Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from COVID-19.Methods:This study applied a cross-sectional approach within...Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from COVID-19.Methods:This study applied a cross-sectional approach within community settings in a southern province of Vietnam.A structured questionnaire featuring socio-demographic information and common long COVID symptoms was employed.Phi correlation coefficients assessed associations among pairs of long COVID symptoms.Additionally,multivariable logistic regression models were performed to investigate the risk factors of long COVID in recovered COVID-19 children and adolescents.Results:Among 422 participants,39.3%reported long COVID symptoms,with a prevalence of 45.2%(SD=0.5)in children and 22.2%(SD=0.4)in adolescents.Common symptoms reported were cough 34.6%(SD=0.5),fatigue 20.6%(SD=0.4),shortness of breath 10.9%(SD=0.3),and lack of appetite 6.6%(SD=0.3).Concerning risk factors of long COVID,a higher risk was observed among demographic groups,including girls(OR 1.25,95%CI 1.15-1.37;P<0.001,reference:boys),children compared to adolescents(OR 1.24,95%CI 1.12-1.37;P<0.001),overweight individuals(OR 1.14,95%CI 1.02-1.27;P=0.018,reference:healthy weight),and participants without any COVID-19 vaccination(OR 1.36,95%CI 1.20-1.54;P<0.001),or have received only one single dose(OR 1.35,95%CI 1.10-1.64;P=0.004)compared to those who have received two doses.Besides,patients with a COVID-19 treatment duration exceeding two weeks also had a higher risk of long COVID(OR 1.32,95%CI 1.09-1.60;P=0.003)than those who recovered less than seven days.Conclusions:The insights from this study provide crucial guidance for predicting the factors associated with the occurrence of long COVID in pediatric patients,contributing to strategic interventions aimed at mitigating the long COVID risks among children and adolescents in Vietnam.展开更多
Long COVID symptoms typically occur within 3 months of an initial COVID-19 infection,last for more than 2 months,and cannot be explained by other diagnoses.The most common symptoms include fatigue,dyspnea,coughing,and...Long COVID symptoms typically occur within 3 months of an initial COVID-19 infection,last for more than 2 months,and cannot be explained by other diagnoses.The most common symptoms include fatigue,dyspnea,coughing,and cognitive impairment.The mechanisms of long COVID are not fully understood,but several hypotheses have been put forth.These include coagulation and fibrosis pathway activation,inflammatory and autoimmune manifestations,persistent virus presence,and Epstein-Barr virus reactivation.Hyperbaric oxygen therapy(HBOT)is a therapeutic method in which a person inhales 100%oxygen under pressure greater than that of the atmosphere.HBOT has some therapeutic effects,including improvement of microcirculation,inhibition of cytokine release leading to a reduction in inflammatory responses,inhibition of autoimmune responses,and promotion of neurological repair.Several clinical trials have been carried out using HBOT to treat long COVID.The results suggest that HBOT helps to improve symptom severity,reduce symptom duration,and enhance patients’quality of life.It is believed that HBOT is an effective option for patients with long COVID,which is worth actively promoting.展开更多
Objective:To investigate the cognitive state,psychological problems such as depression and anxiety,and pain in the musculoskeletal system among young adults with post-COVID-19(long COVID)syndrome.Methods:This descript...Objective:To investigate the cognitive state,psychological problems such as depression and anxiety,and pain in the musculoskeletal system among young adults with post-COVID-19(long COVID)syndrome.Methods:This descriptive study included 361 students studying at the Vocational School of Health Services of Bingöl University in Turkey.Data were collected using the Socio-Demographic Information form,the Beck’s Depression Inventory,the Cognitive Appraisal Scale,and the Visual Analogue Scale for pain.Results:Compared to those without COVID-19,the mean depression score,cognitive appraisal score,and mean Visual Analogue Scale score of the young adults with COVID-19 were significantly higher.There was no significant difference in pain assessment at rest between those with COVID-19 and those without COVID-19.Conclusions:Young adults with COVID-19 are more depressed,their cognitive functions are more easily negatively affected,and experience more pain during exercise.展开更多
Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of the disease. Persistent symptoms such as dry cough, fatigue, and dyspnea can remain after six months of COVI...Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of the disease. Persistent symptoms such as dry cough, fatigue, and dyspnea can remain after six months of COVID-19 cure. Others such as lung fibrosis, kidney injury, and thrombotic risk also are observed. Here, a deep review of each human organ and system infected by the virus was performed aiming to show how molecules expression and cell signaling can induce the organism cure or injuries and, subsequently sequelae. The review also suggests the importance of public health surveillance for these cases including a more comprehensive analysis of molecular biology tools that can clarify and assist in the prognosis, treatment, and preventive methods for potentially more serious disorders in post-COVID-19 patients.展开更多
The main etiopathogenic theories of long coronavirus disease(COVID)are listed and a conjunction of them is carried out with the objective of deciphering the pathophysiology of the entity,finally the main lines of trea...The main etiopathogenic theories of long coronavirus disease(COVID)are listed and a conjunction of them is carried out with the objective of deciphering the pathophysiology of the entity,finally the main lines of treatment existing in real life are discussed(Paxlovid,use of antibiotics in dysbiosis,triple anticoagulant therapy,temelimab).展开更多
The topic of the long-term effects of COVID-19, so-called “long-COVID”, has gained increased attention. The US federal government announced plans to develop an interagency national research action plan to uncover mo...The topic of the long-term effects of COVID-19, so-called “long-COVID”, has gained increased attention. The US federal government announced plans to develop an interagency national research action plan to uncover more insights into the long-term effects of COVID-19. This study contributes to our understanding of the long-term effects of COVID-19 by quantifying patterns of healthcare utilization up to 360 days after an initial COVID-19 diagnosis occurring during the beginning of the pandemic (March-August 2020) in a very large nationally representative population of insured adults. We quantify actual COVID-19-related utilization (as opposed to reported symptoms) by accessing claims data to calculate average medical visits per patient per month by type of encounter (e.g. inpatient stay, physician visit). In contrast to many recent reports in the media, our results show that COVID-19-related utilization declines substantially after the first-month post-diagnosis and continues to decline throughout the study period to very low levels.展开更多
We have been experiencing multiple waves of the coronavirus disease 2019(COVID-19)pandemic.With these unprecedented waves,we have entered into an era of‘new normal’.This pandemic has enforced us to rethink the very ...We have been experiencing multiple waves of the coronavirus disease 2019(COVID-19)pandemic.With these unprecedented waves,we have entered into an era of‘new normal’.This pandemic has enforced us to rethink the very basics of childhood learning:Habits,health etiquette,and hygiene.Rehabilitation has immense importance during this pandemic considering a few aspects.Multidisciplinary COVID-19 rehabilitation clinics are essential to address the demand.The equitable distribution of COVID-19 rehabilitation services for differently-abled individuals during the pandemic is an important aspect.Rehabilitation needs identification and further studies on various rehabilitation interventions are among the key unmet future research needs.展开更多
Objective:To determine the change in the quality of life(QoL)of patients who applied to a tertiary outpatient clinic according to their COVID-19 status.Methods:This cross-sectional study comprised 1370 participants.Sh...Objective:To determine the change in the quality of life(QoL)of patients who applied to a tertiary outpatient clinic according to their COVID-19 status.Methods:This cross-sectional study comprised 1370 participants.Short form-12(SF-12),which includes Physical Component Summary(PCS)and Mental Component Summary(MCS)domains,was used to evaluate the QoL.Different linear regression models created using PCS-12 and MCS-12 were dependent variables.Results:A total of 19.2% of participants had acute COVID-19,and 8.4%had long COVID-19.The most common sypmtoms were fatigue(72.6%),headache(42.5%),and joint pain(39.8%)in patients with long COVID-19.The model including all participants showed that long COVID-19 reduced the QoL in multivariate analysis for both MCS and PCS,while acute COVID-19 had no significant effect on the QoL comparing with those without COVID-19.Model that included participants with COVID-19 showed that long COVID-19 negatively affected the QoL in the multivariate model for PCS-12 and MCS-12.Variables that were significant in the multivariate model for those who had long COVID-19 were having a chronic disease and presence of ongoing symptoms.Females were disadvantaged for PCS-12 and MCS-12 in the multivariate models including all participants,and models including participants who have had COVID-19.Low educational group were disadvantaged for PCS-12 in the multivariate model including all participants.This group were also disadvantaged for PCS-12 and MCS-12 in the multivariate models including participants who had COVID-19.Conclusions:In studies,acute COVID-19 and long COVID-19 should be treated as separate categories.The effects of long COVID-19 should be considered when providing and planning health services.The effect of gender,and education,on QoL shows that health inequalities continue to be effective during the pandemic period.展开更多
