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Mechanism of Herbal Medicine and Food Dandelion Effects May be Related to RNA or DNA Regulation: A Review
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作者 Ying Yang Zhi Chen 《Chinese Medicine》 2023年第2期79-93,共15页
Background: A dandelion is a common plant with a global growth distribution that has been used as a medicinal and food with no adverse effects. Purpose: In this article, the products and effects of dandelions are revi... Background: A dandelion is a common plant with a global growth distribution that has been used as a medicinal and food with no adverse effects. Purpose: In this article, the products and effects of dandelions are reviewed to help further in-depth studies and develop more products derived from dandelions in the future. Method: The literature about dandelion in various databases such as Pubmed is searched. Results: Dandelions have many effects, such as virus inhibition, anti-tumor activity, nutritional value, anti-aging, potential as a vaccine and alleviation of heat stress. The mechanism underlying these effects is analyzed and it was found that dandelions were regulated by RNA or DNA. Conclusion: As a medicinal and food, dandelions are safe and have many effects. Many products derived from dandelions have been developed. The metabolic regulation is related with ribonucleic acid or possibly deoxynucleic acid. Further in-depth studies should be conducted on the regulation of dandelions through RNA or DNA. There will likely be more products derived from dandelions in the future. 展开更多
关键词 DANDELION HERB medicine food NUTRITION RNA DNA Metabolism
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Subcellular Distribution and Chemical Forms of Cadmium in the Medicine Food Homology Plant Platycodon grandiflorum(Jacq.)A.DC.
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作者 Jia An Xiang Wang +7 位作者 Yajiang Jing Jianping Huang Qilong Wang Gang Zhang Jing Gao Liang Peng Wenli Huang Yonggang Yan 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第5期1405-1420,共16页
Although Platycodon grandiflorum(Jacq.)A.DC.is a renowned medicine food homology plant,reports of excessive cadmium(Cd)levels are common,which affects its safety for clinical use and food consumption.To enable its Cd ... Although Platycodon grandiflorum(Jacq.)A.DC.is a renowned medicine food homology plant,reports of excessive cadmium(Cd)levels are common,which affects its safety for clinical use and food consumption.To enable its Cd levels to be regulated or reduced,it is necessary to first elucidate the mechanism of Cd uptake and accumulation in the plant,in addition to its detoxification mechanisms.This present study used inductively couple plasma-mass-spectrometry to analyze the subcellular distribution and chemical forms of Cd in different tissues of P.grandiflorum.The experimental results showed that Cd was mainly accumulated in the roots[predominantly in the cell wall(50.96%-61.42%)],and it was found primarily in hypomobile and hypotoxic forms.The proportion of Cd in the soluble fraction increased after Cd exposure,and the proportion of insoluble phosphate Cd and oxalate Cd increased in roots and leaves,with a higher increase in oxalate Cd.Therefore,it is likely that root retention mechanisms,cell wall deposition,vacuole sequestration,and the formation of low mobility and low toxicity forms are tolerance strategies for Cd detoxification used by P.grandiflorum.The results of this study provide a theoretical grounding for the study of Cd accumulation and detoxification mechanisms in P.grandiflorum,and they can be used as a reference for developing Cd limits and standards for other medicine food homology plants. 展开更多
