namely the cooperative guidance and the Proportional Navigation Guidance(PNG)stage strategy,is developed to realize the spatial-temporal constraints in two dimensions.At the former stage,two controllers are designed and superimposed to satisfy both impact time consensus and impact angle constraints.Once the convergent conditions are satisfied,the flight vehicles will switch to the PNG stage to ensure zero miss distance.To further extend the results to three dimensions,a planar pursuit guidance stage is additionally imposed at the beginning of guidance.Due to the inde-pendence of time-to-go estimation,the proposed guidance strategy possesses great performance in satisfying complex spatial-temporal constraints even under flight speed variation.Finally,several numerical simulations are implemented to verify the effectiveness and advantages of the proposed results under different scenarios. 展开更多
关键词 Cooperative guidance Guided missiles impact time consensus impact angle constraint Spatial-temporal cooperative guidance
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Optimal three-dimensional impact time guidance with seeker’s field-of-view constraint 被引量:13
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作者 Shaoming HE Chang-Hun LEE +1 位作者 Hyo-Sang SHIN Antonios TSOURDOS 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2021年第2期240-251,共12页
This paper proposes a new three-dimensional optimal guidance law for impact time control with seeker’s Field-of-View(FOV) constraint to intercept a stationary target. The proposed guidance law is devised in conjuncti... This paper proposes a new three-dimensional optimal guidance law for impact time control with seeker’s Field-of-View(FOV) constraint to intercept a stationary target. The proposed guidance law is devised in conjunction with the concept of biased Proportional Navigation Guidance(PNG). The guidance law developed leverages a nonlinear function to ensure the boundedness of velocity lead angle to cater to the seeker’s FOV limit. It is proven that the impact time error is nullified in a finite-time under the proposed method. Additionally, the optimality of the biased command is theoretically analyzed. Numerical simulations confirm the superiority of the proposed method and validate the analytic findings. 展开更多
关键词 Applied optimal control Field-of-view constraint impact time control Missile guidance Optimal error dynamics
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Impact time control using biased proportional navigation for missiles with varying velocity 被引量:12
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作者 Guoxin SUN Qiuqiu WEN +1 位作者 Zhiqiang XU Qunli XIA 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第3期956-964,共9页
A feasible guidance scheme with impact time constraint is proposed for attacking a stationary target by missiles with time-varying velocity.The main idea is to replace the constant velocity with the future mean veloci... A feasible guidance scheme with impact time constraint is proposed for attacking a stationary target by missiles with time-varying velocity.The main idea is to replace the constant velocity with the future mean velocity;therefore, the existing time-to-go estimation algorithm of the proportional navigation guidance law can be improved to adapt to varying conditions.In order to obtain the prediction of the velocity profile, the velocity differential equation to the downrange is derived, which can be numerically integrated between the current downrange and the target position by the on-board computer.Then, a third-order polynomial is introduced to fit the velocity profile in order to calculate the future mean velocity.At the beginning of each guidance loop, the future mean velocity is predicted and the time-to-go information is updated, based on which a novel biased proportional navigation guidance law is established to achieve the impact time constraint.Finally,numerical simulation results verified the effectiveness of the time-to-go estimation algorithm and the proposed law. 展开更多
关键词 GUIDANCE Homing missiles impact time Proportional navigation guidance Time-varying velocity
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Trajectory reshaping based guidance with impact time and angle constraints 被引量:8
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作者 Zhao Yao Sheng Yongzhi Liu Xiangdong 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2016年第4期984-994,共11页
This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical ... This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile's capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. 展开更多
关键词 GUIDANCE Homing missiles impact angle impact time Trajectory reshaping
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Two-phase guidance law for impact time control under physical constraints 被引量:7
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作者 Yang TANG Xiaoping ZHU +1 位作者 Zhou ZHOU Fei YAN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第11期2946-2958,共13页
