期刊文献+
共找到84,541篇文章
< 1 2 250 >
每页显示 20 50 100
Influence of substrate effect on near-field radiative modulator based on biaxial hyperbolic materials
1
作者 刘睿一 刘皓佗 +2 位作者 胡杨 崔峥 吴小虎 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期56-64,共9页
Relative rotation between the emitter and receiver could effectively modulate the near-field radiative heat transfer(NFRHT)in anisotropic media.Due to the strong in-plane anisotropy,natural hyperbolic materials can be... Relative rotation between the emitter and receiver could effectively modulate the near-field radiative heat transfer(NFRHT)in anisotropic media.Due to the strong in-plane anisotropy,natural hyperbolic materials can be used to construct near-field radiative modulators with excellent modulation effects.However,in practical applications,natural hyperbolic materials need to be deposited on the substrate,and the influence of substrate on modulation effect has not been studied yet.In this work,we investigate the influence of substrate effect on near-field radiative modulator based onα-MoO_(3).The results show that compared to the situation without a substrate,the presence of both lossless and lossy substrate will reduce the modulation contrast(MC)for different film thicknesses.When the real or imaginary component of the substrate permittivity increases,the mismatch of hyperbolic phonon polaritons(HPPs)weakens,resulting in a reduction in MC.By reducing the real and imaginary components of substrate permittivity,the MC can be significantly improved,reaching 4.64 forε_(s)=3 at t=10 nm.This work indicates that choosing a substrate with a smaller permittivity helps to achieve a better modulation effect,and provides guidance for the application of natural hyperbolic materials in the near-field radiative modulator. 展开更多
关键词 near-field radiative modulator substrate effect hyperbolic material modulation contrast
原文传递
Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state
2
作者 Elena Ambrosini Angela Lanciotti Maria Stefania Brignone 《Neural Regeneration Research》 SCIE CAS 2025年第7期2008-2010,共3页
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental... Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner. 展开更多
关键词 alterations modulator MAINTAIN
下载PDF
Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions
3
作者 Fengwen Huang Stephen Temitayo Bello 《Neural Regeneration Research》 SCIE CAS 2025年第7期1991-1992,共2页
Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodu... Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and noradrenaline.The neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal system.Cholecystokinin(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target regions.For instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety regulation.Conversely,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention. 展开更多
关键词 abundant FUNCTIONS modulator
下载PDF
Exploring the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shiga toxin‑producing E.coli challenged weaned piglets
4
作者 Matthias Dierick Ruben Ongena +2 位作者 Daisy Vanrompay Bert Devriendt Eric Cox 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第3期1278-1291,共14页
Background Post-weaned piglets suffer from F18+Escherichia coli(E.coli)infections resulting in post-weaning diar-rhoea or oedema disease.Frequently used management strategies,including colistin and zinc oxide,have con... Background Post-weaned piglets suffer from F18+Escherichia coli(E.coli)infections resulting in post-weaning diar-rhoea or oedema disease.Frequently used management strategies,including colistin and zinc oxide,have contrib-uted to the emergence and spread of antimicrobial resistance.Novel antimicrobials capable of directly interacting with pathogens and modulating the host immune responses are being investigated.Lactoferrin has shown promising results against porcine enterotoxigenic E.coli strains,both in vitro and in vivo.Results We investigated the influence of bovine lactoferrin(bLF)on the microbiome of healthy and infected weaned piglets.Additionally,we assessed whether bLF influenced the immune responses upon Shiga toxin-producing E.coli(STEC)infection.Therefore,2 in vivo trials were conducted:a microbiome trial and a challenge infection trial,using an F18+STEC strain.BLF did not affect theα-andβ-diversity.However,bLF groups showed a higher relative abundance(RA)for the Actinobacteria phylum and the Bifidobacterium genus in the ileal mucosa.When analysing the immune response upon infection,the STEC group exhibited a significant increase in F18-specific IgG serum levels,whereas this response was absent in the bLF group.Conclusion Taken together,the oral administration of bLF did not have a notable impact on theα-andβ-diversity of the gut microbiome in weaned piglets.Nevertheless,it did increase the RA of the Actinobacteria phylum and Bifi-dobacterium genus,which have previously been shown to play an important role in maintaining gut homeostasis.Furthermore,bLF administration during STEC infection resulted in the absence of F18-specific serum IgG responses. 展开更多