关键词 CADMIUM Platycodon grandiflorum inductively coupled plasma-mass-spectrometry subcellular distribution chemical forms heavy metal tolerance medicine food homology
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Determination of vanadium in food and traditional Chinese medicine by graphite furnace atomic absorption spectroscopy 被引量:3
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作者 ZOUMingqiang JIANGTiansu +1 位作者 WANGDaning ZHAIQingzhou 《Rare Metals》 SCIE EI CAS CSCD 2003年第1期14-18,共5页
Various experimental conditions were described for the vanadium determination by graphite furnace atomic ab-sorption spectroscopy (GFAAS). The experiments showed that when atomization took place under the conditions w... Various experimental conditions were described for the vanadium determination by graphite furnace atomic ab-sorption spectroscopy (GFAAS). The experiments showed that when atomization took place under the conditions where thecombination of a pyrolytic coating graphite tube and fast raising temperature were used and the temperature was stable, thesignal peak shapes could be improved, the sensitivity was enhanced, and the memory effect was removed. The vanadium infood and traditional Chinese medicinal herbs can be accurately determined using the standard curve method. 展开更多
关键词 测定 石墨炉原子吸收光谱法 食物 中药
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Application of the thought of "simultaneous treatment of medicine and food" in the treatment of intractable functional constipation
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作者 Hui-Jing Wang Zhang-Jun Yun +4 位作者 Hong-Ye Peng Si-Dan Long Yi-Chong Wang Shu-Kun Yao Yu Liu 《Journal of Hainan Medical University》 2021年第4期64-68,共5页
Intractable functional constipation is a type of constipation which is difficult to cure,which is usually characterized by persistent constipation,dependence on laxative and/or ineffective treatment of laxative.In rec... Intractable functional constipation is a type of constipation which is difficult to cure,which is usually characterized by persistent constipation,dependence on laxative and/or ineffective treatment of laxative.In recent years,with the change of diet structure,accelerated pace of life and the influence of socio-psychological factors,the incidence rate has increased year by year,seriously affecting the quality of life of patients.Professor Yao Shukun has remarkable clinical effect and experience in the treatment of intractable functional constipation.Professor Yao believes that,combined with the changes of people's diet structure,life style and physique,the main TCM syndrome type of clinical stubborn functional constipation is dampness-heat and blood stasis,and the main treatment should be clearing heat and resolving dampness,regulating qi and removing blood stasis;and we should pay attention to the application of the idea of"Simultaneous Treatment of Medicine and Food"in the process of diagnosis and treatment,and educate patients to change their diet structure in order to fundamentally dispel the etiology. 展开更多
