The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair gro...The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair growth products.Researchers have tried to illustrate the transdermal process with diversified theories and technologies.Directly observing the distribution of topical substances on skin by characteristic imaging is the most convincing approach.Unfortunately,fluorescence labeling imaging,which is commonly used in biochemical research,is limited for transdermal research for most topical substances with a molecular mass less than 500 Da.Label-free imaging technologies possess the advantages of not requiring any macromolecular dyes,no tissue destruction and an extensive substance detection capability,which has enabled rapid development of such technologies in recent years and their introduction to biological tissue analysis,such as skin samples.Through the specific identification of topical substances and endogenous tissue components,label-free imaging technologies can provide abundant tissue distribution information,enrich theoretical and practical guidance for transdermal drug delivery systems.In this review,we expound the mechanisms and applications of the most popular label-free imaging technologies in transdermal research at present,compare their advantages and disadvantages,and forecast development prospects.展开更多
In this paper,we report our attempts to raise the efficiency of liquid reduction method when using high specific surface area TiO2(HSTiO2)by doping Au.Characterization of Au-HSTiO2 was conducted via XRD,UV-vis,SEM,and...In this paper,we report our attempts to raise the efficiency of liquid reduction method when using high specific surface area TiO2(HSTiO2)by doping Au.Characterization of Au-HSTiO2 was conducted via XRD,UV-vis,SEM,and photocurrent intensity.The experimental results show that Au-HSTiO2 exhibits prominently higher photocatalytic hydrogen production than TiO2 and HSTiO2.Enhanced photosynthetic hydrogen production ability of Au-HSTiO2 should be attributed to the presence of abundant surface active sites of HSTiO2,remarkably extending electronic holes in Au doping.This study provides a promising photosynthetic material for hydrogen production.展开更多
Reservoir reconstructions implemented in unconventional oil and gas exploration usually adopt hydraulic fracturing techniques to inject high-pressure fluid into the reservoir and change its pore-fracture connection st...Reservoir reconstructions implemented in unconventional oil and gas exploration usually adopt hydraulic fracturing techniques to inject high-pressure fluid into the reservoir and change its pore-fracture connection structure to enhance production.Hydraulic fracturing changes the reservoir stress and causes the rocks to crack,thus generating microseismic events.One important component of microseismic research is the source mechanism inversion.Through the research on the microseismic focal mechanism,information on the source mechanisms and in-situ stress status variations can be quantitatively revealed to effectively optimize the reservoir reconstruction design for increasing production.This paper reviews the recent progress in hydraulic fracturing induced microseismic focal mechanism research.We summarize their main principles and provide a detailed introduction of the research advances in source modeling,microseismic data synthesis,and focal mechanism inversion.We also discuss the challenges and limitations in the current microseismic focal mechanism research and propose prospects for future research ideas and directions.展开更多
Objective To observe the effect of Fuzheng Kang’ai Recipe(FKR)combined with gefitinib on the proliferation and apoptosis of lung cancer A549 cells,and to study its potential synergistic mechanish with gefitinib.Metho...Objective To observe the effect of Fuzheng Kang’ai Recipe(FKR)combined with gefitinib on the proliferation and apoptosis of lung cancer A549 cells,and to study its potential synergistic mechanish with gefitinib.Methods The effects of FKR(0.211,0.316,0.474,0.711,1.067,1.600,2.400,3.600 mg/mL)combined with展开更多
Depression and insomnia have become a frequent disease in the clinic.Clinically,depression and insomnia occur synchronously.Most researchers believe acupuncture treats insomnia and depression comorbidity through mecha...Depression and insomnia have become a frequent disease in the clinic.Clinically,depression and insomnia occur synchronously.Most researchers believe acupuncture treats insomnia and depression comorbidity through mechanisms such as inflammation theory,HPA axis theory,neurotransmitter theory,nervous system structure theory,immunoregulation theory,etc.Acupuncture has a clear effect on depression and insomnia comorbidity,and is two-way,specific,and integral.Therefore,a summary on the mechanism of using acupuncture to treat depression and insomnia comorbidity is made,to provide reference for future clinical application and laboratory research.展开更多
As a transmission medium. welding arc can be modulated to emit ultrasonic energy by exerting high-frequency electric current. The frequency of exciting electric current has notable influence on the signals recorded by...As a transmission medium. welding arc can be modulated to emit ultrasonic energy by exerting high-frequency electric current. The frequency of exciting electric current has notable influence on the signals recorded by the sensors and the metallographic Structures of the welds. The resonance phenomenon of arc-ultrasonic has been found in the experiment. Both the resonance mechanism and the distribution of resonance frequency are discussed by the built vibration equation.展开更多
The electrocatalytic sulfur reduction reaction(SRR)and sulfur evolution reaction(SER),two fundamental multistep conversion processes in lithium–sulfur batteries(LSBs),are root-cause solutions to overcome sluggish red...The electrocatalytic sulfur reduction reaction(SRR)and sulfur evolution reaction(SER),two fundamental multistep conversion processes in lithium–sulfur batteries(LSBs),are root-cause solutions to overcome sluggish redox kinetics and the polysulfide shuttling effect.Metal–organic framework(MOF)electrocatalysts have emerged as good platforms for catalyzing SRR and SER,but their catalytic performance is challenged by poor electrical conductivity and limited chemical stability.Functionalized MOFs and their hybrids may be beneficial for stabilizing and improving the desired catalytic properties to achieve high-performance LSBs.This review provides a detailed overview of engineering principles for improving the activity,selectivity,and stability of MOFrelated electrocatalysts via composition modulation and nanostructure design as well as hybrid assembly.It presents and discusses the various advances achieved by using in situ characterization techniques,simulations,and theoretical calculations to reveal the dynamic evolution of MOF-related electrocatalysts,enabling an in-depth understanding of the catalysis mechanism at the molecular/atomic level.Lastly,prospects and possible research directions for MOF-related sulfur electrocatalysts are proposed.展开更多
