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血清microRNA-122与肥胖儿童胰岛素抵抗的关系 被引量:8
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作者 陈琼 张耀东 +3 位作者 毋盛楠 陈永兴 刘晓景 卫海燕 《中国当代儿科杂志》 CAS CSCD 北大核心 2019年第9期910-914,共5页
目的研究肥胖儿童血清microRNA-122(miR-122)与胰岛素抵抗的关系。方法选取47例7~14岁重度肥胖儿童为肥胖组,另选取与肥胖组性别及年龄匹配的正常体重健康儿童45例作为健康对照组,分别检测并记录两组儿童的身高、体重、腰围、臀围、空... 目的研究肥胖儿童血清microRNA-122(miR-122)与胰岛素抵抗的关系。方法选取47例7~14岁重度肥胖儿童为肥胖组,另选取与肥胖组性别及年龄匹配的正常体重健康儿童45例作为健康对照组,分别检测并记录两组儿童的身高、体重、腰围、臀围、空腹血糖(FBG)、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、游离脂肪酸(FFA)、白介素-6(IL-6)、miR-122水平,计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR),并进行统计分析。结果与健康对照组相比,肥胖组儿童身高、体重、BMI、WHR及FINS、HOMA-IR、TG、FFA、IL-6、miR-122水平均升高(P < 0.05);肥胖组miR-122水平与FINS、HOMA-IR、IL-6水平呈正相关(分别r=0.408、0.442、0.464,P < 0.05);miR-122的变化与IL-6有线性回归关系,且呈正相关(b'=0.318,P < 0.05)。结论肥胖儿童血清miR-122可能与胰岛素抵抗相关,具体机制尚需进一步研究。 展开更多
关键词 肥胖 micror N A -122 胰岛素抵抗 儿童
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Highly sensitive digital optical sensor with large measurement range based on the dual-microring resonator with waveguide-coupled feedback 被引量:3
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作者 向星烨 王葵如 +3 位作者 苑金辉 晋博源 桑新柱 余重秀 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第3期284-288,共5页
We propose a novel high-performance digital optical sensor based on the Mach-Zehnder interferential effect and the dual-microring resonators with the waveguide-coupled feedback. The simulation results show that the se... We propose a novel high-performance digital optical sensor based on the Mach-Zehnder interferential effect and the dual-microring resonators with the waveguide-coupled feedback. The simulation results show that the sensitivity of the sensor can be orders of magnitude higher than that of aconventional sensor, and high quality factor is not critical in it. Moreover, by optimizing the length of the feedback waveguide to be equal to the perimeter of the ring, the measurement range of the proposed sensor is twice as much as that of the conventional sensor in the weak coupling case. 展开更多
关键词 optical sensor microring resonator high sensitivity large measurement range
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Ultra-low V_(pp)and high-modulation-depth InP-based electro-optic microring modulator 被引量:4
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作者 Dapeng Liu Jian Tang +3 位作者 Yao Meng Wei Li Ninghua Zhu Ming Li 《Journal of Semiconductors》 EI CAS CSCD 2021年第8期55-59,共5页
A modulator is an essential building block in the integrated photonics,connecting the electrical with optical signals.The microring modulator gains much attention because of the small footprint,low drive voltage and h... A modulator is an essential building block in the integrated photonics,connecting the electrical with optical signals.The microring modulator gains much attention because of the small footprint,low drive voltage and high extinction ratio.An ultra-low V_(pp)and high-modulation-depth indium phosphide-based racetrack microring modulator is demonstrated in this paper.The proposed device mainly comprises one racetrack microring,incorporating a semiconductor amplifier,and coupling with a bus waveguide through a multimode interference coupler.Traveling wave electrodes are employed to supply bidirectional bias ports,terminating with a 50-Ω impedance.The on/off extinction ratio of the microring reaches 43.3 dB due to the delicately tuning of the gain.An 11 mV V_(pp),a maximum 42.5 dB modulation depth and a 6.6 GHz bandwidth are realized,respectively.This proposed microring modulator could enrich the functionalities and designability of the fundamental integrated devices. 展开更多
关键词 integrated photonics high-modulation-depth microring modulator
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A large bandwidth photonic delay line using passive cascaded silicon-on-insulator microring resonators 被引量:2
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作者 胡应涛 肖希 +5 位作者 李智勇 李运涛 樊中朝 韩伟华 俞育德 余金中 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第7期216-222,共7页
