AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry...AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^＋/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous lesion.RESULTS： The positive rate of Bmi-1 expression in GC（52.5%） was significantly higher than that in normal gastric mucosa （21.6%, X^2 = 33.088, P 〈 0.05）. The Bmi-1 expression in GC was closely related with the Lauren＇s and Borrmann＇s classification and clinicalstage （X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05）. The expression of ki-67 was related to the Borrmann＇s classification （X^2 = 13.380, P 〈 0.05）.Bcl-2 expression was correlated with the Lauren＇s classification （Z2 = 4.725, P 〈 0.05）, and the Bmi-1 expression both in GC （rk = 0.157, P 〈 0.05） and inintestinal metaplasia （rk = 0.270, P 〈 0.05）.CONCLUSION： Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC.展开更多
多梳家族是一类以转录调控因子为主的基因家族,B细胞特异性莫洛尼氏白血病病毒插入位点1(B-cell specific moloney murine leukemiavirus insertion site 1,Bmi-1)是其中的重要组成成员之一,在调控细胞周期、增殖和分化中发挥重要的转...多梳家族是一类以转录调控因子为主的基因家族,B细胞特异性莫洛尼氏白血病病毒插入位点1(B-cell specific moloney murine leukemiavirus insertion site 1,Bmi-1)是其中的重要组成成员之一,在调控细胞周期、增殖和分化中发挥重要的转录抑制作用。有研究证实Bmi-1基因在多种胸部肿瘤中表达失调,并且与肿瘤的侵袭、转移和预后密切相关,可能是早期诊断、治疗和生存预后评估的新型标志物。本文对Bmi-1在胸部肿瘤中的研究进展进行综述。展开更多
基金Supported by A special fund for Key University Laboratories from Department of Education of Liaoning Province, No. 2008S233
文摘AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^＋/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous lesion.RESULTS： The positive rate of Bmi-1 expression in GC（52.5%） was significantly higher than that in normal gastric mucosa （21.6%, X^2 = 33.088, P 〈 0.05）. The Bmi-1 expression in GC was closely related with the Lauren＇s and Borrmann＇s classification and clinicalstage （X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05）. The expression of ki-67 was related to the Borrmann＇s classification （X^2 = 13.380, P 〈 0.05）.Bcl-2 expression was correlated with the Lauren＇s classification （Z2 = 4.725, P 〈 0.05）, and the Bmi-1 expression both in GC （rk = 0.157, P 〈 0.05） and inintestinal metaplasia （rk = 0.270, P 〈 0.05）.CONCLUSION： Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC.
文摘多梳家族是一类以转录调控因子为主的基因家族,B细胞特异性莫洛尼氏白血病病毒插入位点1(B-cell specific moloney murine leukemiavirus insertion site 1,Bmi-1)是其中的重要组成成员之一,在调控细胞周期、增殖和分化中发挥重要的转录抑制作用。有研究证实Bmi-1基因在多种胸部肿瘤中表达失调,并且与肿瘤的侵袭、转移和预后密切相关,可能是早期诊断、治疗和生存预后评估的新型标志物。本文对Bmi-1在胸部肿瘤中的研究进展进行综述。