Objective:To explore the main physiological mechanism of 15d-PGJ2 promoting periodontal tissue regeneration in patients with jaw defects caused by periodontal disease.Methods:From February 2016 to July 2019,a controll...Objective:To explore the main physiological mechanism of 15d-PGJ2 promoting periodontal tissue regeneration in patients with jaw defects caused by periodontal disease.Methods:From February 2016 to July 2019,a controlled study was conducted on 73 healthy residents(healthy group)and 73 patients(case group)with periodontal disease combined with jaw defects in Changsha medical university.T test was used to compare the growth factors of gingival crevicular fluid between the two groups.Peripheral blood cells;Cement-specific protein;Peripheral blood enzyme;Statistical differences in bone metabolites.The t test method compared the content of each index before and after treatment(15d-PGJ2 was treated at a dose of 200 mu/kg for 14 days).The method of factor analysis explores the internal correlation of each index.Result:RANKL,ICAM-1,TGF-β1,Th17,Treg,PDLSCs,SOST,CAP,HMGB1,CTSK,5-LOX,COX-2,NTX were higher in the case group than in the healthy group.In the case group,RANKL,ICAM-1,TGF-β1,Th17,Treg,PDLSCs,SOST,CAP,HMGB1,CTSK,5-LOX,COX-2,NTX were lower than those in the healthy group.The differences between the groups were statistically significant(P<0.05).Compared with before treatment,IL-1β,IL-17,Bfgf,YKL-40,BMP-2,ICTP,PICP,CTX were significantly decreased after treatment.RANKL,ICAM-1,TGF-β1,Th17,Treg,PDLSCs,SOST,CAP,HMGB1,CTSK,5-LOX,COX-2,NTX were significantly increased.The differences were statistically significant(P<0.05).Factor analysis shows that four common factors can be extracted from 21 indicators,and the cumulative contribution rate is 96.993%.Conclusions:The treatment of 15d-PGJ2 in patients with periodontal disease with maxillary defects can significantly affect the expression of multiple characteristic indicators,which may involve four mechanisms:dysregulation of cell differentiation or migration,local inflammation or immune imbalance,destruction of alveolar bone microstructure,load or stimulation,and remodeling.The specific pathway related to this is still to be further explored.展开更多
Objective:To predict couplet medicinals Cuscuta-Medlar(CM)in treat male infertility and analyze their potential mechanisms by the network pharmacology method.Method:TCMSP,BATMAN and literature were used to obtain comp...Objective:To predict couplet medicinals Cuscuta-Medlar(CM)in treat male infertility and analyze their potential mechanisms by the network pharmacology method.Method:TCMSP,BATMAN and literature were used to obtain components of CM,and male infertility targets were predicted by OMIM and GeneCards databases.Cytoscape software was used to construct the"component-target-disease"network.The STRING web site was used for the analysis of Protein-to-protein interaction(PPI)data between compounds and disease.DAVID 6.8 was carried on GO analysis and KEGG pathway analysis.Result:A total of 52 active ingredients and 242 potential targets of CM were obtained,with 7661 male infertility related genes retrieved from disease database.Then 113 common targets were obtained.Biological processes were related to enzyme binding,signaling receptor binding and molecular function regulator.The biological pathways mainly included TNF signaling pathway,apoptosis-related signaling pathway,PI3K/AKT signaling pathway,FoxO signaling pathway,Thyroid hormone signaling pathway and toll-like receptor signaling pathway.Conclusion:CM may treat male infertility by inhibiting inflammation,inhibiting apoptosis and promoting spermatogenesis.展开更多
Objective:To explore the mechanism of“Radix clematidis-Impatientis semen”in the treatment of esophageal cancer based on network pharmacology.Methods:The active components of Radix clematidis and Impatientis semen we...Objective:To explore the mechanism of“Radix clematidis-Impatientis semen”in the treatment of esophageal cancer based on network pharmacology.Methods:The active components of Radix clematidis and Impatientis semen were searched and selected through the TCMSP database,and supplemented with the literature,the targets of active components were predicted by Swiss Target Prediction platform.The main targets of esophageal cancer were obtained by Genecards,TTD and DisGeNet databases,and the key targets of“Radix clematidis-Impatientis semen”for the treatment of esophageal cancer were obtained by using Venn diagram analysis.The"drug-active ingredient-disease-target"network of“Radix clematidis-Impatientis semen”in the treatment of esophageal cancer was constructed with the help of Cytoscape3.7.2,and the key target PPI network was constructed by using STRING platform and Cytoscape software to find the core target.Metascape platform was used for GO and KEGG enrichment analysis of key targets,and the network diagram of"active componenttarget-pathway"was drawn.Results:There were 17 active components such as quercetin,kaempferol,3-epioleanolic acid and oleanolic acid in“Radix clematidis-Impatientis semen”,corresponding to 379 drug targets.178targets were obtained by mapping with 2396 disease targets of esophageal cancer,including PIK3CA,PIK3R1,SRC,MAPK1,MAPK3 and so on.KEGG enrichment analysis mainly involved PI3K-Akt,Rap1,Ras,VEGF signaling pathways,etc.Conclusion:This study preliminarily discusses the potential mechanism of“Radix clematidis-Impatientis semen”in the treatment of esophageal cancer,which provides a basis and new thought for further experimental research.展开更多
