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Clinical research progress of traumatic brain injury related markers
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作者 LI Ning MO Ye-he +2 位作者 LIU Da-yuan ZAHNG Hua WANG Kang-ning 《Journal of Hainan Medical University》 CAS 2023年第10期66-71,共6页
Traumatic brain injury is a brain injury caused by biomechanics effects on brain tissue,In addition to primary brain injury,secondary brain injury caused by local brain injury,edema and high intracranial pressure on s... Traumatic brain injury is a brain injury caused by biomechanics effects on brain tissue,In addition to primary brain injury,secondary brain injury caused by local brain injury,edema and high intracranial pressure on surrounding brain tissue further aggravates the disease.The improvement of modern medical equipment and medical technology can provide early intervention treatment for patients.However,due to the particularity of the disease and the complexity of pathological and physiological reactions,irreversible damage often occurs in the central nervous system,with high disability rate and mortality.In recent years,it has been found that the related biological markers in the process of TBI are related to brain tissue injury and neurological function,and have important clinical application value in judging the severity of brain injury and prognosis evaluation,which has been widely studied.This paper intends to summarize the clinical research progress of TBI-related prognostic markers. 展开更多
关键词 Traumatic brain injury Relative markers clinical research progress
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Research progress and clinical experience of Banxia Xiexin Decoction in the treatment of insomnia
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作者 Shi-Heng Wang Jian-Feng Liu +2 位作者 Pei-Jie Qin Zhen Dong Ying-Ying Dang 《Journal of Hainan Medical University》 2021年第19期59-62,共4页
Insomnia is a common clinical disease.At present,with the increase of work and life pressure,the incidence of insomnia is increasing year by year,which seriously affects people's physical and mental health and qua... Insomnia is a common clinical disease.At present,with the increase of work and life pressure,the incidence of insomnia is increasing year by year,which seriously affects people's physical and mental health and quality of life.Although stable drugs are effective in the treatment of insomnia,they have long-term side effects.Traditional Chinese medicine has unique advantages in the treatment of insomnia.Among them,Banxia Xiexin Decoction is based on the theory of"stomach disorder,sleep restlessness".Curative effect.By searching relevant literature,this article discusses the research progress of Banxia Xiexin Decoction in the treatment of insomnia from the theory,prescription and clinical research of Banxia Xiexin Decoction,and describes the clinical experience of using Banxia Xiexin Decoction.In order to provide some reference for the clinic. 展开更多
关键词 Banxia Xiexin Decoction INSOMNIA literature research progress clinical experience
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COVID-19 sequelae:Clinical features and research progress