BACKGROUND Coronavirus disease 2019(COVID-19)has crippled humanity since early 2020.Various sequelae of COVID-19 have been reported in different body systems.Musculoskeletal symptoms are widely reported during COVID-1...BACKGROUND Coronavirus disease 2019(COVID-19)has crippled humanity since early 2020.Various sequelae of COVID-19 have been reported in different body systems.Musculoskeletal symptoms are widely reported during COVID-19 infection,but musculoskeletal complications in long COVID-19 are underreported.However,post-COVID-19 survivors have reported complaints of persisting or new-onset fatigue,myalgia,arthralgia,arthritis,muscle weakness,etc in clinical practice.The well-known detrimental effects of steroids on the musculoskeletal system coupled with their over-the-counter availability can also be anticipated since they were the cornerstone of life-saving management in this pandemic.AIM To determine the musculoskeletal complications in long COVID.METHODS We performed a systematic review of‘systematic reviews and meta-analyses’.RESULTS Of the 63 articles screened,24 articles were included.Two articles specifically discussed children and adolescents.One article discussed rehabilitation intervention.No article addressed rehabilitation of musculoskeletal issues in long COVID-19 in particular.Fatigue was the most common musculoskeletal complication.CONCLUSION Fatigue is found to be very common along with myalgia and arthralgia.There were no studies on rehabilitation intervention in musculoskeletal complications specifically.Considering the lacuna in literature and the needs of the current situation,further studies are warranted to standardize effective rehabilitation interventions in musculoskeletal complications.More homogenous studies are needed.Studies on functional impairment due to musculoskeletal involvement are essential.展开更多
Background:An estimated 10 to 30 percent of people who become infected with Severe acute respiratory syndrome coronavirus 2 will experience persistent symptoms after recovering from Coronavirus Disease 2019(COVID-19),...Background:An estimated 10 to 30 percent of people who become infected with Severe acute respiratory syndrome coronavirus 2 will experience persistent symptoms after recovering from Coronavirus Disease 2019(COVID-19),which is known as Long COVID.Social media platforms like Facebook and Twitter are the primary sources to gather and examine people’s opinion and sentiments towards various topics.Methods:In this paper,we aimed to examine sentiments,discover key themes and associated topics in Long COVID-related messages posted by Twitter users in the US between March 2022 and April 2022 using sentiment analysis and topic modeling.Results:A total of 117,789 tweets were examined,of which three dominant themes were identified,ranging from symptoms to social and economic impacts,and preventive measures.We also found that more negative sentiments were expressed in the tweets by users toward long-term COVID-19.Conclusions:Our research throws light on dominant themes,topics and sentiments surrounding the ongoing public health crisis.From the insights gained,we discuss the major implications of this study for health practitioners and policymakers.展开更多
Coronaviruses are pathogens thought to primarily affect the respiratory tracts of humans.The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 was also marked mainly by its symptoms of res...Coronaviruses are pathogens thought to primarily affect the respiratory tracts of humans.The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 was also marked mainly by its symptoms of respiratory illness,which were named coronavirus disease 2019(COVID-19).Since its initial discovery,many other symptoms have been linked to acute SARS-CoV-2 infections as well as to the long-term outcomes of COVID-19 patients.Among these symptoms are different categories of cardiovascular diseases(CVDs),which continue to be the main cause of death worldwide.The World Health Organization estimates that 17.9 million people die from CVDs each year,accounting for~32%of all deaths globally.Physical inactivity is one of the most important behavioral risk factors for CVDs.The COVID-19 pandemic has affected CVDs as well as the physical activity in different ways.Here,we provide an overview of the current status as well as future challenges and possible solutions.展开更多