This paper investigated the design and the characterization of a photonic delay line based on passive cascaded silicon-on-insulator (SOI) microrings. We considered the compromise of group delay, bandwidth and insert... This paper investigated the design and the characterization of a photonic delay line based on passive cascaded silicon-on-insulator (SOI) microrings. We considered the compromise of group delay, bandwidth and insertion loss. A 3-stage double channel side-coupled integrated spaced sequence of resonator (SCISSOR) device was optimized by shifting the resonance of each microring and fabricated with electron beam lithography and dry etching. The group delay was measured to be 17 ps for non-return-to-zero signals at different bit rates and the bandwidth of 78 GHz was achieved. The experiment result agreed well with our simulation. 展开更多
关键词 group delay delay line slow light microring resonator
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MZI wavelength interleaving filter based on double microring structure 被引量:1
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作者 YANG Ziwei ZHENG Yufu +2 位作者 YE Jia SHI Haoqiang WEI Xiaoming 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2021年第1期93-97,共5页
To improve the output characteristics of all-fiber Mach-Zehnder interferometer(MZI)-interleaver,a dual microring-assisted MZI interleaver is designed.According to its structure,the output expression of the device is d... To improve the output characteristics of all-fiber Mach-Zehnder interferometer(MZI)-interleaver,a dual microring-assisted MZI interleaver is designed.According to its structure,the output expression of the device is derived from the signal flow diagram.After simulation analysis,the optimal structural parameters during the transmission process are obtained.In addition,the coupling coefficient and transmission loss of the coupler are analyzed.The results show that the improved interleaver output line wave is closer to the square wave,and its 25 dB cutoff band bandwidth and 0.5 dB passband bandwidth are significantly improved,with the values of 41.2 GHz and 18.9 GHz,respectively.The device has a certain resistantability to deviation,and the transmission loss has less influence on the extinction characteristics of the filter. 展开更多
关键词 optical fiber communication Mach-Zehnder interferometer(MZI) INTERLEAVER dual microring resonator
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Design,fabrication and characterization of a high-performance microring resonator in silicon-on-insulator
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作者 黄庆忠 余金中 +3 位作者 陈少武 徐学俊 韩伟华 樊中朝 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第7期2562-2566,共5页
A high-performance microring resonator in a silicon-on-insulator rib waveguide is realized by using the electron beam lithography followed by inductively coupled plasma etching. The design and the experimental realiza... A high-performance microring resonator in a silicon-on-insulator rib waveguide is realized by using the electron beam lithography followed by inductively coupled plasma etching. The design and the experimental realization of this device are presented in detail. In addition to improving relevant processes to minimize propagation loss, the coupling efficiency between the ring and the bus is carefully chosen to approach a critical coupling for high performance operating. We have measured a quality factor of 21,200 and an extinction ratio of 12.SdB at a resonant wavelength of 1549.32nm. Meanwhile, a low propagation loss of 0.89dB/mm in a curved waveguide with a bending radius of 40μm is demonstrated as well. 展开更多
关键词 integrated photonics microring resonator quality factor SILICON-ON-INSULATOR
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Compact temperature-insensitive modulator based on a silicon microring assistant Mach-Zehnder interferometer
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作者 张雪键 冯雪 +1 位作者 张登科 黄翊东 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第12期250-257,共8页