Objective:To investigate the active compounds,key targets and molecular mechanism of Qizhu Yuling Decoction in the treatment of esophageal carcinoma based on network pharmacology.Methods:The active compounds of Qizhu ...Objective:To investigate the active compounds,key targets and molecular mechanism of Qizhu Yuling Decoction in the treatment of esophageal carcinoma based on network pharmacology.Methods:The active compounds of Qizhu Yuling Decoction with anti-esophageal cancer activity were screened by TCMSP and literature search,and the drug targets were searched by DrugBank and predicted by SwissTargetPrediction.The esophageal cancer-related genes were obtained from GeneCards,OMIM,DrugBank,TTD,DisGeNET,and the intersection network was selected to obtain candidate genes.The"herb-compound-target-disease"network was constructed with Cytoscape,the PPI network was constructed in STRING and core network modules were screened.Gene ontology and KEGG enrichment analysis was performed by using Metascape,and the"pathway-gene"network was constructed to further screen key targets.Results:A total of 47 active compounds(19 Astragalus,4 Zedoary turmeric,11 Atractylodes macrocephala,9 Curcuma longa,5 Clematis root,and 5 Salvia chinensis),297 candidate genes,2413 GO and 119 KEGG pathways were obtained.Conclusion:The active compounds of Qizhu Yuling Decoction in the treatment of esophageal cancer are quercetin,kaempferol,glycine and ursolic acid.The potential targets are AKT1,MAPK1,MAPK3,PIK3R1 and RELA.GO involves oxidative stress,cell cycle,apoptosis and cell death,and KEGG involves typical cancer pathways,MAPK,NF-κB and PI3K-Akt signaling pathways.This study reveals the molecular biological mechanism of Qizhu Yuling Decoction in the treatment of esophageal cancer,and speculates that the function of potential targets focuses on the interaction of multiple signaling pathways,which can antagonize the proliferation,invasion,metastasis and recurrence of esophageal cancer and improve the prognosis of patients.This study provides new evidence for subsequent new drug development,clinical application and experimental study.展开更多
Insomnia is one of the most common clinical health problems,which can lead to a variety of complications and seriously affect human physical and mental health.Acupuncture has been used for treating insomnia for thousa...Insomnia is one of the most common clinical health problems,which can lead to a variety of complications and seriously affect human physical and mental health.Acupuncture has been used for treating insomnia for thousands of years,and is currently widely used as an alternative thehere is still a lack of up-to-date and comprehensive understanding of the mechanism of acupuncture for insorapy for insomnia all over the world.However,the mechanism of acupuncture for insomnia is still unclear,the mechanism research is relatively discrete,and tmnia.After summary and analysis in this study,it is found that acupuncture may improve sleeping by adjusting central neurotransmitter,insomnia-related hormone,circadian rhythm,sleep structure,and brain function.How to scientifically explain the scientific mechanism of acupuncture in treating insomnia has great challenges.I hope this study can provide reference for future research on the mechanism of acupuncture for insomnia.展开更多
To predict the potential mechanism of prevention and treatment of colorectal adenoma canceration by berberine and the docking of main key targets by computer virtual method.Methods:The related targets of berberine,col...To predict the potential mechanism of prevention and treatment of colorectal adenoma canceration by berberine and the docking of main key targets by computer virtual method.Methods:The related targets of berberine,colorectal adenoma and colorectal cancer were collected in various databases;the key targets were obtained by intersection;the protein protein interaction network and 6 kinds of enrichment analysis of key potential targets were completed by corresponding databases;the main key targets and berberine molecules were obtained for molecular docking.Results:There were 319 unique targets for berberine,3,279 for intestinal adenoma and 4,119 for colorectal cancer.The protein protein interaction network of key target involved 66 proteins.In the results of Gene Ontology enrichment,28 items related to biological process,28 items related to cell composition,30 items related to molecular function,26 items related to Kyoto Encyclopedia of Genes and Genomes pathway enrichment,35 items related to TargetScan microRNA,15 items related to Human Phenotype Ontology.TP53 and CYCS are the 2 key targets involved in the system enrichment.After docking,berberine was closely bound to theα-helix and β-fold of TP53 protein,and to theα-helix of CYCS protein.Conclusion:The potential mechanism of berberine in the prevention and treatment of colorectal adenoma canceration may be related to the regulation of cell apoptosis,metabolic pathways and biological activities of various enzymes.berberine,as a small molecular ligand,has the characteristics of multi-target,multi-channel and multi-system mechanism.In the prediction results,berberine,as a small molecular ligand,can closely bind with the main key targets related to colorectal adenoma canceration.展开更多
To explore the potential mechanism of the classic ancient prescription Qinghaobiejiatang(QHBJT)in treating renal interstitial fibrosis.Methods:Obtain the active ingredients of Qinghao(Artemisiae annuae herba),Biejia(T...To explore the potential mechanism of the classic ancient prescription Qinghaobiejiatang(QHBJT)in treating renal interstitial fibrosis.Methods:Obtain the active ingredients of Qinghao(Artemisiae annuae herba),Biejia(Trionycis carapax),Dihuang(Rehmanniae radix),Zhimu(Anemarrhenae rhizoma),and Mudanpi(Moutan cortex)through TCMSP and TCMID databases.Collect disease targets through the GENECARDS database.Use Venny2.1.0 platform to draw Venn diagrams to map drugs and disease targets.Import the key targets into Cytoscape 3.7.2 software to draw a network diagram of“drugs-active ingredients-diseases-key targets”.The STRING11.0 database was used to construct the key target protein interaction network diagram.Use R language for Gene ontology function and kyoto encyclopedia of genes and genomes pathway enrichment analysis.Results:A total of 317 active ingredients were obtained through screening,involving 166 targets,and 102 active ingredients related to disease targets,mainly involved in the regulation of key targets such as FOS,IL6,MTOR,MAPK8,RELA,CCND1,TP53,EGFR,and CASP3 signal pathways related to viral infection,tumor-related,apoptosis,signal transduction,fluid shear stress and atherosclerosis play a synergistic role in the treatment of renal fibrosis.Conclusion:The effect mechanism of QHBJT in treating renal interstitial fibrosis is related to inflammation,oxidative stress,hypoxia,apoptosis,pathological activation and damage of renal tubular epithelial cells mediated by the above pathways.展开更多
