Objectives: The aim of this study was to assess the reliability of the mock transfer during in vitro fertilization process Method: A case-control study was conducted on 134 patients included in IVF/ICSI cycles. From t...Objectives: The aim of this study was to assess the reliability of the mock transfer during in vitro fertilization process Method: A case-control study was conducted on 134 patients included in IVF/ICSI cycles. From the hysterometry obtained during the mock transfer, the ideal embryo replacement site, i.e. two cm from the uterine fundus has been determined. Results: Significant differences were noted between the area estimated from the mock transfer and the area where the embryo was deposited during the actual embryo transfer. In fact, 15.9% of the patients had a difference between four and six cm, and 32% of the patients returning for a subsequent transfer had at least 2 cm of difference between the embryo deposit zones. This difference was significant (P 0.00) Conclusion: More than ultrasound guidance, the challenge with embryo transfer is to be able to minimize variations in the length of the uterus. This would make it possible to determine the ideal transfer depot area without multiple manipulations.展开更多
This paper examines an under-researched phenomenon of mock impoliteness in Chinese online interaction,namely,the practice of hudui(lit.reciprocal jocular abuse)as a solidarity enhancing device among acquaintances.Draw...This paper examines an under-researched phenomenon of mock impoliteness in Chinese online interaction,namely,the practice of hudui(lit.reciprocal jocular abuse)as a solidarity enhancing device among acquaintances.Drawing on data from Qzone interaction among Chinese university students,this study focuses on ritual features,sequential patterns and interpersonal functions of hudui through the lens of Kádár’s(2013,2017)interpersonal ritual theory.The results show that hudui is co-constructed by the online participants with the symmetric pattern of mutual abuse,which distinguishes it from previous studies of jocular abuse(i.e.,the asymmetric pattern of abuser–recipient).They also reveal that hudui accomplishes various kinds of relational work,including fostering intimacy,enhancing mutual affection-based face and creating amusement.展开更多
The China-mock-up test is to evaluate the performance of the compacted Gaomiaozi （GMZ） bentonite under coupled thermo-hydro-mechanical （THM） conditions in deep geological disposal. A numerical study of the test is...The China-mock-up test is to evaluate the performance of the compacted Gaomiaozi （GMZ） bentonite under coupled thermo-hydro-mechanical （THM） conditions in deep geological disposal. A numerical study of the test is conducted in this paper. The principal THM characteristics of the bentonite are presented at first. A THM model is then presented to tackle the complex coupling behavior of the bentonite. The model of Alonso-Gens is incorporated to reproduce the mechanical behavior of the bentonite under unsaturated conditions. With the proposed model, numerical simulations of the China-mock-up test are carried out by using the code of LAGAMINE. The time variations associated with the temperature, degree of saturation, suction and swelling pressure of the compacted bentonite are studied. The results suggest that the proposed model is able to reproduce the mechanical behavior of the bentonite, and to predict moisture motion under coupled THM conditions.展开更多
According to the preliminary concept of the high-level radioactive waste （HLW） repository in China, a large-scale mock-up facility, named China-Mock-Up was constructed in the laboratory of Beijing Research Institute...According to the preliminary concept of the high-level radioactive waste （HLW） repository in China, a large-scale mock-up facility, named China-Mock-Up was constructed in the laboratory of Beijing Research Institute of Uranium Geology （BRIUG）. A heater, which simulates a container of radioactive waste, is placed inside the compacted Gaomiaozi （GMZ）-Na-bentonite blocks and pellets. Water inflow through the barrier from its outer surface is used to simulate the intake of groundwater. The numbers of water injection pipes, injection pressure and the insulation layer were determined based on the nu- merical modeling simulations. The current experimental data of the facility are herein analyzed. The experiment is intended to evaluate the thermo-hydro-mechano-chemical （THMC） processes occurring in the compacted bentonite-buffer during the early stage of HLW disposal and to provide a reliable database for numerical modeling and further investigation of engineered barrier system （EBS）, and the design of HLW repository.展开更多
Objective： To study the anti-angiogenesis effect of melittin on human hepatoma Mock/MHCC97-H cells by regulatingthe expression of cathepsin S （CatS） in vivo. Methods： Models of in situ transplantation tumor of Moc...Objective： To study the anti-angiogenesis effect of melittin on human hepatoma Mock/MHCC97-H cells by regulatingthe expression of cathepsin S （CatS） in vivo. Methods： Models of in situ transplantation tumor of Mock/MHCC97-Hcells and silencing cathepsin shRNA-CatS/ MHCC97-H cells in nude mice were established. The model mice wererandomly divided into four groups. In the A1 group, the mice were inoculated with shRNA-CatS/MHCC97-H cells andtreated with melittin. In the A2 group, the mice were inoculated with shRNA-CatS/MHCC97-H cells and treated withsaline. In the B1 group, the mice were inoculated with Mock/MHCC97-H cells and treated with melittin. In the B2 group,the mice were inoculated with Mock/MHCC97-H cells and treated with saline. The A1 and B1 group were injected withmelittin （80 mg/kg） intraperitoneally every day. The A2 and B2 group were injected with 0.2 mL normal salineintraperitoneally every day. After administration for 25 days, the animals were sacrificed. The tumor size and weight innude mice in each group were recorded. The expression of CD34 protein in the xenograft tumor tissues was detected byimmunohistochemistry. The expression of Cat S, VEGF-A, p-VEGFR2, Ras, Raf, p-Raf, MEK1, p-MEK1, ERK1/2 andp-ERK1/2 proteins were detected by western blot. Results： The B1 group had significantly smaller tumor volumes andlower tumor weights than the B2 group （both P 〈 0.001）. There was no significant difference between the A1 group andA2 group in tumor volumes and weights. The number of CD34-positive microvessels in the B2 group was significantlyhigher than that in the A2 group （P 〈 0.001）. The number of CD34-positive microvessels in the B1 group wassignificantly lesser than that in the A1 group （P 〈 0.001）. Most strikingly, in the model featuring inoculation ofMock/MHCC97-H cells, CatS, VEGF-A, p-VEGFR2, Ras, Raf, p-Raf, MEK1, p-MEK1, ERK1/2 and p-ERK1/2expression were inhibited when treated with melittin. However, in the model featuring the inoculation ofshRNA-CatS/MHCC97-H cells, no such effects were observed with similar treatments. Conclusion： Melittin can inhibitthe growth of tumors and angiogenesis by blocking the CatS-VEGf-A signaling pathway.展开更多
