Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine(ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-randomi...Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine(ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-randomized, controlled trial was conducted on 447 SARS patients treated synchronouslywith western conventional treatment (WM group, n = 171 ) alone and ICWM (ICWM group, n = 276). Thechanges of the cases with normal level (≥95 % ) or abnormal level (＜95 % ) SaO2 were observed dynamically. Results: In the 3rd-14th day of the therapeutic course, the percentage of patients with normal SaO2 in the ICWM group was higher than that in the WM group (OR = 0. 5178, P =0. 0038), and this tendency was more evident in patients of the severe type ( OR = 0.18, P = 0. 0001). However, the statistical significance of difference was only shown in patients for whom the ICWM treatment started in the early period after the onset (≤7 days after it, OR=0. 3803, P=0. 006), but not shown in those who received ICWM treatment later in the mid-late period of SARS (P＞0.05). Conclusion: ICWM treatment, particularly when it is used for inter vention in the early stage, is beneficial for maintaining normal SaO2 in SARS patients.展开更多
Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treat...Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone.展开更多
Objective: To evaluate the efficacy of integrative Chinese and western medicine (ICWM)in treating severe acute respiratory syndrome (SARS) patients. Methods: Through parallel control design,49 SARS patients were obser...Objective: To evaluate the efficacy of integrative Chinese and western medicine (ICWM)in treating severe acute respiratory syndrome (SARS) patients. Methods: Through parallel control design,49 SARS patients were observed. Used as control, there were in the western medicine (WM) group 29 patients, who were treated with Ribavirin, Levofloxacin, Thymopentin, Azithromycin, methylprednisolone,etc. , on the basis of "Recommended Protocol for Infectious Atypical Pneumonia" (abbreviated as "Recommended Protocol") issueed by Ministry of Health. As the treated group, there were in the ICWM 20 cascs. The protocol for treatment of SARS in "Special Science and Technological Action to Prevent and Treat SARS" (abbreviated as "Special S-T Action"), issued by Ministry of Science and Technology, together with the same WM as those for the control group. Results: (1) Time from the disease onset to the symptom improvement were 5.10±2.83 days and 7.62±2.27 days in ICWM and WM group respectively,P＜0. 05; (2) As to corticosteroid (CS) amount and days before reducing dosage, 2 groups showed no significant difference, P＞0.05; (3) There was no significant difference in the time from disease onset to the body temperature normalization and the total amount of CS and the duration of using CS before reducing it to 80 mg between the ICWM group and the WM group; (4) The days and amounts for use CS after reducing between the ICWM group and the WM group were significantly different (P＜0. 05). Conclusion:There were obvious advantages in ICWM to treat SARS, compared with that of WM alone, especially in improving the clinical symptoms, promoting the recovery of immune function, promoting the absorption of pulmonary inflammation and reducing the dosage and duration of CS treatment.展开更多
Objective: To evaluate the effective treatment with integrative Chinese and western medicine (ICWM) of severe acute respiratory syndrome (SARS). Methods: The 65 cases of SARS patients were treated with ICWM and 37 cas...Objective: To evaluate the effective treatment with integrative Chinese and western medicine (ICWM) of severe acute respiratory syndrome (SARS). Methods: The 65 cases of SARS patients were treated with ICWM and 37 cases with western medicine (WM) alone as the control in our hospital from March 11 to April 30, 2003. The results were analyzed, with T subset profile tested for all the 102patients. Results: Sixty-five cases of SARS patients treated with ICWM included 52 mild cases of whom 51cases were cured (98. 