Marginal bone loss during bone healing exists around non-submerged dental implants. The aim of this study was to identify the relationship between different degrees of marginal bone loss during bone healing and the sa...Marginal bone loss during bone healing exists around non-submerged dental implants. The aim of this study was to identify the relationship between different degrees of marginal bone loss during bone healing and the salivary microbiome. One hundred patients were recruited, and marginal bone loss around their implants was measured using cone beam computed tomography during a 3-month healing period. The patients were divided into three groups according to the severity of marginal bone loss.Saliva samples were collected from all subjected and were analysed using 16 SMiSeq sequencing. Although the overall structure of the microbial community was not dramatically altered, the relative abundance of several taxonomic groups noticeably changed. The abundance of species in the phyla Spirochaeta and Synergistetes increased significantly as the bone loss became more severe. Species within the genus Treponema also exhibited increased abundance, whereas Veillonella, Haemophilus and Leptotrichia exhibited reduced abundances, in groups with more bone loss. Porphyromonasgingivalis, Treponemadenticola and Streptococcus intermedius were significantly more abundant in the moderate group and/or severe group. The severity of marginal bone loss around the non-submerged implant was associated with dissimilar taxonomic compositions. An increased severity of marginal bone loss was related to increased proportions of periodontal pathogenic species. These data suggest a potential role of microbes in the progression of marginal bone loss during bone healing.展开更多
Background: Periodontal disease is a bacterial infection that causes bone resorption of bone supporting teeth and leads to change in the normal architecture of the alveolar process. There are instances where the techn...Background: Periodontal disease is a bacterial infection that causes bone resorption of bone supporting teeth and leads to change in the normal architecture of the alveolar process. There are instances where the technique sensitive nature of restorative procedures or the faulty restorative margins may inadvertently lead to conditions which could bring about periodontal disease/ destruction. Therefore, this study was designed to determine the impact of dental restorations type on marginal bone among some patients being treated for chronic periodontitis. Material and Methods: Three hundred patients from the periodontics clinics in college of dentistry, King Khalid university were participated in our study. A total of 292 patients completed the study, 152 males and 140 female. They were divided according to dental reconstructions into three groups: Group I was without dental reconstructions (control group), group II patients received amalgam class II fillings and group III received fixed bridge denture. Plaque index (PLI) gingival index (GI), clinical attachment loss (CAL) and marginal bone loss (MBL) were recorded. All data were collected and were analyzed by ANOVA test. Results: In the present study, the restored teeth revealed significantly higher mean values for PLI, GI, CAL and MBL than the non-restored teeth (p-value Conclusion: Although the limitations of the present study, the patients in group II had the highest clinical attachment loss and value of marginal bone loss which can explain the more extension of amalgam fillings into subgingival direction, leading to increased plaque accumulation and increased periodontal destruction.展开更多
