The pervasive presence of microplastics in marine environments has raised significant concerns. This review addresses the pressing issue of microplastic pollution in marine ecosystems and its potential implications fo...The pervasive presence of microplastics in marine environments has raised significant concerns. This review addresses the pressing issue of microplastic pollution in marine ecosystems and its potential implications for both the environment and human health. It outlines the current state of microplastic occurrence, distribution, and extraction methods within marine organisms. Microplastics have emerged as a significant environmental concern due to their harmful effects on ecosystems and their potential human health risks. These particles infiltrate marine environments through runoff and atmospheric deposition, ultimately contaminating beaches and posing threats to marine life. Despite the gravity of this issue, there has been limited research on the presence and distribution of microplastics in marine organisms. This review aims to bridge this knowledge gap by comprehensively examining the occurrence, distribution, and various extraction methods used to detect microplastics in marine organisms. It emphasizes the urgent need for targeted measures to manage microplastic pollution, highlights the significant role of human activities in contributing to this problem, and underscores the importance of reducing human-induced pollution to safeguard marine ecosystems. While this paper contributes to the understanding of microplastic pollution in marine environments and underscores the critical importance of taking action to protect marine organisms and preserve our oceans for future generations, it also emphasizes that, in effectively tackling the microplastic problem, a well-coordinated approach is essential, involving research initiatives, policy adjustments, public involvement, and innovative technologies. Crucially, prompt and resolute responses must exist to counteract the escalating peril posed by microplastics to the oceans and the global environment.展开更多
Global warming has become a global challenge having dire consequences on different aspects of the environment due to the melting of glaciers, excess carbon dioxide (CO<sub>2</sub>), and excess warming of w...Global warming has become a global challenge having dire consequences on different aspects of the environment due to the melting of glaciers, excess carbon dioxide (CO<sub>2</sub>), and excess warming of water bodies among others. At a faster pace recently, climate change is affecting the marine environment, causing numerous alterations. Here, we address its consequences and the numerous alterations, which are more vital for researchers and global agencies to advocate more on why it’s essential to lessen the impact of climate change. Our review showed that the impacts of climate change are articulated at several stages of the marine ecosystem where it affects the inhabitants and their habitats. In response to climate change (ocean warming) marine species shift their latitudinal range to find suitable conditions leading to the redistribution of species. In addition, we found that growth reduction, sub-optimal behaviors, and reduced immune-competence of marine organisms, are as a result of thermal stress due to climate change. Also, the periodic changes in temperature above or below the optimum have a meditative reproductive effect on marine species, including fish. Finally, we discovered that due to higher water temperatures, several diseases showcase greater virulence in the sense that the marine species become less resistant to these diseases due to stress, increased virulence stimuli, or increased transmission.展开更多
The PI3K/Akt/mTOR signaling pathway is one of the most frequently dysregulated pathways in cancer.Targeting the PI3K-mediated pathway has been an important strategy for developing novel anticancer agents.In the past d...The PI3K/Akt/mTOR signaling pathway is one of the most frequently dysregulated pathways in cancer.Targeting the PI3K-mediated pathway has been an important strategy for developing novel anticancer agents.In the past decades,more than 40 inhibitors of the PI3K/Akt/mTOR pathway have been developed at different clinical stages.Temsirolimus,everolimus,idelalisib,and copanlisib have been approved for clinical use by the Food and Drug Administration of the United States(FDA).However,the toxic-ity and drug resistance limit their efficiency in the treatment.Novel compounds with greater potency and selectivity,as well as im-proved therapeutic indices with reduced toxicity,are clearly required.Over the past three decades,a lot of bioactive ingredients with anticancer effects by affecting the PI3K-mediated pathways have been found from marine organisms.In the present mini-review,anticancer compounds from marine source that target the PI3K/Akt/mTOR signaling were reviewed.The molecular entities and their modes of action were presented.The marine compounds targeting special factors of the PI3K/Akt/mTOR were highlighted.展开更多
Muyingle is a new type of health food prepared from marine organisme. The mammotropic action ofMuyingte was investigated by studying its effect on mammary glands and pituitary glands of lactating miceand the survival ...Muyingle is a new type of health food prepared from marine organisme. The mammotropic action ofMuyingte was investigated by studying its effect on mammary glands and pituitary glands of lactating miceand the survival rate of suckling mice. The results showed that the mammotropic action of Muyingle wasvery effective.The survival rates of suckling mice were 92.90% for the treated group and 0 for the controlgroup (p【0.01). The weights of mammary gland were 163±51.1mg/10g (weight of mouse)for the treatedgroup and 98.5±18.4 mg/10g for the control group (p【0.01). Histological examinations suggestal thatmammary glands from the treated group were at the secreting stages, while those from the control groupwere at the resting stages. Clinical tests also demonstrated that Muyingle was highly effective in promotinglactation and improving the quality of the puerpera’s milk. The efficiency was up to 86.7%.展开更多