Background Coronavirus disease 2019(COVID-19)can involve persistence,sequelae,and other clinical complications that last weeks to months to evolve into long COVID-19.Exploratory studies have suggested that interleukin...Background Coronavirus disease 2019(COVID-19)can involve persistence,sequelae,and other clinical complications that last weeks to months to evolve into long COVID-19.Exploratory studies have suggested that interleukin-6(IL-6)is related to COVID-19;however,the correlation between IL-6 and long COVID-19 is unknown.We designed a systematic review and meta-analysis to assess the relationship between IL-6 levels and long COVID-19.Methods Databases were systematically searched for articles with data on long COVID-19 and IL-6 levels published before September 2022.A total of 22 published studies were eligible for inclusion following the PRISMA guidelines.Analysis of data was undertaken by using Cochran's Q test and the Higgins I-squared(I2)statistic for heterogeneity.Random-effect meta-analyses were conducted to pool the IL-6 levels of long COVID-19 patients and to compare the differences in IL-6 levels among the long COVID-19,healthy,non-postacute sequelae of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection(non-PASC),and acute COVID-19 populations.The funnel plot and Egger's test were used to assess potential publication bias.Sensitivity analysis was used to test the stability of the results.Results An increase in IL-6 levels was observed after SARS-CoV-2 infection.The pooled estimate of IL-6 revealed a mean value of 20.92 pg/ml(95%CI=9.30–32.54 pg/ml,I2=100%,P<0.01)for long COVID-19 patients.The forest plot showed high levels of IL-6 for long COVID-19 compared with healthy controls(mean difference=9.75 pg/ml,95%CI=5.75–13.75 pg/ml,I2=100%,P<0.00001)and PASC category(mean difference=3.32 pg/ml,95%CI=0.22–6.42 pg/ml,I2=88%,P=0.04).The symmetry of the funnel plots was not obvious,and Egger’s test showed that there was no significant small study effect in all groups.Conclusions This study showed that increased IL-6 correlates with long COVID-19.Such an informative revelation suggests IL-6 as a basic determinant to predict long COVID-19 or at least inform on the“early stage”of long COVID-19.展开更多
BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and mortality.COVID-associated cystiti...BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and mortality.COVID-associated cystitis(CAC),presents as new onset or exacerbated urinary symptoms,resembling overactive bladder(OAB)symptoms.AIM To examines the long-term outcomes of patients with CAC in the context of Long COVID.METHODS A cohort of 350 patients admitted to Detroit Hospitals with COVID-19 between May and December 2020,displaying CAC symptoms following discharge,was prospectively followed.Initial urologic evaluations occurred at 10-14 wk and were repeated at 21-28 mo postdischarge.Symptoms were managed conservatively,employing behavioral modifications and standard OAB medications.Participants completed surveys assessing urinary symptoms and quality of life(QoL)at both time points.The primary outcome was the Urology Care Foundation Overactive Bladder Assessment Tool.RESULTS 87%of the final cohort(n=310)reported symptom improvement at 21-28 mo post-discharge.Patients with new onset CAC symptoms showed a median decrease of 9-10 points in OAB and QoL scores,while those with existing symptoms experienced a decrease of 6 points.Overall,95.4%of patients with new onset symptoms reported symptom improvement at follow-up,contrasting with 60.7%among those with existing symptoms.CONCLUSION This study presents the first long-term follow-up of adult patients with CAC,revealing a promising prognosis with conservative management measures in the context of Long COVID.These findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health.展开更多
More than 670 million cases of coronavirus disease 2019(COVID-19)have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic.About 45%of survi...More than 670 million cases of coronavirus disease 2019(COVID-19)have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic.About 45%of survivors of COVID-19 develop a syndrome known as long-term COVID,in which symptoms persist even months after the acute infection.About 76%of patients with long COVID experience neurological manifestations.Moreover,patients who have survived COVID-19 have an increased risk of cerebral venous thrombosis.This case report describes a 41-year-old woman who developed neurological manifestations associated with jugular vein thrombosis 24 h after administration of the Oxford–AstraZeneca(ChAdOx1 nCoV-19)vaccine(AstraZeneca-Serum Institute of India).She had been infected with SARS-CoV-2 three months before vaccination.Although initially suspected to be a case of vaccine-induced immune thrombotic thrombocytopenia(VITT)in view of her recent vaccination,the patient did not have any hallmarks of VITT,such as thrombocytopenia,an increased D-dimer level,or antibodies against platelet factor-4.Moreover,the neurological manifestations were associated with a high concentration of inflammatory cytokines,including interleukin(IL)-6,IL-17A,and IL-21,and elevated neutrophil levels in cerebrospinal fluid,suggesting that inflammatory immune components had a role in the development of thrombotic events and pointing to an alternative diagnosis.In this case,the laboratory results indicated that the neurological manifestations associated with jugular vein thrombosis were not associated with VITT.Therefore,we propose that the thrombosis of the left jugular vein was a sequela of SARS-CoV-2 infection.展开更多
