Objective:Hyaluronic acid (HA), laminin (LN), and collagen IV (CIV) are major serum markers of liver fibrosis. This study evaluated the diagnostic value of various noninvasive indicators for hepatic fibrosis in patien...Objective:Hyaluronic acid (HA), laminin (LN), and collagen IV (CIV) are major serum markers of liver fibrosis. This study evaluated the diagnostic value of various noninvasive indicators for hepatic fibrosis in patients with T2DM and NAFLD.Methods: Between January 2016 and September 2018, a total of 278 patients, which were grouped to normal, NAFLD and T2DM with NAFLD. Routine clinical and laboratory examinations were collected, including age, sex, blood routine, HbA1C, FBG, FCP, AST, AST, ALB, PLT, TC, TG, HDL, LDL, serum fibrosis C-IV, HA, LN. NFS, APRI and FIB4 scores were calculated.Results: No statistical difference was found on age, ALT, AST, GGT, BMI, TG, CHOL, and Glu, APRI, FIB4, CIV, LN, and HA exhibited statistical significance. Further correlation analysis showed that HA, IV-C, LN, were positively correlated with NFS, APRI, and FIB4.Conclusions:Compared with healthy control group, ALT, AST, TC, TG, HDL and LDL in NAFLD group, T2DM patients with NAFLD group increased to different degrees, and the difference was statistically significant. The HA, C-IV, LN, NFS, APRI ratio index and FIB-4 index of T2DM patients with NAFLD were higher than those of NAFLD group and healthy control group, and the HA, C-IV and LN of NAFLD group were higher than those of healthy control group. Compared with non-fibrosis group, HA, LN, C-IV, ALT and AST in fibrosis group were significantly higher. Moreover, HA, LN and C-IV were positively correlated with NFS, APRI ratio index and FIB-4 index.展开更多
Objective:The current study discusses the relationship between sleep apnea-hypopnea syn-drome(OSAHS)and liver fibrosis by determining the level of plasma hyaluronic acid(HA),pro-collagen III(PIII),collagen IV(IVC),and...Objective:The current study discusses the relationship between sleep apnea-hypopnea syn-drome(OSAHS)and liver fibrosis by determining the level of plasma hyaluronic acid(HA),pro-collagen III(PIII),collagen IV(IVC),and laminin(LN)in OSAHS patients and non-OSAHS patients with obesity and normal body weight.Methods:The patients who underwent polysomnographic(PSG)examinations in the outpatient and inpatient departments of our hospital between December 2010 and June 2013 were selected.The patients were divided into two groups based on the apnea-hypopnea index(AHI;OSAHS and non-OSAHS patients),and both groups were further divided based on obesity and normal body weight based on the body mass index(BMI).Sleep breathing indicators,including BMI,AHI,LSaO_(2),and MSaO_(2),were measured in all patients.All of the patients had their blood drawn on the morning after the day of the PSG examination,and the samples were sent to the biochemical laboratory of our hospital for determination of the levels of HA,PIII,IVC,and LN.Results:Among the obese and normoweight patients,the levels of HA,PIII,IVC,and LN in OSAHS patients were higher than the non-OSAHS patients(P value<0.05).Amongst the OSAHS and non-OSAHS patients,the levels of HA,PIII,IVC,and LN in the obese patients were also higher than the non-obese patients(P value<0.05).The levels of HA,PIII,IVC,and LN in the obese OSAHS patients were higher than the remaining three groups(P value<0.05).The levels of HA,PIII,IVC,and LN had positive correlations with the AHI and BMI(r=0.701,0.523,0.639,and 0.421,respectively,P<0.05;and r=0.565,0.441,0.475,and 0.401,respectively,P<0.05),and nega-tive correlations with the LSaO_(2) and MSaO_(2) in OSAHS patients(r=-0.432,-0.394,-0.403,and-0.267,respectively,P<0.05;and r=-0.591,-0.517,-0.533,and-0.484,respectively,P<0.05).Conclusion:The levels of plasma HA,PIII,IVC,and LN in OSAHS patients were related to OSAHS.OSAHS might lead to liver fibrosis.展开更多