The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w ear...The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w earing greatly, and the surface quality of the product is improved to the utmost extent. The design mechanism of the optimal cutting movement trajectory system structure is analyzed incisively. At the same time, the principle of the complex movement of horizontal movement and swing is researched. The optimal design scheme of th e cutting movement trajectory system structure is set up. The choice method to g et the superior value of the movement system structure is found. The mathematics function formula is established which exhibits the relationship between the par ameter of the complex movement structure and that of the system movement structu re. By the formula, the precision value of the offset can be figured out. The r ule is adapted to different types of energy-saving stone-sawing machines. The complex movement structure of horizontal movement and swing is designed to f ulfill the cutting movement. It can make the saw frame move up with the hanging pod deviating from the vertical direction. At the same time, the saw frame have a down-movement. Then the sum of the two movements is near to zero, and the saw blade and the stone can keep in touch during the whole horizontal cutting. The result is that the actual cutting efficiency is 100%. Also, when the hanging pod moves to the limited position, the saw frame can keep the original inertia, and continue to swing up. It makes the back-cutting have high energy-storing. The optimal design of the eccentricity balance wheel is done. The mathematics fo rmula for expressing the movement system structure is deduced. The calculation m ethod and formula is set up which is used to get the value of important componen ts such as offset. The choice method and formula of elasticity distortion coeffi cient is set up when the saw frame moves smoothly. It is concluded that the offs et is the key dimension to actualize the optimal cutting movement trajectory. The resolving of the technical problems discussed above offers a theoretic and technical basis for optimal design of energy-saving stone-sawing machines.展开更多
An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical practice.They are changing the paradigm of preclinical can...An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical practice.They are changing the paradigm of preclinical cancer research because they can recapitulate the heterogeneity and pathophysiology of human cancers and more closely approximate the complex tissue environment and structure found in clinical tumors than in vitro cell lines and animal models.However,the potential applications of cancer organoids remain to be comprehensively summarized.In the review,we firstly describe what is currently known about cancer organoid culture and then discuss in depth the basic mechanisms,including tumorigenesis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological studies.Finally,the present challenges faced by organoid technology in clinical practice and its prospects are discussed.This review highlights that organoids may offer a novel therapeutic strategy for cancer research.展开更多
Tic disorder is a common pediatric neurological disorder that severely affects children’s quality of life.But in fact,there is still a lack of a very effective treatment for tic disorder.Acupuncture as a flexible tre...Tic disorder is a common pediatric neurological disorder that severely affects children’s quality of life.But in fact,there is still a lack of a very effective treatment for tic disorder.Acupuncture as a flexible treatment time,treatment cycle control,easy to operate treatment method,widely used in the field of neurological disorder,widely praised by clinicians and patients.At the same time,tic disorder belongs to the category of chronic inflammatory convulsion in traditional Chinese medicine,and acupuncture has a good effect of relieving spasticity and fewer adverse reactions,which makes acupuncture have a good application prospect.Now,more and more studies about acupuncture treatment of tic disorder in children have been published.The main methods of treating tic disorder are acupuncture,electroacupuncture,scalp acupuncture and ear acupuncture.The efficacy of acupuncture alone or in combination with other drugs such as tiapride hydrochloride and haloperidol has been shown to be good.The safety of acupuncture is also commendable,and clinical trials showing that the combination of acupuncture and medication can reduce the incidence and severity of adverse drug reactions.According to the existing studies,acupuncture can promote the development and repair of the nervous system,regulate the secretion of neurotransmitters,and reduce the occurrence of local discomfort,which may be the main mechanism of acupuncture treatment of tic disorders.展开更多
People have studied the electro-magnetic radiation of rock under pressure.This ishelpful to study on satellite thermal infrared temperature increase. Based on the researcheson the atmospheric gases anomalies and near-...People have studied the electro-magnetic radiation of rock under pressure.This ishelpful to study on satellite thermal infrared temperature increase. Based on the researcheson the atmospheric gases anomalies and near-surface atmospheric electric anomaly beforethe earthquake, we have proposed a mechanism for interpreting the satellite thermalinfrared temperature increase. That is, before an earthquake, the gases such as CH<sub>4</sub> andCO<sub>2</sub> released into the atmosphere are under the influence of electric field and solar radia-tion and cause the temperature to increase in the atmosphere. We have done experiments inlaboratory to verify this supposition.展开更多
文摘The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair growth products.Researchers have tried to illustrate the transdermal process with diversified theories and technologies.Directly observing the distribution of topical substances on skin by characteristic imaging is the most convincing approach.Unfortunately,fluorescence labeling imaging,which is commonly used in biochemical research,is limited for transdermal research for most topical substances with a molecular mass less than 500 Da.Label-free imaging technologies possess the advantages of not requiring any macromolecular dyes,no tissue destruction and an extensive substance detection capability,which has enabled rapid development of such technologies in recent years and their introduction to biological tissue analysis,such as skin samples.Through the specific identification of topical substances and endogenous tissue components,label-free imaging technologies can provide abundant tissue distribution information,enrich theoretical and practical guidance for transdermal drug delivery systems.In this review,we expound the mechanisms and applications of the most popular label-free imaging technologies in transdermal research at present,compare their advantages and disadvantages,and forecast development prospects.
