Chronic hepatitis B (CHB) is currently medically managed with either interferon-alpha or one of the five nucleos(t)ide analogs. However, there are still a large number of CHB patients whose response to the above thera...Chronic hepatitis B (CHB) is currently medically managed with either interferon-alpha or one of the five nucleos(t)ide analogs. However, there are still a large number of CHB patients whose response to the above therapies remains less than satisfactory, and their incomplete or non-response to antiviral therapies has plagued clinicians worldwide. In recent years, a newly proposed optimization therapy has provided us with a new approach to solve this problem. The key points in this optimization therapy are to initiate antiviral therapy with an appropriate agent at the correct time point, and to adjust treatments in patients with poor early responses by adding a second agent or switching to another more potent agent. In this review, we summarize recent developments in optimization therapy for the treatment of CHB, and provide an outlook for future research in this field. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.展开更多
The coscismic deformation produced by 1998 earthquake (M8 = 6.2) in Zhangbei-Shangyi of northern China is measured by the differential synthetic aperture radar interferometry (D-InSAR) technique using the European Rem...The coscismic deformation produced by 1998 earthquake (M8 = 6.2) in Zhangbei-Shangyi of northern China is measured by the differential synthetic aperture radar interferometry (D-InSAR) technique using the European Remote Sensing satellite (ERS) SAR data. Interferograms are constructed from the ERS-1/2 SAR data by the three-pass method. The line-of-sight displacement map indicates that the deformation center of the earthquake is located at E114°20’, N40°57’, with the maximum uplift of 25 cm. The extent of the displacement is around 300 km2. The focal mechanism and earthquake-induced structures are analyzed based on the spatial distribution of the deformation. The results give new insights into the seismic mechanism study.展开更多
基金Supported by The National Twelve-Five Project of China,No.2012ZX10002007-001-003,and No.2013ZX10002001
文摘Chronic hepatitis B (CHB) is currently medically managed with either interferon-alpha or one of the five nucleos(t)ide analogs. However, there are still a large number of CHB patients whose response to the above therapies remains less than satisfactory, and their incomplete or non-response to antiviral therapies has plagued clinicians worldwide. In recent years, a newly proposed optimization therapy has provided us with a new approach to solve this problem. The key points in this optimization therapy are to initiate antiviral therapy with an appropriate agent at the correct time point, and to adjust treatments in patients with poor early responses by adding a second agent or switching to another more potent agent. In this review, we summarize recent developments in optimization therapy for the treatment of CHB, and provide an outlook for future research in this field. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
基金the National Key Basic Research Program (Grant No. G1998040703) and the CAS Knowledge Innovation Key Project. The ERS-1/2 SAR data were provided by ESA for the ERS Project (ERS A03-374).
文摘The coscismic deformation produced by 1998 earthquake (M8 = 6.2) in Zhangbei-Shangyi of northern China is measured by the differential synthetic aperture radar interferometry (D-InSAR) technique using the European Remote Sensing satellite (ERS) SAR data. Interferograms are constructed from the ERS-1/2 SAR data by the three-pass method. The line-of-sight displacement map indicates that the deformation center of the earthquake is located at E114°20’, N40°57’, with the maximum uplift of 25 cm. The extent of the displacement is around 300 km2. The focal mechanism and earthquake-induced structures are analyzed based on the spatial distribution of the deformation. The results give new insights into the seismic mechanism study.