关键词 E.COLI Immune modulation LACTOFERRIN MICROBIOME
下载PDF
Light-field modulation and optimization near metal nanostructures utilizing spatial light modulators
5
作者 Zini Cao Hai Lin +3 位作者 Yuqing Cheng Yixuan Xu Qihuang Gong Guowei Lü 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第10期1-14,共14页
Plasmonic modes within metal nanostructures play a pivotal role in various nanophotonic applications.However,a significant challenge arises from the fixed shapes of nanostructures post-fabrication,resulting in limited... Plasmonic modes within metal nanostructures play a pivotal role in various nanophotonic applications.However,a significant challenge arises from the fixed shapes of nanostructures post-fabrication,resulting in limited modes under ordinary illumination.A promising solution lies in far-field control facilitated by spatial light modulators(SLMs),which enable on-site,real-time,and non-destructive manipulation of plasmon excitation.Through the robust modulation of the incident light using SLMs,this approach enables the generation,optimization,and dynamic control of surface plasmon polariton(SPP)and localized surface plasmon(LSP)modes.The versatility of this technique introduces a rich array of tunable degrees of freedom to plasmon-enhanced spectroscopy,offering novel approaches for signal optimization and functional expansion in this field.This paper provides a comprehensive review of the generation and modulation of SPP and LSP modes through far-field control with SLMs and highlights the diverse applications of this optical technology in plasmon-enhanced spectroscopy. 展开更多
关键词 surface plasmon spatial light modulator dynamic control plasmon-enhanced spectroscopy
原文传递
Identification of FDA-Approved Drugs as Modulators of Multidrug Resistance Protein 2 (MRP2/ABCC2) Expression Levels in MRP2-Overexpressing Cells: Preliminary Data
6
作者 Vivian Osei Poku Surtaj Hussain Iram 《Journal of Biosciences and Medicines》 2024年第10期32-44,共13页
Multidrug Resistance Protein 2 (MRP2) is an ATP-dependent transmembrane protein that plays a pivotal role in the efflux of a wide variety of physiological substrates across the plasma membrane. Several studies have sh... Multidrug Resistance Protein 2 (MRP2) is an ATP-dependent transmembrane protein that plays a pivotal role in the efflux of a wide variety of physiological substrates across the plasma membrane. Several studies have shown that MRP2 can significantly affect the absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles of many therapeutic drugs and chemicals found in the environment and diet. This transporter can also efflux newly developed anticancer agents that target specific signaling pathways and are major clinical markers associated with multidrug resistance (MDR) of several types of cancers. MDR remains a major limitation to the advancement of the combinatorial chemotherapy regimen in cancer treatment. In addition to anticancer agents, MRP2 reduces the efficacy of various drug classes such as antivirals, antimalarials, and antibiotics. The unique role of MRP2 and its contribution to MDR makes it essential to profile drug-transporter interactions for all new and promising drugs. Thus, this current research seeks to identify modulators of MRP2 protein expression levels using cell-based assays. A unique recently approved FDA library (372 drugs) was screened using a high-throughput In-Cell ELISA assay to determine the effect of these therapeutic agents on protein expression levels of MRP2. A total of 49 FDA drugs altered MRP2 protein expression levels by more than 50% representing 13.17% of the compounds screened. Among the identified hits, thirty-nine (39) drugs increased protein expression levels whereas 10 drugs lowered protein expression levels of MRP2 after drug treatment. Our findings from this initial drug screening showed that modulators of MRP2 peregrinate multiple drug families and signify the importance of profiling drug interactions with this transporter. Data from this study provides essential information to improve combinatorial drug therapy and precision medicine as well as reduce the drug toxicity of various cancer chemotherapies. 展开更多