1 %) and no patient died. As to the 13 severe cases in this group, 9 were cured (69.2%) and 2 died (15.4%). Of the 37 cases treated with WM alone, 16 out of the 18 common cases were cured (88.9%) and 10 out of the 19 severe cases were cured (52. 6%), with the other 9 died (47.4%).Comparison between the two groups (P=0. 061) showed the difference was close to the value for statistical significance. But considering that the number of samples was small, more cases are needed for further study. The immune function examination: in cases of the common type, after ICWM treatment, CD4 + T lymphocytes were increased from 360±247 cell/mm3 to 563±479 cell/mm3 (P＜0.05). In the group treated with WM alone, CD4 + T lymphocytes were increased from 331 ±193 cell/mm3 to 772 ±354 cell/mm3(P＜0. 05). As to the severe cases after ICWM treatment, CD4 + T lymphocytes increased from 352± 279cell/mm3 to 525±490 cell/mm3 (P＞0.05). In the group of severe cases treated with WM alone, CD4+ T lymphocytes reduced from 229±69 cell/mm3 to 205 ±108 cell/mm3 (P＞0. 05). While after ICWM treatment, CD4+ T lymphocytes were significantly higher than that of the group treated with WM alone (P＜0.05). Conclusion: Compared with the group treated with WM alone, ICWM can significantly improve the prognosis, reduce the mortality as well as improve the immune function of SARS patients.展开更多
Objective: To understand the clinical manifestation of severe acute respiratory syndrome(SARS) and explore its effective treatment with integrative Chinese and western medicine (ICWM).Methods. The data of patients, wh...Objective: To understand the clinical manifestation of severe acute respiratory syndrome(SARS) and explore its effective treatment with integrative Chinese and western medicine (ICWM).Methods. The data of patients, whose diagnosis of SARS had been confirmed were summarized and analyzed, and clinical observation was conducted when the patients were treated with ICWM. Results: In the early stage of the 42 patients, the symptoms revealed were fever in 100% of SARS patients, headache in 92.9%, aversion to cold in 76.2%, chest stuffiness in 76.2%, cough in 73.8% and myalgia in 88. 1%;pulmonary lesion involves ≥3 lobes in 42. 9%, 2 lobes in 47. 6% and 1 lobe in 9. 5% ；61. 9% of them showed liver function abnormality (increase of ALT or AST), 47. 6% showed elevated myocardial enzyme(CK or CK-MB), 0. 48% showed an inclination of renal function (higher of BUN or Cr) ； in their T lymphocyte subsets, 91.2% (31/34 patients) had lowered CD3 and 76. 5% (26/34 patients) lowered CD4/CD8 ratio. In the mid-late stage, the symptoms were lassitude and weakness in 85.7%, scare in 81.0%, short of breath or chest stuffiness in 71.4%, loss of appetite in 64. 3%; light dark tongue proper in 52.4%,yellow and white tongue coating in 45.2%, and yellow thick coating on the middle-root part of the tonguein 21.4%. Most of them were asymptomatic when discharged from hospital, with 92.8% of their pulmonary lesion, according to chest film, completely absorbed and liver function, myocardial enzyme and renal function all normalized. However, of the 30 patients who had CD3 reexamination, 70% of the CD3 showed lower than normal range and 36.7% showed their CD4/CD3 inclined to lower margin, follow-up should be done for these patients. Of the 42 patients, who received western medicine (WM) alone in the early stage and ICWM in the mid-late stage, 10 were severe cases and 3 critical cases, but none of them died. The mean defervescent time was 3. 52±0. 85 days, the time for complete absorption of pulmonary lesion judged by chest X-ray film was 26.82±5. 98 days, and the mean hospitalization time was 33. 60±4. 37 days. Condusion: The manifestation of SARS is multifarious, showing that there were damage in multiple organs.The T lymphocyte count percentage and its subsets, CD3 and CD4/CD3 ratio, are valuable for early diagnosis and follow-up in the rehabilitation stage. Majority of the patients could be clinically cured. Combined treatment of WM and TCM according to syndrome differentiation and psychiatric intervention are beneficial to remit partial symptoms and promote rehabilitation.展开更多