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作者 Na Li Zhe Wang +4 位作者 Yun-Li Bao Hai-Ru Tang Jun Huang Xiao-Hui Yu Jiu-Cong Zhang 《Journal of Hainan Medical University》 2022年第14期1-8,共8页
With the increasing number of COVID-19 patients cured and discharged,the emergence of associated sequelae has become a new global health crisis following acute infection.The sequela of COVID-19 involves many systems s... With the increasing number of COVID-19 patients cured and discharged,the emergence of associated sequelae has become a new global health crisis following acute infection.The sequela of COVID-19 involves many systems such as respiration,circulation,nerve,digestion,psychological cognition,and so on,with varying duration and severity,seriously affecting people's physical and mental health,as well as the development of society.This paper summarizes the clinical characteristics and research progress of COVID-19 sequelae through extensive review of relevant domestic and foreign literature,in order to provide reference for the development of a comprehensive and systematic management system. 展开更多
关键词 SARS-CoV-2 COVID-19 SEQUELA clinical features research progress
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Clinical Application and Research Progress of Accelerated Rehabilitation Surgery in Perioperative Period of Advanced Gastric Cancer in the Elderly 被引量:2
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作者 Chengpeng Ran Guangwei Gong 《International Journal of Clinical Medicine》 2020年第3期101-110,共10页
Enhanced recovery after surgery (ERAS) has been used in various surgical professions in recent years and is widely accepted by doctors. This concept not only helps patients speed up postoperative recovery, reduce the ... Enhanced recovery after surgery (ERAS) has been used in various surgical professions in recent years and is widely accepted by doctors. This concept not only helps patients speed up postoperative recovery, reduce the incidence of related complications and shorten hospital stays, but also has been proved to be effective and safe in the perioperative application of gastric cancer. This article reviews the clinical application and research progress of enhanced recovery after surgery in the perioperative period of advanced gastric cancer in the elderly. 展开更多
关键词 Enhanced Recovery after SURGERY ELDERLY Patients Advanced GASTRIC Cancer PERIOPERATIVE Period clinical Application research progress
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Research Progress of Animal-specific Antibiotics
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作者 SHI Zhi-hai LI Wan-li +2 位作者 LAN Ya-li LIN Ping WANG Wen-jia 《Animal Husbandry and Feed Science》 CAS 2013年第3期138-140,144,共4页
[Objective]In order to summarize the research progress of animal-specific antibiotics. [Methods]Mechanism of action and clinical application of animal-specific antibiotics which were commonly used in clinical were sim... [Objective]In order to summarize the research progress of animal-specific antibiotics. [Methods]Mechanism of action and clinical application of animal-specific antibiotics which were commonly used in clinical were simply summarized. [Results] The most common animal-specific antibiotics are cephalosporins,aminoglycoside,pleuromutilin,macrolides,quinolones and chloramphenicols. [Conclusions] The study provides a reference for clinical veterinary staff. 展开更多