关键词 ABC Transporters Multidrug Resistance MRP2/ABCC2 MRP2 modulators ELISA
下载PDF
A high-contrast imaging coronagraph for segmented-mirror large aperture telescopes using a spatial light modulator
7
作者 Jiangpei Dou Huanyu Dong 《Astronomical Techniques and Instruments》 CSCD 2024年第3期166-170,共5页
The primary mirrors of current and future large telescopes always employ a segmented mirror configuration.The small but non-negligible gaps between neighboring segments cause additional diffraction,which restricts the... The primary mirrors of current and future large telescopes always employ a segmented mirror configuration.The small but non-negligible gaps between neighboring segments cause additional diffraction,which restricts the performance of high-contrast coronagraph.To solve this problem,we propose a coronagraph system based on a single liquid crystal spatial light modulator(SLM).This spatial light modulator is used for amplitude apodization,and its feasibility and potential performance are demonstrated using a laboratory setup using the stochastic parallel gradient descent(SPGD)algorithm to control the spatial light modulator,which is based on point spread function(PSF)sensing and evaluation and optimized for maximum contrast in the discovery working area as a merit function.The system delivers a contrast in the order of 10−6,and shows excellent potential to be used in current and future large aperture telescopes,both on the ground and in space. 展开更多
关键词 Liquid crystal spatial light modulator Amplitude apodized pupil Large aperture telescopes
下载PDF
Harnessing immunity:Immunomodulatory therapies in COVID-19
8
作者 Tsvetelina Velikova Hristo Valkov +3 位作者 Anita Aleksandrova Monika Peshevska-Sekulovska Metodija Sekulovski Russka Shumnalieva 《World Journal of Virology》 2024年第2期34-47,共14页
An overly exuberant immune response,characterized by a cytokine storm and uncontrolled inflammation,has been identified as a significant driver of severe coronavirus disease 2019(COVID-19)cases.Consequently,decipherin... An overly exuberant immune response,characterized by a cytokine storm and uncontrolled inflammation,has been identified as a significant driver of severe coronavirus disease 2019(COVID-19)cases.Consequently,deciphering the intricacies of immune dysregulation in COVID-19 is imperative to identify specific targets for intervention and modulation.With these delicate dynamics in mind,immunomodulatory therapies have emerged as a promising avenue for miti-gating the challenges posed by COVID-19.Precision in manipulating immune pathways presents an opportunity to alter the host response,optimizing antiviral defenses while curbing deleterious inflammation.This review article compre-hensively analyzes immunomodulatory interventions in managing COVID-19.We explore diverse approaches to mitigating the hyperactive immune response and its impact,from corticosteroids and non-steroidal drugs to targeted biologics,including anti-viral drugs,cytokine inhibitors,JAK inhibitors,convalescent plasma,monoclonal antibodies(mAbs)to severe acute respiratory syndrome coronavirus 2,cell-based therapies(i.e.,CAR T,etc.).By summarizing the current evidence,we aim to provide a clear roadmap for clinicians and researchers navigating the complex landscape of immunomodulation in COVID-19 treatment.CS Glucocorticoids are among the most widely prescribed drugs with their immune-suppressive and anti-inflammatory effect[84].The current guidelines for the treatment of COVID-19 recommend against the use of dexamethasone or other systemic CS in non-hospitalized patients in the absence of another indication[70].The RECOVERY trial demonstrates the reduced 28-d mortality among hospitalized patients with COVID-19 using dexamethasone compared to the usual standard of care,along with other investigators,such as Ahmed and Hassan[85].The benefit of dexamethasone was seen only among participants receiving either oxygen alone or invasive mechanical ventilation at randomization but not