BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive ne...BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive network(CEN),allowing for a better understanding of cognitive deficits observed in mental disorders,as well as other characteristic psychopathological phenomena such as thought and behavior disorganization.AIM To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia(SCH)and mood disorders.METHODS The sample comprised 58 patients with either paranoid syndrome in the context of SCH(n=26)or depressive syndrome(Ds)(n=32),in the context of major depressive disorder or bipolar disorder.The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN,SN and CEN.RESULTS A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula(aI)was observed in the SCH patient group,whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group.CONCLUSION The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders,and inform differential diagnosis and precise treatment targeting.展开更多
Functional magnetic resonance imaging studies have shown that the insular cortex has a significant role in pain identification and information integration, while the default mode network is associated with cognitive a...Functional magnetic resonance imaging studies have shown that the insular cortex has a significant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the default mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy subjects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the importance of the interaction between these regions in pain processing.展开更多
With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Yao Dezhong’s group at the Key Laboratory For NeuroInformation of Ministry of Education,Sc...With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Yao Dezhong’s group at the Key Laboratory For NeuroInformation of Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,reported enhanced functional connectivity(FC)and increased gray matter volume(GMV)of展开更多
Zircons from the auriferous quartz vein in the Rushan gold deposit, Jiaodong Peninsula, have high common Pb contents (206Pbc = 2.00%—15.88%) and Th/U ratios (0.31—1.35), and trap primary CO2-H2O fluid inclusion simi...Zircons from the auriferous quartz vein in the Rushan gold deposit, Jiaodong Peninsula, have high common Pb contents (206Pbc = 2.00%—15.88%) and Th/U ratios (0.31—1.35), and trap primary CO2-H2O fluid inclusion similar to ore-forming fluids, indicating that they grew from high Th/U ratio ore-forming fluids responsible for gold min- eralization. SHRIMP U-Pb analyses of these zircons gave an age of 117±3 Ma comparable with the ages reported by the former researches in the other areas in the Jiaodong Penin- sula, which is interpreted as the age of gold mineralization at Rushan. The age of SHRIMP zircon U-Pb dating with 160±3 Ma from host rock Kunyushan monzogranite is different from that of the gold mineralization, indicating that there is no genetic relationship between gold mineralization and the granitic magmatism. SHRIMP U-Pb dating on hydrothermal zircons from auriferous quartz veins could be used to con- strain the timing of lode gold mineralization and the rela- tionship to relevant hydrothermal event.展开更多
文摘BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive network(CEN),allowing for a better understanding of cognitive deficits observed in mental disorders,as well as other characteristic psychopathological phenomena such as thought and behavior disorganization.AIM To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia(SCH)and mood disorders.METHODS The sample comprised 58 patients with either paranoid syndrome in the context of SCH(n=26)or depressive syndrome(Ds)(n=32),in the context of major depressive disorder or bipolar disorder.The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN,SN and CEN.RESULTS A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula(aI)was observed in the SCH patient group,whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group.CONCLUSION The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders,and inform differential diagnosis and precise treatment targeting.
基金supported by the Science and Technology Foundation of Guangdong Province of China,No.2012B031800305
文摘Functional magnetic resonance imaging studies have shown that the insular cortex has a significant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the default mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy subjects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the importance of the interaction between these regions in pain processing.
文摘With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Yao Dezhong’s group at the Key Laboratory For NeuroInformation of Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,reported enhanced functional connectivity(FC)and increased gray matter volume(GMV)of
文摘Zircons from the auriferous quartz vein in the Rushan gold deposit, Jiaodong Peninsula, have high common Pb contents (206Pbc = 2.00%—15.88%) and Th/U ratios (0.31—1.35), and trap primary CO2-H2O fluid inclusion similar to ore-forming fluids, indicating that they grew from high Th/U ratio ore-forming fluids responsible for gold min- eralization. SHRIMP U-Pb analyses of these zircons gave an age of 117±3 Ma comparable with the ages reported by the former researches in the other areas in the Jiaodong Penin- sula, which is interpreted as the age of gold mineralization at Rushan. The age of SHRIMP zircon U-Pb dating with 160±3 Ma from host rock Kunyushan monzogranite is different from that of the gold mineralization, indicating that there is no genetic relationship between gold mineralization and the granitic magmatism. SHRIMP U-Pb dating on hydrothermal zircons from auriferous quartz veins could be used to con- strain the timing of lode gold mineralization and the rela- tionship to relevant hydrothermal event.
