目的探讨奥扎格雷钠联合阿加曲班对急性脑梗死(acute cerebral infarction,ACI)患者的应用效果及对血清脑源性神经因子(brain-derived neurofactor,BDNF)和血液流变学的影响。方法选取收治的ACI患者100例,随机均分为观察组(n=50)和对照...目的探讨奥扎格雷钠联合阿加曲班对急性脑梗死(acute cerebral infarction,ACI)患者的应用效果及对血清脑源性神经因子(brain-derived neurofactor,BDNF)和血液流变学的影响。方法选取收治的ACI患者100例,随机均分为观察组(n=50)和对照组(n=50)。对照组用奥扎格雷钠治疗,观察组在对照组治疗的基础上联合应用阿加曲班治疗,均持续治疗14 d。比较2组患者的临床疗效;采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评估患者的神经功能,采用格拉斯哥昏迷评分(Glasgow coma scale,GCS)评估患者的意识状况;比较2组患者的血液流变学指标;比较2组患者的BDNF和脑血管储备能力;比较2组患者治疗期间不良反应的发生率。结果治疗后,观察组患者的总有效率(96.00%)高于对照组(84.00%);观察组患者的NIHSS评分低于对照组(P<0.05),GCS评分高于对照组(P<0.05);观察组患者的全血高切黏度、全血低切黏度和血浆黏度均显著低于对照组(P<0.05);观察组患者的血清BDNF和脑血管储备能力均高于对照组(P<0.05);治疗期间2组不良反应发生率比较差异无统计学意义(P>0.05)。结论采用奥扎格雷钠联合阿加曲班治疗ACI有良好的的临床效果,可有效改善患者的血清BDNF和血液流变学水平。展开更多
BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and p...BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.展开更多
文摘目的探讨奥扎格雷钠联合阿加曲班对急性脑梗死(acute cerebral infarction,ACI)患者的应用效果及对血清脑源性神经因子(brain-derived neurofactor,BDNF)和血液流变学的影响。方法选取收治的ACI患者100例,随机均分为观察组(n=50)和对照组(n=50)。对照组用奥扎格雷钠治疗,观察组在对照组治疗的基础上联合应用阿加曲班治疗,均持续治疗14 d。比较2组患者的临床疗效;采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评估患者的神经功能,采用格拉斯哥昏迷评分(Glasgow coma scale,GCS)评估患者的意识状况;比较2组患者的血液流变学指标;比较2组患者的BDNF和脑血管储备能力;比较2组患者治疗期间不良反应的发生率。结果治疗后,观察组患者的总有效率(96.00%)高于对照组(84.00%);观察组患者的NIHSS评分低于对照组(P<0.05),GCS评分高于对照组(P<0.05);观察组患者的全血高切黏度、全血低切黏度和血浆黏度均显著低于对照组(P<0.05);观察组患者的血清BDNF和脑血管储备能力均高于对照组(P<0.05);治疗期间2组不良反应发生率比较差异无统计学意义(P>0.05)。结论采用奥扎格雷钠联合阿加曲班治疗ACI有良好的的临床效果,可有效改善患者的血清BDNF和血液流变学水平。
文摘BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.