among those receiving no respiratory support at enrollment[85].In a systematic review and meta-analysis,Albuquerque et al[86]showed that in comparison to tocilizumab,baricitinib,and sarilumab are associated with high probabilities of similar mortality reductions among hospitalized COVID-19 concurrently treated with CS.As a result of the absence of SARS-CoV-2-specific antiviral medications,the effectiveness of COVID-19 treatments is reduced.Several COVID-19 therapies are now under investigation.However,the majority of them lack specificity,efficacy,and safety[87].Immunotherapy is a ground-breaking medical treatment that manipulates the immune system to fight diseases.Translational research is rapidly progressing,recognized as a significant breakthrough in 2013[88].Among the immunotherapeutic options for treating COVID-19 are Immunoglobulin,CP,antibodies,mAbs(mAbs),NK cells,T cells,TLR,cytokine therapies and immune modulators. 展开更多
关键词 IMMUNOmodulATION COVID-19 SARS-CoV-2 IMMUNOTHERAPY Antiviral immune response Cytokine storm Adaptive immunity Therapeutic strategies Immune modulators Viral infection Host immune response
下载PDF
Optical transmitter module with hybrid integration of DFB laser diode and proton-exchanged LiNbO_(3)modulator chip
9
作者 Xuyang Wang He Jia +2 位作者 Junhui Li Yumei Guo Yu Liu 《Journal of Semiconductors》 EI CAS CSCD 2022年第6期34-39,共6页
In this work,a hybrid integrated optical transmitter module was designed and fabricated.A proton-exchanged Mach–Zehnder lithium niobate(LiNbO_(3))modulator chip was chosen to enhance the output extinction ratio.A fib... In this work,a hybrid integrated optical transmitter module was designed and fabricated.A proton-exchanged Mach–Zehnder lithium niobate(LiNbO_(3))modulator chip was chosen to enhance the output extinction ratio.A fiber was used to adjust the rotation of the polarization direction caused by the optical isolator.The whole optical path structure,including the laser chip,lens,fiber,and modulator chip,was simulated to achieve high optical output efficiency.After a series of process improvements,a module with an output extinction ratio of 34 dB and a bandwidth of 20.5 GHz(from 2 GHz)was obtained.The optical output efficiency of the whole module reached approximately 21%.The link performance of the module was also measured. 展开更多
关键词 optical transmitter module hybrid integration DFB laser chip LiNbO3 modulator chip
下载PDF
Improved time-interleaved error feedback delta sigma modulator for digital transmitter application
10
作者 Hua Zaijun Fan Xiangning Liao Yilong 《High Technology Letters》 EI CAS 2018年第4期337-342,共6页
Time-interleaved structure can promote the equivalent processing speed of a digital signal processing system. An improved time-interleaved error feedback delta sigma modulator( TI-EF-DSM)for digital transmitter applic... Time-interleaved structure can promote the equivalent processing speed of a digital signal processing system. An improved time-interleaved error feedback delta sigma modulator( TI-EF-DSM)for digital transmitter application is presented in this paper. Two TI-EF-DSMs are compared,one is a conventional directly implemented and the other is the improved. The processing speed of the proposed two-channel improved time-interleaved error feedback delta sigma modulator( ITI-EF-DSM) is higher than the conventional directly implemented TI-EF-DSM for shortened critical path. A digital transmitter based on the ITI-EF-DSM is implemented on field progrmmable gate array( FPGA). The long term evolution( LTE) signals with different bandwidths of 5 MHz,10 MHz and 20 MHz are used as the signal source to evaluate the transmitter. The achieved SNR is 41 dB for the 20 MHz LTE signal with the processing clock of only 184 MHz. 展开更多
关键词 time-interleaved error feedback delta sigma modulator(EF-DSM) digital transmitter long term evolution(LTE)
下载PDF
A new digital transmitter based on delta sigma modulator with bus-splitting
11
作者 Hua Zaijun Fan Xiangning Liao Yilong 《High Technology Letters》 EI CAS 2018年第2期117-124,共8页
