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Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam 被引量:2
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作者 Carlos A. Soria Carolina Remedi +1 位作者 Luciana D’Alessio Emilio J. A. Roldán 《Open Journal of Psychiatry》 2018年第3期212-232,共21页
Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been... Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been described for the general population. In this observational study we describe the effects of sex and age on AL variables, in a cohort of patients with general anxiety disorders and neuroticism treated with alprazolam during 12 weeks, before and after treatment. Methods: Patients with general (DSM IV) anxiety disorders with >6 in Hamilton scale, AL (>1 Crimmins and Seeman AL modified criteria) and neuroticism >18 (NEO-FFI inventory), were included. All patients completed psychiatric assessment, AL index determination before (&minus;1 week) and after 12 weeks of treatment with alprazolam (0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular, metabolic and inflammatory variables. Univariate analysis (two-way ANOVA), Student’s t-test (related variables) and Pearson correlations were determined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19 males (44.2 ± 12.8 years) with general anxiety disorder were included;28 patients with Conclusions: In this preliminary analysis we described sex and age differences in psychiatry aspects and AL indexes in patients with general anxiety disorders in the short-term treatment with alprazolam. These considerations remark the need of pondering sex and age differences during the use of drugs for protracted periods. 展开更多
关键词 CHRONIC Stress neuroticism ALPRAZOLAM ANXIETY Allostatic Load
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Effects of the menstrual cycle and neuroticism on women's sadness emotion and physiological responses based on an emotion-inducing experiment
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作者 Hao Wu Tianfang Wang +6 位作者 Yu Wei Mengying Wu Yamei Huang Min Zheng Renlai Zhou Qingguo Wang Yan Zhao 《Journal of Traditional Chinese Medical Sciences》 2019年第2期138-146,共9页
Objective:To investigate the diversity of experiences of sadness emotion and physiological responses among female college students with high neuroticism (HN) and low neuroticism (LN) during the late luteal phase (LLP)... Objective:To investigate the diversity of experiences of sadness emotion and physiological responses among female college students with high neuroticism (HN) and low neuroticism (LN) during the late luteal phase (LLP) and early follicular phase (EFP).Methods:Forty-two participants were classified as the HN group and 41 as the LN group based on their neuroticism score (Eysenck Personality Questionnaire Short Scale for Chinese).Participants watched sadness-inducing experimental films during the LLP and EFP.Results:The HN group showed similar sadness intensities in both phases.The LN group showed higher sadness intensity in the LLP than the EFP.The LN group's sadness scale assessments were lower than the HN group in both phases.The blood volume pulse in the HN group fell in both the LLP and EFP (both P <.001).The root mean square standard deviation of NN intervals rose in the EFP in the HN group before and after watching experimental films (P =.027),but fell in the LN group (P >.05).Between-group comparisons showed heart rate was significantly lower in the HN group than the LN group during EFP (P =.009),but there were no statistically significant differences in subjective experience and physiological data during LLP.The HN group had stronger sadness feelings and greater sadness arousal than the LN group during EFP.There were significant associations between menstrual cycle-related changes in sadness ratings and changes in physiological outcomes.Conclusion:Women with HN have less fluctuation in sadness than those with LN during the menstrual cycle,but experience strong sadness feelings in the LLP.Women with HN show stronger physiological responses in the EFP than those with LN,and have the highest responses in the LLP. 展开更多
关键词 neuroticism MENSTRUATION SADNESS EMOTIONAL responses
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Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome 被引量:10
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作者 Maria Rosaria A Muscatello Antonio Bruno +2 位作者 Giuseppe Scimeca Gianluca Polfo Rocco A Zoccali 《World Journal of Gastroenterology》 SCIE CAS 2014年第24期7570-7586,共17页
Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role.The biopsychosocial model applied to the understanding of IBS pathophysiology... Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role.The biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors,interacting with peripheral/central neuroendocrine and immune changes,may induce symptoms of IBS,modulate symptom severity,influence illness experience and quality of life,and affect outcome.The present review focuses on the role of negative affects,including depression,anxiety,and anger,on pathogenesis and clinical expression of IBS.The potential role of the autonomic nervous system,stress-hormone system,and immune system in the pathophysiology of both negative affects and IBS are taken into account.Psychiatric comorbidity and subclinical variations in levels of depression,anxiety,and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS,such as sensorimotor functions,gut microbiota,inflammation/immunity,and symptom reporting. 展开更多
关键词 DEPRESSION ANXIETY ANGER Mood disorders Irritable bowel syndrome neuroticism Stress Brain-gut axis MICROBIOTA Hypothalamic-pituitary-adrenal axis
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Personality factors and profiles in variants of irritable bowel syndrome 被引量:10
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作者 Alireza Farnam Mohammad H Somi +2 位作者 Firouz Sarami Sara Farhang Sanaz Yasrebinia 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第47期6414-6418,共5页
AIM: To study the association between irritable bowel syndrome (IBS) variants (constipation,diarrhea,or both) and personality traits in non-psychiatric patients. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic... AIM: To study the association between irritable bowel syndrome (IBS) variants (constipation,diarrhea,or both) and personality traits in non-psychiatric patients. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria after exclusion of organic bowel pathology. The entry of each patient was confirmed following a psychiatric interview. Personality traits and the score of each factor were evaluated using the NEO Five Factor Inventory. RESULTS: One hundred and fifty patients were studied. The mean age (± SD) was 33.4 (± 11.0) year (62% female). Subjects scored higher in neuroticism (26.25 ± 7.80 vs 22.92 ± 9.54,P < 0.0005),openness (26.25 ± 5.22 vs 27.94 ± 4.87,P < 0.0005) and conscientiousness (32.90 ± 7.80 vs 31.62 ± 5.64,P < 0.01) compared to our general population derived from universities of Iran. Our studied population consisted of 71 patients with Diarrhea dominant-IBS,33 with Constipation dominant-IBS and 46 with Altering type-IBS. Scores of conscientiousness and neuroticism were significantly higher in C-IBS compared to D-IBS and A-IBS (35.79 ± 5.65 vs 31.95 ± 6.80,P = 0.035 and 31.97 ± 9.87,P = 0.043,respectively). Conscientiousness was the highest dimension of personality in each of the variants. Patients with C-IBS had almost similar personality profiles,composed of higher scores for neuroticism and conscientiousness,with low levels of agreeableness,openness and extraversion that were close to those of the general population. CONCLUSION: Differences were observed between IBS patients and the general population,as well as between IBS subtypes,in terms of personality factors. Patients with constipation-predominant IBS showed similar personality profiles. Patients with each subtype of IBS may benefit from psychological interventions,which can be focused considering the characteristics of each subtype. 展开更多
关键词 Irritable bowel syndrome PERSONALITY CONSCIENTIOUSNESS neuroticism OPENNESS Constipation-predominant
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Personality traits and emotional patterns in irritable bowel syndrome 被引量:8
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作者 Maria Rosaria A Muscatello Antonio Bruno +2 位作者 Carmela Mento Gianluca Pandolfo Rocco A Zoccali 《World Journal of Gastroenterology》 SCIE CAS 2016年第28期6402-6415,共14页
The review focuses on those personality traits(neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness), constructs(alexithymia and distressed- Type D personality) and emotional pattern... The review focuses on those personality traits(neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness), constructs(alexithymia and distressed- Type D personality) and emotional patterns(negative and positive) that are of particular concern in health psychology, with the aim to highlight their potential role on the pathogenesis, onset, symptom clusters, clinical course, and outcome of irritable bowel syndrome(IBS). Personality traits and emotional patterns play key roles in affecting autonomic, immune, inflammatory, and endocrine functions, thus contributing not only to IBS clinical expression and symptomatic burden, but also to disease physiopathology. In this sense, psychological treatments should address those personality traits and emotional features that are constitutive of, and integral to IBS. The biopsychosocial model of illness applied to IBS acknowledges the interaction between biological, psychological, environmental, and social factors in relation to pain and functional disability. A holistic approach to IBS should take into account the heterogeneous nature of the disorder, and differentiate treatments for different types of IBS, also considering the marked individual differences in prevalent personality traits and emotional patterns. Beyond medications, and lifestyle/dietary interventions, psychological and educational treatments may provide the optimal chance of addressing clinical symptoms, comorbid conditions, and quality of life in IBS patients. 展开更多