关键词 Animal-specific antibiotics Mechanism of action clinical application research progress
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Study on The Current Status and Progress of Clinical Application of Ciprofol
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作者 Lihua Liu Xiaokun Shen 《Journal of Clinical and Nursing Research》 2024年第6期166-170,共5页
Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl gr... Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl group in the isopropyl side chain of propofol,constructs a new type of chiral molecule,which significantly enhances the spatial effect,and improves the affinity for GABA receptors.Its pharmacological properties are characterized by high potency,rapid onset of action,rapid recovery,low accumulation,and minimal adverse reactions.Therefore,it has a wide range of applications in various endoscopic diagnostic and therapeutic operations,ICU sedation,and general anesthesia.In this paper,the related knowledge of ciprofol and the development of clinical application research are comprehensively sorted out and synthesized,to provide a solid theoretical basis for the rational application of ciprofol in clinical practice.At the same time,the future research direction of ciprofol will also be prospected to provide valuable references for research in related fields. 展开更多
关键词 Ciprofol clinical application Application status research progress
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Recent Progress in Basic and Clinical Research on Disorders of Consciousness 被引量:5
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作者 Tianzi Jiang 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第4期589-591,共3页
Severe brain injury can lead to disorders of consciousness (DOCs). Since DOC patients cannot communicate functionally or behave purposefully, most remain bedridden and require laborious care. The medical community i... Severe brain injury can lead to disorders of consciousness (DOCs). Since DOC patients cannot communicate functionally or behave purposefully, most remain bedridden and require laborious care. The medical community is often confronted with the expectations of the families of chronic DOC patients, and the social, economic, and ethical consequences are tremendous. Research on DOCs is attracting increasing attention from scientists and physicians in various fields. With the development of modern neuroimaging and neuromodulation techniques, much progress has been made in the diagnosis, prognosis, treatment, and rehabilitation of DOCs in the last decade. 展开更多
关键词 In Recent progress in Basic and clinical research on Disorders of Consciousness
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Precious Literature Necessary for Clinical Research 1981-2008 Bound CD of English Version of JTCM
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《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2019年第4期595-595,共1页