目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSvie...目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSviewer软件生成知识图谱。结果:共鉴定出768篇文章,发文涉及美国、意大利和中国为首的319个国家/地区和4 366个机构,领先的研究机构是梅奥诊所和哈佛医学院。New England Journal of Medicine是该领域最常被引用的期刊。在6 687位作者中,Arbelo Elena撰写的研究最多,Guo T被共同引用的次数最多,心房纤颤是最常见的关键词。结论:随着COVID-19的暴发,对COVID-19所致新发/进行性心律失常事件的研究蓬勃发展,未来的研究者可能会对COVID-19感染后新发或遗留的快速性心律失常/缓慢性心律失常的发生机制进行进一步的探索。展开更多
文摘Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from COVID-19.Methods:This study applied a cross-sectional approach within community settings in a southern province of Vietnam.A structured questionnaire featuring socio-demographic information and common long COVID symptoms was employed.Phi correlation coefficients assessed associations among pairs of long COVID symptoms.Additionally,multivariable logistic regression models were performed to investigate the risk factors of long COVID in recovered COVID-19 children and adolescents.Results:Among 422 participants,39.3%reported long COVID symptoms,with a prevalence of 45.2%(SD=0.5)in children and 22.2%(SD=0.4)in adolescents.Common symptoms reported were cough 34.6%(SD=0.5),fatigue 20.6%(SD=0.4),shortness of breath 10.9%(SD=0.3),and lack of appetite 6.6%(SD=0.3).Concerning risk factors of long COVID,a higher risk was observed among demographic groups,including girls(OR 1.25,95%CI 1.15-1.37;P<0.001,reference:boys),children compared to adolescents(OR 1.24,95%CI 1.12-1.37;P<0.001),overweight individuals(OR 1.14,95%CI 1.02-1.27;P=0.018,reference:healthy weight),and participants without any COVID-19 vaccination(OR 1.36,95%CI 1.20-1.54;P<0.001),or have received only one single dose(OR 1.35,95%CI 1.10-1.64;P=0.004)compared to those who have received two doses.Besides,patients with a COVID-19 treatment duration exceeding two weeks also had a higher risk of long COVID(OR 1.32,95%CI 1.09-1.60;P=0.003)than those who recovered less than seven days.Conclusions:The insights from this study provide crucial guidance for predicting the factors associated with the occurrence of long COVID in pediatric patients,contributing to strategic interventions aimed at mitigating the long COVID risks among children and adolescents in Vietnam.
文摘Long COVID symptoms typically occur within 3 months of an initial COVID-19 infection,last for more than 2 months,and cannot be explained by other diagnoses.The most common symptoms include fatigue,dyspnea,coughing,and cognitive impairment.The mechanisms of long COVID are not fully understood,but several hypotheses have been put forth.These include coagulation and fibrosis pathway activation,inflammatory and autoimmune manifestations,persistent virus presence,and Epstein-Barr virus reactivation.Hyperbaric oxygen therapy(HBOT)is a therapeutic method in which a person inhales 100%oxygen under pressure greater than that of the atmosphere.HBOT has some therapeutic effects,including improvement of microcirculation,inhibition of cytokine release leading to a reduction in inflammatory responses,inhibition of autoimmune responses,and promotion of neurological repair.Several clinical trials have been carried out using HBOT to treat long COVID.The results suggest that HBOT helps to improve symptom severity,reduce symptom duration,and enhance patients’quality of life.It is believed that HBOT is an effective option for patients with long COVID,which is worth actively promoting.
文摘Objective:To investigate the cognitive state,psychological problems such as depression and anxiety,and pain in the musculoskeletal system among young adults with post-COVID-19(long COVID)syndrome.Methods:This descriptive study included 361 students studying at the Vocational School of Health Services of Bingöl University in Turkey.Data were collected using the Socio-Demographic Information form,the Beck’s Depression Inventory,the Cognitive Appraisal Scale,and the Visual Analogue Scale for pain.Results:Compared to those without COVID-19,the mean depression score,cognitive appraisal score,and mean Visual Analogue Scale score of the young adults with COVID-19 were significantly higher.There was no significant difference in pain assessment at rest between those with COVID-19 and those without COVID-19.Conclusions:Young adults with COVID-19 are more depressed,their cognitive functions are more easily negatively affected,and experience more pain during exercise.
