The preparation of highly sensitive and stable non-enzymatic glucose sensors is critical to the prevention and treatment of diabetes.Fe_(3)O_(4)@Au@Co Fe-LDH is prepared through a spontaneous galvanic displacement rea...The preparation of highly sensitive and stable non-enzymatic glucose sensors is critical to the prevention and treatment of diabetes.Fe_(3)O_(4)@Au@Co Fe-LDH is prepared through a spontaneous galvanic displacement reaction.A series of structural characterizations testify the successful formation of Fe_(3)O_(4)@Au@Co FeLDH electrocatalyst,with the Au intercalating between Fe_(3)O_(4)and LDH to form the sandwich structure.Cyclic voltammetry tests indicate that Au is responsible for the electrocatalytic oxidation of glucose.The characterizations of the electrochemical sensor for glucose detection indicate that Fe_(3)O_(4)@Au@Co FeLDH possesses high sensitivity of 6342μA m M^(-1)cm^(-2),with an extremely low oxidation potential of 0.82 V vs.RHE.Even with the high glucose concentration of 15 m M,the sensitivity remains at 4359μA m M^(-1)cm^(-2).Due to the broad linear detection range(0.0375 to 15.64 m M)and the low limit of detection(12.7μM),Fe_(3)O_(4)@Au@Co Fe-LDH is applicable towards practical application.Thanks to the sandwich structure,which confines the Au in between Fe_(3)O_(4)and Co Fe-LDH,the Fe_(3)O_(4)@Au@Co Fe-LDH glucose sensor shows high long-term stability and satisfactory selectivity.The successful synthesis of the sandwichstructured Fe_(3)O_(4)@Au@Co Fe-LDH provides a new conception for the design of highly sensitive and stable non-enzymatic glucose electrodes.展开更多
In this study,the application of bovine serum albumin(BSA)as a carrier to glucose-sensitive materials for the detection of glucose was proposed.Au-Cu O bimetallic nanoclusters(Au-Cu O/BSA)were prepared using BSA as a ...In this study,the application of bovine serum albumin(BSA)as a carrier to glucose-sensitive materials for the detection of glucose was proposed.Au-Cu O bimetallic nanoclusters(Au-Cu O/BSA)were prepared using BSA as a template,the new sensing material(Au-Cu O/BSA/MWCNTs)was synthesized by mixing with multi-walled carbon nanotubes(MWCNT)and applied to non-enzymatic electrochemical sensors to detect glucose stably and effectively under neutral condition.The scanning electron microscopy was used to investigate the morphology of the synthesized nanocomposite.The electrochemical properties of the sensor were studied by cyclic voltammetry.Glucose detection experiments show that Au-Cu O/BSA/MWCNTs/Au electrode has good glucose detection ability,stability,accuracy,repeatability,and high selectivity in neutral environment.Unlike existing glucose-sensitive materials,due to the use of BSA,the composite material is firmly fixed to the electrode surface without a Nafion solution,which reduces the current blocking effect on the modified electrode.The composite materials can be effectively preserved for extremely long periods,higher than 80%activity is maintained at room temperature in a closed environment for 3 to 4 months,due to the special effects of BSA.In addition,the feasibility of using BSA in glucose-sensitive materials is confirmed.展开更多
基金financially supported by the National Natural Science Foundation of China(No.21805308)the Taishan Scholar Project of Shandong Province,the Fundamental Research Funds for the Central Universities(No.19CX05001A)the Graduate Innovation Project of China University of Petroleum(No.YCX2020052)。
文摘The preparation of highly sensitive and stable non-enzymatic glucose sensors is critical to the prevention and treatment of diabetes.Fe_(3)O_(4)@Au@Co Fe-LDH is prepared through a spontaneous galvanic displacement reaction.A series of structural characterizations testify the successful formation of Fe_(3)O_(4)@Au@Co FeLDH electrocatalyst,with the Au intercalating between Fe_(3)O_(4)and LDH to form the sandwich structure.Cyclic voltammetry tests indicate that Au is responsible for the electrocatalytic oxidation of glucose.The characterizations of the electrochemical sensor for glucose detection indicate that Fe_(3)O_(4)@Au@Co FeLDH possesses high sensitivity of 6342μA m M^(-1)cm^(-2),with an extremely low oxidation potential of 0.82 V vs.RHE.Even with the high glucose concentration of 15 m M,the sensitivity remains at 4359μA m M^(-1)cm^(-2).Due to the broad linear detection range(0.0375 to 15.64 m M)and the low limit of detection(12.7μM),Fe_(3)O_(4)@Au@Co Fe-LDH is applicable towards practical application.Thanks to the sandwich structure,which confines the Au in between Fe_(3)O_(4)and Co Fe-LDH,the Fe_(3)O_(4)@Au@Co Fe-LDH glucose sensor shows high long-term stability and satisfactory selectivity.The successful synthesis of the sandwichstructured Fe_(3)O_(4)@Au@Co Fe-LDH provides a new conception for the design of highly sensitive and stable non-enzymatic glucose electrodes.
基金supported by the National Natural Science Foundation of China(No.61704035)the Natural Science Foundation of Guangxi Province(2017GXNSFBA198125)the Guangxi Technology Projects(No.AD19110076 and No.AD19110063)。
文摘In this study,the application of bovine serum albumin(BSA)as a carrier to glucose-sensitive materials for the detection of glucose was proposed.Au-Cu O bimetallic nanoclusters(Au-Cu O/BSA)were prepared using BSA as a template,the new sensing material(Au-Cu O/BSA/MWCNTs)was synthesized by mixing with multi-walled carbon nanotubes(MWCNT)and applied to non-enzymatic electrochemical sensors to detect glucose stably and effectively under neutral condition.The scanning electron microscopy was used to investigate the morphology of the synthesized nanocomposite.The electrochemical properties of the sensor were studied by cyclic voltammetry.Glucose detection experiments show that Au-Cu O/BSA/MWCNTs/Au electrode has good glucose detection ability,stability,accuracy,repeatability,and high selectivity in neutral environment.Unlike existing glucose-sensitive materials,due to the use of BSA,the composite material is firmly fixed to the electrode surface without a Nafion solution,which reduces the current blocking effect on the modified electrode.The composite materials can be effectively preserved for extremely long periods,higher than 80%activity is maintained at room temperature in a closed environment for 3 to 4 months,due to the special effects of BSA.In addition,the feasibility of using BSA in glucose-sensitive materials is confirmed.
基金financially supported by the Scientific Research Start-up Funds of Hexi University(KYQD2022004)the 13th Innovation Program Science and Technology for college students of Hexi University(138)。