关键词 ALEXITHYMIA Depression Anxiety ANGER CONSCIENTIOUSNESS Irritable bowel syndrome Emotions PERSONALITY neuroticism EXTRAVERSION
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Cognitive behavioral approach to understanding irritable bowel syndrome 被引量:1
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作者 Goran Hauser Sanda Pletikosic Mladenka Tkalcic 《World Journal of Gastroenterology》 SCIE CAS 2014年第22期6744-6758,共15页
Irritable bowel syndrome(IBS)is considered a biopsychosocial disorder,whose onset and precipitation are a consequence of interaction among multiple factors which include motility disturbances,abnormalities of gastroin... Irritable bowel syndrome(IBS)is considered a biopsychosocial disorder,whose onset and precipitation are a consequence of interaction among multiple factors which include motility disturbances,abnormalities of gastrointestinal sensation,gut inflammation and infection,altered processing of afferent sensory information,psychological distress,and affective disturbances.Several models have been proposed in order to describe and explain IBS,each of them focusing on specific aspects or mechanisms of the disorder.This review attempts to present and discuss different determinants of IBS and its symptoms,from a cognitive behavioral therapy framework,distinguishing between the developmental predispositions and precipitants of the disorder,and its perpetuating cognitive,behavioral,affective and physiological factors.The main focus in understanding IBS will be placed on the numerouspsychosocial factors,such as personality traits,early experiences,affective disturbances,altered attention and cognitions,avoidance behavior,stress,coping and social support.In conclusion,a symptom perpetuation model is proposed. 展开更多
关键词 ANXIETY ATTENTION Irritable bowel syndrome neuroticism STRESS
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Cognitive behavioral therapy on personality characteristics of cancer patients 被引量:1
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作者 Xiao-Hui Yuan Juan Peng +2 位作者 Shu-Wei Hu Yong Yang Yu-Ju Bai 《World Journal of Clinical Cases》 SCIE 2021年第31期9386-9394,共9页
BACKGROUND The main treatment methods for cancer include surgery,radiotherapy,chemotherapy,targeted drug therapy and so on.Patients often feel anger,anxiety,depression,and other negative psychological reactions in the... BACKGROUND The main treatment methods for cancer include surgery,radiotherapy,chemotherapy,targeted drug therapy and so on.Patients often feel anger,anxiety,depression,and other negative psychological reactions in the process of treatment.AIM To explore the effects of cognitive behavioral therapy on the personality characteristics of cancer patients.METHODS According to the matching design requirements,150 cancer patients were divided into 3 groups based on sex,age,condition,and cultural background.Patients in the control group received conventional treatment.Patients in experimental group 1 received an intervention based on conventional treatment combined with cognitive behavioral therapy.Patients in experimental group 2 received family members'participation in addition to the treatment given in experimental group 1.An Eysenck personality questionnaire was used to investigate all the patients before and after the intervention,and the scores for psychosis,introversion,neuroticism,and concealment degree were analyzed.RESULTS Compared with the control group,for experimental group 1 and experimental group 2 before and after the intervention,the four dimensions of mental quality,neuroticism,introversion and concealment degree all decreased,and the difference was statistically significant(P<0.05).After the intervention,there were no obvious or statistically significant differences(P>0.05)among the control group,experimental group 1,and experimental group 2 for two personality traits,psychoticism and neuroticism,both inside and outside degree and all four dimensions.CONCLUSION Simple cognitive behavioral therapy could not change the personality characteristics of cancer patients quickly,but the patients’personality characteristics were significantly improved after treatment. 展开更多