The composition of chlorophenols in marine organisms from the southern coast of Hangzhou Bay, China, was analyzed and the health risks posed to humans assessed. A total of 19 chlorophenols from 16 types of marine orga...The composition of chlorophenols in marine organisms from the southern coast of Hangzhou Bay, China, was analyzed and the health risks posed to humans assessed. A total of 19 chlorophenols from 16 types of marine organism were analyzed across nine survey sections in Hangzhou Bay. The chlorophenols were analyzed by gas chromatography-mass spectrometry using a DB-5MS quartz capillary column. The concentrations of monochlorophenol, dichlorophenol, trichlorophenol, tetrachlorophenol, and pentachlorophenol ranged from below the detection limit(ND) to 132 μg/kg, ND–51.0 μg/kg, ND–42.5 μg/kg, ND–69.0 μg/kg, and ND–9.06 μg/kg, respectively. Additionally, concentration differences between each type of chlorophenol were not significant( P >0.05). However, significant differences were found between monochlorophenol( F =8.13, P <0.01) and total chlorophenol(F =5.19, P <0.01) concentrations. As the noncarcinogenic risk indices were <0.1(10-5 –10-2) for all of the organisms, no high risk was posed by 2-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, 2,4,5-trichlorophenol, 2,3,4,6-tetrachlorophenol, and pentachlorophenol to humans consuming marine organisms from the study area. Furthermore, the carcinogenic risks posed by 2,4,6-trichlorophenol and pentachlorophenol were lower than limits set by the International Commission on Radiological Protection and the US Environmental Protection Agency. However, the noncarcinogenic and carcinogenic risks posed by chlorophenols in marine organisms from four of the survey sections(Sizaopu, Niluoshan, Longshan Town and Xinhong zha) were higher than the other survey sections.展开更多
This study aimed at investigating the content of heavy metals in some marine organisms of the Cameroon Atlantic coast and assessing the health risk due to their consumption by the population. Nine fish and one shrimp ...This study aimed at investigating the content of heavy metals in some marine organisms of the Cameroon Atlantic coast and assessing the health risk due to their consumption by the population. Nine fish and one shrimp species were collected for this study. These fish species were Ethmolosa fimbriata, Drepane africana, Dentex moroccanus, Arius latiscotatus, Scarus hoefleri, Cynoglossus browni, Sardinella madorensis, Pseudotolithus elongatus, Pseudotolithus typus. The shrimp species was Macrobranchium macrobranchium. The elements investigated in this study were: Fe, Co, Cu, Cd and Pb. For seven fish species it was found that the concentration of heavy metals followed the order Fe > Co > Cd > Cu > Pb. For most fish species the Target Hazard Quotient (THQ) value calculated showed the following trend Cd > Co > Pb > Fe ≥ Cu. Cadmium was found to be the main contributor to health risk that may result from the consumption of the fish species under study. The THQ for this element was in the range 0.7 - 1.2 while the Target Cancer Risk (TR) due to ingestion of this metal was in the range (3 × 10<sup>-</sup><sup>4</sup> - 6 × 10<sup>-</sup><sup>4</sup>). These values are slightly above the threshold limits established for both carcinogenic and non carcinogenic risks by the United States, Environmental Protection Agency. The estimated weekly intake of cadmium due to consumption of some fishes under study was greater or equal to the Provisional Tolerable Weekly Intake (PTWI) determined by Food and Agriculture Organization/World Health Organization.展开更多
The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-...The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-coding RNAs have been reported to mediate pathophysiological developments such as metastasis as well as immune suppression within the TME.Given the complex biology of BC,novel personalized therapeutic strategies that address its diverse pathophysiologies are needed to improve clinical outcomes.In this review,we describe the advances in the biology of breast neoplasia,including cellular and molecular biology,heterogeneity,and TME.We review the role of novel molecules such as long non-coding RNAs in the pathophysiology of BC.Finally,we provide an up-to-date overview of anticancer compounds extracted from marine microorganisms,crustaceans,and fishes and their synergistic effects in combination with other anticancer drugs.Marine compounds are a new discipline of research in BC and offer a wide range of anti-cancer effects that could be harnessed to target the various pathways involved in BC development,thus assisting current therapeutic regimens.展开更多
Recent researches have shown that some compounds isolated from marine organisms have striking structural similarities with the metabolites from known microorganisms. It is inferred from the researches that the symbiot...Recent researches have shown that some compounds isolated from marine organisms have striking structural similarities with the metabolites from known microorganisms. It is inferred from the researches that the symbiotic or associated marine microorganisms may be the true sources of those compounds or at least involved in the biosynthesizing process. This view has been further evidenced by the researches for many sponges and sponge-associated microorganisms. Importantly, growing evidence has highlighted that the symbiotic or associated marine microorganisms live in the microenvironment within the hosts, and they also produce secondary metabolites which are new and original in structure and unique in activity. All these suggest that the microorganisms associated with marine organisms are the sources with very high potential to be new natural bioactive agents. This article reviews briefly the research advances in the study of new bioactive metabolites from marine organisms-associated microorganisms since 2000.展开更多
An monitoring and early-warning system is proposed for marine organisms and the cause of water intake blockage is analyzed. Based on the intelligent sensing technology, computer software and hardware technology and di...An monitoring and early-warning system is proposed for marine organisms and the cause of water intake blockage is analyzed. Based on the intelligent sensing technology, computer software and hardware technology and digital signal processing technology, the buoy monitoring platform system is developed by internet of things technology, cloud computing and the application of large data. Remote real-time monitoring of aquatic organisms and foreign bodies is realized based on underwater acoustic detection and low light imaging technology. Data processing center is estab-lished to store, analyze and process monitoring information and display it in real time, and provide emergency decision support. Through develop-ment and test of relevant key equipments, the reliability of cold source system of nuclear power plants is improved, which effectively reduces the influence of marine biological invasion on security and economic operation of the units.展开更多
The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and materials.This study it is to develop a Machine learni...The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and materials.This study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-Li alloys in the marine environment.We obtained the mechanical properties of Al-Li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure experiments.We obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural networks.Then,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-Li alloys.The main conclusions are as follows:1.The variation law of mechanical properties of2297-T8 in the Marine atmosphere is revealed.With the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.2.The prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.3.This study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure experiments.The results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.展开更多