Objective: To observe the clinical effect of integrative Chinese a nd western medicine (ICWM) in treatment of patients with severe acute respirator y syndrome (SARS) and its influence on their T lymphocyte subsets.Met...Objective: To observe the clinical effect of integrative Chinese a nd western medicine (ICWM) in treatment of patients with severe acute respirator y syndrome (SARS) and its influence on their T lymphocyte subsets.Methods: Fifty one patients with SARS of severe type were obser ved with synchronous non randomized controlled method. They were divided into the ICWM group (29 patients) and the western medicine (WM) group (22 patients). Western medical treatment was applied to both groups, but to the ICWM group, Ch inese medicine was given additionally. The therapeutic course was 2-3 weeks for both groups. Clinical effect and changes of T lymphocyte subsets (CD4 +) aft er treatment were observed.Results: In the ICWM group, 26 patients (89.66%) were cured and 3 (10.34%) died, while in the WM group, 12 (54.55%) cur ed and 10 (45.45%) died, thus comparison of the cure rate between the two groups showing significant difference ( P <0.01). The score of clinical symptoms in the ICWM group was decreased from 7.14±5.20 scores before treatment to 1.82±3. 75 scores after treatment, while in the WM group, it lowered from 7.36±3.84 sco res before treatment to 5.17±4.17 scores after treatment, significant diffe rence shown in the comparison of the values between the two groups after treatme nt (P<0.01). Immunological function test showed that CD4 + T lymphocyte in the ICWM group rose from 361±278 cells/mm 3 before treatment to 630±454 c ells/mm 3 after treatment, showing significant difference( P <0.01 );bu t in the WM group, it merely rose from 288±186 cells/mm 3 to 376±285 cells/mm 3 in the corresponding period (P>0.05). Conclusion: ICWM could improve the clinical symptoms of SARS pa tients markedly, enhance their T lymphocyte immune function, and reduce their mortality.展开更多
Severe acute pancreatitis (SAP),one of the crucial acute abdominal diseases,has high mortality for its quick initiation,severe condition,long duration,and frequent complication with multiple organ failure.In this pape...Severe acute pancreatitis (SAP),one of the crucial acute abdominal diseases,has high mortality for its quick initiation,severe condition,long duration,and frequent complication with multiple organ failure.In this paper,the clinical progress in the treatment of SAP with integrative Chinese and Western medicine is inspected and summarized.展开更多
基金This item is one of the items of State 863 Plan (No.2003AA208101) a special subject of clinical study of State administration of TCM an important item of Beijing Scientific-Technology Plan(No. H020920010031)
文摘Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine(ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-randomized, controlled trial was conducted on 447 SARS patients treated synchronouslywith western conventional treatment (WM group, n = 171 ) alone and ICWM (ICWM group, n = 276). Thechanges of the cases with normal level (≥95 % ) or abnormal level (＜95 % ) SaO2 were observed dynamically. Results: In the 3rd-14th day of the therapeutic course, the percentage of patients with normal SaO2 in the ICWM group was higher than that in the WM group (OR = 0. 5178, P =0. 0038), and this tendency was more evident in patients of the severe type ( OR = 0.18, P = 0. 0001). However, the statistical significance of difference was only shown in patients for whom the ICWM treatment started in the early period after the onset (≤7 days after it, OR=0. 3803, P=0. 006), but not shown in those who received ICWM treatment later in the mid-late period of SARS (P＞0.05). Conclusion: ICWM treatment, particularly when it is used for inter vention in the early stage, is beneficial for maintaining normal SaO2 in SARS patients.
文摘Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone.