关键词 Cognitive behavioral therapy Cancer patients Personality characteristics PSYCHOSIS INTROVERSION neuroticism Degree of validity
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Mindfulness as a Factor in the Relationship between Insecure Attachment Style, Neurotic Personality and Disordered Eating Behavior
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作者 Aileen Pidgeon Alexandra Grainger 《Open Journal of Medical Psychology》 2013年第4期25-33,共9页
Mindfulness, conceptualized as a dispositional trait that differs across individuals, may potentially influence disordered eating behaviors. Previous research has independently identified insecure attachment style and... Mindfulness, conceptualized as a dispositional trait that differs across individuals, may potentially influence disordered eating behaviors. Previous research has independently identified insecure attachment style and neurotic personality traits as correlates of disordered eating behavior. Thus this current study will investigate whether neurotic personality traits, insecure attachment style and mindfulness predict disordered eating behavior controlling for gender differences. Participants (N = 126) completed the Adult Attachment Scale [1], the Three Factor Eating Questionnaire – Revised 18 [2], The Cognitive and Affective Mindfulness Scale – Revised [3] and the International Personality Item Pool [4]. The results of this cross-sectional study indicated that neurotic personality traits, insecure attachment style and mindfulness were related to disordered eating behaviors. The variance in disordered eating behaviors that was accounted for by neurotic personality traits and insecure attachment style was significantly reduced with the introduction of mindfulness. The results provides preliminary support for the inclusion of mindfulness training in disordered eating behavior interventions for individuals exhibiting an insecure attachment style and neurotic personality traits. Limitations and implications for further research are discussed. 展开更多
关键词 MINDFULNESS DISORDERED EATING Behavior neuroticism ATTACHMENT
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Dispositional Trait, Discrete Emotion, and Occupational Commitment
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作者 Hsiu-Tsu Cho Chun-Han Yu 《Journalism and Mass Communication》 2014年第5期337-344,共8页
Accompanied by growing dispatched workers in workplace, occupational commitment is more important than ever. Despite the importance of understanding the emotional aspects of occupational commitment, previous research ... Accompanied by growing dispatched workers in workplace, occupational commitment is more important than ever. Despite the importance of understanding the emotional aspects of occupational commitment, previous research has paid less attention to the role of emotion in occupational commitment. This article attempts to fill this gap by examining the relationship between dispositional trait and occupational commitment. The study examined how two dispositional traits-neuroticism and extroversion-influence occupational commitment through the linking of two discrete emotions including fear and enthusiasm. A survey study with questionnaires was conducted and sample consisted of 144 respondents from the home carers in Taiwan. The predictions were then tested through the SEM approach, with acceptable fit resulted. Results showed that enthusiasm mediated the effect of extroversion on occupational commitment but fear partially mediated the impact of neuroticism on occupational commitment. These findings suggest that workers with distinguish dispositional trait have different occupational commitment, supporting the mediating role of discrete emotion on the relationship between dispositional trait and occupational commitment. 展开更多
关键词 occupational commitment neuroticism EXTROVERSION FEAR ENTHUSIASM
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Forty Cases of Gastrointestinal Neurosis Treated by Acupunture 被引量:3
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作者 赵亚萍 丁敏 +1 位作者 王艳君 段树民 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2008年第1期15-17,共3页
Objective: To compare the therapeutic effect of acupuncture for gastrointestinal neurosis with that of oral remedy. Methods: Eighty cases were randomly divided into the following 2 groups. In the treatment group, ac... Objective: To compare the therapeutic effect of acupuncture for gastrointestinal neurosis with that of oral remedy. Methods: Eighty cases were randomly divided into the following 2 groups. In the treatment group, acupuncture was given for one month at the main points of Zhongwan (CV 12), Zusanli (ST 36), Taichong (LR 3) and Shenmen (HT 7), with the auxiliary points selected according to TCM differentiation. In the control group, Domperidone was orally administered for one month. Results: The total effective rate was 92.5% in the treatment group and 75.0% in the control group, with a significant difference between the 2 groups 0(2=4.423, P〈0.05). Acupuncture was superior to the oral remedy in therapeutic effects. Conclusions: Acupuncture may show better results for gastrointestinal neurosis and with less toxic side effects. 展开更多