Island ecosystems support diverse aquatic invertebrate communities comprising endemic taxa.Documentation of existing species is important for conservation.In this study,a checklist of marine opisthobranch from the Rep...Island ecosystems support diverse aquatic invertebrate communities comprising endemic taxa.Documentation of existing species is important for conservation.In this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered lagoons.Morphological and molecular analysis were used for identification.Species composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis similarity.The checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new records.The findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian Ocean.Molecular analysis of the undescribed Gymnodoris sp.showed it resembled Gymnodoris sp.from Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of opisthobranch.These areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and abundance.The order Nudibranchia was reported as most speciose,with 86 species.The Sacoglossa and Nudibranchia were observed only on macroalgae and sponges respectively.High abundance was also recorded on shipwrecks which are the most common form of artificial reefs.With the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.展开更多
UAV marine monitoring plays an essential role in marine environmental protection because of its flexibility and convenience,low cost and convenient maintenance.In marine environmental monitoring,the similarity between...UAV marine monitoring plays an essential role in marine environmental protection because of its flexibility and convenience,low cost and convenient maintenance.In marine environmental monitoring,the similarity between objects such as oil spill and sea surface,Spartina alterniflora and algae is high,and the effect of the general segmentation algorithm is poor,which brings new challenges to the segmentation of UAV marine images.Panoramic segmentation can do object detection and semantic segmentation at the same time,which can well solve the polymorphism problem of objects in UAV ocean images.Currently,there are few studies on UAV marine image recognition with panoptic segmentation.In addition,there are no publicly available panoptic segmentation datasets for UAV images.In this work,we collect and annotate UAV images to form a panoptic segmentation UAV dataset named UAV-OUC-SEG and propose a panoptic segmentation method named PanopticUAV.First,to deal with the large intraclass variability in scale,deformable convolution and CBAM attention mechanism are employed in the backbone to obtain more accurate features.Second,due to the complexity and diversity of marine images,boundary masks by the Laplacian operator equation from the ground truth are merged into feature maps to improve boundary segmentation precision.Experiments demonstrate the advantages of PanopticUAV beyond the most other advanced approaches on the UAV-OUC-SEG dataset.展开更多
The microstructure and precipitated phases of as-cast Mg-5Y-1.5Nd-x Zn-0.5Zr(x=0,2,4,6 wt.%)alloys were investigated by optical microscopy,scanning electron microscopy,energy-dispersive spectrometry and X-ray Diffract...The microstructure and precipitated phases of as-cast Mg-5Y-1.5Nd-x Zn-0.5Zr(x=0,2,4,6 wt.%)alloys were investigated by optical microscopy,scanning electron microscopy,energy-dispersive spectrometry and X-ray Diffraction.The exposure corrosion experiment of these magnesium alloys was tested in South China Sea and KEXUE vessel atmospheric environment.The corrosion characteristic and mechanism of magnesium alloys of Mg-5Y-1.5Nd-x Zn-0.5Zr(x=0,2,4,6 wt.%)alloys were analyzed by weight loss rate,corrosion depth,corrosion products and corrosion morphologies.The electrochemical corrosion tests were also measured in the natural seawater.The comprehensive results showed that Mg-5Y-1.5Nd-4Zn-0.5Zr magnesium alloy existed the best corrosion resistance whether in the marine atmospheric environment and natural seawater environment.That depended on the microstructure,type and distribution of precipitated phases in Mg-5Y-1.5Nd-4Zn-0.5Zr magnesium alloy.Sufficient quantity anodic precipitated phases in the microstructure of Mg-5Y-1.5Nd-4Zn-0.5Zr alloy played the key role in the corrosion resistance.展开更多
Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore structures.The interface friction behavior between mar...Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore structures.The interface friction behavior between marine clay and structural materials with different roughness was studied in this paper by using 3D optical scanning tests,a modified direct shear device and numerical simulation.Relationships between the surface roughness of structures,water content and interface friction angle were presented by model tests.The increase of water contents decreased the interface friction angles.For interfaces with different roughness,the interface friction angles will be smaller than that of the soil when the water content exceeds a certain value.The roughness of the interface and the water content of the soil are mutually coupled to influence the coefficient of friction(COF).This paper proposed a Finite Element Method(FEM)to simulate the interface direct shear tests of structures with different roughness.The surface models with different roughness are established based on the structure data obtained by 3D scanning.The Coupled Eulerian-Lagrangian(CEL)approach was employed to analyse soils sheared by irregular surfaces.The interface behavior for interfaces with different roughness under cyclic shear stresses was analyzed by FEM.展开更多
The application of microorganisms as probiotics is limited due to lack of safety evaluation.Here,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from ...The application of microorganisms as probiotics is limited due to lack of safety evaluation.Here,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from marine mangrove microorganisms.Its safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing analysis.Results showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely found.Hyphal morphogenesis genes(SIT4,HOG1,SPA2,ERK1,ICL1,CST20,HSP104,TPS1,and RHO1)and phospholipase secretion gene(VPS4)were annotated.True hyphae and phospholipase were absent.Only one retroelement(Tad1-65_BG)was found.Major biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined thresholds.GXDK6 had no resistance to common antifungal drugs.Virulence enzymes,such as gelatinase,DNase,hemolytic,lecithinase,and thrombin were absent.Acute toxicity test with mice demonstrated that GXDK6 is safe.GXDK6 has a good reproduction ability in the simulation gastrointestinal tract.GXDK6 also has a strong antioxidant ability,β-glucosidase,and inulinase activity.To sum up,GXDK6 is considered as a safe probiotic for human consumption and food fermentation.展开更多