基金The study is supporded by The Ministry of Science Technology of 863 Programme "The Developing the Key of Technique and Products for Preventing SARS" (No.2003AA208101)
文摘Objective: To evaluate the efficacy of integrative Chinese and western medicine (ICWM)in treating severe acute respiratory syndrome (SARS) patients. Methods: Through parallel control design,49 SARS patients were observed. Used as control, there were in the western medicine (WM) group 29 patients, who were treated with Ribavirin, Levofloxacin, Thymopentin, Azithromycin, methylprednisolone,etc. , on the basis of "Recommended Protocol for Infectious Atypical Pneumonia" (abbreviated as "Recommended Protocol") issueed by Ministry of Health. As the treated group, there were in the ICWM 20 cascs. The protocol for treatment of SARS in "Special Science and Technological Action to Prevent and Treat SARS" (abbreviated as "Special S-T Action"), issued by Ministry of Science and Technology, together with the same WM as those for the control group. Results: (1) Time from the disease onset to the symptom improvement were 5.10±2.83 days and 7.62±2.27 days in ICWM and WM group respectively,P＜0. 05; (2) As to corticosteroid (CS) amount and days before reducing dosage, 2 groups showed no significant difference, P＞0.05; (3) There was no significant difference in the time from disease onset to the body temperature normalization and the total amount of CS and the duration of using CS before reducing it to 80 mg between the ICWM group and the WM group; (4) The days and amounts for use CS after reducing between the ICWM group and the WM group were significantly different (P＜0. 05). Conclusion:There were obvious advantages in ICWM to treat SARS, compared with that of WM alone, especially in improving the clinical symptoms, promoting the recovery of immune function, promoting the absorption of pulmonary inflammation and reducing the dosage and duration of CS treatment.
基金This work is supported by Clinical Study of Integrative Chinese and Western Medicine in Treating SARS (No. Jing Zhong Ke SARS-01)
文摘Objective: To evaluate the effective treatment with integrative Chinese and western medicine (ICWM) of severe acute respiratory syndrome (SARS). Methods: The 65 cases of SARS patients were treated with ICWM and 37 cases with western medicine (WM) alone as the control in our hospital from March 11 to April 30, 2003. The results were analyzed, with T subset profile tested for all the 102patients. Results: Sixty-five cases of SARS patients treated with ICWM included 52 mild cases of whom 51cases were cured (98. 1 %) and no patient died. As to the 13 severe cases in this group, 9 were cured (69.2%) and 2 died (15.4%). Of the 37 cases treated with WM alone, 16 out of the 18 common cases were cured (88.9%) and 10 out of the 19 severe cases were cured (52. 6%), with the other 9 died (47.4%).Comparison between the two groups (P=0. 061) showed the difference was close to the value for statistical significance. But considering that the number of samples was small, more cases are needed for further study. The immune function examination: in cases of the common type, after ICWM treatment, CD4 + T lymphocytes were increased from 360±247 cell/mm3 to 563±479 cell/mm3 (P＜0.05). In the group treated with WM alone, CD4 + T lymphocytes were increased from 331 ±193 cell/mm3 to 772 ±354 cell/mm3(P＜0. 05). As to the severe cases after ICWM treatment, CD4 + T lymphocytes increased from 352± 279cell/mm3 to 525±490 cell/mm3 (P＞0.05). In the group of severe cases treated with WM alone, CD4+ T lymphocytes reduced from 229±69 cell/mm3 to 205 ±108 cell/mm3 (P＞0. 05). While after ICWM treatment, CD4+ T lymphocytes were significantly higher than that of the group treated with WM alone (P＜0.05). Conclusion: Compared with the group treated with WM alone, ICWM can significantly improve the prognosis, reduce the mortality as well as improve the immune function of SARS patients.
