Firstly,connotation of fruit industrialization is introduced,pointing out that fruit leading enterprise is an important vector of the operation of fruit industrialization,as well as the economic entity for the market ...Firstly,connotation of fruit industrialization is introduced,pointing out that fruit leading enterprise is an important vector of the operation of fruit industrialization,as well as the economic entity for the market exploitation,production and processing,and service offering of fruit industry.Secondly,advantages and disadvantages of the three typical interest sharing modes during fruit industrialization are analyzed from the perspective of benefit sharing.In the organizational mode of "leading enterprise + fruit farmer" in contractual relationship,fruit enterprise plays a major role and is at a dominant position in the negotiation;while fruit farmer is at a relatively weak position,which has seriously frustrated the enthusiasm of fruit farmers.In the organizational mode of "specialized market + fruit farmer" in market transaction relationship,due to the restriction of certain factors,few agricultural enterprises participate in this mode;while fruit farmers are at a relatively weak position.Therefore,this mode can hardly promote the development of industrialization.In the organizational mode of "specialized agricultural association or cooperative + fruit farmer" in cooperative organization pattern,specialized association or cooperative protects the interests of fruit farmers,but neglects the interests of fruit enterprises.Finally,the vertical-horizontal integrated mode is put forward based on the development experience of the world and the actual situation of China,so as to provide guidance and reference for the fruit industrialization in China.展开更多
Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good effic...Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good efficiency remain unavailable. With the objective of developing an advanced method with shorter runtimes, a simple, precise, accurate stability-indicating LC method was developed for the determination of purity of Linezolid drug substance and drug products in bulk samples and pharmaceutical dosage forms in the presence of its impurities and degradation products. This method is capable of separating all the related substances of Linezolid along with the chiral impurity. This method can also be used for the estimation of assay of Linezolid in drug substance as well as in drug product. The method was developed using Chiralpak IA (250 mm 4.6 mm, 5 mm) column. A mixture of acetonitrile, ethanol, n-butyl amine and trifluoro acetic acid in 96:4:0.10:0.16 (v/v/v/v) ratio was used as a mobile phase. The eluted compounds were monitored at 254 nm. Linezolid was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. The degradation products were well resolved from main peak and its impurities, proving the stability-indicating power of the method. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and system suitability.展开更多
文摘Firstly,connotation of fruit industrialization is introduced,pointing out that fruit leading enterprise is an important vector of the operation of fruit industrialization,as well as the economic entity for the market exploitation,production and processing,and service offering of fruit industry.Secondly,advantages and disadvantages of the three typical interest sharing modes during fruit industrialization are analyzed from the perspective of benefit sharing.In the organizational mode of "leading enterprise + fruit farmer" in contractual relationship,fruit enterprise plays a major role and is at a dominant position in the negotiation;while fruit farmer is at a relatively weak position,which has seriously frustrated the enthusiasm of fruit farmers.In the organizational mode of "specialized market + fruit farmer" in market transaction relationship,due to the restriction of certain factors,few agricultural enterprises participate in this mode;while fruit farmers are at a relatively weak position.Therefore,this mode can hardly promote the development of industrialization.In the organizational mode of "specialized agricultural association or cooperative + fruit farmer" in cooperative organization pattern,specialized association or cooperative protects the interests of fruit farmers,but neglects the interests of fruit enterprises.Finally,the vertical-horizontal integrated mode is put forward based on the development experience of the world and the actual situation of China,so as to provide guidance and reference for the fruit industrialization in China.
文摘Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good efficiency remain unavailable. With the objective of developing an advanced method with shorter runtimes, a simple, precise, accurate stability-indicating LC method was developed for the determination of purity of Linezolid drug substance and drug products in bulk samples and pharmaceutical dosage forms in the presence of its impurities and degradation products. This method is capable of separating all the related substances of Linezolid along with the chiral impurity. This method can also be used for the estimation of assay of Linezolid in drug substance as well as in drug product. The method was developed using Chiralpak IA (250 mm 4.6 mm, 5 mm) column. A mixture of acetonitrile, ethanol, n-butyl amine and trifluoro acetic acid in 96:4:0.10:0.16 (v/v/v/v) ratio was used as a mobile phase. The eluted compounds were monitored at 254 nm. Linezolid was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. The degradation products were well resolved from main peak and its impurities, proving the stability-indicating power of the method. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and system suitability.