Dredged marine soils(DMS)have poor engineering properties,which limit their usage in construction projects.This research examines the application of reactive magnesia(rMgO)containing supplementary cementitious materia...Dredged marine soils(DMS)have poor engineering properties,which limit their usage in construction projects.This research examines the application of reactive magnesia(rMgO)containing supplementary cementitious materials(SCMs)to stabilize DMS under ambient and carbon dioxide(CO_(2))curing conditions.Several proprietary experimental tests were conducted to investigate the stabilized DMS.Furthermore,the carbonation-induced mineralogical,thermal,and microstructural properties change of the samples were explored.The findings show that the compressive strength of the stabilized DMS fulfilled the 7-d requirement(0.7-2.1 MPa)for pavement and building foundations.Replacing rMgO with SCMs such as biochar or ground granulated blast-furnace slag(GGBS)altered the engineering properties and particle packing of the stabilized soils,thus influencing their performances.Biochar increased the porosity of the samples,facilitating higher CO_(2) uptake and improved ductility,while GGBS decreased porosity and increased the dry density of the samples,resulting in higher strength.The addition of SCMs also enhanced the water retention capacity and modified the pH of the samples.Microstructural analysis revealed that the hydrated magnesium carbonates precipitated in the carbonated samples provided better cementation effects than brucite formed during rMgO hydration.Moreover,incorporating SCMs reduced the overall global warming potential and energy demand of the rMgO-based systems.The biochar mixes demonstrated lower toxicity and energy consumption.Ultimately,the rMgO and biochar blend can serve as an environmentally friendly additive for soft soil stabilization and permanent fixation of significant amounts of CO_(2) in soils through mineral carbonation,potentially reducing environmental pollution while meeting urbanization needs.展开更多
[Objectives]To study the phosphorus removal performance of phosphate accumulating organisms(PAOs).[Methods]Activated sludge from domestic sewage treatment plant was used as the strain source,and phosphate accumulating...[Objectives]To study the phosphorus removal performance of phosphate accumulating organisms(PAOs).[Methods]Activated sludge from domestic sewage treatment plant was used as the strain source,and phosphate accumulating organisms were screened by plate streaking method and dilution coating plate method.Six kinds of excellent phosphate accumulating organisms were obtained by metachromatic granule staining experiment,total phosphorus experiment and simulated sewage phosphorus removal experiment to assist the observation of bac-terial morphology and experiment of phosphorus removal capacity.In addition,the influencing factors of phosphorus removal capacity(nitrogen source,trace metal ions)were analyzed.[Results]In the case of simulated sewage,the phosphorus removal rate of strain b was the highest,reaching 66.25%,while the phosphorus removal rate of strain e and f was about 10%lower than that of the phosphorus uptake experiment.[Conclusions]This study is expected to provide a theoretical reference for the gradual optimization of the screening method of phosphorus re-moval bacteria in domestic sewage treatment.展开更多
Xinjiang’s aquatic products gain popularity in the domestic market,As a landlocked region,northwest China’s Xinjiang Uygur Autonomous Region is renowned for its fruits,vegetables,as well as beef and mutton.But in re...Xinjiang’s aquatic products gain popularity in the domestic market,As a landlocked region,northwest China’s Xinjiang Uygur Autonomous Region is renowned for its fruits,vegetables,as well as beef and mutton.But in recent years,salmon,tilapia,crab,Australian lobster,and other marine delicacies from the region have not only made it to Chinese dining tables,but are also exported to other countries like Russia and Singapore.For those who think of the region as a land covered with saline-alkaline soil and the Gobi Desert,a question naturally arises:how can seafood be produced without the sea?展开更多
This article explores the development path of the green marine economy in the era of ecological civilization.It highlights the importance of developing a green marine economy and how it has become a global consensus.T...This article explores the development path of the green marine economy in the era of ecological civilization.It highlights the importance of developing a green marine economy and how it has become a global consensus.The article suggests that China should take proactive measures to optimize its marine industrial structure,promote marine scientific and technological innovation,strengthen marine resource protection and environmental governance,and enhance the competitiveness of the marine economy.The ultimate objective is to achieve sustainable development of the ocean,expand the blue economic space,and accomplish the goal of green marine economic development.展开更多
文摘The pervasive presence of microplastics in marine environments has raised significant concerns. This review addresses the pressing issue of microplastic pollution in marine ecosystems and its potential implications for both the environment and human health. It outlines the current state of microplastic occurrence, distribution, and extraction methods within marine organisms. Microplastics have emerged as a significant environmental concern due to their harmful effects on ecosystems and their potential human health risks. These particles infiltrate marine environments through runoff and atmospheric deposition, ultimately contaminating beaches and posing threats to marine life. Despite the gravity of this issue, there has been limited research on the presence and distribution of microplastics in marine organisms. This review aims to bridge this knowledge gap by comprehensively examining the occurrence, distribution, and various extraction methods used to detect microplastics in marine organisms. It emphasizes the urgent need for targeted measures to manage microplastic pollution, highlights the significant role of human activities in contributing to this problem, and underscores the importance of reducing human-induced pollution to safeguard marine ecosystems. While this paper contributes to the understanding of microplastic pollution in marine environments and underscores the critical importance of taking action to protect marine organisms and preserve our oceans for future generations, it also emphasizes that, in effectively tackling the microplastic problem, a well-coordinated approach is essential, involving research initiatives, policy adjustments, public involvement, and innovative technologies. Crucially, prompt and resolute responses must exist to counteract the escalating peril posed by microplastics to the oceans and the global environment.