基金financially supported by the National Natural Science Foundation of China(Nos.31540035,61308095,21801092,and 11904128)the Program for the Development of Science and Technology of Jilin Province(Nos.20180520002JH and 20190103100JH)+1 种基金the 13th Five-Year Program for Science and Technology of Education Department of Jilin Province(Nos.JJKH20180769KJ and JJKH20180778KJ)the Graduate Innovation Project of Jilin Normal University(No.201941)。
文摘In this paper,we report our attempts to raise the efficiency of liquid reduction method when using high specific surface area TiO2(HSTiO2)by doping Au.Characterization of Au-HSTiO2 was conducted via XRD,UV-vis,SEM,and photocurrent intensity.The experimental results show that Au-HSTiO2 exhibits prominently higher photocatalytic hydrogen production than TiO2 and HSTiO2.Enhanced photosynthetic hydrogen production ability of Au-HSTiO2 should be attributed to the presence of abundant surface active sites of HSTiO2,remarkably extending electronic holes in Au doping.This study provides a promising photosynthetic material for hydrogen production.
基金the National Natural Science Foundation of China(Grant Nos.41974156 and 41804050)the National Science and Technology Major Project(Grant No.2017ZX05049002)。
文摘Reservoir reconstructions implemented in unconventional oil and gas exploration usually adopt hydraulic fracturing techniques to inject high-pressure fluid into the reservoir and change its pore-fracture connection structure to enhance production.Hydraulic fracturing changes the reservoir stress and causes the rocks to crack,thus generating microseismic events.One important component of microseismic research is the source mechanism inversion.Through the research on the microseismic focal mechanism,information on the source mechanisms and in-situ stress status variations can be quantitatively revealed to effectively optimize the reservoir reconstruction design for increasing production.This paper reviews the recent progress in hydraulic fracturing induced microseismic focal mechanism research.We summarize their main principles and provide a detailed introduction of the research advances in source modeling,microseismic data synthesis,and focal mechanism inversion.We also discuss the challenges and limitations in the current microseismic focal mechanism research and propose prospects for future research ideas and directions.
文摘Objective To observe the effect of Fuzheng Kang’ai Recipe(FKR)combined with gefitinib on the proliferation and apoptosis of lung cancer A549 cells,and to study its potential synergistic mechanish with gefitinib.Methods The effects of FKR(0.211,0.316,0.474,0.711,1.067,1.600,2.400,3.600 mg/mL)combined with
基金Guangdong Province Key Field Research and Development Plan Project(No.2020B1111100007)Guangxi University of Traditional Chinese Medicine 2021 Graduate Education Innovation Plan Project(No.YCXJ2021074)。
文摘Depression and insomnia have become a frequent disease in the clinic.Clinically,depression and insomnia occur synchronously.Most researchers believe acupuncture treats insomnia and depression comorbidity through mechanisms such as inflammation theory,HPA axis theory,neurotransmitter theory,nervous system structure theory,immunoregulation theory,etc.Acupuncture has a clear effect on depression and insomnia comorbidity,and is two-way,specific,and integral.Therefore,a summary on the mechanism of using acupuncture to treat depression and insomnia comorbidity is made,to provide reference for future clinical application and laboratory research.
基金the National Natural Science Foundation of China !(Grallt No.59775061).
文摘As a transmission medium. welding arc can be modulated to emit ultrasonic energy by exerting high-frequency electric current. The frequency of exciting electric current has notable influence on the signals recorded by the sensors and the metallographic Structures of the welds. The resonance phenomenon of arc-ultrasonic has been found in the experiment. Both the resonance mechanism and the distribution of resonance frequency are discussed by the built vibration equation.
基金supported by the National Key R&D Program of China(2021YFB3800300)Beijing Outstanding Young Scientists Program(BJJWZYJH01201910007023)Yuanguang Scholars Program,Hebei University of Technology(282022554).
