The vulnerable plaques in atherosclerosis can cause severe outcome with great danger of acute cardiovascular events.Thus,timely diagnosis and treatment of vulnerable plaques in early stage can effectively benefit the ...The vulnerable plaques in atherosclerosis can cause severe outcome with great danger of acute cardiovascular events.Thus,timely diagnosis and treatment of vulnerable plaques in early stage can effectively benefit the clinical management of atherosclerosis.In this work,a targeting theranostic strategy on early-stage vulnerable plaques in atherosclerosis is realized by a LAID nanoplatform with X-CT and fluorescent dual-mode imaging and lipid-inflammation integrated regulation abilities.The iodinated contrast agents(ICA),phenylboronic acid modified astaxanthin and oxidized-dextran(oxDEX)jointly construct the nanoparticles loaded with the lipid-specific probe LFP.LAID indicates an active targeting to plaques along with the dual-responsive disassembly in oxidative stress and acidic microenvironment of atherosclerosis.The X-CT signals of ICA execute the location of early-stage plaques,while the LFP combines with lipid cores and realizes the recognition of vulnerable plaques.Meanwhile,the treatment based on astaxanthin is performed for restraining the progression of plaques.Transcriptome sequencing suggests that LAID can inhibit the lipid uptake and block NF-κB pathway,which synergistically demonstrates a lipid-inflammation integrated regulation to suppression the plaques growing.The in vivo investigations suggest that LAID delivers a favorable theranostics to the early-stage vulnerable plaques,which provides an impressive prospect for reducing the adverse prognosis of atherosclerosis.展开更多
Granular power management in a power-efficient system on a chip(SoC)requires multiple integrated voltage regulators with a small area,process scalability,and low supply voltage.Conventional on-chip analog low-dropout ...Granular power management in a power-efficient system on a chip(SoC)requires multiple integrated voltage regulators with a small area,process scalability,and low supply voltage.Conventional on-chip analog low-dropout regulators(ALDOs)can hardly meet these requirements,while digital LDOs(DLDOs)are good alternatives.However,the conventional DLDO,with synchronous control,has inherently slow transient response limited by the power-speed trade-off.Meanwhile,it has a poor power supply rejection(PSR),because the fully turned-on power switches in DLDO are vulnerable to power supply ripples.In this comparative study on DLDOs,first,we compare the pros and cons between ALDO and DLDO in general.Then,we summarize the recent DLDO advanced techniques for fast transient response and PSR enhancement.Finally,we discuss the design trends and possible directions of DLDO.展开更多
With the introduction and development of evidence-based medicine in China, it has been spread rapidly in the area of integrative medicine（IM） and has become a new unique discipline. During almost 20 years, as one of...With the introduction and development of evidence-based medicine in China, it has been spread rapidly in the area of integrative medicine（IM） and has become a new unique discipline. During almost 20 years, as one of the most important parts of evidence-based IM, systematic review（SR）/meta-analysis（MA） of IM have shown a good development momentum in the aspects of quantity, depth, breadth and influence, but also face the harsh situation of the uncontrolled quantity and quality, especially for SRs in Chinese. Therefore, how to supervise and standardize this area effectively becomes a problem to be solved. Based on the experience both at home and abroad, the authors put forward several kinds of solutions for laying the foundation for further development such as promoting the registration system of SR/MA of IM, effectively setting up the regulatory platform of quality and quantity, launching professional training for SR/MA reviewers, formingqualification registration, developing the data transfer and sharing platform to realize the transparency of evidence process.展开更多
This paper presents a multiple target implementation technique for a doubly fed induction generator （DFIG） under unbalanced and distorted grid voltage based on direct power control （DPC）. Based on the mathematical...This paper presents a multiple target implementation technique for a doubly fed induction generator （DFIG） under unbalanced and distorted grid voltage based on direct power control （DPC）. Based on the mathematical model of DFIG under unbalanced and distorted voltage, the proportional and integral （PI） regulator is adopted to regulate the DFIG average active and reactive powers, while the vector P1 （VPI） resonant regulator is used to achieve three alternative control targets： （1） balanced and sinusoidal stator current; （2） smooth instantaneous stator active and reactive powers; （3） smooth electromagnetic torque and instantaneous stator reactive power. The major advantage of the proposed control strategy over the conventional method is that neither negative and harmonic sequence decomposition of grid voltage nor complicated control reference calculation is required. The insensitivity of the proposed control strategy to DFIG parameter deviation is analyzed. Finally, the DFIG experimental system is developed to validate the availability of the proposed DPC strategy under unbalanced and distorted grid voltage,展开更多
Animals can sense many environment stimuli simultaneously and integrate these signals within the nervous system. However, the neural system and molecular
基金supported by National Natural Science Foundation of China (No.32201128,No.82270262,and No.82070408)Zhejiang TCM Science and Technology Program TCM modernization Special project,China (No.2022ZX012).
