In order to improve the comprehensive utilization rate of highfines sand(HFS)produced by the mine,full solid waste shotcrete(HFS-BFRS)was prepared with HFS asfine aggregate in cooperation with basaltfiber(BF).The strengt...In order to improve the comprehensive utilization rate of highfines sand(HFS)produced by the mine,full solid waste shotcrete(HFS-BFRS)was prepared with HFS asfine aggregate in cooperation with basaltfiber(BF).The strength growth characteristics of HFS-BFRS were analyzed.And thefitting equation of compressive strength growth characteristics of HFS-BFRS under the synergistic effect of multiple factors was given.And based on the orthogonal experimental method,the effects on the compressive strength,splitting tensile strength andflex-ural strength of HFS-BFRS under the action of different levels of influencing factors were investigated.The effect of three factors on the mechanical properties of HFS-BFRS,3,and 28 d,respectively,was revealed by choosing the colloidal sand ratio(C/H),basaltfiber volume fraction(BF Vol)and naphthalene high-efficiency water reducing agent(FDN)as the design variables,combined with indoor tests and theoretical analysis.The results show that the sensitivity of the three factors on compressive strength andflexural strength is C/H>FDN>BF Vol,and split-ting tensile strength is BF Vol>FDN>C/H.Finally,thefitting ratio of HFS-BFRS was optimized by the factor index method,and the rationality was verified by thefield test.For thefluidity of HFS-BFRS,the slump can be improved by 139%under the action of 1.2%FDN,which guarantees the pump-ability of HFS-BFRS.展开更多
[Objectives]This study aimed to optimize the ultrasonic-assisted extraction process of quercetin from Flos Sophorae Immaturus.[Methods]The natural product quercetin in Flos Sophorae Immaturus was extracted by ultrason...[Objectives]This study aimed to optimize the ultrasonic-assisted extraction process of quercetin from Flos Sophorae Immaturus.[Methods]The natural product quercetin in Flos Sophorae Immaturus was extracted by ultrasonic-assisted method,and the content of quercetin in the extract was determined by ultraviolet spectrophotometry.The effect of ethanol concentration,solid/liquid ratio,temperature,time and ultrasonic power on the yield of quercetin in Flos Sophorae Immaturus was investigated by using single-factor experiments.Based on the results of single-factor experiments,an orthogonal experiment was designed to optimize the extraction process.The experimental data obtained were subjected to range analysis,analysis of variance and SSR test using SPSS 20.0 software to obtain the optimal extraction process.The results concluded were verified.[Results]The optimal ultrasonic-assisted extraction process for quercetin in Flos Sophorae Immaturus was as follows:temperature of 85℃,time of 30 min,solid/liquid ratio of 1∶20 g/mL,ethanol concentration of 50%.Under the optimal extraction conditions,the yield of quercetin in Flos Sophorae Immaturus was the highest.[Conclusions]This study provides a theoretical basis for the application of quercetin in Flos Sophorae Immaturus.展开更多
Background:To facilitate the preparation of traditional Chinese medicines they are pre-mashed,i.e.,mashed in advance.However,storage conditions for pre-mashed traditional Chinese medicines are based on subjective judg...Background:To facilitate the preparation of traditional Chinese medicines they are pre-mashed,i.e.,mashed in advance.However,storage conditions for pre-mashed traditional Chinese medicines are based on subjective judgments of pharmacists,and the best storage conditions have not generally been determined.Semen Zizyphi Spinosae is a commonly used traditional Chinese medicine,and it is usually used after it is fried.The medicine needs to be mashed in a timely manner to ensure its effectiveness.The Chinese Pharmacopoeia provides a limit for its aflatoxin content.Methods:The orthogonal experimental design method optimizes the best plan for pre-mashed fried Semen Zizyphi Spinosae.Experimental conditions were defined using the L^(9)(3^(4))orthogonal design table.Four factors and three levels were used to study storage conditions.The four factors and three levels are as follows:storage temperature(10°C,20°C,and 30°C),storage humidity(45%,60%,and 75%),storage times(10,20 and 30 days),and particle sizes for the powder(coarsest,coarse and medium powders).The contents of jujuboside A,spinosin,aflatoxin B1,total aflatoxins(aflatoxins B1,B2,G1,and G2),moisture,total ash,acid value,and saponification values were measured.Results:The results demonstrated that the highest jujuboside A and spinosin contents were obtained using a storage temperature of 20°C,a storage humidity of 75%,a storage time of 10 days,and with a coarse powder particle size.Aflatoxin B1 and total aflatoxins(aflatoxins B1,B2,G1 and G2)were not detected under these conditions.Conclusion:There is no requirement for traditional Chinese medicines to be pre-mashed.This study evaluated various storage conditions for pre-mashed fried Semen Zizyphi Spinosae,and considered the influence of four factors on the contents of jujuboside A,spinolin and aflatoxin for quality control to provide a reference for other pre-mashed traditional Chinese medicines.展开更多