On the silicon-on-insulator platform, an ultra compact temperature-insensitive modulator based on a cascaded microring assistant Mach-Zehnder interferometer is proposed and demonstrated with numerical simulation. Acco... On the silicon-on-insulator platform, an ultra compact temperature-insensitive modulator based on a cascaded microring assistant Mach-Zehnder interferometer is proposed and demonstrated with numerical simulation. According to the calculated results, the tolerated variation of ambient temperature can be as high as 134 ℃ while the footprint of such a silicon modulator is only 340 μm2. 展开更多
关键词 integrated modulator temperature sensitivity microrING Mach-Zehnder interferometer
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Modeling and analysis of silicon-on-insulator elliptical microring resonators for future high-density integrated photonic circuits
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作者 熊康 肖希 +4 位作者 胡应涛 李智勇 储涛 俞育德 余金中 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第7期298-303,共6页
We propose a novel resonator containing an elliptical microring based on a silicon-on-insulator platform. Simu- lations using the three-dimensional finite-difference time-domain method show that the novel elliptical m... We propose a novel resonator containing an elliptical microring based on a silicon-on-insulator platform. Simu- lations using the three-dimensional finite-difference time-domain method show that the novel elliptical microring can efficiently enhance the mode coupling between straight bus waveguides and resonator waveguides or between adjacent resonators while preserving relatively high intrinsic quality factors with large free spectral range. The proposed resonator would be an alternative choice for future high-density integrated photonic circuits. 展开更多
关键词 elliptical microring resonator SILICON-ON-INSULATOR mode coupling intrinsic quality factor
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Bandwidth-tunable silicon nitride microring resonators
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作者 Jiacheng Liu Chao Wu +3 位作者 Gongyu Xia Qilin Zheng Zhihong Zhu Ping Xu 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第1期263-266,共4页
We designed a reconfigurable dual-interferometer coupled silicon nitride microring resonator.By tuning the integrated heater on interferometer's arms,the"critical coupling"bandwidth of resonant mode is c... We designed a reconfigurable dual-interferometer coupled silicon nitride microring resonator.By tuning the integrated heater on interferometer's arms,the"critical coupling"bandwidth of resonant mode is continuously adjustable whose quality factor varies from 7.9×10^(4) to 1.9×10^(5) with the extinction ratio keeping higher than 25 dB.Also a variety of coupling spanning from"under-coupling"to"over-coupling"were achieved,showing the ability to tune the quality factor from 6.0×10^(3) to 2.3×10^(5).Our design can provide an adjustable filtering method on silicon nitride photonic chip and contribute to optimize the nonlinear process for quantum photonics and all-optical signal processing. 展开更多
关键词 silicon nitride microring resonators Mach-Zehnder interferometer ring filter nonlinear optics
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Improving the spectral purity of single photons by a single-interferometer-coupled microring
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作者 Yang Wang Pingyu Zhu +4 位作者 Shichuan Xue Yingwen Liu Junjie Wu Xuejun Yang Ping Xu 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第3期311-315,共5页