An impact-time-control guidance law is required for the simultaneous attack of suicide attack unmanned aerial vehicles.Based on the nonlinear model,a two-phase guidance strategy is proposed.The impact time is derived ... An impact-time-control guidance law is required for the simultaneous attack of suicide attack unmanned aerial vehicles.Based on the nonlinear model,a two-phase guidance strategy is proposed.The impact time is derived in a simple analytical form of initial states and switching states,and it can be controlled by switching at an appropriate range.Firstly,a two-phase guidance law is designed to make the magnitude of the heading error decrease monotonically from its initial value to zero.And then,the feasible interval of the switching ranges and of the impact times under the acceleration constraint are given analytically in sequence.Furthermore,a general form of twophase guidance law is proposed,which allows the magnitude of the heading error to increase in the first phase,to improve the applicability of the methodology.Having the same structure as proportional navigation guidance with a time-varying gain,the proposed algorithms are simple and easy to implement.The corresponding feedback form is presented for realistic implementation.When a predefined impact time is taken within its permissible set,the constraints on the acceleration and fieldof-view will not be violated during the interception.Finally,simulations validate the effectiveness of the methodology in impact time control and salvo attack. 展开更多
关键词 Acceleration constraint Field-of-view constraint GUIDANCE impact time control Switching
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Leader-following cooperative guidance law with specified impact time 被引量:5
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作者 LI GuoFei LI Qing +2 位作者 WU YunJie XU PengYa LIU JianWei 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2020年第11期2349-2356,共8页
The problem of guidance law is investigated for multiple interceptors to attack a target cooperatively.A leader-following cooperative guidance strategy is presented to render the leader and the followers reach the tar... The problem of guidance law is investigated for multiple interceptors to attack a target cooperatively.A leader-following cooperative guidance strategy is presented to render the leader and the followers reach the target at specified impact time.The guidance law of leader is given to meet the demand of specified impact time.The arrival time is synchronized by enforcing the ranges-to-go of followers keep consensus with that of leader.The convergence time bound is estimated without dependence on the initial states,since the proposed leader-following cooperative guidance law is fixed-time convergent.The simulation is developed to validate the availability of proposed cooperative guidance law. 展开更多
关键词 cooperative guidance leader-following specified impact time fixed-time convergence
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Guidance law with impact time and impact angle constraints 被引量:54
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作者 Zhang Youan Ma Guoxin Liu Aili 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2013年第4期960-966,共7页
A novel closed-form guidance law with impact time and impact angle constraints is pro- posed for salvo attack of anti-ship missiles, which employs missile's normal acceleration (not jerk) as the control command dir... A novel closed-form guidance law with impact time and impact angle constraints is pro- posed for salvo attack of anti-ship missiles, which employs missile's normal acceleration (not jerk) as the control command directly. Firstly, the impact time control problem is formulated as tracking the designated time-to-go (the difference between the designated impact time and the current flight time) for the actual time-to-go of missile, and the impact angle control problem is formulated as tracking the designated heading angle for the actual heading angle of missile. Secondly, a biased proportional navigation guidance (BPNG) law with designated heading angle constraint is constructed, and the actual time-to-go estimation for this BPNG is derived analytically by solving the system differential equations. Thirdly, by adding a feedback control to this constructed BPNG to eliminate the time-to-go errorthe difference between the standard time-to-go and the actual time-to-go, a guidance law with adjustable coefficients to control the impact time and impact angle simultaneously is developed. Finally, simulation results demonstrate the performance and feasibility of the proposed approach. 展开更多
关键词 Feedback control Guidance law impact angle impact time Missiles Proportional navigation guidance
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Impact Angle/Time Constraint Guidance Design Based on Fast Terminal Error Dynamics
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作者 QIN XUESHENG LIU YUANHE +1 位作者 LI KEBO LIANG YANGANG 《Journal of Shanghai Jiaotong university(Science)》 EI 2022年第6期823-832,共10页
Considering the problem that the optimal error dynamics can only converge at the terminal time,an impact angle/time constraint missile guidance law with finite-time convergence is designed in this paper,which is based... Considering the problem that the optimal error dynamics can only converge at the terminal time,an impact angle/time constraint missile guidance law with finite-time convergence is designed in this paper,which is based on the pure proportional navigation(PPN)guidance law and the fast terminal error dynamics(FTED)approach.The missile guidance model and FTED equation are given first,and the dynamic equation of impact angle/time error based on PPN is also derived.Then,the guidance law is designed based on FTED,and the guidance error can converge to 0 in a finite time.Furthermore,considering the field of view constraint,the guidance law is improved by using the saturation function mapping method.Finally,a numerical simulation example is given to verify the effectiveness of the guidance law,which shows that the guidance law proposed in this paper can make the missile quickly adjust to the desired states in advance,and effectively relieve the overload saturation pressure of the actuator. 展开更多
