Aim:The aim was to investigate the electro-physiological characteristics in disease progression of Guillain-Barre syndrome(GBS)and observe the effect of conduction block(CB)in classification and severity of the diseas...Aim:The aim was to investigate the electro-physiological characteristics in disease progression of Guillain-Barre syndrome(GBS)and observe the effect of conduction block(CB)in classification and severity of the disease.Methods:Two hundred and ninety-four patients with GBS were divided into acute inflammatory demyelinating poly-neuropathy(AIDP)group,acute motor axonal neuropathy(AMAN)group and equivocal group according to their electro-physiological results and then reclassificated after electro-physiological review.All of the patients were followed for 6 months since their attacks.Results:Bad prognosis is more pronounced in AMAN group than in AIDP group(P<0.05).Most of the patients classificated as AIDP transformed into AMAN when CB occurred in the early phase of the disease.There is a positive relationship between CB in the early phase of the disease and severity of illness(P<0.05),but CB showed no correlation with prognosis of the patients(P>0.05).Conclusion:CB in the early phase of GBS indicates the probability of AIDP transforming into AMAN;it suggests that patients with CB in the early phase of the disease might be in serious conditions in a certain extent.展开更多
文摘Aim:The aim was to investigate the electro-physiological characteristics in disease progression of Guillain-Barre syndrome(GBS)and observe the effect of conduction block(CB)in classification and severity of the disease.Methods:Two hundred and ninety-four patients with GBS were divided into acute inflammatory demyelinating poly-neuropathy(AIDP)group,acute motor axonal neuropathy(AMAN)group and equivocal group according to their electro-physiological results and then reclassificated after electro-physiological review.All of the patients were followed for 6 months since their attacks.Results:Bad prognosis is more pronounced in AMAN group than in AIDP group(P<0.05).Most of the patients classificated as AIDP transformed into AMAN when CB occurred in the early phase of the disease.There is a positive relationship between CB in the early phase of the disease and severity of illness(P<0.05),but CB showed no correlation with prognosis of the patients(P>0.05).Conclusion:CB in the early phase of GBS indicates the probability of AIDP transforming into AMAN;it suggests that patients with CB in the early phase of the disease might be in serious conditions in a certain extent.