最小二乘支持向量机(Least Squares Support Vector Machine,LSSVM)通过求解一个线性等式方程组来提高支持向量机(Support Vector Machine,SVM)的运算速度。但是,LSSVM没有考虑间隔分布对于LSSVM模型的影响,导致其精度较低。为了增强LS...最小二乘支持向量机(Least Squares Support Vector Machine,LSSVM)通过求解一个线性等式方程组来提高支持向量机(Support Vector Machine,SVM)的运算速度。但是,LSSVM没有考虑间隔分布对于LSSVM模型的影响,导致其精度较低。为了增强LSSVM模型的泛化性能,提高其分类能力,提出一种具有间隔分布优化的最小二乘支持向量机(LSSVM with margin distribution optimization,MLSSVM)。首先,重新定义间隔均值和间隔方差,深入挖掘数据的间隔分布信息,增强模型的泛化性能;其次,引入权重线性损失,进一步优化了间隔均值,提升模型的分类精度;然后,分析目标函数,剔除冗余项,进一步优化间隔方差;最后,保留LSSVM的求解机制,保障模型的计算效率。实验表明,新提出的分类模型具有良好的泛化性能和运行时间。展开更多
加权线性损失孪生支持向量机(weighted linear loss twin support vector machine,WLTSVM)是针对大规模问题而构建的支持向量机(support vector machine,SVM)模型,其表现出较好的泛化性能。与SVM类似,WLTSVM中并未考虑样本集整体的间隔...加权线性损失孪生支持向量机(weighted linear loss twin support vector machine,WLTSVM)是针对大规模问题而构建的支持向量机(support vector machine,SVM)模型,其表现出较好的泛化性能。与SVM类似,WLTSVM中并未考虑样本集整体的间隔分布,而间隔分布已经被证明对泛化性能起着至关重要的作用。因此,为了取得更优性能,提出了一个加权线性损失孪生大间隔分布机(weighted linear loss twin large margin distribution machine,WLTLDM)。WLTLDM以一对非平行超平面模型为基础,构建了其对应的间隔均值和方差来优化间隔分布,并采用加权线性损失函数来度量类内样本的损失,使用平方损失函数来度量类间样本的损失。在真实数据集上的实验结果表明,WLTLDM是一个有效的间隔分布模型,其性能显著优于其他基准模型。展开更多
目的探讨伴有牙源性上颌窦炎(odontogenic maxillary sinusitis,OMS)患牙拔除后因骨量不足行上颌窦底提升术及种植修复的临床效果,为临床提供参考。方法本研究已通过单位伦理委员会审查批准,并获得患者知情同意。上颌后牙区患牙无保留...目的探讨伴有牙源性上颌窦炎(odontogenic maxillary sinusitis,OMS)患牙拔除后因骨量不足行上颌窦底提升术及种植修复的临床效果,为临床提供参考。方法本研究已通过单位伦理委员会审查批准,并获得患者知情同意。上颌后牙区患牙无保留价值且确诊为OMS,拔牙后6~8个月骨高度不足行上颌窦底提升术及同期种植45例作为研究组。同期随机纳入上颌后牙区患牙无保留价值但未诊断为OMS,拔牙后6~8个月因种植区域骨高度不足行上颌窦底提升术及同期种植48例作为对照组。研究组中部分上颌窦底骨质不连续及上颌窦底剩余牙槽骨高度<4 mm的病例行侧壁开窗上颌窦底提升术共13例,其余32例行穿嵴顶上颌窦底提升术。对照组上颌窦底剩余牙槽骨高度<4 mm的病例行侧壁开窗上颌窦底提升术共8例,其余40例行穿嵴顶上颌窦底提升术。种植术后6~8个月行二期修复治疗。种植术后21 d、3个月、8个月及修复后每6个月进行随访,修复后24个月比较2组上颌窦内成骨高度(sinus bone gain,SBG)、种植体尖端成骨高度(apical bone height,ABH)和种植体边缘骨吸收(marginal bone loss,MBL)情况。结果研究组45例种植术前上颌窦黏膜厚度均值(1.556±0.693)mm,大于对照组(1.229±0.425)mm,差异有统计学意义(P<0.001),但上颌窦底提升术均无上颌窦黏膜穿孔。修复后24个月,研究组SBG、ABH和MBL与对照组差异均无统计学意义(P>0.05)。结论伴OMS的患牙拔除后,上颌窦炎症减退、缺牙区骨质高度和密度得到一定程度的恢复,通过上颌窦底提升手术及种植修复,可以达到与非OMS患牙拔除后上颌窦底提升术及种植修复同样的效果。展开更多
基金supported by grants from the National Natural Science Foundation of China(NSFC8137117381571001)+2 种基金State Key Laboratory of Oral Diseases(SKLOD201704)International Team for Implantology(Grant No.975_2014,Basel,Switzerland)to Quan Yuanthe National Key R&D Program of China during the 13th Five-Year Plan(2016YFC1102700)to Xue-Dong Zhou
文摘Marginal bone loss during bone healing exists around non-submerged dental implants. The aim of this study was to identify the relationship between different degrees of marginal bone loss during bone healing and the salivary microbiome. One hundred patients were recruited, and marginal bone loss around their implants was measured using cone beam computed tomography during a 3-month healing period. The patients were divided into three groups according to the severity of marginal bone loss.Saliva samples were collected from all subjected and were analysed using 16 SMiSeq sequencing. Although the overall structure of the microbial community was not dramatically altered, the relative abundance of several taxonomic groups noticeably changed. The abundance of species in the phyla Spirochaeta and Synergistetes increased significantly as the bone loss became more severe. Species within the genus Treponema also exhibited increased abundance, whereas Veillonella, Haemophilus and Leptotrichia exhibited reduced abundances, in groups with more bone loss. Porphyromonasgingivalis, Treponemadenticola and Streptococcus intermedius were significantly more abundant in the moderate group and/or severe group. The severity of marginal bone loss around the non-submerged implant was associated with dissimilar taxonomic compositions. An increased severity of marginal bone loss was related to increased proportions of periodontal pathogenic species. These data suggest a potential role of microbes in the progression of marginal bone loss during bone healing.