After introducing the present status of digital mock-up (DMU) technology in product development and research,the modeling and its key technologies in product design are described. The architecture of digital design pl...After introducing the present status of digital mock-up (DMU) technology in product development and research,the modeling and its key technologies in product design are described. The architecture of digital design platform system for main DMU model is developed. Based on the architecture,a method of skeleton design has been applied to the development of digital design system.展开更多
Background: Management of the acutely ill children represents one of the more complex clinical skills required of pediatric physicians. Our goal was to develop and evaluate a multidisciplinary pediatric mock code trai...Background: Management of the acutely ill children represents one of the more complex clinical skills required of pediatric physicians. Our goal was to develop and evaluate a multidisciplinary pediatric mock code training program for the pediatric residents in our institution. Methods: We performed a before and after evaluation of pediatric residents. The residents were educated by attending five mock code scenarios, followed by debriefing. Before and after the five sessions, the residents completed a self-assessment questionnaire. Results: Residents reported a significant improvement in their comfort in all aspects of managing pediatric resuscitations, with notable improvement seen in running a resuscitation requiring airway management, managing fluid resuscitation and performing endotracheal intubation. The most prominent change was demonstrated in the comfort level of the overall management of a pediatric resuscitation. Conclusion: The pediatric mock code educational training program improved residents’ self-reported knowledge and comfort level in managing pediatric emergency situations.展开更多
Tungsten is a promising candidate for plasma-facing materials to cover the surface of the divertor plate in the design of an international thermonuclear experimental reactor （ITER）. Copper as a heat sink material se...Tungsten is a promising candidate for plasma-facing materials to cover the surface of the divertor plate in the design of an international thermonuclear experimental reactor （ITER）. Copper as a heat sink material serves to transfer heat excellently. Divertor mock-ups with W/Cu graded interlayers were designed to reduce thermal stresses. Thermally induced stresses and temperature in a W/Cu divertor mock-up were analyzed using the finite element method. The graded structures with different exponents p and thick- nesses were designed and discussed. The conclusions drawn from these analyses are that thermal stresses reach the minimum and the temperature is suitable when exponent p is 1.5 and the thickness of five graded interlayers is 5 mm.展开更多
The internalization of motivation in second/foreign language(L2)learning and the use of mock conferences(MCs)to prepare translating and interpreting learners for future professional careers have been widely researched...The internalization of motivation in second/foreign language(L2)learning and the use of mock conferences(MCs)to prepare translating and interpreting learners for future professional careers have been widely researched by scholars,but whether MC can facilitate the internalization of T&I learners’motivation is under-researched.Based on self-determination theory(SDT),this thesis investigates the effectiveness of MC in facilitating internalization of motivation through an empirical study which involves a 2-week long pedagogical experiment on two parallel classes of T&I learners taught by the same teacher in their 1st year of graduate study at Graduate School of Translation and Interpretation,Beijing Foreign Studies University.The research shows that compared with traditional teachercentered teaching model,MCs can better facilitate internalization of T&I learners’motivation.This article justifies the use of MCs as a situated approach in interpreting teaching and describes the design of MCs according to the psychological needs of SDT.In addition,the paper offers suggestions for further improvement of MCs design at the postgraduate level.展开更多
基金Supported by National Natural Science Foundation of China (11871258)the Young Backbone Teachers in Henan Province (2020GGJS194)the Young Backbone Teachers in Luoyang Normal College (2019XJGGJS-10)。
文摘Objectives: The aim of this study was to assess the reliability of the mock transfer during in vitro fertilization process Method: A case-control study was conducted on 134 patients included in IVF/ICSI cycles. From the hysterometry obtained during the mock transfer, the ideal embryo replacement site, i.e. two cm from the uterine fundus has been determined. Results: Significant differences were noted between the area estimated from the mock transfer and the area where the embryo was deposited during the actual embryo transfer. In fact, 15.9% of the patients had a difference between four and six cm, and 32% of the patients returning for a subsequent transfer had at least 2 cm of difference between the embryo deposit zones. This difference was significant (P 0.00) Conclusion: More than ultrasound guidance, the challenge with embryo transfer is to be able to minimize variations in the length of the uterus. This would make it possible to determine the ideal transfer depot area without multiple manipulations.