The CD retrieval svstem of Journal of Traditional Chinese Medicine(JTCM)contains all of the periodicals of JTCM published from 1981 to 2008.You can read any articles on computer bv searching any words or combination o... The CD retrieval svstem of Journal of Traditional Chinese Medicine(JTCM)contains all of the periodicals of JTCM published from 1981 to 2008.You can read any articles on computer bv searching any words or combination of the words.The retrieval results can be printed or downloaded.You may retrieve the relevant articles about a certain disease,therapy or drug in a few seconds,user-friendly with convenient handling. 展开更多
关键词 Precious literature Necessary for clinical research 1981-2008 BOUND CD of ENGLISH Version of JTCM
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Precious Literature Necessary for Clinical Research 1981-2008 Bound CD of English Version of JTCM
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《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2019年第1期153-153,共1页
The CD retrieval system of Journal of Traditional Chinese Medicine (JTCM) contains all of the periodicals of JTCM published from 1981 to 2008. You can read any articles on computer by searching any words or combinatio... The CD retrieval system of Journal of Traditional Chinese Medicine (JTCM) contains all of the periodicals of JTCM published from 1981 to 2008. You can read any articles on computer by searching any words or combination of the words.The retrieval results can be printed or downloaded. You may retrieve the relevant articles about a certain disease. 展开更多
关键词 Precious literature Necessary for clinical research 1981-2008 BOUND CD of ENGLISH Version of JTCM CD
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A study of clinical psychological nursing research hotspots in China and variation trends based on word frequency analysis and visualization analysis 被引量:4
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作者 Shi-Fan Han Rui-Fang Zhu Jiao Zhao 《Chinese Nursing Research》 CAS 2017年第4期186-191,共6页
Objective: To analyze clinical psychological nursing research hotspots in China and variation trends in order to provide reference points on the current state of development of clinical psychological nursing and futur... Objective: To analyze clinical psychological nursing research hotspots in China and variation trends in order to provide reference points on the current state of development of clinical psychological nursing and future research hotspots.Method: Clinical psychological nursing research literature sourced from Wanfang Data for the three periods of 2007-2009, 2010-2012, and 2013-2015 were selected as the research sample. A bibliographic co-occurrence analysis system(BICOMB software) was used to perform keyword word frequency analysis and generate a keyword co-occurrence matrix. In addition, Ucinet software's Netdraw tool was used to create visualized network diagrams.Results: A total of 27890 articles were retrieved, and word frequency analysis revealed that the highestfrequency keywords consisted of anxiety, depression, the elderly, expectant women, coronary heart disease, diabetes, breast cancer, perioperative period, quality of life, and psychological intervention.Research hotspot analysis revealed that consistent hotspots comprised anxiety, depression, health education, and perioperative period; expectant women became a hotspot during 2010-2012, and quality of life and efficacy became hotspots during 2013-2015.Conclusions: In addition to the care process, clinical psychological nursing research hotspots in China have increasingly included the effectiveness of psychological nursing and impact on patient quality of life. In addition, research hotspots have been influenced by the incidence of illnesses and people's health consciousness. 