文摘Objective: To understand the clinical manifestation of severe acute respiratory syndrome(SARS) and explore its effective treatment with integrative Chinese and western medicine (ICWM).Methods. The data of patients, whose diagnosis of SARS had been confirmed were summarized and analyzed, and clinical observation was conducted when the patients were treated with ICWM. Results: In the early stage of the 42 patients, the symptoms revealed were fever in 100% of SARS patients, headache in 92.9%, aversion to cold in 76.2%, chest stuffiness in 76.2%, cough in 73.8% and myalgia in 88. 1%;pulmonary lesion involves ≥3 lobes in 42. 9%, 2 lobes in 47. 6% and 1 lobe in 9. 5% ；61. 9% of them showed liver function abnormality (increase of ALT or AST), 47. 6% showed elevated myocardial enzyme(CK or CK-MB), 0. 48% showed an inclination of renal function (higher of BUN or Cr) ； in their T lymphocyte subsets, 91.2% (31/34 patients) had lowered CD3 and 76. 5% (26/34 patients) lowered CD4/CD8 ratio. In the mid-late stage, the symptoms were lassitude and weakness in 85.7%, scare in 81.0%, short of breath or chest stuffiness in 71.4%, loss of appetite in 64. 3%; light dark tongue proper in 52.4%,yellow and white tongue coating in 45.2%, and yellow thick coating on the middle-root part of the tonguein 21.4%. Most of them were asymptomatic when discharged from hospital, with 92.8% of their pulmonary lesion, according to chest film, completely absorbed and liver function, myocardial enzyme and renal function all normalized. However, of the 30 patients who had CD3 reexamination, 70% of the CD3 showed lower than normal range and 36.7% showed their CD4/CD3 inclined to lower margin, follow-up should be done for these patients. Of the 42 patients, who received western medicine (WM) alone in the early stage and ICWM in the mid-late stage, 10 were severe cases and 3 critical cases, but none of them died. The mean defervescent time was 3. 52±0. 85 days, the time for complete absorption of pulmonary lesion judged by chest X-ray film was 26.82±5. 98 days, and the mean hospitalization time was 33. 60±4. 37 days. Condusion: The manifestation of SARS is multifarious, showing that there were damage in multiple organs.The T lymphocyte count percentage and its subsets, CD3 and CD4/CD3 ratio, are valuable for early diagnosis and follow-up in the rehabilitation stage. Majority of the patients could be clinically cured. Combined treatment of WM and TCM according to syndrome differentiation and psychiatric intervention are beneficial to remit partial symptoms and promote rehabilitation.
基金This study was supported by the Item of Special Scientific and Technological Action in Preventing and Treating SARS funded by State Administration of TCM ( No. 2003AA20810)
文摘Objective: To observe the clinical effect of integrative Chinese a nd western medicine (ICWM) in treatment of patients with severe acute respirator y syndrome (SARS) and its influence on their T lymphocyte subsets.Methods: Fifty one patients with SARS of severe type were obser ved with synchronous non randomized controlled method. They were divided into the ICWM group (29 patients) and the western medicine (WM) group (22 patients). Western medical treatment was applied to both groups, but to the ICWM group, Ch inese medicine was given additionally. The therapeutic course was 2-3 weeks for both groups. Clinical effect and changes of T lymphocyte subsets (CD4 +) aft er treatment were observed.Results: In the ICWM group, 26 patients (89.66%) were cured and 3 (10.34%) died, while in the WM group, 12 (54.55%) cur ed and 10 (45.45%) died, thus comparison of the cure rate between the two groups showing significant difference ( P <0.01). The score of clinical symptoms in the ICWM group was decreased from 7.14±5.20 scores before treatment to 1.82±3. 75 scores after treatment, while in the WM group, it lowered from 7.36±3.84 sco res before treatment to 5.17±4.17 scores after treatment, significant diffe rence shown in the comparison of the values between the two groups after treatme nt (P<0.01). Immunological function test showed that CD4 + T lymphocyte in the ICWM group rose from 361±278 cells/mm 3 before treatment to 630±454 c ells/mm 3 after treatment, showing significant difference( P <0.01 );bu t in the WM group, it merely rose from 288±186 cells/mm 3 to 376±285 cells/mm 3 in the corresponding period (P>0.05). Conclusion: ICWM could improve the clinical symptoms of SARS pa tients markedly, enhance their T lymphocyte immune function, and reduce their mortality.
文摘Severe acute pancreatitis (SAP),one of the crucial acute abdominal diseases,has high mortality for its quick initiation,severe condition,long duration,and frequent complication with multiple organ failure.In this paper,the clinical progress in the treatment of SAP with integrative Chinese and Western medicine is inspected and summarized.