基金support the Department of Education of Guangdong Province and Center for Linguistics and Applied Linguistics at Guangdong University of Foreign Studies, China, for the project (2018WZDXM006) on the frontier research and theoretical innovations in interpersonal pragmaticsthe Youth Fund Project (Project No.: 19QN34) of Guangdong University of Foreign Studiesthe support from the Chinese Ministry of Education Research Project of Humanities and Social Science (Project No.: 16JJD740006) conducted by the Center for Linguistics and Applied Linguistics, Guangdong University of Foreign Studies.
文摘This paper examines an under-researched phenomenon of mock impoliteness in Chinese online interaction,namely,the practice of hudui(lit.reciprocal jocular abuse)as a solidarity enhancing device among acquaintances.Drawing on data from Qzone interaction among Chinese university students,this study focuses on ritual features,sequential patterns and interpersonal functions of hudui through the lens of Kádár’s(2013,2017)interpersonal ritual theory.The results show that hudui is co-constructed by the online participants with the symmetric pattern of mutual abuse,which distinguishes it from previous studies of jocular abuse(i.e.,the asymmetric pattern of abuser–recipient).They also reveal that hudui accomplishes various kinds of relational work,including fostering intimacy,enhancing mutual affection-based face and creating amusement.
文摘The China-mock-up test is to evaluate the performance of the compacted Gaomiaozi （GMZ） bentonite under coupled thermo-hydro-mechanical （THM） conditions in deep geological disposal. A numerical study of the test is conducted in this paper. The principal THM characteristics of the bentonite are presented at first. A THM model is then presented to tackle the complex coupling behavior of the bentonite. The model of Alonso-Gens is incorporated to reproduce the mechanical behavior of the bentonite under unsaturated conditions. With the proposed model, numerical simulations of the China-mock-up test are carried out by using the code of LAGAMINE. The time variations associated with the temperature, degree of saturation, suction and swelling pressure of the compacted bentonite are studied. The results suggest that the proposed model is able to reproduce the mechanical behavior of the bentonite, and to predict moisture motion under coupled THM conditions.
文摘According to the preliminary concept of the high-level radioactive waste （HLW） repository in China, a large-scale mock-up facility, named China-Mock-Up was constructed in the laboratory of Beijing Research Institute of Uranium Geology （BRIUG）. A heater, which simulates a container of radioactive waste, is placed inside the compacted Gaomiaozi （GMZ）-Na-bentonite blocks and pellets. Water inflow through the barrier from its outer surface is used to simulate the intake of groundwater. The numbers of water injection pipes, injection pressure and the insulation layer were determined based on the nu- merical modeling simulations. The current experimental data of the facility are herein analyzed. The experiment is intended to evaluate the thermo-hydro-mechano-chemical （THMC） processes occurring in the compacted bentonite-buffer during the early stage of HLW disposal and to provide a reliable database for numerical modeling and further investigation of engineered barrier system （EBS）, and the design of HLW repository.
基金This work was supported by grants from the National Science Foundation of China （No. 81360372）.