关键词 GASTROINTESTINAL Neurotic Disorders ACUPUNCTURE ORAL MONTH
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The Major Psychocutaneous Disorders in Iraqi Patients
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作者 Khalifa E. Sharquie Adil A. Noaimi +1 位作者 Maha S. Younis Bashar S. Al-Sultani 《Journal of Cosmetics, Dermatological Sciences and Applications》 2015年第2期53-61,共9页
Background: Many skin diseases can be evoked by psychological problems. Dermatological conditions could also lead to psychological disorders;hence psychodermatology is an emerging subspecialty that focuses on the inte... Background: Many skin diseases can be evoked by psychological problems. Dermatological conditions could also lead to psychological disorders;hence psychodermatology is an emerging subspecialty that focuses on the interface of psychiatry and dermatology. Objective: To assess the frequency of the major disorders of so-called psychocutaneous disorders which are commonly seen among Iraqi population. Patients and Methods: This case descriptive study had been done in Department of Dermatology-Baghdad Teaching Hospital, Medical City, Baghdad, Iraq during the period from March 2011 to October 2013. All cases were collected and categorized according to the disease problem. Patients were interviewed to search for the main triggering and precipitating factors involved in pathogenesis of these disorders. The clinical picture was well described in order to reach a final diagnosis. Psychological interview and analysis were performed for all patients to reach the specific emotional and psychiatric disease by consultant psychiatrist. Results: A total of 100 patients with major psychocutaneous disorders were seen and evaluated. Nineteen were males and 81 were females with female to male ratio: 4.26:1. Their ages ranged from 7 - 73 (26.5 ± 5.217) years. The frequency of these diseases was as follows: trichotillomania 53%, dermatitis artifacta 37%, delusion of parasitosis 6% and neurotic excoriation 4%. Conclusions: The major psychocutaneous diseases in Iraqi population were: trichotillomania, dermatitis artifacta and these are problems of mainly young females while delusion of parasitosis and neurotic excoriations were diseases of middle age females. 展开更多
关键词 TRICHOTILLOMANIA Dermatitis Artifacta DELUSION of PARASITOSIS Neurotic Excoriation Psychocutaneous DISORDERS IRAQI PATIENTS
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About a Case of Neurotic Angioedema Induced by Angiotensin Converting Enzyme Inhibitor
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作者 Rakotoniaina Andriamiarimbola Irène Fenomana Jocia +1 位作者 Riel Andry Mampionona Rasamindrakotroka Andry 《Case Reports in Clinical Medicine》 2017年第11期295-300,共6页
Neurotic angioedema may be secondary to ACE (Angiotensin-converting enzyme) inhibitor. From a case of neurotic angioedema in a hypertensive man under ACE (Angiotensin-converting enzyme) inhibitor, we expose the clinic... Neurotic angioedema may be secondary to ACE (Angiotensin-converting enzyme) inhibitor. From a case of neurotic angioedema in a hypertensive man under ACE (Angiotensin-converting enzyme) inhibitor, we expose the clinical characteristics typical of the edema and its evolution. A 73-year-old man has consulted for edema of the face and redness of the palmar surface of the hand not pruriginous for 2 days. He has already had conventional anti-edematous treatments but no changes. In the absence of a technical platform, no paraclinical examination was carried out. The cessation of ACE inhibitor and the administration of tranexamic acid were made immediately. Signs regressed within 24 hours. Neurotic angioedema is a diagnostic problem in countries where biological examination is still limited and if practitioners are unaware of the possibility of its occurrence during IEC treatment. While the patient’s prognosis depends on the precocity of management. 展开更多
关键词 Neurotic ANGIOEDEMA ACE INHIBITOR DIAGNOSIS Treatment
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300 CASES OF MENOPAUSAL SYNDROME TREATED BY ACUPUNCTURE
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作者 武连仲 周新 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 1998年第4期259-262,共4页