展开更多
关键词 clinical PSYCHOLOGICAL NURSING Word frequency ANALYSIS VISUALIZATION ANALYSIS research HOTSPOTS NURSING research literature
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Risk factors, preventive interventions, overlapping symptoms, and clinical measures of delirium in elderly patients 被引量:1
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作者 Xi Mei Yue-Hong Liu +1 位作者 Ya-Qing Han Cheng-Ying Zheng 《World Journal of Psychiatry》 SCIE 2023年第12期973-984,共12页
Delirium is an acute reversible neuropsychiatric syndrome caused by multiple factors.It is associated with many adverse clinical outcomes including cognitive impairment,functional decline,prolonged hospitalization,and... Delirium is an acute reversible neuropsychiatric syndrome caused by multiple factors.It is associated with many adverse clinical outcomes including cognitive impairment,functional decline,prolonged hospitalization,and increased nursing service.The prevalence of delirium was high in department of cardiology,geriatric,and intensive care unit of hospital.With the increase in the aged population,further increases in delirium seem likely.However,it remains poorly recognized in the clinical practice.This article comprehensively discusses the latest research perspectives on the epidemiological data,risk factors,preventive interventions,overlapping symptoms,and clinical measures of delirium,including specific measures to manage delirium in clinical real-world situations.This article helps readers improve their knowledge and understanding of delirium and helps clinicians quickly identify and implement timely therapeutic measures to address various delirium subtypes that occur in the clinical settings to ensure patients are treated as aggressively as possible. 展开更多
关键词 DELIRIUM Risk factors Preventive interventions research progress REVIEW clinical practice
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富油煤研究进展与趋势 被引量:2
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作者 王双明 鲍园 +4 位作者 郝永辉 王生全 师庆民 李丹 胡宜亮 《煤田地质与勘探》 EI CAS CSCD 北大核心 2024年第4期1-11,共11页
富油煤是集煤、油、气属性于一身的煤基油气资源,针对国内“相对富煤、缺油、少气”的能源禀赋,开发富油煤对缓解我国紧张的油气资源供应局势、实现煤炭的绿色开发和低碳利用具有重要的意义。以富油煤为主要关键词,通过CNKI和Web of Sci... 富油煤是集煤、油、气属性于一身的煤基油气资源,针对国内“相对富煤、缺油、少气”的能源禀赋,开发富油煤对缓解我国紧张的油气资源供应局势、实现煤炭的绿色开发和低碳利用具有重要的意义。以富油煤为主要关键词,通过CNKI和Web of Science数据库检索自1985-2023年底已公开发表的学术论文和专利,统计分析富油煤的发展历程和主要研究内容,梳理了富油煤研究的热点方向与前沿领域,展望了未来发展趋势。研究发现:富油煤热解、赋存特征及沉积环境、孔隙和分子结构、焦油产率预测、微生物降解、资源潜力及开发利用是当前富油煤研究热点内容。富油煤含有热解可生成油气的富氢结构,如脂肪结构的侧链与桥键及缩合芳香核周缘的弱键结构;富油煤多形成于陆相沉积物供应稳定、气候温暖湿润、强还原条件下的沉积环境;孔隙结构影响富油煤的热解反应效率、焦油析出和油气运移,而分子结构(主要为脂肪族氢含量和富氢弱键)决定了富油煤的生油潜力;富油煤通过微生物的水解、发酵、产氢产乙酸和产甲烷4个阶段向油气转化。随着地质选区技术瓶颈突破及多学科交叉与融合,富油煤富油性评价指标与预测方法、富氢组分的来源与定量判识、原位开发围岩封闭性及其评价方法、微生物降解与热解联作技术将成为今后研究的热点方向。研究成果为厘清当前富油煤的研究方向和未来走势奠定了基础。 展开更多