We experimentally engineer a high-spectral-purity single-photon source using a single-interferometer-coupled silicon microring. By the reconfiguration of the interferometer, different coupling conditions can be obtain... We experimentally engineer a high-spectral-purity single-photon source using a single-interferometer-coupled silicon microring. By the reconfiguration of the interferometer, different coupling conditions can be obtained, corresponding to different quality factors for the pump and signal/idler. The ratio between the quality factor of the pump and signal/idler ranges from 0.29 to 2.57. By constructing the signal–idler joint spectral intensity, we intuitively demonstrate the spectral correlation of the signal and idler. As the ratio between the quality factor of the pump and signal/idler increases, the spectral correlation of the signal and idler decreases, i.e., the spectral purity of the signal/idler photons increases. Furthermore,time-integrated second-order correlation of the signal photons is measured, giving a value up to 94.95 ± 3.46%. Such high-spectral-purity photons will improve the visibility of quantum interference and facilitate the development of on-chip quantum information processing. 展开更多
关键词 spectral-purity microrING asymmetric Mach–Zehnder interferometer
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Bright 547-dimensional Hilbert-space entangled resource in 28-pair modes biphoton frequency comb from a reconfigurable silicon microring resonator
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作者 Qilin Zheng Jiacheng Liu +8 位作者 Chao Wu Shichuan Xue Pingyu Zhu Yang Wang Xinyao Yu Miaomiao Yu Mingtang Deng Junjie Wu Ping Xu 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第2期129-134,共6页
High-dimensional entanglement provides valuable resources for quantum technologies,including quantum communication,quantum optical coherence tomography,and quantum computing.Obtaining a high brightness and dimensional... High-dimensional entanglement provides valuable resources for quantum technologies,including quantum communication,quantum optical coherence tomography,and quantum computing.Obtaining a high brightness and dimensional entanglement source has significant value.Here we utilize a tunable asymmetric Mach–Zehnder interferometer coupled silicon microring resonator with 100 GHz free spectral range to achieve this goal.With the strategy of the tunable coupler,the dynamical and extensive tuning range of quality factors of the microring can be obtained,and then the biphoton pair generation rate can be optimized.By selecting and characterizing 28 pairs from a more than 30-pair modes biphoton frequency comb,we obtain a Schmidt number of at least 23.4 and on-chip pair generation rate of 19.9 MHz/m W;under a low on-chip pump power,which corresponds to 547 dimensions Hilbert space in frequency freedom.These results will prompt the wide applications of quantum frequency comb and boost the further large density and scalable on-chip quantum information processing. 展开更多
关键词 silicon microring resonator quantum entanglement biphoton frequency comb
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Ultralow cross talk arrayed waveguide grating integrated with tunable microring filter array
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作者 胡鹤鸣 刘世平 +3 位作者 李天文 范永杰 陈华 方青 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第3期50-54,共5页
The silicon-based arrayed waveguide grating(AWG)is widely used due to its compact footprint and its compatibility with the mature CMOS process.However,except for AWGs with ridged waveguides of a few micrometers of cro... The silicon-based arrayed waveguide grating(AWG)is widely used due to its compact footprint and its compatibility with the mature CMOS process.However,except for AWGs with ridged waveguides of a few micrometers of cross section,any small process error will cause a large phase deviation in other AWGs,resulting in an increasing cross talk.In this paper,an ultralow cross talk AWG via a tunable microring resonator(MRR)filter is demonstrated on the SOI platform.The measured insertion loss and minimum adjacent cross talk of the designed AWG are approximately 3.2 and-45.1 d B,respectively.Compared with conventional AWG,its cross talk is greatly reduced. 展开更多
关键词 SOI platform arrayed waveguide grating cross talk microring filter array thermo-optic effect