文摘The electrocatalytic sulfur reduction reaction(SRR)and sulfur evolution reaction(SER),two fundamental multistep conversion processes in lithium–sulfur batteries(LSBs),are root-cause solutions to overcome sluggish redox kinetics and the polysulfide shuttling effect.Metal–organic framework(MOF)electrocatalysts have emerged as good platforms for catalyzing SRR and SER,but their catalytic performance is challenged by poor electrical conductivity and limited chemical stability.Functionalized MOFs and their hybrids may be beneficial for stabilizing and improving the desired catalytic properties to achieve high-performance LSBs.This review provides a detailed overview of engineering principles for improving the activity,selectivity,and stability of MOFrelated electrocatalysts via composition modulation and nanostructure design as well as hybrid assembly.It presents and discusses the various advances achieved by using in situ characterization techniques,simulations,and theoretical calculations to reveal the dynamic evolution of MOF-related electrocatalysts,enabling an in-depth understanding of the catalysis mechanism at the molecular/atomic level.Lastly,prospects and possible research directions for MOF-related sulfur electrocatalysts are proposed.
基金Hunan university students’innovation and entrepreneurship training program(No.[2019]191-2440)Zhejiang provincial natural fund(No.GF18H140006)。
文摘Objective:To explore the main physiological mechanism of 15d-PGJ2 promoting periodontal tissue regeneration in patients with jaw defects caused by periodontal disease.Methods:From February 2016 to July 2019,a controlled study was conducted on 73 healthy residents(healthy group)and 73 patients(case group)with periodontal disease combined with jaw defects in Changsha medical university.T test was used to compare the growth factors of gingival crevicular fluid between the two groups.Peripheral blood cells;Cement-specific protein;Peripheral blood enzyme;Statistical differences in bone metabolites.The t test method compared the content of each index before and after treatment(15d-PGJ2 was treated at a dose of 200 mu/kg for 14 days).The method of factor analysis explores the internal correlation of each index.Result:RANKL,ICAM-1,TGF-β1,Th17,Treg,PDLSCs,SOST,CAP,HMGB1,CTSK,5-LOX,COX-2,NTX were higher in the case group than in the healthy group.In the case group,RANKL,ICAM-1,TGF-β1,Th17,Treg,PDLSCs,SOST,CAP,HMGB1,CTSK,5-LOX,COX-2,NTX were lower than those in the healthy group.The differences between the groups were statistically significant(P<0.05).Compared with before treatment,IL-1β,IL-17,Bfgf,YKL-40,BMP-2,ICTP,PICP,CTX were significantly decreased after treatment.RANKL,ICAM-1,TGF-β1,Th17,Treg,PDLSCs,SOST,CAP,HMGB1,CTSK,5-LOX,COX-2,NTX were significantly increased.The differences were statistically significant(P<0.05).Factor analysis shows that four common factors can be extracted from 21 indicators,and the cumulative contribution rate is 96.993%.Conclusions:The treatment of 15d-PGJ2 in patients with periodontal disease with maxillary defects can significantly affect the expression of multiple characteristic indicators,which may involve four mechanisms:dysregulation of cell differentiation or migration,local inflammation or immune imbalance,destruction of alveolar bone microstructure,load or stimulation,and remodeling.The specific pathway related to this is still to be further explored.
基金General project of the national natural science foundation of China(No.81774320)。
文摘Objective:To predict couplet medicinals Cuscuta-Medlar(CM)in treat male infertility and analyze their potential mechanisms by the network pharmacology method.Method:TCMSP,BATMAN and literature were used to obtain components of CM,and male infertility targets were predicted by OMIM and GeneCards databases.Cytoscape software was used to construct the"component-target-disease"network.The STRING web site was used for the analysis of Protein-to-protein interaction(PPI)data between compounds and disease.DAVID 6.8 was carried on GO analysis and KEGG pathway analysis.Result:A total of 52 active ingredients and 242 potential targets of CM were obtained,with 7661 male infertility related genes retrieved from disease database.Then 113 common targets were obtained.Biological processes were related to enzyme binding,signaling receptor binding and molecular function regulator.The biological pathways mainly included TNF signaling pathway,apoptosis-related signaling pathway,PI3K/AKT signaling pathway,FoxO signaling pathway,Thyroid hormone signaling pathway and toll-like receptor signaling pathway.Conclusion:CM may treat male infertility by inhibiting inflammation,inhibiting apoptosis and promoting spermatogenesis.
基金NSFC(No.81673961,81774294)Natural Science Foundation of Beijing(No.7172186)。
文摘Objective:To explore the mechanism of“Radix clematidis-Impatientis semen”in the treatment of esophageal cancer based on network pharmacology.Methods:The active components of Radix clematidis and Impatientis semen were searched and selected through the TCMSP database,and supplemented with the literature,the targets of active components were predicted by Swiss Target Prediction platform.The main targets of esophageal cancer were obtained by Genecards,TTD and DisGeNet databases,and the key targets of“Radix clematidis-Impatientis semen”for the treatment of esophageal cancer were obtained by using Venn diagram analysis.The"drug-active ingredient-disease-target"network of“Radix clematidis-Impatientis semen”in the treatment of esophageal cancer was constructed with the help of Cytoscape3.7.2,and the key target PPI network was constructed by using STRING platform and Cytoscape software to find the core target.Metascape platform was used for GO and KEGG enrichment analysis of key targets,and the network diagram of"active componenttarget-pathway"was drawn.Results:There were 17 active components such as quercetin,kaempferol,3-epioleanolic acid and oleanolic acid in“Radix clematidis-Impatientis semen”,corresponding to 379 drug targets.178targets were obtained by mapping with 2396 disease targets of esophageal cancer,including PIK3CA,PIK3R1,SRC,MAPK1,MAPK3 and so on.KEGG enrichment analysis mainly involved PI3K-Akt,Rap1,Ras,VEGF signaling pathways,etc.Conclusion:This study preliminarily discusses the potential mechanism of“Radix clematidis-Impatientis semen”in the treatment of esophageal cancer,which provides a basis and new thought for further experimental research.