关键词 Simultaneous treatment of medicine and food Stubbornness Functional constipation APPLICATION
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Samples of the Collection of Old Medicine Raw Materials of the Department of Pharmacognosy of St.Petersburg Chemical Pharmaceutical University,Which Can Be Used in Food
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作者 A.V.Klemper 《Journal of Food Science and Engineering》 2019年第2期52-59,共8页
In the world there are many collections of the pharmaceutical trend.In America,the exhibits of this profile are in the Smithsonian Museum of Natural History in Washington,in Europe these are collections of pharmacy mu... In the world there are many collections of the pharmaceutical trend.In America,the exhibits of this profile are in the Smithsonian Museum of Natural History in Washington,in Europe these are collections of pharmacy museums in Heidelberg(Germany),Krakow and Warsaw(Poland),Basel(Switzerland),Riga(Latvia),and others.Some of them have many thousands of exhibits.There are also separate collections of pharmaceutical items for educational institutions,for example,a collection of old medicinal raw materials in Vigan’s Cabinet,Queen College,Cambridge(Great Britain).All these meetings,however,have long been known and described in detail.Most of them do not have a strict orientation and are presented,along with old medicinal raw materials,as well as tools and appliances,dishes,books,herbaria and various auxiliary items.All the more interesting is the collection indicated in the title of the article,which arose literally from non-existence.She was transferred to the educational institution at its creation,and this year she,like him,turns a hundred years old.It has a strict focus and is represented almost exclusively by medicinal raw materials.Studying the samples of this old collection,as a whole of medical profile,makes it possible to understand that many plants,which initially had only food use,gradually became pharmaceutical objects.Probably,it was the long practice of food use,with the fixing of associated pharmacological effects in the memory,that became the reason for choosing certain types of raw materials as medicinal.Ordinary foods,protein and starchy,began to be perceived as strengthening,mucous—as enveloping and anti-ulcer,some fruits and herbs—as antiscorbutic,sharp—as appetizing and improving the work of the stomach,and so on. 展开更多
关键词 food medicinal raw materials COLLECTION OLD SAMPLES
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Clinical Application of Radix Notoginseng and Its Homology of Medicine and Food
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作者 Hao HUANG Xiumei MA +2 位作者 Zujie QIN Hong LEI Wen ZHONG 《Medicinal Plant》 CAS 2022年第4期47-49,52,共4页