文摘Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of the disease. Persistent symptoms such as dry cough, fatigue, and dyspnea can remain after six months of COVID-19 cure. Others such as lung fibrosis, kidney injury, and thrombotic risk also are observed. Here, a deep review of each human organ and system infected by the virus was performed aiming to show how molecules expression and cell signaling can induce the organism cure or injuries and, subsequently sequelae. The review also suggests the importance of public health surveillance for these cases including a more comprehensive analysis of molecular biology tools that can clarify and assist in the prognosis, treatment, and preventive methods for potentially more serious disorders in post-COVID-19 patients.
文摘The main etiopathogenic theories of long coronavirus disease(COVID)are listed and a conjunction of them is carried out with the objective of deciphering the pathophysiology of the entity,finally the main lines of treatment existing in real life are discussed(Paxlovid,use of antibiotics in dysbiosis,triple anticoagulant therapy,temelimab).
文摘The topic of the long-term effects of COVID-19, so-called “long-COVID”, has gained increased attention. The US federal government announced plans to develop an interagency national research action plan to uncover more insights into the long-term effects of COVID-19. This study contributes to our understanding of the long-term effects of COVID-19 by quantifying patterns of healthcare utilization up to 360 days after an initial COVID-19 diagnosis occurring during the beginning of the pandemic (March-August 2020) in a very large nationally representative population of insured adults. We quantify actual COVID-19-related utilization (as opposed to reported symptoms) by accessing claims data to calculate average medical visits per patient per month by type of encounter (e.g. inpatient stay, physician visit). In contrast to many recent reports in the media, our results show that COVID-19-related utilization declines substantially after the first-month post-diagnosis and continues to decline throughout the study period to very low levels.
文摘We have been experiencing multiple waves of the coronavirus disease 2019(COVID-19)pandemic.With these unprecedented waves,we have entered into an era of‘new normal’.This pandemic has enforced us to rethink the very basics of childhood learning:Habits,health etiquette,and hygiene.Rehabilitation has immense importance during this pandemic considering a few aspects.Multidisciplinary COVID-19 rehabilitation clinics are essential to address the demand.The equitable distribution of COVID-19 rehabilitation services for differently-abled individuals during the pandemic is an important aspect.Rehabilitation needs identification and further studies on various rehabilitation interventions are among the key unmet future research needs.
文摘Objective:To determine the change in the quality of life(QoL)of patients who applied to a tertiary outpatient clinic according to their COVID-19 status.Methods:This cross-sectional study comprised 1370 participants.Short form-12(SF-12),which includes Physical Component Summary(PCS)and Mental Component Summary(MCS)domains,was used to evaluate the QoL.Different linear regression models created using PCS-12 and MCS-12 were dependent variables.Results:A total of 19.2% of participants had acute COVID-19,and 8.4%had long COVID-19.The most common sypmtoms were fatigue(72.6%),headache(42.5%),and joint pain(39.8%)in patients with long COVID-19.The model including all participants showed that long COVID-19 reduced the QoL in multivariate analysis for both MCS and PCS,while acute COVID-19 had no significant effect on the QoL comparing with those without COVID-19.Model that included participants with COVID-19 showed that long COVID-19 negatively affected the QoL in the multivariate model for PCS-12 and MCS-12.Variables that were significant in the multivariate model for those who had long COVID-19 were having a chronic disease and presence of ongoing symptoms.Females were disadvantaged for PCS-12 and MCS-12 in the multivariate models including all participants,and models including participants who have had COVID-19.Low educational group were disadvantaged for PCS-12 in the multivariate model including all participants.This group were also disadvantaged for PCS-12 and MCS-12 in the multivariate models including participants who had COVID-19.Conclusions:In studies,acute COVID-19 and long COVID-19 should be treated as separate categories.The effects of long COVID-19 should be considered when providing and planning health services.The effect of gender,and education,on QoL shows that health inequalities continue to be effective during the pandemic period.