文摘Objective:Hyaluronic acid (HA), laminin (LN), and collagen IV (CIV) are major serum markers of liver fibrosis. This study evaluated the diagnostic value of various noninvasive indicators for hepatic fibrosis in patients with T2DM and NAFLD.Methods: Between January 2016 and September 2018, a total of 278 patients, which were grouped to normal, NAFLD and T2DM with NAFLD. Routine clinical and laboratory examinations were collected, including age, sex, blood routine, HbA1C, FBG, FCP, AST, AST, ALB, PLT, TC, TG, HDL, LDL, serum fibrosis C-IV, HA, LN. NFS, APRI and FIB4 scores were calculated.Results: No statistical difference was found on age, ALT, AST, GGT, BMI, TG, CHOL, and Glu, APRI, FIB4, CIV, LN, and HA exhibited statistical significance. Further correlation analysis showed that HA, IV-C, LN, were positively correlated with NFS, APRI, and FIB4.Conclusions:Compared with healthy control group, ALT, AST, TC, TG, HDL and LDL in NAFLD group, T2DM patients with NAFLD group increased to different degrees, and the difference was statistically significant. The HA, C-IV, LN, NFS, APRI ratio index and FIB-4 index of T2DM patients with NAFLD were higher than those of NAFLD group and healthy control group, and the HA, C-IV and LN of NAFLD group were higher than those of healthy control group. Compared with non-fibrosis group, HA, LN, C-IV, ALT and AST in fibrosis group were significantly higher. Moreover, HA, LN and C-IV were positively correlated with NFS, APRI ratio index and FIB-4 index.
文摘Objective:The current study discusses the relationship between sleep apnea-hypopnea syn-drome(OSAHS)and liver fibrosis by determining the level of plasma hyaluronic acid(HA),pro-collagen III(PIII),collagen IV(IVC),and laminin(LN)in OSAHS patients and non-OSAHS patients with obesity and normal body weight.Methods:The patients who underwent polysomnographic(PSG)examinations in the outpatient and inpatient departments of our hospital between December 2010 and June 2013 were selected.The patients were divided into two groups based on the apnea-hypopnea index(AHI;OSAHS and non-OSAHS patients),and both groups were further divided based on obesity and normal body weight based on the body mass index(BMI).Sleep breathing indicators,including BMI,AHI,LSaO_(2),and MSaO_(2),were measured in all patients.All of the patients had their blood drawn on the morning after the day of the PSG examination,and the samples were sent to the biochemical laboratory of our hospital for determination of the levels of HA,PIII,IVC,and LN.Results:Among the obese and normoweight patients,the levels of HA,PIII,IVC,and LN in OSAHS patients were higher than the non-OSAHS patients(P value<0.05).Amongst the OSAHS and non-OSAHS patients,the levels of HA,PIII,IVC,and LN in the obese patients were also higher than the non-obese patients(P value<0.05).The levels of HA,PIII,IVC,and LN in the obese OSAHS patients were higher than the remaining three groups(P value<0.05).The levels of HA,PIII,IVC,and LN had positive correlations with the AHI and BMI(r=0.701,0.523,0.639,and 0.421,respectively,P<0.05;and r=0.565,0.441,0.475,and 0.401,respectively,P<0.05),and nega-tive correlations with the LSaO_(2) and MSaO_(2) in OSAHS patients(r=-0.432,-0.394,-0.403,and-0.267,respectively,P<0.05;and r=-0.591,-0.517,-0.533,and-0.484,respectively,P<0.05).Conclusion:The levels of plasma HA,PIII,IVC,and LN in OSAHS patients were related to OSAHS.OSAHS might lead to liver fibrosis.