Clinical application of Radix Notoginseng in the last ten years is summarized,such as Radix Notoginseng powder,compatibility of Radix Notoginseng with other traditional Chinese medicines,and related preparations of Ra... Clinical application of Radix Notoginseng in the last ten years is summarized,such as Radix Notoginseng powder,compatibility of Radix Notoginseng with other traditional Chinese medicines,and related preparations of Radix Notoginseng,as well as application of Radix Notoginseng in homology of medicine and food,such as preventing and controlling gynecological diseases,rheumatoid arthritis,hypertension,gastric cancer,arthritis,and anemia. 展开更多
关键词 Radix Notoginseng Clinical application Homology of medicine and food
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The Protective Effect of Jiujiuguiyi, a Medicine and Food Homologous Formula, on Acute Alcohol Poisoning Mice
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作者 Yang-Fan Zhou Tian-Ze Zhang +4 位作者 Si-Qi Deng Meng Zhang Yu-Jiao Zhan Yi-Fang Li Rong-Rong He 《TMR Modern Herbal Medicine》 2019年第3期121-130,共10页
急性酒精中毒已成为当代中国的第三大社会问题,而目前市面上的主流解酒产品主要是单一机制,通过提高与酒精代谢有关的酶活性来加速酒精代谢。因此,我们研发了一款可以同时做到保肝、减缓中枢异常兴奋、改善肌肉松弛的新型解酒配方——... 急性酒精中毒已成为当代中国的第三大社会问题,而目前市面上的主流解酒产品主要是单一机制,通过提高与酒精代谢有关的酶活性来加速酒精代谢。因此,我们研发了一款可以同时做到保肝、减缓中枢异常兴奋、改善肌肉松弛的新型解酒配方——九酒归一。方法:给予0.12ml/10g50%乙醇灌胃,建立小鼠急性酒精中毒模型。连续20天给予九酒归一灌胃。接着,将小鼠随机分成8组,每组8只,分别为对照组(CON)、模型组(M)、海王金樽阳性对照组(HWJZ)、实验组(AL,AH,BL,BH,AB)。检测各组小鼠的步态、转棒爬行时间、肝脏和血清中的AST、ALT、SOD活性、血清中的MDA活性、肝脏中的ADH、ALDH、GSH-PX活性以及肝脏切片。结果:与模型组相比,九酒归一使肝脏和血清中的AST、ALT活性、血清中的MDA活性明显降低,同时使肝脏中的ADH、ALDH以及肝脏和血清中的SOD活性明显升高,显示肝脏代谢酒精能力增强、肝损伤降低。HE染色同样证明了九酒归一可以减少干细胞损伤,并且先药后酒组效果更好。而且,九酒归一明显延长了急性酒精中毒小鼠的转棒爬行时间,改善了急性酒精中毒小鼠的步态。结论:本研究证明,九酒归一可以有效保肝、减缓中枢异常兴奋、改善肌肉松弛。其作用机制主要是调节酒精代谢酶和抗氧化酶活性. 展开更多
关键词 九酒归一 急性酒精中毒小鼠 药食同源 行为学检测
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Exploring a natural MDR reversal agent: potential of medicinal food supplement Nerium oleander leaf distillate 被引量:1
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作者 Meltem Demirel Kars Ufuk Gündüz +1 位作者 Kamilüney AhmetLevent Ba 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2013年第8期644-649,共6页
Objective:To investigate the molecular effects ofNerium oleanderleaf distillate on paclitaxel and vincristine resistant(MCF-7/Pac and MCF-7/Vinc)cells and sensitive(MCF-7/S)cell lines.Methods:Nerium oleander(N.oleande... Objective:To investigate the molecular effects ofNerium oleanderleaf distillate on paclitaxel and vincristine resistant(MCF-7/Pac and MCF-7/Vinc)cells and sensitive(MCF-7/S)cell lines.Methods:Nerium oleander(N.oleander)leaf extract was obtained by hydrodistillation method.The toxicological effects ofN.oleanderdistillate,previously suggested as medicinal food supplement,on drug resistant cells were evaluated by XTT tests.MDR modulation potential of the plant material was evaluated by flow cytometry and fluorescent microscopy.Paclitaxel and vincristine were applied to the sublines in combination with N.oleanderdistillate.Results:Fractional inhibitory indices show thatN.oleanderdistillate did not increase the antiproliferative effects of anticancer drugs.N.oleandertreatment in to MCF-7/Pac and MCF-7/Vinc did not inhibit P-gp activity and MDR1 gene expression level.Conclusions:As a result it may be suggested that althoughN.oleanderdistillate has some medicinal effects as food supplement it may not be suitable as an MDR modulator for drug resistant breast cancer cells. 展开更多