文摘BACKGROUND Coronavirus disease 2019(COVID-19)has crippled humanity since early 2020.Various sequelae of COVID-19 have been reported in different body systems.Musculoskeletal symptoms are widely reported during COVID-19 infection,but musculoskeletal complications in long COVID-19 are underreported.However,post-COVID-19 survivors have reported complaints of persisting or new-onset fatigue,myalgia,arthralgia,arthritis,muscle weakness,etc in clinical practice.The well-known detrimental effects of steroids on the musculoskeletal system coupled with their over-the-counter availability can also be anticipated since they were the cornerstone of life-saving management in this pandemic.AIM To determine the musculoskeletal complications in long COVID.METHODS We performed a systematic review of‘systematic reviews and meta-analyses’.RESULTS Of the 63 articles screened,24 articles were included.Two articles specifically discussed children and adolescents.One article discussed rehabilitation intervention.No article addressed rehabilitation of musculoskeletal issues in long COVID-19 in particular.Fatigue was the most common musculoskeletal complication.CONCLUSION Fatigue is found to be very common along with myalgia and arthralgia.There were no studies on rehabilitation intervention in musculoskeletal complications specifically.Considering the lacuna in literature and the needs of the current situation,further studies are warranted to standardize effective rehabilitation interventions in musculoskeletal complications.More homogenous studies are needed.Studies on functional impairment due to musculoskeletal involvement are essential.
文摘Background:An estimated 10 to 30 percent of people who become infected with Severe acute respiratory syndrome coronavirus 2 will experience persistent symptoms after recovering from Coronavirus Disease 2019(COVID-19),which is known as Long COVID.Social media platforms like Facebook and Twitter are the primary sources to gather and examine people’s opinion and sentiments towards various topics.Methods:In this paper,we aimed to examine sentiments,discover key themes and associated topics in Long COVID-related messages posted by Twitter users in the US between March 2022 and April 2022 using sentiment analysis and topic modeling.Results:A total of 117,789 tweets were examined,of which three dominant themes were identified,ranging from symptoms to social and economic impacts,and preventive measures.We also found that more negative sentiments were expressed in the tweets by users toward long-term COVID-19.Conclusions:Our research throws light on dominant themes,topics and sentiments surrounding the ongoing public health crisis.From the insights gained,we discuss the major implications of this study for health practitioners and policymakers.
基金supported by the MWK Lower Saxony,Germanythe COVID-19 Forschungsnetzwerk Niedersachsen(COFONI)。
文摘Coronaviruses are pathogens thought to primarily affect the respiratory tracts of humans.The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 was also marked mainly by its symptoms of respiratory illness,which were named coronavirus disease 2019(COVID-19).Since its initial discovery,many other symptoms have been linked to acute SARS-CoV-2 infections as well as to the long-term outcomes of COVID-19 patients.Among these symptoms are different categories of cardiovascular diseases(CVDs),which continue to be the main cause of death worldwide.The World Health Organization estimates that 17.9 million people die from CVDs each year,accounting for~32%of all deaths globally.Physical inactivity is one of the most important behavioral risk factors for CVDs.The COVID-19 pandemic has affected CVDs as well as the physical activity in different ways.Here,we provide an overview of the current status as well as future challenges and possible solutions.
文摘Background Coronavirus disease 2019(COVID-19)can involve persistence,sequelae,and other clinical complications that last weeks to months to evolve into long COVID-19.Exploratory studies have suggested that interleukin-6(IL-6)is related to COVID-19;however,the correlation between IL-6 and long COVID-19 is unknown.We designed a systematic review and meta-analysis to assess the relationship between IL-6 levels and long COVID-19.Methods Databases were systematically searched for articles with data on long COVID-19 and IL-6 levels published before September 2022.A total of 22 published studies were eligible for inclusion following the PRISMA guidelines.Analysis of data was undertaken by using Cochran's Q test and the Higgins I-squared(I2)statistic for heterogeneity.Random-effect meta-analyses were conducted to pool the IL-6 levels of long COVID-19 patients and to compare the differences in IL-6 levels among the long COVID-19,healthy,non-postacute sequelae of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection(non-PASC),and acute COVID-19 populations.The funnel plot and Egger's test were used to assess potential publication bias.Sensitivity analysis was used to test the stability of the results.Results An increase in IL-6 levels was observed after SARS-CoV-2 infection.The pooled estimate of IL-6 revealed a mean value of 20.92 pg/ml(95%CI=9.30–32.54 pg/ml,I2=100%,P<0.01)for long COVID-19 patients.The forest plot showed high levels of IL-6 for long COVID-19 compared with healthy controls(mean difference=9.75 pg/ml,95%CI=5.75–13.75 pg/ml,I2=100%,P<0.00001)and PASC category(mean difference=3.32 pg/ml,95%CI=0.22–6.42 pg/ml,I2=88%,P=0.04).The symmetry of the funnel plots was not obvious,and Egger’s test showed that there was no significant small study effect in all groups.Conclusions This study showed that increased IL-6 correlates with long COVID-19.Such an informative revelation suggests IL-6 as a basic determinant to predict long COVID-19 or at least inform on the“early stage”of long COVID-19.