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Chiral exceptional point and coherent suppression of backscattering in silicon microring with low loss Mie scatterer 被引量:7
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作者 Hwaseob Lee Ali Kecebas +3 位作者 Feifan Wang Lorry Chang Sahin K.Ozdemir Tingyi Gu 《eLight》 2023年第1期66-74,共9页
Non-Hermitian systems with their spectral degeneracies known as exceptional points(EPs)have been explored for lasing,controlling light transport,and enhancing a sensor’s response.A ring resonator can be brought to an... Non-Hermitian systems with their spectral degeneracies known as exceptional points(EPs)have been explored for lasing,controlling light transport,and enhancing a sensor’s response.A ring resonator can be brought to an EP by controlling the coupling between its frequency degenerate clockwise and counterclockwise traveling modes.This has been typically achieved by introducing two or more nanotips into the resonator’s mode volume.While this method provides a route to study EP physics,the basic understanding of how the nanotips’shape and size symmetry impact the system’s non-Hermicity is missing,along with additional loss from both in-plane and out-of-plane scattering.The limited resonance stability poses a challenge for leveraging EP effects for switches or modulators,which requires stable cavity resonance and fixed laser-cavity detuning.Here we use lithographically defined asymmetric and symmetric Mie scatterers,which enable subwavelength control of wave transmission and reflections without deflecting to additional radiation channels.We show that those pre-defined Mie scatterers can bring the system to an EP without post tuning,as well as enable chiral light transport within the resonator.Counterintuitively,the Mie scatterer results in enhanced quality factor measured on the transmission port,through coherently suppressing the backscattering from the waveguide surface roughness.The proposed device platform enables pre-defined chiral light propagation and backscattering-free resonances,needed for various applications such as frequency combs,solitons,sensing,and other nonlinear optical processes such as photon blockade,and regenerative oscillators. 展开更多
关键词 Non-Hermicity Exceptional point Mie scatterers microring resonator Silicon photonics
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Ultra-low-loss multi-layer 8×8 microring optical switch 被引量:4
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作者 XIN LI WEI GAO +2 位作者 LIANGJUN LU JIANPING CHEN LINJIE ZHOU 《Photonics Research》 SCIE EI CAS CSCD 2023年第5期712-723,共12页
Microring-based optical switches are promising for wavelength-selective switching with the merits of compact size and low power consumption.However,the large insertion loss,the high fabrication,and the temperature sen... Microring-based optical switches are promising for wavelength-selective switching with the merits of compact size and low power consumption.However,the large insertion loss,the high fabrication,and the temperature sensitivity hinder the scalability of silicon microring optical switch fabrics.In this paper,we utilize a three-dimensional(3D)microring-based optical switch element(SE)on a multi-layer Si_(3)N_(4)-on-SOI platform to realize highperformance large-scale optical switch fabrics.The 3D microring-based SE consists of a Si∕Si_(3)N_(4) waveguide overpass crossing in the bottom and the top layers,and Si_(3)N_(4) dual-coupled microring resonators(MRRs)in the middle layer.The switch is calibration-free and has low insertion loss.With the 3D microring-based SEs,we implement an 8×8 crossbar optical switch fabric.As the resonance wavelengths of all SEs are well aligned,only one SE needs to be turned on in each routing path,which greatly reduces the complexity of the switch control.The optical transmission spectra show a box-like shape,with a passband width of~69 GHz and an average on-state loss of~0.37 dB.The chip has a record-low on-chip insertion loss of 0.52-2.66 dB.We also implement a non-duplicate polarization-diversity optical switch by using the bidirectional transmission characteristics of the crossbar architecture,which is highly favorable for practical applications.100 Gb/s dual-polarization quadrature-phase-shift-keying(DP-QPSK)signal is transmitted through the switch without significant degradation.To the best of our knowledge,this is the first time that 3D MRRs have been used to build highly scalable polarization-diversity optical switch fabrics. 展开更多