关键词 Nerium oleander MCF-7 FRSA activity MDR REVERSAL medicinAL food SUPPLEMENT
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East to west:research progress in traditional Chinese medicine for antiaging strategies
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作者 Jing-Ning Yan Cong Hu Xiang-Long Meng 《Traditional Medicine Research》 2020年第5期305-321,共17页
Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and ... Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and traditional Chinese medicine(TCM).In this review,we summarize the current state of antiaging research related to both modern medicine and TCM and provide suggestions for further research.Various theories related to the aging process have been proposed,including the free radical theory,mitochondrial DNA damage theory,telomere theory,cross-linking theory,and intestinal flora theory,and a number of antiaging chemical treatments have been developed using modern medicine.These theories and achievements have resulted in major advancements in antiaging research.TCM is based on practical experience and has a long history with unique advantages in antiaging research.Some antiaging practices such as moderate diet consumption,acupuncture,Tai Chi(a traditional Chinese martial art that can relax the nerves to slow down the aging process),and Wuqin Xi(a traditional Chinese exercise to strengthen the body)have been adopted to maintain health.Several TCMs and prescriptions,particularly those related to medicine food homology,have been used in antiaging treatment,and their antiaging properties have been demonstrated to be effective based on pharmacological experiments and clinical applications. 展开更多
关键词 ANTIAGING Modern medicine Traditional Chinese medicine medicine food homology Pharmacological experiments Clinical applications
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Methods of preparation of egg and therapeutic uses:a review perspective of Persian Medicine
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作者 Fatemeh Moradi Malihe Tabarrai Fatemeh Nejatbakhsh 《Food Therapy and Health Care》 2020年第1期32-39,共8页
Background:The nutrients in eggs play an important role in the health of different body organs like the brain,cardiometabolic system,musculoskeletal system,skin and eyes and so the eggs can be considered as functional... Background:The nutrients in eggs play an important role in the health of different body organs like the brain,cardiometabolic system,musculoskeletal system,skin and eyes and so the eggs can be considered as functional foods.In order to maintain the highest nutrient content of an egg,it is recommended to cook it properly,but no specific clinical research has been carried out yet on the role that the cooking of an egg plays in its food and health properties.For this reason,this study has collected and discussed the topics related to a variety of methods of cooking eggs,based on the texts of Persian Medicine,and conducted a comparison with modern sources of nutrition.Methods:The present study is a review in which sources of Persian Medicine(PM)were searched in software JamiTib(Version 1.5)and Persian electronic banks,sites of PubMed,Google Scholar,ScienceDirect,and Embase and websites of health reference of American food and water.Finally,the results obtained