Nano-enabled agriculture is an emerging hot topic.To facilitate the development of nano-enabled agriculture,reviews addressing or discussing the applications,knowledge gap,future research needs,and possible new resear...Nano-enabled agriculture is an emerging hot topic.To facilitate the development of nano-enabled agriculture,reviews addressing or discussing the applications,knowledge gap,future research needs,and possible new research field of plant nanobiotechnology in agricultural production are encouraged.Here we review the following topics in plant nanobiotechnology for agriculture:1)improving stress tolerance,2)stress sensing and early detection,3)targeted delivery and controlled release of agrochemicals,4)transgenic events in non-model crop species,and 5)seed nanopriming.We discuss the knowledge gaps in these topics.Besides the use of nanomaterials for harvesting more electrons to improve photosynthetic performance,they could be used to convert n IR and UV to visible light to expand the light spectrum for photosynthesis.We discuss this approach to maintaining plant photosynthesis under light-insufficient conditions.Our aim in this review is to aid researchers to learn quickly how to use plant nanobiotechnology for improving agricultural production.展开更多
Nanostructured manganese oxides (nano-MnO_(x)) have shown great promises as versatile agrochemicals in nano-enabled sustainable agriculture,owing to the coupled benefits of controlled release of dissolved Mn2+,an esse...Nanostructured manganese oxides (nano-MnO_(x)) have shown great promises as versatile agrochemicals in nano-enabled sustainable agriculture,owing to the coupled benefits of controlled release of dissolved Mn2+,an essential nutrient needed by plants,and oxidative destruction of environmental organic pollutants.Here,we show that three δ-MnO_(2)nanomaterials consisting of nanosheet-assembled flower-like nanospheres not only exhibit greater kinetics in citrate-promoted dissolution,but also are less prone to passivation,compared with three α-MnO_(2)nanowire materials.The better performance of the δ-MnO_(2)nanomaterials can be attributed to their higher abundance of surface unsaturated Mn atoms–particularly Mn(Ⅲ)–that is originated from their specific exposed facets and higher abundance of surface defects sites.Our results underline the great potential of modulating nanomaterial surface atomic configuration to improve their performance in sustainable agricultural applications.展开更多
Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment.Another major advance...Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment.Another major advance is the observation of immunological responses associated with nano-enabled hyperthermia,which introduces a new avenue,allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery,i.e.,long-lasting and/or systemic anti-tumor immunity.This perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors receiving nano-enabled hyperthermia.This includes the discussion about underlying mechanism such as immunogenic cell death,which initiates a profound immunological chain reaction.In order to propagate the immune activation as a viable therapeutic principle,we further discussed the tumor type-specific complexity in the immunological tumor microenvironment,including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.展开更多
Metals are essential components of both micronutrients and macronutrients in living organisms and are involved in a variety of immune processes in the forms of free ions or protein-coupled complexes(metalloproteins).M...Metals are essential components of both micronutrients and macronutrients in living organisms and are involved in a variety of immune processes in the forms of free ions or protein-coupled complexes(metalloproteins).Multiple aspects of the immune system,from the structural and functional control of immune-related proteins to the cellular responses to immunotherapy,could be affected by metals.Therefore,the employment of metal for the regulation of immunity,termed as metalloimmunology,is gaining interest as a prevalent and efficacious approach to combating cancer.However,the manipulation of metalloimmunology using traditional drugs presents several challenges,including limited bioavailability,adverse effects,and a lack of targeting specificity.This review provides an overview of the latest findings in metal and metal-regulatory therapeutic agents for the treatment of cancer.Essential trace metal elements,such as iron,zinc,copper,manganese,magnesium,and calcium,as well as heavy metal drugs and their mechanisms of action,will be discussed with a particular focus on their roles in regulating the tumor-immune interplay.The latest nanotechnology employed in the administration of metal-regulatory drugs and the design concepts for tailored therapeutic interventions will be discussed.These concepts and information offer promising clinical possibilities of modulating cancer immunology by targeting metal metabolism.展开更多
基金supported by the National Natural Science Foundation of China(32071971,31901464)Fundamental Research Funds for the Central Universities(2662020ZKPY001)the Joint Project from Shenzhen Institute of Nutrition and Health,Huazhong Agricultural University and Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences to Honghong Wu(SZYJY2021008)。
文摘Nano-enabled agriculture is an emerging hot topic.To facilitate the development of nano-enabled agriculture,reviews addressing or discussing the applications,knowledge gap,future research needs,and possible new research field of plant nanobiotechnology in agricultural production are encouraged.Here we review the following topics in plant nanobiotechnology for agriculture:1)improving stress tolerance,2)stress sensing and early detection,3)targeted delivery and controlled release of agrochemicals,4)transgenic events in non-model crop species,and 5)seed nanopriming.We discuss the knowledge gaps in these topics.Besides the use of nanomaterials for harvesting more electrons to improve photosynthetic performance,they could be used to convert n IR and UV to visible light to expand the light spectrum for photosynthesis.We discuss this approach to maintaining plant photosynthesis under light-insufficient conditions.Our aim in this review is to aid researchers to learn quickly how to use plant nanobiotechnology for improving agricultural production.