文摘Global warming has become a global challenge having dire consequences on different aspects of the environment due to the melting of glaciers, excess carbon dioxide (CO<sub>2</sub>), and excess warming of water bodies among others. At a faster pace recently, climate change is affecting the marine environment, causing numerous alterations. Here, we address its consequences and the numerous alterations, which are more vital for researchers and global agencies to advocate more on why it’s essential to lessen the impact of climate change. Our review showed that the impacts of climate change are articulated at several stages of the marine ecosystem where it affects the inhabitants and their habitats. In response to climate change (ocean warming) marine species shift their latitudinal range to find suitable conditions leading to the redistribution of species. In addition, we found that growth reduction, sub-optimal behaviors, and reduced immune-competence of marine organisms, are as a result of thermal stress due to climate change. Also, the periodic changes in temperature above or below the optimum have a meditative reproductive effect on marine species, including fish. Finally, we discovered that due to higher water temperatures, several diseases showcase greater virulence in the sense that the marine species become less resistant to these diseases due to stress, increased virulence stimuli, or increased transmission.
基金The study was supported by the National Natural Sci-ence Foundation of China(Nos.81573457 and 81773776)We are also grateful to the support from the Taishan Talents Project of Shandong Province and the Department of Science and Technology in Shandong Province of China(Nos.ZR2017MH117,2018YYSP025,and ZR2017MH 027)Department of Science and Technology of Si-chuan Province,China(Nos.2017HH0104 and 2019YFS 0116).
文摘The PI3K/Akt/mTOR signaling pathway is one of the most frequently dysregulated pathways in cancer.Targeting the PI3K-mediated pathway has been an important strategy for developing novel anticancer agents.In the past decades,more than 40 inhibitors of the PI3K/Akt/mTOR pathway have been developed at different clinical stages.Temsirolimus,everolimus,idelalisib,and copanlisib have been approved for clinical use by the Food and Drug Administration of the United States(FDA).However,the toxic-ity and drug resistance limit their efficiency in the treatment.Novel compounds with greater potency and selectivity,as well as im-proved therapeutic indices with reduced toxicity,are clearly required.Over the past three decades,a lot of bioactive ingredients with anticancer effects by affecting the PI3K-mediated pathways have been found from marine organisms.In the present mini-review,anticancer compounds from marine source that target the PI3K/Akt/mTOR signaling were reviewed.The molecular entities and their modes of action were presented.The marine compounds targeting special factors of the PI3K/Akt/mTOR were highlighted.
文摘Muyingle is a new type of health food prepared from marine organisme. The mammotropic action ofMuyingte was investigated by studying its effect on mammary glands and pituitary glands of lactating miceand the survival rate of suckling mice. The results showed that the mammotropic action of Muyingle wasvery effective.The survival rates of suckling mice were 92.90% for the treated group and 0 for the controlgroup (p【0.01). The weights of mammary gland were 163±51.1mg/10g (weight of mouse)for the treatedgroup and 98.5±18.4 mg/10g for the control group (p【0.01). Histological examinations suggestal thatmammary glands from the treated group were at the secreting stages, while those from the control groupwere at the resting stages. Clinical tests also demonstrated that Muyingle was highly effective in promotinglactation and improving the quality of the puerpera’s milk. The efficiency was up to 86.7%.