were classified and a content analysis was carried out.Results:In the PM books,in addition to referring to the different properties of eggs,different effects of different egg preparation have been investigated.The wise men of the school of medicine have proposed at least five methods of egg preparation,including very soft boiled,soft-boiled,hardboiled,fried,and omelet.In the texts,the healing properties of each case and the quality of digestion in the body were separately investigated.Among the five main methods of preparation eggs,the therapeutic and digestive effects of soft-boiled eggs are emphasized to a greater extent,because easy digestion leads to more beneficial effects of the yolk of the eggs.Conclusion:Though the wise men of Persian Medicine have proposed a variety of methods to cook eggs,ease of digestion is one of the most important factors in their decision-making while proposing the type of cooking method for therapeutic prescriptions.In contrast,in modern nutrition research,regardless of the method of cooking eggs,the effect of its use on diseases like heart disease or diabetes has been studied.Owing to the fact that many cases of eggs,as mentioned,have been confirmed in PM texts during modern scientific surveys,it appears that clinical studies on the relevant issues of eggs in this context are useful in better understanding therapeutic effects. 展开更多
关键词 EGGS Cooking PREPARATION food NUTRIENTS Persian medicine
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The research progress of Chinese medicinal food therapy on infertility
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作者 Zhong Zhang Zhe-Feng Liu 《Food Therapy and Health Care》 2022年第1期11-15,共5页
Infertility is one of the common gynecological diseases,and the incidence has been on the rise in recent years,and according to WHO,infertility will become the third most serious disease after tumor and cardiovascular... Infertility is one of the common gynecological diseases,and the incidence has been on the rise in recent years,and according to WHO,infertility will become the third most serious disease after tumor and cardiovascular disease in the 21st century.Food therapy and medicine in China has a long history,Sun Simiao Valuable Prescriptions for emergencies:"If you can use food to calm the disease,release the emotions and dispel the disease,can be said to be good workers",which is also an important embodiment of the Chinese medicine"cure the disease"idea.With the improvement of the living standard of Chinese residents in recent years,food therapy and medicinal food have become popular as a new treatment method because of its efficacy and ease of acceptance.The author summarizes and summarizes the research results of Chinese medicine and medicinal food in the treatment of infertility in recent years in order to provide reference for clinical treatment of infertility. 展开更多
关键词 dietary therapy medicinal food INFERTILITY
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药食同源产品开发思路探讨 被引量:1
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作者 李峰杰 石贺 马晓娟 《中国药业》 CAS 2024年第1期1-4,共4页