基金National Natural Science Foundation of China(No.81774289)Beijing Science and Technology Plan Major Fund Project(No.D161100005116004)China Academy of Chinese Medical Sciences(No.ZZ11-028)。
文摘Objective:To investigate the active compounds,key targets and molecular mechanism of Qizhu Yuling Decoction in the treatment of esophageal carcinoma based on network pharmacology.Methods:The active compounds of Qizhu Yuling Decoction with anti-esophageal cancer activity were screened by TCMSP and literature search,and the drug targets were searched by DrugBank and predicted by SwissTargetPrediction.The esophageal cancer-related genes were obtained from GeneCards,OMIM,DrugBank,TTD,DisGeNET,and the intersection network was selected to obtain candidate genes.The"herb-compound-target-disease"network was constructed with Cytoscape,the PPI network was constructed in STRING and core network modules were screened.Gene ontology and KEGG enrichment analysis was performed by using Metascape,and the"pathway-gene"network was constructed to further screen key targets.Results:A total of 47 active compounds(19 Astragalus,4 Zedoary turmeric,11 Atractylodes macrocephala,9 Curcuma longa,5 Clematis root,and 5 Salvia chinensis),297 candidate genes,2413 GO and 119 KEGG pathways were obtained.Conclusion:The active compounds of Qizhu Yuling Decoction in the treatment of esophageal cancer are quercetin,kaempferol,glycine and ursolic acid.The potential targets are AKT1,MAPK1,MAPK3,PIK3R1 and RELA.GO involves oxidative stress,cell cycle,apoptosis and cell death,and KEGG involves typical cancer pathways,MAPK,NF-κB and PI3K-Akt signaling pathways.This study reveals the molecular biological mechanism of Qizhu Yuling Decoction in the treatment of esophageal cancer,and speculates that the function of potential targets focuses on the interaction of multiple signaling pathways,which can antagonize the proliferation,invasion,metastasis and recurrence of esophageal cancer and improve the prognosis of patients.This study provides new evidence for subsequent new drug development,clinical application and experimental study.
基金National Administration of Traditional Chinese Medicine(No.ZZ-06)。
文摘Insomnia is one of the most common clinical health problems,which can lead to a variety of complications and seriously affect human physical and mental health.Acupuncture has been used for treating insomnia for thousands of years,and is currently widely used as an alternative thehere is still a lack of up-to-date and comprehensive understanding of the mechanism of acupuncture for insorapy for insomnia all over the world.However,the mechanism of acupuncture for insomnia is still unclear,the mechanism research is relatively discrete,and tmnia.After summary and analysis in this study,it is found that acupuncture may improve sleeping by adjusting central neurotransmitter,insomnia-related hormone,circadian rhythm,sleep structure,and brain function.How to scientifically explain the scientific mechanism of acupuncture in treating insomnia has great challenges.I hope this study can provide reference for future research on the mechanism of acupuncture for insomnia.
文摘To predict the potential mechanism of prevention and treatment of colorectal adenoma canceration by berberine and the docking of main key targets by computer virtual method.Methods:The related targets of berberine,colorectal adenoma and colorectal cancer were collected in various databases;the key targets were obtained by intersection;the protein protein interaction network and 6 kinds of enrichment analysis of key potential targets were completed by corresponding databases;the main key targets and berberine molecules were obtained for molecular docking.Results:There were 319 unique targets for berberine,3,279 for intestinal adenoma and 4,119 for colorectal cancer.The protein protein interaction network of key target involved 66 proteins.In the results of Gene Ontology enrichment,28 items related to biological process,28 items related to cell composition,30 items related to molecular function,26 items related to Kyoto Encyclopedia of Genes and Genomes pathway enrichment,35 items related to TargetScan microRNA,15 items related to Human Phenotype Ontology.TP53 and CYCS are the 2 key targets involved in the system enrichment.After docking,berberine was closely bound to theα-helix and β-fold of TP53 protein,and to theα-helix of CYCS protein.Conclusion:The potential mechanism of berberine in the prevention and treatment of colorectal adenoma canceration may be related to the regulation of cell apoptosis,metabolic pathways and biological activities of various enzymes.berberine,as a small molecular ligand,has the characteristics of multi-target,multi-channel and multi-system mechanism.In the prediction results,berberine,as a small molecular ligand,can closely bind with the main key targets related to colorectal adenoma canceration.
文摘To explore the potential mechanism of the classic ancient prescription Qinghaobiejiatang(QHBJT)in treating renal interstitial fibrosis.Methods:Obtain the active ingredients of Qinghao(Artemisiae annuae herba),Biejia(Trionycis carapax),Dihuang(Rehmanniae radix),Zhimu(Anemarrhenae rhizoma),and Mudanpi(Moutan cortex)through TCMSP and TCMID databases.Collect disease targets through the GENECARDS database.Use Venny2.1.0 platform to draw Venn diagrams to map drugs and disease targets.Import the key targets into Cytoscape 3.7.2 software to draw a network diagram of“drugs-active ingredients-diseases-key targets”.The STRING11.0 database was used to construct the key target protein interaction network diagram.Use R language for Gene ontology function and kyoto encyclopedia of genes and genomes pathway enrichment analysis.Results:A total of 317 active ingredients were obtained through screening,involving 166 targets,and 102 active ingredients related to disease targets,mainly involved in the regulation of key targets such as FOS,IL6,MTOR,MAPK8,RELA,CCND1,TP53,EGFR,and CASP3 signal pathways related to viral infection,tumor-related,apoptosis,signal transduction,fluid shear stress and atherosclerosis play a synergistic role in the treatment of renal fibrosis.Conclusion:The effect mechanism of QHBJT in treating renal interstitial fibrosis is related to inflammation,oxidative stress,hypoxia,apoptosis,pathological activation and damage of renal tubular epithelial cells mediated by the above pathways.