基金supported by the National Key Research and Development Program of China (Nos. 2018YFC1800705 and 2019YFC1804202)the Fundamental Research Funds for the Central Universities (Nankai University 63211078)+1 种基金the Ministry of Education of China (No. T2017002)Tianjin Municipal Science and Technology Bureau (No. 20JCQNJC02050)。
文摘Nanostructured manganese oxides (nano-MnO_(x)) have shown great promises as versatile agrochemicals in nano-enabled sustainable agriculture,owing to the coupled benefits of controlled release of dissolved Mn2+,an essential nutrient needed by plants,and oxidative destruction of environmental organic pollutants.Here,we show that three δ-MnO_(2)nanomaterials consisting of nanosheet-assembled flower-like nanospheres not only exhibit greater kinetics in citrate-promoted dissolution,but also are less prone to passivation,compared with three α-MnO_(2)nanowire materials.The better performance of the δ-MnO_(2)nanomaterials can be attributed to their higher abundance of surface unsaturated Mn atoms–particularly Mn(Ⅲ)–that is originated from their specific exposed facets and higher abundance of surface defects sites.Our results underline the great potential of modulating nanomaterial surface atomic configuration to improve their performance in sustainable agricultural applications.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.31671017 and 81872809)the startup funding support from The Cancer Hospital of the University of Chinese Academy of Sciences(CAS),Institute of Basic Medicine and Cancer(IBMC),CAS.HM thanks the start-up packages of NCNST,CAS.
文摘Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment.Another major advance is the observation of immunological responses associated with nano-enabled hyperthermia,which introduces a new avenue,allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery,i.e.,long-lasting and/or systemic anti-tumor immunity.This perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors receiving nano-enabled hyperthermia.This includes the discussion about underlying mechanism such as immunogenic cell death,which initiates a profound immunological chain reaction.In order to propagate the immune activation as a viable therapeutic principle,we further discussed the tumor type-specific complexity in the immunological tumor microenvironment,including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.
基金supported by grants from the National Key R&D Program of China(Nos.2021YFA1201100,and 2022YFA1206100)the National Natural Science Foundation of China(Nos.32271449,32201158,and 51773188)+2 种基金CAS Project for Young Scientists in Basic Research(No.YSBR-036)Key Project of Natural Science Foundation of Shandong Province(No.ZR2020KE016)Shandong Provincial Key Research and Development Program(Major Scientific and Technological Innovation Project,No.2022CXGC010505).
文摘Metals are essential components of both micronutrients and macronutrients in living organisms and are involved in a variety of immune processes in the forms of free ions or protein-coupled complexes(metalloproteins).Multiple aspects of the immune system,from the structural and functional control of immune-related proteins to the cellular responses to immunotherapy,could be affected by metals.Therefore,the employment of metal for the regulation of immunity,termed as metalloimmunology,is gaining interest as a prevalent and efficacious approach to combating cancer.However,the manipulation of metalloimmunology using traditional drugs presents several challenges,including limited bioavailability,adverse effects,and a lack of targeting specificity.This review provides an overview of the latest findings in metal and metal-regulatory therapeutic agents for the treatment of cancer.Essential trace metal elements,such as iron,zinc,copper,manganese,magnesium,and calcium,as well as heavy metal drugs and their mechanisms of action,will be discussed with a particular focus on their roles in regulating the tumor-immune interplay.The latest nanotechnology employed in the administration of metal-regulatory drugs and the design concepts for tailored therapeutic interventions will be discussed.These concepts and information offer promising clinical possibilities of modulating cancer immunology by targeting metal metabolism.