基金Supported by the National Special Research Fund for Non-Profit Sector(Agriculture)(No.201303047)the Key Programs for Science and Technology Development of Ningbo,China(No.2013C11027)
文摘The composition of chlorophenols in marine organisms from the southern coast of Hangzhou Bay, China, was analyzed and the health risks posed to humans assessed. A total of 19 chlorophenols from 16 types of marine organism were analyzed across nine survey sections in Hangzhou Bay. The chlorophenols were analyzed by gas chromatography-mass spectrometry using a DB-5MS quartz capillary column. The concentrations of monochlorophenol, dichlorophenol, trichlorophenol, tetrachlorophenol, and pentachlorophenol ranged from below the detection limit(ND) to 132 μg/kg, ND–51.0 μg/kg, ND–42.5 μg/kg, ND–69.0 μg/kg, and ND–9.06 μg/kg, respectively. Additionally, concentration differences between each type of chlorophenol were not significant( P >0.05). However, significant differences were found between monochlorophenol( F =8.13, P <0.01) and total chlorophenol(F =5.19, P <0.01) concentrations. As the noncarcinogenic risk indices were <0.1(10-5 –10-2) for all of the organisms, no high risk was posed by 2-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, 2,4,5-trichlorophenol, 2,3,4,6-tetrachlorophenol, and pentachlorophenol to humans consuming marine organisms from the study area. Furthermore, the carcinogenic risks posed by 2,4,6-trichlorophenol and pentachlorophenol were lower than limits set by the International Commission on Radiological Protection and the US Environmental Protection Agency. However, the noncarcinogenic and carcinogenic risks posed by chlorophenols in marine organisms from four of the survey sections(Sizaopu, Niluoshan, Longshan Town and Xinhong zha) were higher than the other survey sections.
文摘This study aimed at investigating the content of heavy metals in some marine organisms of the Cameroon Atlantic coast and assessing the health risk due to their consumption by the population. Nine fish and one shrimp species were collected for this study. These fish species were Ethmolosa fimbriata, Drepane africana, Dentex moroccanus, Arius latiscotatus, Scarus hoefleri, Cynoglossus browni, Sardinella madorensis, Pseudotolithus elongatus, Pseudotolithus typus. The shrimp species was Macrobranchium macrobranchium. The elements investigated in this study were: Fe, Co, Cu, Cd and Pb. For seven fish species it was found that the concentration of heavy metals followed the order Fe > Co > Cd > Cu > Pb. For most fish species the Target Hazard Quotient (THQ) value calculated showed the following trend Cd > Co > Pb > Fe ≥ Cu. Cadmium was found to be the main contributor to health risk that may result from the consumption of the fish species under study. The THQ for this element was in the range 0.7 - 1.2 while the Target Cancer Risk (TR) due to ingestion of this metal was in the range (3 × 10<sup>-</sup><sup>4</sup> - 6 × 10<sup>-</sup><sup>4</sup>). These values are slightly above the threshold limits established for both carcinogenic and non carcinogenic risks by the United States, Environmental Protection Agency. The estimated weekly intake of cadmium due to consumption of some fishes under study was greater or equal to the Provisional Tolerable Weekly Intake (PTWI) determined by Food and Agriculture Organization/World Health Organization.
文摘The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-coding RNAs have been reported to mediate pathophysiological developments such as metastasis as well as immune suppression within the TME.Given the complex biology of BC,novel personalized therapeutic strategies that address its diverse pathophysiologies are needed to improve clinical outcomes.In this review,we describe the advances in the biology of breast neoplasia,including cellular and molecular biology,heterogeneity,and TME.We review the role of novel molecules such as long non-coding RNAs in the pathophysiology of BC.Finally,we provide an up-to-date overview of anticancer compounds extracted from marine microorganisms,crustaceans,and fishes and their synergistic effects in combination with other anticancer drugs.Marine compounds are a new discipline of research in BC and offer a wide range of anti-cancer effects that could be harnessed to target the various pathways involved in BC development,thus assisting current therapeutic regimens.
基金supported by the National Natural Science Foundation of China(No.39825126)the Cheung Kong Scholar from the Cheung Kong Scholars Program of Ministry of Education of China+2 种基金the Hi-Tech Research and Development Program of China(Nos.2002AA628130 and 2003AA624020)the Natural Science Foundation of Shandong Province(No.Z2001C01)the High Technology Research and Development Program of Shandong Province(No.0121100107).
文摘Recent researches have shown that some compounds isolated from marine organisms have striking structural similarities with the metabolites from known microorganisms. It is inferred from the researches that the symbiotic or associated marine microorganisms may be the true sources of those compounds or at least involved in the biosynthesizing process. This view has been further evidenced by the researches for many sponges and sponge-associated microorganisms. Importantly, growing evidence has highlighted that the symbiotic or associated marine microorganisms live in the microenvironment within the hosts, and they also produce secondary metabolites which are new and original in structure and unique in activity. All these suggest that the microorganisms associated with marine organisms are the sources with very high potential to be new natural bioactive agents. This article reviews briefly the research advances in the study of new bioactive metabolites from marine organisms-associated microorganisms since 2000.
文摘An monitoring and early-warning system is proposed for marine organisms and the cause of water intake blockage is analyzed. Based on the intelligent sensing technology, computer software and hardware technology and digital signal processing technology, the buoy monitoring platform system is developed by internet of things technology, cloud computing and the application of large data. Remote real-time monitoring of aquatic organisms and foreign bodies is realized based on underwater acoustic detection and low light imaging technology. Data processing center is estab-lished to store, analyze and process monitoring information and display it in real time, and provide emergency decision support. Through develop-ment and test of relevant key equipments, the reliability of cold source system of nuclear power plants is improved, which effectively reduces the influence of marine biological invasion on security and economic operation of the units.