A new digital transmitter based on delta sigma modulator( DSM) with bus-splitting is presented in this paper. The second order low pass error-feedback delta sigma modulator( EF-DSM) is focused. The signal to noise rat... A new digital transmitter based on delta sigma modulator( DSM) with bus-splitting is presented in this paper. The second order low pass error-feedback delta sigma modulator( EF-DSM) is focused. The signal to noise ratio( SNR) of the EF-DSM is derived for different bus-splitting bits.Following the EF-DSM,a multi-bit digital up mixer is used for carrier frequency transform. In order to validate the theory of bus-splitting,two types of transmitters are implemented on FPGA for comparison,in which one is with non-bus-splitting and the other is with bus-splitting. The FPGA implemented transmitter with bus-splitting promotes the maximum operation speed by 39%,and reduces hardware consumptions more than 16%. Both single tone and orthogonal frequency division multiplexing( OFDM) signal source are used to evaluate the proposed transmitter. 展开更多
关键词 bus-splitting error-feedback delta sigma modulator (EF-DSM) signal to noiseratio (SNR) digital transmitter digital up mixer
下载PDF
Heat stroke alters hippocampal and cerebellar transmitter metabonomics 被引量:2
12
作者 Guoxin He Ancong Xu +2 位作者 Xichong Yu Fan Huang Lei Su 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2023年第4期287-293,共7页
BACKGROUND:The mechanisms underlying heat stroke(HS)-induced hippocampal injury remain unclear.This study aimed to evaluate the HS-induced metabonomics of hippocampal and cerebellar transmitters.METHODS:The HS model w... BACKGROUND:The mechanisms underlying heat stroke(HS)-induced hippocampal injury remain unclear.This study aimed to evaluate the HS-induced metabonomics of hippocampal and cerebellar transmitters.METHODS:The HS model was established with male Sprague-Dawley rats subjected to heat exposure of up to 42℃ at a humidity of(55.0±5.0)%.The hippocampal and cerebellar transmitters and metabolites of rats were tested via ultra-high-performance liquid chromatography–mass spectrometry(UPLC-MS/MS).The primary transmitters and metabolites were identified by principal component analysis(PCA)and orthogonal partial least square-discriminant analysis(OPLS-DA).The major metabolic pathways for HS were selected after enrichment.The brain injury was evaluated by histological tests.RESULTS:HS induced hippocampal and cerebellar injuries in rats.HS upregulated the protein levels of hippocampal glutamate,glutamine,gamma-aminobutyric acid,L-tryptophan(Trp),5-hydroxy-indoleacetic acid,and kynurenine;however,it downregulated asparagine,tryptamine,5-hydroxytryptophan,melatonin,3,4-dihydroxyphenylalanine(L-DOPA),and vanillylmandelic acid.HS also sharply elevated the protein levels of cerebellar methionine and Trp,and decreased the levels of serotonin,L-alanine,L-asparagine,L-aspartate,cysteine,norepinephrine,spermine,spermidine,and tyrosine.Hippocampal glutamate,monoamine transmitters,cerebellar aspartate acid,and catecholamine transmitters’metabolic pathways were identified as the main metablic pathways in HS.CONCLUSION:The hippocampus and cerebellum were injured in rats with HS,possibly induced the disorder of hippocampal glutamate and serotonin metabolism,cerebellar aspartate acid and catecholamine transmitter metabolism,and related metabolic pathways. 展开更多
关键词 Heat stroke transmitters Rat HIPPOCAMPUS CEREBELLUM METABONOMICS
下载PDF
Broadband all-fiber optical phase modulator based on photo-thermal effect in a gas-filled hollow-core fiber 被引量:2
13
作者 Shoulin Jiang Feifan Chen +4 位作者 Yan Zhao Shoufei Gao Yingying Wang Hoi Lut Ho Wei Jin 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2023年第5期10-16,共7页
We report broadband all-fiber optical phase modulation based on the photo-thermal effect in a gas-filled hollow-core fiber.The phase modulation dynamics are studied by multi-physics simulation.A phase modulator is fab... We report broadband all-fiber optical phase modulation based on the photo-thermal effect in a gas-filled hollow-core fiber.The phase modulation dynamics are studied by multi-physics simulation.A phase modulator is fabricated using a 5.6-cm-long anti-resonant hollow-core fiber with pure acetylene filling.It has a half-wave optical power of 289 mW at 100 kHz and an average insertion loss 0.6 dB over a broad wavelength range from 1450 to 1650 nm.The rise and fall time constants are 3.5 and 3.7μs,respectively,2–3 orders of magnitude better than the previously reported microfiber-based photo-thermal phase modulators.The gas-filled hollow-core waveguide configuration is promising for optical phase modulation from ultraviolet to mid-infrared which is challenging to achieve with solid optical fibers. 展开更多