文摘The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w earing greatly, and the surface quality of the product is improved to the utmost extent. The design mechanism of the optimal cutting movement trajectory system structure is analyzed incisively. At the same time, the principle of the complex movement of horizontal movement and swing is researched. The optimal design scheme of th e cutting movement trajectory system structure is set up. The choice method to g et the superior value of the movement system structure is found. The mathematics function formula is established which exhibits the relationship between the par ameter of the complex movement structure and that of the system movement structu re. By the formula, the precision value of the offset can be figured out. The r ule is adapted to different types of energy-saving stone-sawing machines. The complex movement structure of horizontal movement and swing is designed to f ulfill the cutting movement. It can make the saw frame move up with the hanging pod deviating from the vertical direction. At the same time, the saw frame have a down-movement. Then the sum of the two movements is near to zero, and the saw blade and the stone can keep in touch during the whole horizontal cutting. The result is that the actual cutting efficiency is 100%. Also, when the hanging pod moves to the limited position, the saw frame can keep the original inertia, and continue to swing up. It makes the back-cutting have high energy-storing. The optimal design of the eccentricity balance wheel is done. The mathematics fo rmula for expressing the movement system structure is deduced. The calculation m ethod and formula is set up which is used to get the value of important componen ts such as offset. The choice method and formula of elasticity distortion coeffi cient is set up when the saw frame moves smoothly. It is concluded that the offs et is the key dimension to actualize the optimal cutting movement trajectory. The resolving of the technical problems discussed above offers a theoretic and technical basis for optimal design of energy-saving stone-sawing machines.
基金supported by grants from the Project Nn10 of Harbin Medical University Cancer Hospital,Heilongjiang,China(No.Nn102017-02)the National Natural Science Foundation of China(No.81972706,81872149,82173235,82072904,82103325)+3 种基金Outstanding Youth Project of Heilongjiang Provincial Natural Science Foundation,Heilongjiang,China(No.YQ2019H027)Distinguished Young Scholars of Harbin Medical University Cancer Hospital,Heilongjiang,China(No.JCQN2018-03)Yong Elite Training Foundation Grant of Harbin Medical University Cancer Hospital,Heilongjiang,China(No.JY2016-02)Haiyan Fund Project of Harbin Medical University Cancer Hospital,Heilongjiang,China(No.JJMS 2022-17).
文摘An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical practice.They are changing the paradigm of preclinical cancer research because they can recapitulate the heterogeneity and pathophysiology of human cancers and more closely approximate the complex tissue environment and structure found in clinical tumors than in vitro cell lines and animal models.However,the potential applications of cancer organoids remain to be comprehensively summarized.In the review,we firstly describe what is currently known about cancer organoid culture and then discuss in depth the basic mechanisms,including tumorigenesis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological studies.Finally,the present challenges faced by organoid technology in clinical practice and its prospects are discussed.This review highlights that organoids may offer a novel therapeutic strategy for cancer research.
文摘Tic disorder is a common pediatric neurological disorder that severely affects children’s quality of life.But in fact,there is still a lack of a very effective treatment for tic disorder.Acupuncture as a flexible treatment time,treatment cycle control,easy to operate treatment method,widely used in the field of neurological disorder,widely praised by clinicians and patients.At the same time,tic disorder belongs to the category of chronic inflammatory convulsion in traditional Chinese medicine,and acupuncture has a good effect of relieving spasticity and fewer adverse reactions,which makes acupuncture have a good application prospect.Now,more and more studies about acupuncture treatment of tic disorder in children have been published.The main methods of treating tic disorder are acupuncture,electroacupuncture,scalp acupuncture and ear acupuncture.The efficacy of acupuncture alone or in combination with other drugs such as tiapride hydrochloride and haloperidol has been shown to be good.The safety of acupuncture is also commendable,and clinical trials showing that the combination of acupuncture and medication can reduce the incidence and severity of adverse drug reactions.According to the existing studies,acupuncture can promote the development and repair of the nervous system,regulate the secretion of neurotransmitters,and reduce the occurrence of local discomfort,which may be the main mechanism of acupuncture treatment of tic disorders.
文摘People have studied the electro-magnetic radiation of rock under pressure.This ishelpful to study on satellite thermal infrared temperature increase. Based on the researcheson the atmospheric gases anomalies and near-surface atmospheric electric anomaly beforethe earthquake, we have proposed a mechanism for interpreting the satellite thermalinfrared temperature increase. That is, before an earthquake, the gases such as CH<sub>4</sub> andCO<sub>2</sub> released into the atmosphere are under the influence of electric field and solar radia-tion and cause the temperature to increase in the atmosphere. We have done experiments inlaboratory to verify this supposition.