文摘Objective： To study the anti-angiogenesis effect of melittin on human hepatoma Mock/MHCC97-H cells by regulatingthe expression of cathepsin S （CatS） in vivo. Methods： Models of in situ transplantation tumor of Mock/MHCC97-Hcells and silencing cathepsin shRNA-CatS/ MHCC97-H cells in nude mice were established. The model mice wererandomly divided into four groups. In the A1 group, the mice were inoculated with shRNA-CatS/MHCC97-H cells andtreated with melittin. In the A2 group, the mice were inoculated with shRNA-CatS/MHCC97-H cells and treated withsaline. In the B1 group, the mice were inoculated with Mock/MHCC97-H cells and treated with melittin. In the B2 group,the mice were inoculated with Mock/MHCC97-H cells and treated with saline. The A1 and B1 group were injected withmelittin （80 mg/kg） intraperitoneally every day. The A2 and B2 group were injected with 0.2 mL normal salineintraperitoneally every day. After administration for 25 days, the animals were sacrificed. The tumor size and weight innude mice in each group were recorded. The expression of CD34 protein in the xenograft tumor tissues was detected byimmunohistochemistry. The expression of Cat S, VEGF-A, p-VEGFR2, Ras, Raf, p-Raf, MEK1, p-MEK1, ERK1/2 andp-ERK1/2 proteins were detected by western blot. Results： The B1 group had significantly smaller tumor volumes andlower tumor weights than the B2 group （both P 〈 0.001）. There was no significant difference between the A1 group andA2 group in tumor volumes and weights. The number of CD34-positive microvessels in the B2 group was significantlyhigher than that in the A2 group （P 〈 0.001）. The number of CD34-positive microvessels in the B1 group wassignificantly lesser than that in the A1 group （P 〈 0.001）. Most strikingly, in the model featuring inoculation ofMock/MHCC97-H cells, CatS, VEGF-A, p-VEGFR2, Ras, Raf, p-Raf, MEK1, p-MEK1, ERK1/2 and p-ERK1/2expression were inhibited when treated with melittin. However, in the model featuring the inoculation ofshRNA-CatS/MHCC97-H cells, no such effects were observed with similar treatments. Conclusion： Melittin can inhibitthe growth of tumors and angiogenesis by blocking the CatS-VEGf-A signaling pathway.
文摘After introducing the present status of digital mock-up (DMU) technology in product development and research,the modeling and its key technologies in product design are described. The architecture of digital design platform system for main DMU model is developed. Based on the architecture,a method of skeleton design has been applied to the development of digital design system.
文摘Background: Management of the acutely ill children represents one of the more complex clinical skills required of pediatric physicians. Our goal was to develop and evaluate a multidisciplinary pediatric mock code training program for the pediatric residents in our institution. Methods: We performed a before and after evaluation of pediatric residents. The residents were educated by attending five mock code scenarios, followed by debriefing. Before and after the five sessions, the residents completed a self-assessment questionnaire. Results: Residents reported a significant improvement in their comfort in all aspects of managing pediatric resuscitations, with notable improvement seen in running a resuscitation requiring airway management, managing fluid resuscitation and performing endotracheal intubation. The most prominent change was demonstrated in the comfort level of the overall management of a pediatric resuscitation. Conclusion: The pediatric mock code educational training program improved residents’ self-reported knowledge and comfort level in managing pediatric emergency situations.
基金This work was financially supported by the National High-Tech Research and Development Program of China ("863" Program)(No.2003AA305340)
文摘Tungsten is a promising candidate for plasma-facing materials to cover the surface of the divertor plate in the design of an international thermonuclear experimental reactor （ITER）. Copper as a heat sink material serves to transfer heat excellently. Divertor mock-ups with W/Cu graded interlayers were designed to reduce thermal stresses. Thermally induced stresses and temperature in a W/Cu divertor mock-up were analyzed using the finite element method. The graded structures with different exponents p and thick- nesses were designed and discussed. The conclusions drawn from these analyses are that thermal stresses reach the minimum and the temperature is suitable when exponent p is 1.5 and the thickness of five graded interlayers is 5 mm.
文摘The internalization of motivation in second/foreign language(L2)learning and the use of mock conferences(MCs)to prepare translating and interpreting learners for future professional careers have been widely researched by scholars,but whether MC can facilitate the internalization of T&I learners’motivation is under-researched.Based on self-determination theory(SDT),this thesis investigates the effectiveness of MC in facilitating internalization of motivation through an empirical study which involves a 2-week long pedagogical experiment on two parallel classes of T&I learners taught by the same teacher in their 1st year of graduate study at Graduate School of Translation and Interpretation,Beijing Foreign Studies University.The research shows that compared with traditional teachercentered teaching model,MCs can better facilitate internalization of T&I learners’motivation.This article justifies the use of MCs as a situated approach in interpreting teaching and describes the design of MCs according to the psychological needs of SDT.In addition,the paper offers suggestions for further improvement of MCs design at the postgraduate level.