目的 为药食同源产品的开发提供思路。方法 采用计算机检索关于中药保健食品相关专利及药食同源相关文献,分析近年来中药保健食品和药食同源产品的相关政策、研发现状及市场前景。结果 药食同源产品可发挥中医药治未病的独特优势,药食... 目的 为药食同源产品的开发提供思路。方法 采用计算机检索关于中药保健食品相关专利及药食同源相关文献,分析近年来中药保健食品和药食同源产品的相关政策、研发现状及市场前景。结果 药食同源产品可发挥中医药治未病的独特优势,药食同源产业是“健康中国”战略中不可或缺的一环。国家卫生部门发布了102种药食同源的中药材,提供了基于这102种药食同源目录中药材开发的药食同源产品具有保健功效的可能性依据。药食同源产品的开发,应基于性味归经及功效,遵循中医药调理配伍原则,现代生理功效相结合的组方原则,以及产品开发与市场需求紧密结合的开发原则,可从肿瘤类、不孕不育类、糖脂代谢类疾病及增强免疫力4个方面开发产品,还需注意产品体感与功效相结合。结论 基于102种药食同源目录中药材的药食同源产品是对中药保健食品的极大补充,也是中医药大健康产品的关键所在。 展开更多
关键词 药食同源产品 中药保健食品 中医药
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药食同源中药铁皮石斛的研究进展
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作者 胡杨 赵勉 +5 位作者 邱雨轩 叶德宝 刘洋清 张朝凤 王海波 程建明 《南京中医药大学学报》 CAS CSCD 2024年第1期94-108,共15页
铁皮石斛Dendrobii Officinalis Caulis是具有益胃生津,滋阴清热之效的药食同源中药。有丰富的化学成分以及药理活性,具有抗炎、抑菌、抗氧化、抗肿瘤、免疫调节、降血压、调节血糖等作用。常作为药膳以及保健品使用,在药品上也应用广泛... 铁皮石斛Dendrobii Officinalis Caulis是具有益胃生津,滋阴清热之效的药食同源中药。有丰富的化学成分以及药理活性,具有抗炎、抑菌、抗氧化、抗肿瘤、免疫调节、降血压、调节血糖等作用。常作为药膳以及保健品使用,在药品上也应用广泛,如石斛夜光丸、复方鲜石斛颗粒等,具有很高的药用价值和经济价值。通过对铁皮石斛的资源分布、化学成分、药理活性、药食两用产品开发等多个方面进行概述,对其应用现状进行分析,为铁皮石斛的可持续发展、药食同源开发和综合利用奠定理论基础。 展开更多
关键词 铁皮石斛 药食同源 资源分布 活性成分 产品开发
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肺积源流考
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作者 张倩倩 张念志 《实用中医内科杂志》 2024年第2期20-21,共2页
肺积为中医病名,主要类同于现代医学中的原发性支气管肺癌,临床以咳嗽、胸痛、咯血、体倦乏力为主要表现,其病程缠绵,迁延难愈,文章收集有关文献,了解古人对肺积病因病机及治则治法的认识,主要从肺积一词的由来,肺积的病因病机、治则治... 肺积为中医病名,主要类同于现代医学中的原发性支气管肺癌,临床以咳嗽、胸痛、咯血、体倦乏力为主要表现,其病程缠绵,迁延难愈,文章收集有关文献,了解古人对肺积病因病机及治则治法的认识,主要从肺积一词的由来,肺积的病因病机、治则治法等方面探讨,希冀以经典理论之精髓,用于指导临床,基于整体观念,辨证施治之诊病根本,为中医药治疗肺积提供思路。 展开更多
关键词 肺积 金水相生 培土生金 药食同源
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欧盟与中国禽蛋食品安全农兽药残留限量对比分析
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作者 李明珠 王雅蓉 +6 位作者 卢立志 曾涛 沈晓芳 邓琳 黄茜 吴炜 蔡朝霞 《食品安全质量检测学报》 CAS 2024年第5期260-268,共9页
近年来,由于我国与欧盟(European Union,EU)在制定蛋制品中农兽药最大残留限量(maximum residues limits, MRLs)上的不同,我国出口欧洲的蛋制品中农兽药残留超标及检出违禁药物的食品安全事件频繁报道,严重阻碍了中国禽蛋出口贸易的发... 近年来,由于我国与欧盟(European Union,EU)在制定蛋制品中农兽药最大残留限量(maximum residues limits, MRLs)上的不同,我国出口欧洲的蛋制品中农兽药残留超标及检出违禁药物的食品安全事件频繁报道,严重阻碍了中国禽蛋出口贸易的发展。为了解我国与欧盟在禽蛋中农兽药残留限量标准方面的差异,提升中国禽蛋产品在国际市场的竞争力,本文对欧盟和中国禽蛋中农药和兽药残留的种类和最大残留限量值进行对比分析,发现目前我国禽蛋农兽药残留限量标准存在种类尚不全面、残留限量指标的严宽程度有待研究等问题。针对我国实际,本文提出一些完善蛋制品农兽药残留标准体系的思路和对策措施,为保障食品安全与产品出口提供重要参考依据。 展开更多
关键词 禽蛋 农药 兽药 欧盟 中国 最大残留限量 食品安全
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文冠果食药资源的开发与应用研究进展
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作者 梁子龙 陆健康 +1 位作者 张春兰 王伟华 《食品安全质量检测学报》 CAS 2024年第5期157-164,共8页
文冠果是我国独有的珍贵木本类油料树种兼药用植物,在食品、医药、生态、人文等领域具有较大的研究价值和发展潜力。文冠果研究部位主要涉及到文冠果的种子、叶、花、果壳和茎木;化学成分主要包括蛋白质、脂肪酸、黄酮类、三萜类、植物... 文冠果是我国独有的珍贵木本类油料树种兼药用植物,在食品、医药、生态、人文等领域具有较大的研究价值和发展潜力。文冠果研究部位主要涉及到文冠果的种子、叶、花、果壳和茎木;化学成分主要包括蛋白质、脂肪酸、黄酮类、三萜类、植物甾醇和香豆素类;功能活性主要包括抗氧化及抑菌、抗肿瘤及抗病毒、改善记忆及神经保护、抗炎症、抗肥胖及降血脂、免疫调节等。由于文冠果种类差异大、野生种坐果率低、知名度小等原因,导致对文冠果的研究不深入、不全面,其资源没有得到较好的开发利用,目前国家大力支持木本油料发展,因此发展文冠果及其产业意义深远。文章综述了文冠果各部位的研究现状、化学成分、功能活性、在食品和医药方面的应用,以期为文冠果的研究、开发和应用提供参考。 展开更多
关键词 文冠果 食药物质 资源开发 化学成分 功能活性
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药食同源物协同血管紧张素转化酶抑制肽微胶囊的制备及其降压作用
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作者 夏宇 李晓东 +4 位作者 刘璐 周文利 贾志斌 焦阳 解庆刚 《食品科学》 EI CAS CSCD 2024年第3期84-93,共10页