关键词 optical modulators photo-thermal effects hollow-core fibers
下载PDF
A review of liquid crystal spatial light modulators:devices and applications 被引量:4
14
作者 Yiqian Yang Andrew Forbes Liangcai Cao 《Opto-Electronic Science》 2023年第8期1-29,共29页
Spatial light modulators,as dynamic flat-panel optical devices,have witnessed rapid development over the past two decades,concomitant with the advancements in micro-and opto-electronic integration technology.In partic... Spatial light modulators,as dynamic flat-panel optical devices,have witnessed rapid development over the past two decades,concomitant with the advancements in micro-and opto-electronic integration technology.In particular,liquid-crystal spatial light modulator(LC-SLM)technologies have been regarded as versatile tools for generating arbitrary optical fields and tailoring all degrees of freedom beyond just phase and amplitude.These devices have gained significant interest in the nascent field of structured light in space and time,facilitated by their ease of use and real-time light manipulation,fueling both fundamental research and practical applications.Here we provide an overview of the key working principles of LC-SLMs and review the significant progress made to date in their deployment for various applications,covering topics as diverse as beam shaping and steering,holography,optical trapping and tweezers,measurement,wavefront coding,optical vortex,and quantum optics.Finally,we conclude with an outlook on the potential opportunities and technical challenges in this rapidly developing field. 展开更多
关键词 liquid crystal spatial light modulators liquid crystal devices structured light HOLOGRAPHY APPLICATIONS
下载PDF
High photoelectric conversion efficiency and fast relaxation time of FA_(0.4)MA_(0.6)PbI_(3) applied in ultrafast modulation of terahertz waves 被引量:2
15
作者 Zhibo Xu Ying Zeng +5 位作者 Xinran Zhao Xiaoyin Chen Aoyu Fan Furi Ling Jiang Li Jianquan Yao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第4期299-305,共7页
Active control of terahertz(THz)waves is attracting tremendous attentions in terahertz communications and active photonic devices.Perovskite,due to its excellent photoelectric conversion performance and simple manufac... Active control of terahertz(THz)waves is attracting tremendous attentions in terahertz communications and active photonic devices.Perovskite,due to its excellent photoelectric conversion performance and simple manufacturing process,has emerged as a promising candidate for optoelectronic applications.However,the exploration of perovskites in optically controlled THz modulators is still limited.In this work,the photoelectric properties and carrier dynamics of FA_(0.4)MA_(0.6)PbI_(3)perovskite films were investigated by optical pumped terahertz probe(OPTP)system.The ultrafast carrier dynamics reveal that FA_(0.4)MA_(0.6)PbI_(3)thin film exhibits rapid switching and relaxation time within picosecond level,suggesting that FA_(0.4)MA_(0.6)PbI_(3)is an ideal candidate for active THz devices with ultrafast response.Furthermore,as a proof of concept,a FA_(0.4)MA_(0.6)PbI_(3)-based metadevice with integrating plasma-induced transparency(PIT)effect was fabricated to achieve ultrafast modulation of THz wave.The experimental results demonstrated that the switching time of FA_(0.4)MA_(0.6)PbI_(3)-based THz modulator is near to 3.5 ps,and the threshold of optical pump is as low as 12.7μJ cm^(-2).The simulation results attribute the mechanism of ultrafast THz modulation to photo-induced free carriers in the FA_(0.4)MA_(0.6)PbI_(3)layer,which progressively shorten the capacitive gap of PIT resonator.This study not only illuminates the potential of FA_(0.4)MA_(0.6)PbI_(3)in THz modulation,but also contributes to the field of ultrafast photonic devices. 展开更多
关键词 Terahertz modulation Perovskites METAMATERIALS Plasmon-induced transparency
下载PDF
Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases 被引量:1
16
作者 Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos 《World Journal of Gastroenterology》 SCIE CAS 2023年第1期110-125,共16页