关键词 富油煤 原位热解 富氢结构 研究进展 前景展望 文献统计
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近五年地榆的药理作用机制研究进展 被引量:1
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作者 吴杰 谢开勇 +6 位作者 袁丽 田朝娥 李丹 汤柳 宋伟 刘刚 周本宏 《环球中医药》 CAS 2024年第8期1669-1678,共10页
传统中药地榆具有凉血止血、解毒敛疮的功效。现代研究对地榆的止血凝血作用、抗氧化作用、抗过敏作用、抗炎作用、抗菌作用、抗肿瘤作用、肾保护作用、升高白细胞作用等药理机制进行了广泛研究,机制明确。其中止血凝血作用机制是通过... 传统中药地榆具有凉血止血、解毒敛疮的功效。现代研究对地榆的止血凝血作用、抗氧化作用、抗过敏作用、抗炎作用、抗菌作用、抗肿瘤作用、肾保护作用、升高白细胞作用等药理机制进行了广泛研究,机制明确。其中止血凝血作用机制是通过作用凝血酶及促进巨核细胞分化和血小板生成;抗氧化作用机制是上调抗氧化酶表达和清除氧自由基;抗过敏作用机制是抑制β-己糖氨酶和白介素-4的产生、释放或促进血红素加氧酶-1表达及激活;抗炎作用机制与巨噬细胞极化、聚集和迁移、脂质代谢、改善肠道菌群失调、信号传导与转录激活因子1及细胞外调节蛋白激酶激活、自噬、核因子κB/含pyrin结构域NOD样受体家族3、Toll样受体4/核因子κB、磷酯酰肌醇-3-激酶—丝氨酸/苏氨酸激酶/核因子κB/信号转导与转录激活因子3信号通路等相关;抗菌作用机制破坏细菌细胞壁、细胞膜结构和内部微观结构、干扰细菌总蛋白的合成、降低细胞膜流动性及改变代谢通路等相关基因表达,或抑制青霉素结合蛋白2a表达和mecA基因表达;抗肿瘤作用机制与血管内皮生长因子/磷酯酰肌醇-3-激酶—丝氨酸/苏氨酸激酶/雷帕霉素靶蛋白、表皮生长因子受体/丝裂原活化蛋白激酶表皮生长因子受体/磷酯酰肌醇-3-激酶—丝氨酸/苏氨酸激酶/核因子κB、缺氧诱导因子1、丝裂原化蛋白激酶、丝裂原活化蛋白激酶、肾素—血管紧张素/丝裂原活化的细胞外信号调节激酶/细胞外调节蛋白激酶、Wnt、自噬等信号通路及脂质磷酸酶活性相关;肾保护作用机制是抗氧化、抗炎、抗脂质过氧化、抑制肾小管上皮细胞的增殖;升高白细胞作用机制与自噬、造血系统相关通路和相关基因、造血生长因子等表达、糖代谢、氨基酸和核苷酸代谢的途径相关。在临床上用于消化道出血等出血症、过敏性紫癜及急性湿疹、烧烫伤、痤疮及压疮、急慢性肾小球肾炎等,且地榆制剂地榆升白片常用于白细胞减少症,临床效果明确,表明应用现代科学技术促进了传统中药地榆临床应用。本文对地榆的药理作用机制研究进行综述,为地榆的研究及临床应用提供参考。 展开更多
关键词 地榆 药理作用机制 临床应用 地榆升白片 研究进展
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矿物类中药治疗失眠的药理作用及临床应用研究进展 被引量:1
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作者 柴士伟 范栢爽 +1 位作者 宋学姣 庄朋伟 《天津中医药》 CAS 2024年第3期403-408,共6页
矿物类中药发挥重镇安神作用治疗失眠时疗效显著,通过检索相关著作和文献,发现治疗失眠的矿物药共16种。临床常用于治疗围绝经期失眠、糖尿病相关失眠、抑郁性失眠,顽固性失眠等多种形式引起的慢性失眠。主要通过调节神经递质的异常表达... 矿物类中药发挥重镇安神作用治疗失眠时疗效显著,通过检索相关著作和文献,发现治疗失眠的矿物药共16种。临床常用于治疗围绝经期失眠、糖尿病相关失眠、抑郁性失眠,顽固性失眠等多种形式引起的慢性失眠。主要通过调节神经递质的异常表达,减少炎性因子、氧化应激因子的释放,下调下丘脑-垂体-肾上腺(HPA)轴激素的分泌,延长慢波和快速动眼睡眠期等发挥治疗作用。现对矿物药的药理研究及临床应用进展作一综述,以期为矿物药在治疗失眠方面的开发与利用提供参考。 展开更多
关键词 矿物药 失眠 药理作用 临床应用 研究进展
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内服中药复方治疗非酒精性脂肪性肝病的临床研究进展 被引量:1
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作者 李艳 刘丽丽 +1 位作者 施卫兵 张国梁 《实用中医内科杂志》 2024年第6期72-75,共4页
近年来,非酒精性脂肪性肝病(NAFLD)的发生率逐年上升,是临床常见的慢性肝病之一,由于其发病机制复杂,现代医学的治疗不仅限于肝脏本身病变,还要控制代谢紊乱。非酒精性脂肪性肝病属于“肝癖”“积聚”“胁痛”等范畴,病位在肝、脾、肾,... 近年来,非酒精性脂肪性肝病(NAFLD)的发生率逐年上升,是临床常见的慢性肝病之一,由于其发病机制复杂,现代医学的治疗不仅限于肝脏本身病变,还要控制代谢紊乱。非酒精性脂肪性肝病属于“肝癖”“积聚”“胁痛”等范畴,病位在肝、脾、肾,病理产物有痰、湿、瘀、热等,为虚实夹杂之病。中医药有着多靶点、多途径、整体调节的优势,现就内服中药复方治疗NAFLD的临床研究进行归纳,发现苓桂术甘汤、五苓散、苦黄颗粒、益肾化痰方、桂附理中汤、养肝消脂茶、大黄利胆胶囊、柴胡疏肝散、柴胡化浊饮等中药复方在改善非酒精性脂肪性肝病患者临床症状、肝功能、脂代谢、肝脏影像学指标、胰岛素抵抗、肠道功能、抗炎、血管性疾病危险因素等方面作用显著。 展开更多
关键词 非酒精性脂肪性肝病 中药 临床研究进展
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大黄[庶虫]虫丸临床应用及实验研究进展
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作者 荣宝山 石志强 翟佳滨 《中华中医药学刊》 CAS 北大核心 2024年第8期54-58,共5页
大黄[庶虫]虫丸为张仲景治疗虚劳干血的有效方剂。该方是在抵挡汤的基础上加苦杏仁、黄芩、地黄、白芍等8味中药组成,具有活血破瘀、缓中补虚之功,即峻药丸服,以缓攻瘀血,瘀血去则新血生,最终达扶正不留瘀、祛瘀不伤正的目的。适用于虚... 大黄[庶虫]虫丸为张仲景治疗虚劳干血的有效方剂。该方是在抵挡汤的基础上加苦杏仁、黄芩、地黄、白芍等8味中药组成,具有活血破瘀、缓中补虚之功,即峻药丸服,以缓攻瘀血,瘀血去则新血生,最终达扶正不留瘀、祛瘀不伤正的目的。适用于虚劳后期、因虚致瘀之证,故此方兼具扶正与祛邪双重功效。临床运用方面,单用大黄[庶虫]虫丸治疗相关疾病的报道偏少,多以其加减方或联合其他方剂或联合西药,治疗肝、心、肺、肾、妇科、男科等各类疾病。实验研究方面,大黄[庶虫]虫丸具有抗炎、抗纤维化,改善血糖、改善血脂、改善血管功能,改善微循环等作用,多针对某一具体疾病探讨其作用、机制,故其物质基础研究相对薄弱。通过查阅近10年大黄[庶虫]虫丸临床应用及实验研究情况,对其临床应用及实验研究进展进行归纳总结,为大黄[庶虫]虫丸深入研究、运用提供参考。 展开更多
关键词 大黄[庶虫]虫丸证 临床应用 实验研究 进展
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《中医药防治新型冠状病毒感染专家共识》临床问题的确定