基金supported by the Southwest Institute of Technology and Engineering cooperation fund(Grant No.HDHDW5902020104)。
文摘The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and materials.This study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-Li alloys in the marine environment.We obtained the mechanical properties of Al-Li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure experiments.We obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural networks.Then,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-Li alloys.The main conclusions are as follows:1.The variation law of mechanical properties of2297-T8 in the Marine atmosphere is revealed.With the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.2.The prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.3.This study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure experiments.The results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.
文摘Island ecosystems support diverse aquatic invertebrate communities comprising endemic taxa.Documentation of existing species is important for conservation.In this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered lagoons.Morphological and molecular analysis were used for identification.Species composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis similarity.The checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new records.The findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian Ocean.Molecular analysis of the undescribed Gymnodoris sp.showed it resembled Gymnodoris sp.from Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of opisthobranch.These areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and abundance.The order Nudibranchia was reported as most speciose,with 86 species.The Sacoglossa and Nudibranchia were observed only on macroalgae and sponges respectively.High abundance was also recorded on shipwrecks which are the most common form of artificial reefs.With the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.
基金This work was partially supported by the National Key Research and Development Program of China under Grant No.2018AAA0100400the Natural Science Foundation of Shandong Province under Grants Nos.ZR2020MF131 and ZR2021ZD19the Science and Technology Program of Qingdao under Grant No.21-1-4-ny-19-nsh.
文摘UAV marine monitoring plays an essential role in marine environmental protection because of its flexibility and convenience,low cost and convenient maintenance.In marine environmental monitoring,the similarity between objects such as oil spill and sea surface,Spartina alterniflora and algae is high,and the effect of the general segmentation algorithm is poor,which brings new challenges to the segmentation of UAV marine images.Panoramic segmentation can do object detection and semantic segmentation at the same time,which can well solve the polymorphism problem of objects in UAV ocean images.Currently,there are few studies on UAV marine image recognition with panoptic segmentation.In addition,there are no publicly available panoptic segmentation datasets for UAV images.In this work,we collect and annotate UAV images to form a panoptic segmentation UAV dataset named UAV-OUC-SEG and propose a panoptic segmentation method named PanopticUAV.First,to deal with the large intraclass variability in scale,deformable convolution and CBAM attention mechanism are employed in the backbone to obtain more accurate features.Second,due to the complexity and diversity of marine images,boundary masks by the Laplacian operator equation from the ground truth are merged into feature maps to improve boundary segmentation precision.Experiments demonstrate the advantages of PanopticUAV beyond the most other advanced approaches on the UAV-OUC-SEG dataset.
基金National Natural Science Foundation of China for Exploring Key Scientific Instrument(No.41827805)the Open Funds of the State Key Laboratory of Rare Earth Resource Utilization(No.RERU2021017)Hainan Province Science and Technology Special Fund(ZDYF2021GXJS210)for providing support。
文摘The microstructure and precipitated phases of as-cast Mg-5Y-1.5Nd-x Zn-0.5Zr(x=0,2,4,6 wt.%)alloys were investigated by optical microscopy,scanning electron microscopy,energy-dispersive spectrometry and X-ray Diffraction.The exposure corrosion experiment of these magnesium alloys was tested in South China Sea and KEXUE vessel atmospheric environment.The corrosion characteristic and mechanism of magnesium alloys of Mg-5Y-1.5Nd-x Zn-0.5Zr(x=0,2,4,6 wt.%)alloys were analyzed by weight loss rate,corrosion depth,corrosion products and corrosion morphologies.The electrochemical corrosion tests were also measured in the natural seawater.The comprehensive results showed that Mg-5Y-1.5Nd-4Zn-0.5Zr magnesium alloy existed the best corrosion resistance whether in the marine atmospheric environment and natural seawater environment.That depended on the microstructure,type and distribution of precipitated phases in Mg-5Y-1.5Nd-4Zn-0.5Zr magnesium alloy.Sufficient quantity anodic precipitated phases in the microstructure of Mg-5Y-1.5Nd-4Zn-0.5Zr alloy played the key role in the corrosion resistance.
基金supported by a grant from the National Natural Science Foundations of China(No.52171282)supported by Taishan Scholars Program of Shandong Province,China(No.tsqn202306098)the Shandong Provincial Key Research and Development Plan,China(No.2021ZLGX04).
文摘Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore structures.The interface friction behavior between marine clay and structural materials with different roughness was studied in this paper by using 3D optical scanning tests,a modified direct shear device and numerical simulation.Relationships between the surface roughness of structures,water content and interface friction angle were presented by model tests.The increase of water contents decreased the interface friction angles.For interfaces with different roughness,the interface friction angles will be smaller than that of the soil when the water content exceeds a certain value.The roughness of the interface and the water content of the soil are mutually coupled to influence the coefficient of friction(COF).This paper proposed a Finite Element Method(FEM)to simulate the interface direct shear tests of structures with different roughness.The surface models with different roughness are established based on the structure data obtained by 3D scanning.The Coupled Eulerian-Lagrangian(CEL)approach was employed to analyse soils sheared by irregular surfaces.The interface behavior for interfaces with different roughness under cyclic shear stresses was analyzed by FEM.