文摘Background: Periodontal disease is a bacterial infection that causes bone resorption of bone supporting teeth and leads to change in the normal architecture of the alveolar process. There are instances where the technique sensitive nature of restorative procedures or the faulty restorative margins may inadvertently lead to conditions which could bring about periodontal disease/ destruction. Therefore, this study was designed to determine the impact of dental restorations type on marginal bone among some patients being treated for chronic periodontitis. Material and Methods: Three hundred patients from the periodontics clinics in college of dentistry, King Khalid university were participated in our study. A total of 292 patients completed the study, 152 males and 140 female. They were divided according to dental reconstructions into three groups: Group I was without dental reconstructions (control group), group II patients received amalgam class II fillings and group III received fixed bridge denture. Plaque index (PLI) gingival index (GI), clinical attachment loss (CAL) and marginal bone loss (MBL) were recorded. All data were collected and were analyzed by ANOVA test. Results: In the present study, the restored teeth revealed significantly higher mean values for PLI, GI, CAL and MBL than the non-restored teeth (p-value Conclusion: Although the limitations of the present study, the patients in group II had the highest clinical attachment loss and value of marginal bone loss which can explain the more extension of amalgam fillings into subgingival direction, leading to increased plaque accumulation and increased periodontal destruction.
文摘最小二乘支持向量机(Least Squares Support Vector Machine,LSSVM)通过求解一个线性等式方程组来提高支持向量机(Support Vector Machine,SVM)的运算速度。但是,LSSVM没有考虑间隔分布对于LSSVM模型的影响,导致其精度较低。为了增强LSSVM模型的泛化性能,提高其分类能力,提出一种具有间隔分布优化的最小二乘支持向量机(LSSVM with margin distribution optimization,MLSSVM)。首先,重新定义间隔均值和间隔方差,深入挖掘数据的间隔分布信息,增强模型的泛化性能;其次,引入权重线性损失,进一步优化了间隔均值,提升模型的分类精度;然后,分析目标函数,剔除冗余项,进一步优化间隔方差;最后,保留LSSVM的求解机制,保障模型的计算效率。实验表明,新提出的分类模型具有良好的泛化性能和运行时间。
文摘加权线性损失孪生支持向量机(weighted linear loss twin support vector machine,WLTSVM)是针对大规模问题而构建的支持向量机(support vector machine,SVM)模型,其表现出较好的泛化性能。与SVM类似,WLTSVM中并未考虑样本集整体的间隔分布,而间隔分布已经被证明对泛化性能起着至关重要的作用。因此,为了取得更优性能,提出了一个加权线性损失孪生大间隔分布机(weighted linear loss twin large margin distribution machine,WLTLDM)。WLTLDM以一对非平行超平面模型为基础,构建了其对应的间隔均值和方差来优化间隔分布,并采用加权线性损失函数来度量类内样本的损失,使用平方损失函数来度量类间样本的损失。在真实数据集上的实验结果表明,WLTLDM是一个有效的间隔分布模型,其性能显著优于其他基准模型。
文摘目的探讨伴有牙源性上颌窦炎(odontogenic maxillary sinusitis,OMS)患牙拔除后因骨量不足行上颌窦底提升术及种植修复的临床效果,为临床提供参考。方法本研究已通过单位伦理委员会审查批准,并获得患者知情同意。上颌后牙区患牙无保留价值且确诊为OMS,拔牙后6~8个月骨高度不足行上颌窦底提升术及同期种植45例作为研究组。同期随机纳入上颌后牙区患牙无保留价值但未诊断为OMS,拔牙后6~8个月因种植区域骨高度不足行上颌窦底提升术及同期种植48例作为对照组。研究组中部分上颌窦底骨质不连续及上颌窦底剩余牙槽骨高度<4 mm的病例行侧壁开窗上颌窦底提升术共13例,其余32例行穿嵴顶上颌窦底提升术。对照组上颌窦底剩余牙槽骨高度<4 mm的病例行侧壁开窗上颌窦底提升术共8例,其余40例行穿嵴顶上颌窦底提升术。种植术后6~8个月行二期修复治疗。种植术后21 d、3个月、8个月及修复后每6个月进行随访,修复后24个月比较2组上颌窦内成骨高度(sinus bone gain,SBG)、种植体尖端成骨高度(apical bone height,ABH)和种植体边缘骨吸收(marginal bone loss,MBL)情况。结果研究组45例种植术前上颌窦黏膜厚度均值(1.556±0.693)mm,大于对照组(1.229±0.425)mm,差异有统计学意义(P<0.001),但上颌窦底提升术均无上颌窦黏膜穿孔。修复后24个月,研究组SBG、ABH和MBL与对照组差异均无统计学意义(P>0.05)。结论伴OMS的患牙拔除后,上颌窦炎症减退、缺牙区骨质高度和密度得到一定程度的恢复,通过上颌窦底提升手术及种植修复,可以达到与非OMS患牙拔除后上颌窦底提升术及种植修复同样的效果。