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作者 王雪飞 苏右竹 +6 位作者 廖星 王烁 王宇琛 赵春霞 陈腾飞 刘清泉 苏芮 《中国中医急症》 2024年第3期377-382,共6页
目的确定《中医药防治新型冠状病毒感染专家共识》的临床问题,为该共识形成推荐意见提供基础,为突发急性传染病相关共识的制定提供参考。方法采用文献调研与德尔菲法相结合的方法,开展文献研究和专家学术观点的梳理,采用德尔菲法开展第... 目的确定《中医药防治新型冠状病毒感染专家共识》的临床问题,为该共识形成推荐意见提供基础,为突发急性传染病相关共识的制定提供参考。方法采用文献调研与德尔菲法相结合的方法,开展文献研究和专家学术观点的梳理,采用德尔菲法开展第一轮问卷调查,确定临床一线医生关注的主要临床问题形成条目池,在此基础上制定第二轮调查问卷,以票选率>70%为标准纳入原始问题清单。梳理共14个临床问题及15个结局指标,开展第三轮问卷调查,得票率>70%的项目纳入指南问题清单及结局指标。结果最终纳入文献145篇,专家对新冠病毒感染的病因、病机、分期及治疗方面的认识比较一致,认为“湿”为本病的核心病机,普遍认同分消走泄、疏通气机是治疗关键,在病名的命名方面分歧比较明显。第一轮德尔菲法回收82份问卷,第二轮德尔菲法回收92份问卷,形成原始问题清单;第三轮问卷调查最终采纳14项临床问题及12个结局指标。结论规范地在文献研究及与德尔菲法问卷调查基础上筛选制定的临床问题能够比较全面地反映临床一线需求、主要学术观点及外感热病经典理论,能够提高指南的可推广性和可行性。 展开更多
关键词 新型冠状病毒感染 专家共识 临床问题 德尔菲法 文献研究
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基于CiteSpace的岩溶地下水硝酸盐示踪研究进展
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作者 杨平恒 华茂松 +1 位作者 罗为群 郭文静 《中国岩溶》 CAS CSCD 北大核心 2024年第3期563-574,共12页
硝酸盐(NO_(3)^(-))是地下水中主要的污染物之一,其浓度一旦超标,将会对水生态和人类健康产生不良影响。文章分析2003-2022年岩溶地下水硝酸盐来源的同位素示踪进展,在中国知网(CNKI)收录的全部期刊数据库检索,以“岩溶地下水”“岩溶... 硝酸盐(NO_(3)^(-))是地下水中主要的污染物之一,其浓度一旦超标,将会对水生态和人类健康产生不良影响。文章分析2003-2022年岩溶地下水硝酸盐来源的同位素示踪进展,在中国知网(CNKI)收录的全部期刊数据库检索,以“岩溶地下水”“岩溶含水层”“喀斯特地下水”“喀斯特含水层”“硝酸盐”“硝态氮”“氮同位素”“氧同位素”“MixSIAR”“硝酸盐源”“氮转化”“硝酸盐污染”“硝酸盐双同位素”为主题词,得到1191篇论文;并在Web of Science(WOS)核心合集数据库中以“karst groundwater”“karst aquifer”“nitrate”“NOx-N”“nitrogen isotope”“oxygen isotope”“MixSIAR”“nitrate source”“nitrogen transformation”“nitrate contamination”和“dual nitrate isotopes”为主题词,得到2232篇文献。利用知识网络分析软件CiteSpace,对检索到的文献进行统计和研究热点分析。结果表明:在中文文献方面,中国地质科学院岩溶地质研究所在国内岩溶地下水硝酸盐研究领域优势巨大,中文文献发文量最多;关键词聚类知识图谱可概括为岩溶水文与水资源、水化学与水环境、岩溶地下水硝酸盐污染溯源3个研究热点;在英文文献方面,美国、中国和德国的发文数量最多,存在较为密切的合作关系。从研究单位来看,中国科学院的发文量最多;英文关键词聚类知识图谱可以概括为岩溶生态与水文、岩溶地下水硝酸盐的转化(氮循坏)、岩溶地下水硝酸盐污染溯源3个研究热点。硝酸盐氮氧同位素技术为岩溶地下水硝酸盐溯源与生物地球化学研究提供了强有力的支持;在定量溯源时,应考虑同位素分馏效应,以提高结果的准确性。 展开更多
关键词 岩溶水 硝酸盐 溯源 研究进展 文献可视化分析
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从临床表现的多样性及复杂性再认识眼部带状疱疹
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作者 王庆强 王峰 +3 位作者 杜晓军 李慧林 贾新国 陈春丽 《国际眼科杂志》 CAS 2024年第12期1950-1953,共4页
眼部带状疱疹(HZO)为潜伏在三叉神经节的水痘-带状疱疹病毒(VZV)再激活复制后,累及三叉神经眼支所致,通常发生于老年人和免疫功能低下的人群。眼部带状疱疹的临床表现复杂多样,不仅可以表现为角结膜炎、葡萄膜炎,而且可以表现为视网膜... 眼部带状疱疹(HZO)为潜伏在三叉神经节的水痘-带状疱疹病毒(VZV)再激活复制后,累及三叉神经眼支所致,通常发生于老年人和免疫功能低下的人群。眼部带状疱疹的临床表现复杂多样,不仅可以表现为角结膜炎、葡萄膜炎,而且可以表现为视网膜坏死、视神经病变,极少数还可能发生中枢神经系统病变。部分病例没有典型的皮肤损害,极易造成漏诊、误诊、误治,严重影响患者的生活质量。文章总结了近年来文献中眼部带状疱疹病例的临床特点,全面再认识眼部带状疱疹临床表现的多样性、复杂性,可以更好地诊断和治疗该病,提高该病的诊断率、治愈率,最大限度地减少视力损害,也为眼部带状疱疹的精准诊疗提供更多的循证证据。 展开更多
关键词 眼部带状疱疹 临床表现 研究进展
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清金化痰汤治疗呼吸系统疾病的研究进展
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作者 罗成 叶远航 +4 位作者 宁博 左婉曌 吕安淇 姜成 柯佳 《世界中医药》 CAS 北大核心 2024年第18期2846-2853,共8页
经典名方清金化痰汤源于《医学统旨》,具有清热化痰、宣降肺气的功效,临床广泛用于以痰热壅肺证为主的呼吸系统疾病的治疗。研究证明,临床上清金化痰汤治疗肺炎、重症肺炎、慢性阻塞性肺疾病急性加重期、支气管扩张症、慢性支气管炎、... 经典名方清金化痰汤源于《医学统旨》,具有清热化痰、宣降肺气的功效,临床广泛用于以痰热壅肺证为主的呼吸系统疾病的治疗。研究证明,临床上清金化痰汤治疗肺炎、重症肺炎、慢性阻塞性肺疾病急性加重期、支气管扩张症、慢性支气管炎、肺癌等呼吸系统疾病疗效确切,能缓解临床症状、提高免疫力、改善肺功能及血气分析、降低炎症反应指标等。基础研究上清金化痰汤可以通过调控自噬、调控铁代谢、提高免疫功能、抗病毒、介导各种信号通路等,减轻炎症反应,减少肺部损伤,来达到治疗呼吸系统疾病的作用。为了使清金化痰汤更好地应用于现代呼吸系统疾病,现从清金化痰汤的古代文献分析、临床研究以及基础研究3方面,对其进行整理与总结,为今后经典名方清金化痰汤的治疗呼吸系统疾病以及新药研发提供科学依据。 展开更多
关键词 清金化痰汤 呼吸系统疾病 文献研究 临床研究 基础研究 中医药 治疗 研究进展
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