关键词 POLARIZATION microrING optical
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Self-calibrating microring synapse with dual-wavelength synchronization 被引量:2
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作者 JUNWEI CHENG ZHENMING HE +7 位作者 YUHAO GUO BO WU HAILONG ZHOU TEYAN CHEN YIXIN WU WENWEI XU JIANJI DONG XINLIANG ZHANG 《Photonics Research》 SCIE EI CAS CSCD 2023年第2期347-356,共10页
As a resonator-based optical hardware in analog optical computing, a microring synapse can be straightforwardly configured to simulate the connection weights between neurons, but it faces challenges in precision and s... As a resonator-based optical hardware in analog optical computing, a microring synapse can be straightforwardly configured to simulate the connection weights between neurons, but it faces challenges in precision and stability due to cross talk and environmental perturbations. Here, we propose and demonstrate a self-calibration scheme with dual-wavelength synchronization to monitor and calibrate the synaptic weights without interrupting the computation tasks. We design and fabricate an integrated 4 × 4 microring synapse and deploy our self-calibration scheme to validate its effectiveness. The precision and robustness are evaluated in the experiments with favorable performance, achieving 2-bit precision improvement and excellent robustness to environmental temperature fluctuations(the weights can be corrected within 1 s after temperature changes 0.5°C). Moreover, we demonstrate matrix inversion tasks based on Newton iterations beyond 7-bit precision using this microring synapse. Our scheme provides an accurate and real-time weight calibration independently parallel from computations and opens up new perspectives for precision boost solutions to large-scale analog optical computing. 展开更多
关键词 SYNCHRONIZATION microrING RESONATOR
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Reconfigurable multichannel amplitude equalizer based on cascaded silicon photonic microrings
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作者 CHANGPING ZHANG SHUJUN LIU +6 位作者 HAO YAN DAJIAN LIU LONG ZHANG HUAN LI YAOCHENG SHI LIU LIU DAOXIN DAI 《Photonics Research》 SCIE EI CAS CSCD 2023年第5期742-749,共8页
A compact on-chip reconfigurable multichannel amplitude equalizer based on cascaded elliptical microrings is proposed and demonstrated experimentally.With the optimized structure of the elliptical microring with adiab... A compact on-chip reconfigurable multichannel amplitude equalizer based on cascaded elliptical microrings is proposed and demonstrated experimentally.With the optimized structure of the elliptical microring with adiabatically varied radii/widths,the average excess loss for each channel in the initialized state is measured to be less than 0.5 d B,while the attenuation dynamic range can be over 20 d B.Flexible tunability through the overlapping of the resonance peaks of adjacent wavelength-channels enables even higher attenuation dynamic ranges up to50 d B.Leveraging the thermo-optic effect and fine wavelength-tuning linearity,precise tuning of the resonance peak can be implemented,enabling dynamic power equalization of each wavelength-channel in wavelengthdivision-multiplexing(WDM)systems and optical frequency combs.The proposed architecture exhibits excellent scalability,which can facilitate the development of long-haul optical transport networks and high-capacity neuromorphic computing systems,while improving the overall performance of optical signals in WDM-related systems. 展开更多