研究药食同源复合物(枸杞∶山楂∶决明子=4∶1∶1,质量比,下同)协同血管紧张素转化酶(angiotensin convertingenzyme,ACE)抑制肽微胶囊对自发性高血压大鼠(spontaneouslyhypertensiverats,SHR)的降压作用。当ACE抑制肽与复合物的质量之... 研究药食同源复合物(枸杞∶山楂∶决明子=4∶1∶1,质量比,下同)协同血管紧张素转化酶(angiotensin convertingenzyme,ACE)抑制肽微胶囊对自发性高血压大鼠(spontaneouslyhypertensiverats,SHR)的降压作用。当ACE抑制肽与复合物的质量之比为1∶2时,ACE抑制率为78.19%,显著高于单一药食同源复合物(69.46%)及ACE抑制肽(71.48%)(P<0.05)。通过优化包埋工艺(固含物为10%、进风温度为160℃、芯壁比为1∶15、壁材为变性淀粉∶麦芽糊精=1∶4)制备药食同源物协同ACE抑制肽微胶囊包埋率为82.76%,在肠道中消化240 min后的释放率为81.4%,苦味显著降低(P<0.05)。动物实验结果发现药食同源物协同ACE抑制肽能够明显降低SHR的血压值,显著增加大鼠血浆中ACE2及血管紧张素1-7含量,降低血浆中ACE及血浆、心脏、肾脏及胸主动脉中血管紧张素II的含量(P<0.05),作用效果优于单一复合物及ACE抑制肽,证明药食同源物与ACE抑制肽存在协同效果,可通过调节肾素-血管紧张素系统降压,还可显著降低SHR心脏及胸主动脉纤维程度,从而改善由高血压引起的脏器损伤。 展开更多
关键词 药食同源物 血管紧张素转化酶抑制活性 微胶囊 降压
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药食同源圆苞车前子壳复方治疗2型糖尿病的临床疗效研究
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作者 李茂清 钟俊杰 +3 位作者 李晓慧 罗海龙 刘益平 吴志机 《中国实用医药》 2024年第5期147-150,共4页
目的 观察药食同源圆苞车前子壳复方治疗2型糖尿病的临床疗效。方法 60例2型糖尿病患者,使用随机数字表法分成治疗组和对照组,每组30例。两组均给予西医常规治疗,治疗组在此基础上给予药食同源圆苞车前子壳复方治疗。比较两组疗效,治疗... 目的 观察药食同源圆苞车前子壳复方治疗2型糖尿病的临床疗效。方法 60例2型糖尿病患者,使用随机数字表法分成治疗组和对照组,每组30例。两组均给予西医常规治疗,治疗组在此基础上给予药食同源圆苞车前子壳复方治疗。比较两组疗效,治疗后安全性,治疗前后糖化血红蛋白(HbA1c)、中医证候积分。结果 治疗组显效13例、有效7例、无效10例;对照组显效4例、有效4例、无效22例。治疗组疗效优于对照组,差异有统计学意义(Z=-3.135, P=0.002<0.05)。治疗后,两组HbA1c与本组治疗前比较均下降,差异有统计学意义(P<0.05);两组治疗后HbA1c比较,差异无统计学意义(P>0.05)。治疗后,两组主症积分、次症积分、舌脉积分、总积分与本组治疗前比较均下降,且治疗组主症积分、次症积分、舌脉积分、总积分分别为(0.43±0.68)、(0.90±0.61)、(0.90±0.94)、(2.23±1.14)分,低于对照组的(1.87±0.82)、(1.73±0.98)、(1.37±0.81)、(4.97±1.35)分,差异有统计学意义(P<0.05)。两组治疗后心电图、血常规、生化常规、二便常规均未见特殊异常,也无明显药物毒副反应。结论 药食同源圆苞车前子壳复方治疗2型糖尿病的疗效确切,安全性好,能更有效改善患者中医临床症状和HbA1c指标。 展开更多
关键词 2型糖尿病 中医药疗法 药食同源 圆苞车前子壳复方
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李海霞治疗恶性肿瘤术后血液高凝状态经验
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作者 李梓宁 焦倩 +4 位作者 孙迪 马婧 李姗姗 陈浩琛 李海霞 《辽宁中医杂志》 CAS 2024年第1期26-28,共3页
恶性肿瘤术后血液高凝状态严重威胁肿瘤患者的生命,干预恶性术后肿瘤血液高凝状态,能够有效降低患者死亡率。其临床表现与中医学中“血瘀证”的概念相接近。研究表明在术后抗凝、放置滤器、溶栓等治疗的基础上,配合中医药治疗疗效显著... 恶性肿瘤术后血液高凝状态严重威胁肿瘤患者的生命,干预恶性术后肿瘤血液高凝状态,能够有效降低患者死亡率。其临床表现与中医学中“血瘀证”的概念相接近。研究表明在术后抗凝、放置滤器、溶栓等治疗的基础上,配合中医药治疗疗效显著。李海霞教授对恶性肿瘤术后血液高凝状态的病因病机进行归纳:其一是癌症患者本身正气亏虚,久病伤阳,五脏六腑功能失调,此为根本;其二是肿瘤患者本身即有气血不足,手术后更伤气血,血脉不和,血不归经;其三为情志内伤,心神失司,肝气失于疏泄,气滞血瘀。治疗用附子、干姜、人参等温阳益气调和五脏;以神曲、麦芽、砂仁、白术等顾护健运脾胃;桃仁、红花、水蛭等活血理血,祛瘀生新;用桂枝、柴胡等条达情志,理气行滞。李教授基于此辨治原则,治疗恶性肿瘤术后血液高凝状态,在中药治疗的同时,嘱患者以小米粥恢复胃气,药食并行,取得了显著的临床疗效。 展开更多
关键词 恶性肿瘤术后 高凝状态 药食并行 扶阳活血
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精苓鹜枣固体饮料对COPD小鼠肺部炎症因子的影响
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作者 何娜祯 田慧 +3 位作者 许志 陈光宇 李亮 谢梦洲 《湖南中医药大学学报》 CAS 2024年第4期580-586,共7页
目的观察精苓鹜枣固体饮料对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)模型小鼠肺组织中炎症反应的影响,探讨其可能的作用机制,为该方的临床应用提供实验依据,也为中医药膳防治COPD提供一定的思路借鉴。方法将24... 目的观察精苓鹜枣固体饮料对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)模型小鼠肺组织中炎症反应的影响,探讨其可能的作用机制,为该方的临床应用提供实验依据,也为中医药膳防治COPD提供一定的思路借鉴。方法将24只雄性C57BL/6小鼠随机分为正常组、模型组、精苓鹜枣组(2.5 g/kg)、地塞米松组(1.0 mg/kg),每组6只。除正常组外,其他组均采用鼻滴脂多糖联合香烟烟雾建立COPD小鼠模型。干预30 d后取材,采用HE染色观察各组小鼠肺组织及脂肪组织iWAT、BAT的病理形态学变化;ELISA检测小鼠血清和支气管肺泡灌洗液(broncho alveolar lavage fluid,BALF)中肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin 6,IL-6)含量;qRT-PCR检测小鼠肺组织中TNF-α、ICAM-1、SELE、SP-A、SP-D mRNA相对表达水平。结果与正常组比较,模型组小鼠可见大量炎性细胞浸润,肺泡壁破坏融合出现肺大泡,脂肪细胞直径较大,血清及BALF中的TNF-α和IL-6的浓度显著升高(P<0.01),TNF-α、ICAM-1、SELE mRNA表达水平均显著升高(P<0.01);与模型组相比,精苓鹜枣组和地塞米松组小鼠肺组织损伤减轻,iWAT细胞变小紧致,具有棕色化趋势,BAT细胞分布增多且排列紧密,血清中TNF-α和IL-6水平均降低(P<0.05),精苓鹜枣组和地塞米松组TNF-α、ICAM-1、SELE、SP-A mRNA水平降低(P<0.05)。结论精苓鹜枣固体饮料能改善COPD模型小鼠肺组织形态,抑制炎性反应,促进肺组织修复。 展开更多
关键词 精苓鹜枣固体饮料 COPD 气道炎症 炎症因子 小鼠模型 药食同源
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