Inflammatory bowel disease(IBD)is chronic inflammation of the gastrointestinal tract that has a high epidemiological prevalence worldwide.The increasing disease burden worldwide,lack of response to current biologic th... Inflammatory bowel disease(IBD)is chronic inflammation of the gastrointestinal tract that has a high epidemiological prevalence worldwide.The increasing disease burden worldwide,lack of response to current biologic therapeutics,and treatment-related immunogenicity have led to major concerns regarding the clinical management of IBD patients and treatment efficacy.Understanding disease pathogenesis and disease-related molecular mechanisms is the most important goal in developing new and effective therapeutics.Sphingosine-1-phosphate(S1P)receptor(S1PR)modulators form a class of oral small molecule drugs currently in clinical development for IBD have shown promising effects on disease improvement.S1P is a sphingosine-derived phospholipid that acts by binding to its receptor S1PR and is involved in the regulation of several biological processes including cell survival,differentiation,migration,proliferation,immune response,and lymphocyte trafficking.T lymphocytes play an important role in regulating inflammatory responses.In inflamed IBD tissue,an imbalance between T helper(Th)and regulatory T lymphocytes and Th cytokine levels was found.The S1P/S1PR signaling axis and metabolism have been linked to inflammatory responses in IBD.S1P modulators targeting S1PRs and S1P metabolism have been developed and shown to regulate inflammatory responses by affecting lymphocyte trafficking,lymphocyte number,lymphocyte activity,cytokine production,and contributing to gut barrier function. 展开更多
关键词 Inflammatory bowel disease Sphingosine-1-phosphate Intestinal inflammation T helper 1/T helper 17 Sphingosine 1 phosphate modulators Immune responses
下载PDF
Design of Protograph LDPC-Coded MIMO-VLC Systems with Generalized Spatial Modulation 被引量:1
17
作者 Dai Lin Fang Yi +1 位作者 Guan Yongliang Mohsen Guizani 《China Communications》 SCIE CSCD 2024年第3期118-136,共19页
This paper investigates the bit-interleaved coded generalized spatial modulation(BICGSM) with iterative decoding(BICGSM-ID) for multiple-input multiple-output(MIMO) visible light communications(VLC). In the BICGSM-ID ... This paper investigates the bit-interleaved coded generalized spatial modulation(BICGSM) with iterative decoding(BICGSM-ID) for multiple-input multiple-output(MIMO) visible light communications(VLC). In the BICGSM-ID scheme, the information bits conveyed by the signal-domain(SiD) symbols and the spatial-domain(SpD) light emitting diode(LED)-index patterns are coded by a protograph low-density parity-check(P-LDPC) code. Specifically, we propose a signal-domain symbol expanding and re-allocating(SSER) method for constructing a type of novel generalized spatial modulation(GSM) constellations, referred to as SSERGSM constellations, so as to boost the performance of the BICGSM-ID MIMO-VLC systems.Moreover, by applying a modified PEXIT(MPEXIT) algorithm, we further design a family of rate-compatible P-LDPC codes, referred to as enhanced accumulate-repeat-accumulate(EARA) codes,which possess both excellent decoding thresholds and linear-minimum-distance-growth property. Both analysis and simulation results illustrate that the proposed SSERGSM constellations and P-LDPC codes can remarkably improve the convergence and decoding performance of MIMO-VLC systems. Therefore, the proposed P-LDPC-coded SSERGSM-mapped BICGSMID configuration is envisioned as a promising transmission solution to satisfy the high-throughput requirement of MIMO-VLC applications. 展开更多
关键词 bit-interleaved coded modulation generalized spatial modulation multiple-input multipleoutput protograph LDPC codes visible light communication
下载PDF
A Novel Multiple DBC-staked units Package to Parallel More Chips for SiC Power Module 被引量:1
18
作者 Xiaoshuang Hui Puqi Ning +4 位作者 Tao Fan Yuhui Kang Kai Wang Yunhui Mei Guangyin Lei 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2024年第1期72-79,共8页
Silicon carbide(SiC) power modules play an essential role in the electric vehicle drive system. To improve their performance, reduce their size, and increase production efficiency, this paper proposes a multiple stake... Silicon carbide(SiC) power modules play an essential role in the electric vehicle drive system. To improve their performance, reduce their size, and increase production efficiency, this paper proposes a multiple staked direct bonded copper(DBC) unit based power module packaging method to parallel more chips. This method utilizes mutual inductance cancellation effect to reduce parasitic inductance. Because the conduction area in the new package is