关键词 tuning MULTICHANNEL microrING
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Highly reliable integrated W-band transmitter based on an on-chip dual-mode DFB laser and cascaded microring modulators
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作者 XUYING LIU WENJIA ZHANG +4 位作者 YUE JIANG HAN WANG DAN LU FAN YANG ZUYUAN HE 《Photonics Research》 SCIE EI CAS CSCD 2023年第8期1431-1436,共6页
We propose an integrated W-band transmitter enabled by an integrated dual-mode distributed feedback(DFB)laser and cascaded silicon photonic microring modulators for next-generation wireless communication.10 Gb/s error... We propose an integrated W-band transmitter enabled by an integrated dual-mode distributed feedback(DFB)laser and cascaded silicon photonic microring modulators for next-generation wireless communication.10 Gb/s error-free intensity modulation and direct detection W-band transmission are achieved in experiments by using the dual-mode DFB laser and two free-running lasers.Moreover,we conduct an experiment of dual-carrier modulation based on cascaded microring modulators,achieving 3 dB signal-to-noise ratio improvement and better signaling integrity for wireless communication.The proposed photonic integrated W-band transmitter will be a viable solution for a high-speed and low-power wireless communication system. 展开更多
关键词 Gb/s cascaded microrING
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基于光学微环谐振器的甲醛传感器模拟研究
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作者 杨国辉 安士龙 高劭宏 《传感器与微系统》 CSCD 北大核心 2024年第8期68-71,共4页
针对在日常生活使用广泛但危害性极大的甲醛溶液,基于光学微环谐振器,设计了一种灵敏度高、动态范围大的折射率传感器,用来检测甲醛溶液浓度。本文利用波导微扰理论,确定了使系统灵敏度最大化的波导核心尺寸,利用有限元进行模拟计算。... 针对在日常生活使用广泛但危害性极大的甲醛溶液,基于光学微环谐振器,设计了一种灵敏度高、动态范围大的折射率传感器,用来检测甲醛溶液浓度。本文利用波导微扰理论,确定了使系统灵敏度最大化的波导核心尺寸,利用有限元进行模拟计算。结果发现:利用该传感器如果检测到10^(-5)的相对波长位移,那么就可以检测到10^(-4)的相对折射率变化,并且通过包层去除方法还可进一步提升该传感器的灵敏度,与其他方法相比,这种甲醛溶液探测传感器的灵敏度有了很大程度的提升,对实际甲醛溶液的测量有着实际指导意义。 展开更多
关键词 微环谐振器 折射率传感器 甲醛 有效折射率
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Microring-Assisted Coupling Between Dissimilar Waveguides
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作者 V. Van P.-T. Ho 《Tsinghua Science and Technology》 SCIE EI CAS 2010年第2期145-150,共6页
The use of microdng resonators to assist in the evanescent field coupling between dissimilar waveguides is proposed and analyzed. Theoretical analysis based on the coupled mode theory and numerical example show that c... The use of microdng resonators to assist in the evanescent field coupling between dissimilar waveguides is proposed and analyzed. Theoretical analysis based on the coupled mode theory and numerical example show that complete cross power transfers can be obtained near the microring resonances. Applications of the device include power dividers, low-power thermo-optic or electro-optic switches, and modulators. 展开更多
关键词 microring resonators microring-assisted coupling resonance-assisted coupling coupled mode theory
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2型糖尿病脾虚证患者血清microRNA表达谱和生物信息学分析(英文) 被引量:4
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作者 杨泽民 洪敏 +6 位作者 陈滢宇 陈龙辉 杨小蓉 唐思梦 袁前发 何震宇 陈蔚文 《中华中医药杂志》 CAS CSCD 北大核心 2017年第8期3677-3683,共7页
目的:通过对2型糖尿病脾虚证患者血清micro RNA(miRNA)表达谱和生物信息学分析,从miRNA水平上探讨脾虚证的发病机制和辨证分型。方法:选择5例2型糖尿病脾虚证患者和5名健康志愿者,从他们的血清标本中提取RNA,进行miRNA定量PCR芯片实验... 目的:通过对2型糖尿病脾虚证患者血清micro RNA(miRNA)表达谱和生物信息学分析,从miRNA水平上探讨脾虚证的发病机制和辨证分型。方法:选择5例2型糖尿病脾虚证患者和5名健康志愿者,从他们的血清标本中提取RNA,进行miRNA定量PCR芯片实验。筛选出两组之间差异表达的miRNA,利用miRSystem数据库进行靶基因预测和功能注释。结果:在2型糖尿病脾虚证患者和健康志愿者的血清中发现16个差异表达的miRNA。聚类分析显示,这16个差异表达的miRNA能够将2型糖尿病脾虚证患者和健康志愿者很好的区分。靶基因预测和功能注释显示,14个上调miRNA的调控122个靶基因显著富集到6个KEGG通路和6个GO分子功能。这些富集的KEGG通路包括与脂肪酸、氨基酸和2型糖尿病相关的营养物质代谢通路,钙离子信号通路,致病的大肠杆菌感染通路和亨廷顿氏舞蹈病通路。这些富集的GO分子功能包括羧酸、脂类、辅因子和药物结合功能,和酶激活剂和转录抑制剂活性功能。然而,2个下调miRNA调控的10个靶基因显著富集到2个KEGG通路。它们是内质网中的蛋白质加工通路和志贺氏菌病通路。结论:本研究可能为2型糖尿病脾虚证患者的临床辨证提供了一些血清miRNA标志物,同时从miRNA水平上为脾虚证患者的发病机制提供了依据。 展开更多
关键词 脾虚证 2型糖尿病 血清微小RNA 靶基因预测 功能注释
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