基金The study was reviewed and approved by the Wayne State University Institutional Review Board(Protocol Number:IRB-20-04-2126).
文摘BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and mortality.COVID-associated cystitis(CAC),presents as new onset or exacerbated urinary symptoms,resembling overactive bladder(OAB)symptoms.AIM To examines the long-term outcomes of patients with CAC in the context of Long COVID.METHODS A cohort of 350 patients admitted to Detroit Hospitals with COVID-19 between May and December 2020,displaying CAC symptoms following discharge,was prospectively followed.Initial urologic evaluations occurred at 10-14 wk and were repeated at 21-28 mo postdischarge.Symptoms were managed conservatively,employing behavioral modifications and standard OAB medications.Participants completed surveys assessing urinary symptoms and quality of life(QoL)at both time points.The primary outcome was the Urology Care Foundation Overactive Bladder Assessment Tool.RESULTS 87%of the final cohort(n=310)reported symptom improvement at 21-28 mo post-discharge.Patients with new onset CAC symptoms showed a median decrease of 9-10 points in OAB and QoL scores,while those with existing symptoms experienced a decrease of 6 points.Overall,95.4%of patients with new onset symptoms reported symptom improvement at follow-up,contrasting with 60.7%among those with existing symptoms.CONCLUSION This study presents the first long-term follow-up of adult patients with CAC,revealing a promising prognosis with conservative management measures in the context of Long COVID.These findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health.
基金UNAM-DGAPA-PAPIIT,Grant/Award Number:IA208222Initiative Innova-UNAM and Alianza UCMX of the University of California+3 种基金Alzheimer's Association,Grant/Award Number:AARF-21-722869UNAM-DGAPA-PAPIIT,Grant/Award Number:IA203421UNAMDGAPA-PAPIIT,Grant/Award Number:IN222523CONACYT,Grant/Award Number:A1-S-15601。
文摘More than 670 million cases of coronavirus disease 2019(COVID-19)have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic.About 45%of survivors of COVID-19 develop a syndrome known as long-term COVID,in which symptoms persist even months after the acute infection.About 76%of patients with long COVID experience neurological manifestations.Moreover,patients who have survived COVID-19 have an increased risk of cerebral venous thrombosis.This case report describes a 41-year-old woman who developed neurological manifestations associated with jugular vein thrombosis 24 h after administration of the Oxford–AstraZeneca(ChAdOx1 nCoV-19)vaccine(AstraZeneca-Serum Institute of India).She had been infected with SARS-CoV-2 three months before vaccination.Although initially suspected to be a case of vaccine-induced immune thrombotic thrombocytopenia(VITT)in view of her recent vaccination,the patient did not have any hallmarks of VITT,such as thrombocytopenia,an increased D-dimer level,or antibodies against platelet factor-4.Moreover,the neurological manifestations were associated with a high concentration of inflammatory cytokines,including interleukin(IL)-6,IL-17A,and IL-21,and elevated neutrophil levels in cerebrospinal fluid,suggesting that inflammatory immune components had a role in the development of thrombotic events and pointing to an alternative diagnosis.In this case,the laboratory results indicated that the neurological manifestations associated with jugular vein thrombosis were not associated with VITT.Therefore,we propose that the thrombosis of the left jugular vein was a sequela of SARS-CoV-2 infection.
文摘目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSviewer软件生成知识图谱。结果:共鉴定出768篇文章,发文涉及美国、意大利和中国为首的319个国家/地区和4 366个机构,领先的研究机构是梅奥诊所和哈佛医学院。New England Journal of Medicine是该领域最常被引用的期刊。在6 687位作者中,Arbelo Elena撰写的研究最多,Guo T被共同引用的次数最多,心房纤颤是最常见的关键词。结论:随着COVID-19的暴发,对COVID-19所致新发/进行性心律失常事件的研究蓬勃发展,未来的研究者可能会对COVID-19感染后新发或遗留的快速性心律失常/缓慢性心律失常的发生机制进行进一步的探索。