doubled, the overall area of power module can be reduced. Entire power module is divided into smaller units to enhance manufacture yield, and improve design freedom. This paper provides a detailed design, analysis and fabrication procedure for the proposed package structure. Additionally, this paper offers several feasible solutions for the connection between power terminals and DBC untis. With the structure, 18dies were paralleled for each phase-leg in a econodual size power module. Both simulation and double pulse test results demonstrate that, compared to conventional layouts, the proposed package method has 74.8% smaller parasitic inductance and 34.9% lower footprint. 展开更多
关键词 Silicon carbide Electric vehicle Power modules PACKAGE
下载PDF
From VIB‑to VB‑Group Transition Metal Disulfides:Structure Engineering Modulation for Superior Electromagnetic Wave Absorption 被引量:1
19
作者 Junye Cheng Yongheng Jin +10 位作者 Jinghan Zhao Qi Jing Bailong Gu Jialiang Wei Shenghui Yi Mingming Li Wanli Nie Qinghua Qin Deqing Zhang Guangping Zheng Renchao Che 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第2期218-257,共40页
The laminated transition metal disulfides(TMDs),which are well known as typical two-dimensional(2D)semiconductive materials,possess a unique layered structure,leading to their wide-spread applications in various field... The laminated transition metal disulfides(TMDs),which are well known as typical two-dimensional(2D)semiconductive materials,possess a unique layered structure,leading to their wide-spread applications in various fields,such as catalysis,energy storage,sensing,etc.In recent years,a lot of research work on TMDs based functional materials in the fields of electromagnetic wave absorption(EMA)has been carried out.Therefore,it is of great significance to elaborate the influence of TMDs on EMA in time to speed up the application.In this review,recent advances in the development of electromagnetic wave(EMW)absorbers based on TMDs,ranging from the VIB group to the VB group are summarized.Their compositions,microstructures,electronic properties,and synthesis methods are presented in detail.Particularly,the modulation of structure engineering from the aspects of heterostructures,defects,morphologies and phases are systematically summarized,focusing on optimizing impedance matching and increasing dielectric and magnetic losses in the EMA materials with tunable EMW absorption performance.Milestones as well as the challenges are also identified to guide the design of new TMDs based dielectric EMA materials with high performance. 展开更多
关键词 Transition metal disulfides Electromagnetic wave absorption Impedance matching Structure engineering modulation
下载PDF
Waveguide-integrated optical modulators with two-dimensional materials
20
作者 Haitao Chen Hongyuan Cao +2 位作者 Zejie Yu Weike Zhao Daoxin Dai 《Journal of Semiconductors》 EI CAS CSCD 2023年第11期8-25,共18页
Waveguide-integrated optical modulators are indispensable for on-chip optical interconnects and optical computing.To cope with the ever-increasing amount of data being generated and consumed,ultrafast waveguide-integr... Waveguide-integrated optical modulators are indispensable for on-chip optical interconnects and optical computing.To cope with the ever-increasing amount of data being generated and consumed,ultrafast waveguide-integrated optical modulators with low energy consumption are highly demanded.In recent years,two-dimensional(2D)materials have attracted a lot of attention and have provided tremendous opportunities for the development of high-performance waveguide-integrated optical modulators because of their extraordinary optoelectronic properties and versatile compatibility.This paper reviews the state-of-the-art waveguide-integrated optical modulators with 2D materials,providing researchers with the developing trends in the field and allowing them to identify existing challenges and promising potential solutions.First,the concept and fundamental mechanisms of optical modulation with 2D materials are summarized.Second,a review of waveguide-integrated optical modulators employing electro-optic,all-optic,and thermo-optic effects is provided.Finally,the challenges and perspectives of waveguide-integrated modulators with 2D materials are discussed. 展开更多
关键词 optical modulation two-dimensional(2D)materials ON-CHIP WAVEGUIDE
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部