基金This research was supported by the Funding Project of Chinese Central Government Guiding to the Guangxi Local Science and Technology Development(GUIKEZY21195021)the Natural Science Fund for Distinguished Young Scholars of Guangxi Zhuang Autonomous Region of China(2019GXNSFFA245011)+3 种基金the Funding Project of Chinese Central Government Guiding to the Nanning Local Science and Technology Development(20231012)the Funding Projects of Guangxi Key Research and Development Plan(GUIKE AB23075173)the Funding Project of Technological Development from Angel Yeast(Chongzuo)Co.,Ltd.(JS1006020230722019)the Innovation Project of Guangxi Graduate Education(YCBZ2021012).
文摘The application of microorganisms as probiotics is limited due to lack of safety evaluation.Here,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from marine mangrove microorganisms.Its safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing analysis.Results showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely found.Hyphal morphogenesis genes(SIT4,HOG1,SPA2,ERK1,ICL1,CST20,HSP104,TPS1,and RHO1)and phospholipase secretion gene(VPS4)were annotated.True hyphae and phospholipase were absent.Only one retroelement(Tad1-65_BG)was found.Major biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined thresholds.GXDK6 had no resistance to common antifungal drugs.Virulence enzymes,such as gelatinase,DNase,hemolytic,lecithinase,and thrombin were absent.Acute toxicity test with mice demonstrated that GXDK6 is safe.GXDK6 has a good reproduction ability in the simulation gastrointestinal tract.GXDK6 also has a strong antioxidant ability,β-glucosidase,and inulinase activity.To sum up,GXDK6 is considered as a safe probiotic for human consumption and food fermentation.
基金This work was supported by the Creative Groups of Natural Science Foundation of Hubei Province(Grant No.2021CFA030).Onyekwena Chikezie Chimere is an awardee for the ANSO Scholarship 2020-PhD.Ishrat Hameed Alvi is a recipient of the 2021 PhD ANSO Scholarship.
文摘Dredged marine soils(DMS)have poor engineering properties,which limit their usage in construction projects.This research examines the application of reactive magnesia(rMgO)containing supplementary cementitious materials(SCMs)to stabilize DMS under ambient and carbon dioxide(CO_(2))curing conditions.Several proprietary experimental tests were conducted to investigate the stabilized DMS.Furthermore,the carbonation-induced mineralogical,thermal,and microstructural properties change of the samples were explored.The findings show that the compressive strength of the stabilized DMS fulfilled the 7-d requirement(0.7-2.1 MPa)for pavement and building foundations.Replacing rMgO with SCMs such as biochar or ground granulated blast-furnace slag(GGBS)altered the engineering properties and particle packing of the stabilized soils,thus influencing their performances.Biochar increased the porosity of the samples,facilitating higher CO_(2) uptake and improved ductility,while GGBS decreased porosity and increased the dry density of the samples,resulting in higher strength.The addition of SCMs also enhanced the water retention capacity and modified the pH of the samples.Microstructural analysis revealed that the hydrated magnesium carbonates precipitated in the carbonated samples provided better cementation effects than brucite formed during rMgO hydration.Moreover,incorporating SCMs reduced the overall global warming potential and energy demand of the rMgO-based systems.The biochar mixes demonstrated lower toxicity and energy consumption.Ultimately,the rMgO and biochar blend can serve as an environmentally friendly additive for soft soil stabilization and permanent fixation of significant amounts of CO_(2) in soils through mineral carbonation,potentially reducing environmental pollution while meeting urbanization needs.
基金Supported by Zhaoqing University Innovation and Entrepreneurship Training Program for College Students(202310580018).
文摘[Objectives]To study the phosphorus removal performance of phosphate accumulating organisms(PAOs).[Methods]Activated sludge from domestic sewage treatment plant was used as the strain source,and phosphate accumulating organisms were screened by plate streaking method and dilution coating plate method.Six kinds of excellent phosphate accumulating organisms were obtained by metachromatic granule staining experiment,total phosphorus experiment and simulated sewage phosphorus removal experiment to assist the observation of bac-terial morphology and experiment of phosphorus removal capacity.In addition,the influencing factors of phosphorus removal capacity(nitrogen source,trace metal ions)were analyzed.[Results]In the case of simulated sewage,the phosphorus removal rate of strain b was the highest,reaching 66.25%,while the phosphorus removal rate of strain e and f was about 10%lower than that of the phosphorus uptake experiment.[Conclusions]This study is expected to provide a theoretical reference for the gradual optimization of the screening method of phosphorus re-moval bacteria in domestic sewage treatment.
文摘Xinjiang’s aquatic products gain popularity in the domestic market,As a landlocked region,northwest China’s Xinjiang Uygur Autonomous Region is renowned for its fruits,vegetables,as well as beef and mutton.But in recent years,salmon,tilapia,crab,Australian lobster,and other marine delicacies from the region have not only made it to Chinese dining tables,but are also exported to other countries like Russia and Singapore.For those who think of the region as a land covered with saline-alkaline soil and the Gobi Desert,a question naturally arises:how can seafood be produced without the sea?
文摘This article explores the development path of the green marine economy in the era of ecological civilization.It highlights the importance of developing a green marine economy and how it has become a global consensus.The article suggests that China should take proactive measures to optimize its marine industrial structure,promote marine scientific and technological innovation,strengthen marine resource protection and environmental governance,and enhance the competitiveness of the marine economy.The ultimate objective is to achieve sustainable development of the ocean,expand the blue economic space,and accomplish the goal of green marine economic development.