Caused by hypo-ovarianism, menopausal syndrome usually occurs in women aged from 45-55 years. With high incidence and various symptoms, the disease often severely jeopardize the health of the women. The authors had tr... Caused by hypo-ovarianism, menopausal syndrome usually occurs in women aged from 45-55 years. With high incidence and various symptoms, the disease often severely jeopardize the health of the women. The authors had treated 300 cases of menopausal syndrome by acupuncture and obtained a good result. 展开更多
关键词 Acupuncture Therapy MENOPAUSE ADULT FEMALE Humans Middle Aged Neurotic Disorders SYNDROME Yang Deficiency Yin Deficiency
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Decision-making Impairments in Primary Angle-closure Glaucoma Patients 被引量:3
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作者 Hui Pu YongWang +6 位作者 Qiang Wei Hui-Juan Ma Pan-Pan Hu Shou-Ling Li Hong-Bo Pang Yang-Hua Tian Kai Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第12期1424-1428,共5页
Background: Primary angle-closure glaucoma (PACG) is a common eye disease and a common cause of blindness. Inappropriate medical decisions severely affect the prognosis. This study investigated decision-making unde... Background: Primary angle-closure glaucoma (PACG) is a common eye disease and a common cause of blindness. Inappropriate medical decisions severely affect the prognosis. This study investigated decision-making under risk in PACG patients.Methods: Thirty patients with first acute attack of PACG before surgery and thirty healthy controls were included in the study. Decision-making under risk was evaluated with the game of dice task (GDT). The results of Eysenck Personality Questionnaire (EPQ) and GDT between PACG patients and healthy controls were compared. Results: Risky decisions in PACG patients were more than those in healthy controls as measured by mean score ofGDT ( 12.47 ±5.72 vs. 4.33± 3.30, P 〈 0.001). Higher neuroticism score in EPQ was found in PACG patients compared to healthy controls (14.97 ± 3.93 vs. 9.90 ± 4.49, P 〈 0.001 ). Neuroticism scores in EPQ were associated with decision-making performance (r = 0.417, P = 0.001 ). Conclusions: Neuroticism positively correlated with risky decisions. Decision-making might be influenced by neuroticism. Future studies will show whether therapy compliance will be improved by emotional management and psychological intervention in PACG patients. 展开更多
关键词 COGNITIVE Decision-making: neuroticism PERSONALITY Primary Angle-closure Glaucoma
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Reality Through Insanity——A Survey of the Neurotic Heroes in American Novels of the 1960s (Continued)
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作者 侯维瑞 《外国语》 CSSCI 北大核心 1989年第3期41-45,共5页
Norman Mailer has made a profound analysisof the mad logic of the Vietnam war in his Armiesof the Night, a novel of new journalism whichconcludes the schizophrenic environment of Ameri-can society is at the root of th... Norman Mailer has made a profound analysisof the mad logic of the Vietnam war in his Armiesof the Night, a novel of new journalism whichconcludes the schizophrenic environment of Ameri-can society is at the root of this lunatic war: "He (Norman Mailer) came at last to the saddest conclusion ... that the centre of America might be insane. The country had been living with a controlled, even fiercely controlled, schizophrenia which had been deepening with the years. Perhaps the point had now been passed." (AN. 188)Traditional Christianity as a unifying force inlife has been able for many years to keep somekind of sanity. But it may now be on the decline. 展开更多
关键词 Reality Through Insanity A Survey of the Neurotic Heroes in American Novels of the 1960s Continued
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REALITY THROUGH INSANITY——A Survey of the Neurotic Heroes in American Novels of thc 1960s
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作者 侯维瑞 《外国语》 CSSCI 北大核心 1989年第2期31-35,共5页
As if neurosis has become an epidemic disease,so many of the protagonists in American novelsof the 60s are mentally ill in one way or another:Herzog, with his wide-ranging disordered thoughts,is described psychologica... As if neurosis has become an epidemic disease,so many of the protagonists in American novelsof the 60s are mentally ill in one way or another:Herzog, with his wide-ranging disordered thoughts,is described psychologically as depressive andoccasionally paraniod. Yossarian, the absurdhero of Catch-22, is a manci depressive" withfear of conspired death as his main symptom.Oedina in The Crying of Lot 49 sincerely wishes shewere mentally ill after her long mysterious questafter an underground delivery system which mayeither be a real discovery or a paranoid fantasy.With numerous and murderous crimes on record,Howard Campell, a Nazi propagandist in MotherNight, is on the edge of madness and despair. 展开更多
关键词 REALITY THROUGH INSANITY A Survey of the Neurotic Heroes in American Novels of thc 1960s
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