文摘The vulnerable plaques in atherosclerosis can cause severe outcome with great danger of acute cardiovascular events.Thus,timely diagnosis and treatment of vulnerable plaques in early stage can effectively benefit the clinical management of atherosclerosis.In this work,a targeting theranostic strategy on early-stage vulnerable plaques in atherosclerosis is realized by a LAID nanoplatform with X-CT and fluorescent dual-mode imaging and lipid-inflammation integrated regulation abilities.The iodinated contrast agents(ICA),phenylboronic acid modified astaxanthin and oxidized-dextran(oxDEX)jointly construct the nanoparticles loaded with the lipid-specific probe LFP.LAID indicates an active targeting to plaques along with the dual-responsive disassembly in oxidative stress and acidic microenvironment of atherosclerosis.The X-CT signals of ICA execute the location of early-stage plaques,while the LFP combines with lipid cores and realizes the recognition of vulnerable plaques.Meanwhile,the treatment based on astaxanthin is performed for restraining the progression of plaques.Transcriptome sequencing suggests that LAID can inhibit the lipid uptake and block NF-κB pathway,which synergistically demonstrates a lipid-inflammation integrated regulation to suppression the plaques growing.The in vivo investigations suggest that LAID delivers a favorable theranostics to the early-stage vulnerable plaques,which provides an impressive prospect for reducing the adverse prognosis of atherosclerosis.
基金supported by the National Natural Science Foundation of China(No.61974046)the Provincial Key Research and Development Program of Guangdong(2019B010140002)the Macao Science&Technology Development Fund(FDCT)145/2019/A3 and SKL-AMSV(UM)-2020-2022.
文摘Granular power management in a power-efficient system on a chip(SoC)requires multiple integrated voltage regulators with a small area,process scalability,and low supply voltage.Conventional on-chip analog low-dropout regulators(ALDOs)can hardly meet these requirements,while digital LDOs(DLDOs)are good alternatives.However,the conventional DLDO,with synchronous control,has inherently slow transient response limited by the power-speed trade-off.Meanwhile,it has a poor power supply rejection(PSR),because the fully turned-on power switches in DLDO are vulnerable to power supply ripples.In this comparative study on DLDOs,first,we compare the pros and cons between ALDO and DLDO in general.Then,we summarize the recent DLDO advanced techniques for fast transient response and PSR enhancement.Finally,we discuss the design trends and possible directions of DLDO.
基金Supported by Funding of Major Supporting Departments(KFKFC) of Rehabilitation Medicine,Wuxi People's Hospital Affiliated to Nanjing Medical Universitythe Second Batch of National "Ten Thousand Talents Plan" of Scientific and Technological Innovation Leading Talents(No.W02020052)
文摘With the introduction and development of evidence-based medicine in China, it has been spread rapidly in the area of integrative medicine（IM） and has become a new unique discipline. During almost 20 years, as one of the most important parts of evidence-based IM, systematic review（SR）/meta-analysis（MA） of IM have shown a good development momentum in the aspects of quantity, depth, breadth and influence, but also face the harsh situation of the uncontrolled quantity and quality, especially for SRs in Chinese. Therefore, how to supervise and standardize this area effectively becomes a problem to be solved. Based on the experience both at home and abroad, the authors put forward several kinds of solutions for laying the foundation for further development such as promoting the registration system of SR/MA of IM, effectively setting up the regulatory platform of quality and quantity, launching professional training for SR/MA reviewers, formingqualification registration, developing the data transfer and sharing platform to realize the transparency of evidence process.
基金Project supported by the National High-Tech R&D Program(863)of China(No.2011AA050204)the National Natural Science Foundation of China(No.51277159)
文摘This paper presents a multiple target implementation technique for a doubly fed induction generator （DFIG） under unbalanced and distorted grid voltage based on direct power control （DPC）. Based on the mathematical model of DFIG under unbalanced and distorted voltage, the proportional and integral （PI） regulator is adopted to regulate the DFIG average active and reactive powers, while the vector P1 （VPI） resonant regulator is used to achieve three alternative control targets： （1） balanced and sinusoidal stator current; （2） smooth instantaneous stator active and reactive powers; （3） smooth electromagnetic torque and instantaneous stator reactive power. The major advantage of the proposed control strategy over the conventional method is that neither negative and harmonic sequence decomposition of grid voltage nor complicated control reference calculation is required. The insensitivity of the proposed control strategy to DFIG parameter deviation is analyzed. Finally, the DFIG experimental system is developed to validate the availability of the proposed DPC strategy under unbalanced and distorted grid voltage,
文摘Animals can sense many environment stimuli simultaneously and integrate these signals within the nervous system. However, the neural system and molecular