关键词 design of guidance law fast terminal error dynamics field-of-view angle impact time impact angle
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Improved Fixed-Time Convergence Guidance Scheme Design and Its Application to Missile
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作者 Lei Cui Kang Zhang +3 位作者 Xijing Hu Zhe Li Jianying Yang Nan Jin 《Guidance, Navigation and Control》 2023年第4期85-110,共26页
This study presents a fixed-time convergence guidance scheme for impact time and angle control.First,two improved fixed-time stable systems are presented,which have smaller initial control command and better terminal ... This study presents a fixed-time convergence guidance scheme for impact time and angle control.First,two improved fixed-time stable systems are presented,which have smaller initial control command and better terminal convergence.16 An improved fixed-time extended state observer is proposed to provide accurate estimation of system states and disturbance,which effectively solves peaking value problem.Furthermore,an improved fixed-time sliding mode controller is derived,which avoids the singular problem and achieves faster convergence rate with smaller initial control command.Second,a new guidance scheme with impact angle and impact time constraints is proposed for intercepting a stationary target.By introducing a virtual target,the guidance process is divided into two stages.The proposed fixed-time controller is employed in the first stage.The method with a virtual leader ensures that the missile intercept the virtual target with desired line-of-sight angles at a specific time.By using the proportional navigation guidance law,the missile keeps travelling with desired flight-path angles to hit the real target in the second stage,17 so as to achieve the impact time and angle control.Finally,the feasibility and effectiveness of the proposed guidance scheme in different engagement scenarios are verified by numerical simulations with comparisons. 展开更多
关键词 Fixed-time stable sliding mode control extended state observer guidance scheme impact time and angle control
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Microstructure Evolution and Microhardness of Ultrafine-grained High Carbon Steel during Multiple Laser Shock Processing 被引量:2
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作者 Yi XIONG Tian-tian HE +3 位作者 Feng-zhang REN Peng-yan LI Lu-fei CHEN Alex A.VOLINSKY 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2015年第1期55-59,共5页
Surface microstructure and microhardness of (ferrite+ cementite) microduplex structure of the ultrafine- grained high carbon steel after laser shock processing (LSP) with different impact times were investigated ... Surface microstructure and microhardness of (ferrite+ cementite) microduplex structure of the ultrafine- grained high carbon steel after laser shock processing (LSP) with different impact times were investigated by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and microhardness measurements. Equiaxed ferrite grains were refined from 400 to 150 nm, and the cementite lamellae were fully spheroidized, with a decrease of the particle diameter from 150 to 100 nm as the impact times increased. The cementite dissolution was enhanced significantly. Correspondingly, the lattice parameter of α-Fe and microhard- hess increased with the impact times. 展开更多
关键词 ultrafine-grained high carbon steel laser shock processing impact times MICROSTRUCTURE MICROHARDNESS
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Cooperative Guidance for Multimissile Salvo Attack 被引量:78
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作者 Zhao Shiyu Zhou Rui 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第6期533-539,共7页
Cooperative guidance problems of multiple missiles are considered in this article. A cooperative guidance scheme, where coordination algorithms and local guidance laws are combined together, is proposed. This scheme a... Cooperative guidance problems of multiple missiles are considered in this article. A cooperative guidance scheme, where coordination algorithms and local guidance laws are combined together, is proposed. This scheme actually builds up a hierarchical cooperative guidance architecture, which may provide a general solution to the multimissile cooperative guidance problems. In the case of salvo attacks which require missiles to hit the target simultaneously, both centralized and distributed coordination algorithms are derived based on the impact-time-control guidance (ITCG) law. Numerical simulations are performed to demonstrate the effectiveness of the proposed approaches. 展开更多
关键词 COOPERATIVE GUIDANCE impact time constraints multiple missiles salvo attack
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