As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the...As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the population in SMO is not abundant.Thus,this paper focuses on how to reconstruct SMO to improve its performance,and a novel spider monkey optimization algorithm with opposition-based learning and orthogonal experimental design(SMO^(3))is developed.A position updatingmethod based on the historical optimal domain and particle swarmfor Local Leader Phase(LLP)andGlobal Leader Phase(GLP)is presented to improve the diversity of the population of SMO.Moreover,an opposition-based learning strategy based on self-extremum is proposed to avoid suffering from premature convergence and getting stuck at locally optimal values.Also,a local worst individual elimination method based on orthogonal experimental design is used for helping the SMO algorithm eliminate the poor individuals in time.Furthermore,an extended SMO^(3)named CSMO^(3)is investigated to deal with constrained optimization problems.The proposed algorithm is applied to both unconstrained and constrained functions which include the CEC2006 benchmark set and three engineering problems.Experimental results show that the performance of the proposed algorithm is better than three well-known SMO algorithms and other evolutionary algorithms in unconstrained and constrained problems.展开更多
As a kind of natural fiber,ramie fiber has distinctive advantages in textile application,but the application is limited due to the traditional degumming mode.Compared with the traditional degumming process,the microbi...As a kind of natural fiber,ramie fiber has distinctive advantages in textile application,but the application is limited due to the traditional degumming mode.Compared with the traditional degumming process,the microbial degumming process has many advantages.To obtain the optimal conditions for degumming ramie with Bacillus subtilis DZ_(5)(BS DZ_(5)),a combined statistical approach of orthogonal array design(OAD)and response surface methodology(RSM)was used.The influences of initial pH of the bacteria medium,culture temperature,shaking speed,degumming time and inoculum size on submerged fermentation degumming were evaluated by using fractional factorial design.The main factors in the analysis were culture temperature,shaking speed and initial pH.The residual gum mass fraction was used as the optimization index,and the optimal conditions for degumming were determined by central composite design and RSM.Thus with only a limited number of experiments,an optimal ramie microbial degumming condition was found as the culture temperature of 40℃,the initial pH in the culture medium of 8.5,the shaking speed of 205 r/min,the degumming time of 96 h and the inoculum size of 5%.After microbial degumming of ramie under the optimal conditions,there was only 10.6%residual gum by mass in the fiber.In addition,the effective degumming of BS DZ_(5)was also confirmed by a scanning electron microscope(SEM).展开更多
When the amphibious vehicle navigates in water,the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics.In the relevant research on reducing the navig...When the amphibious vehicle navigates in water,the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics.In the relevant research on reducing the navigation resistance of amphibious vehicles by adjusting the angle of the anti-wave plate,there is a lack of scientific selection of parameters and reasonable research of simulation results by using mathematical methods,and the influence of the center of gravity position on navigation characteristics is not considered at the same time.To study the influence of the combinations of the angle of the anti-wave plate and the position of the center of gravity on the resistance reduction characteristics,a numerical calculation model of the amphibious unmanned vehicle was established by using the theory of computational fluid dynamics,and the experimental data verified the correctness of the numerical model.Based on this numerical model,the navigation characteristics of the amphibious unmanned vehicle were studied when the center of gravity was located at different positions,and the orthogonal experimental design method was used to optimize the parameters of the angle of the anti-wave plate and the position of the center of gravity.The results show that through the parameter optimization analysis based on the orthogonal experimental method,the combination of the optimal angle of the anti-wave plate and the position of the center of gravity is obtained.And the numerical simulation result of resistance is consistent with the predicted optimal solution.Compared with the maximum navigational resistance,the parameter optimization reduces the navigational resistance of the amphibious unmanned vehicle by 24%.展开更多
A biconical liner was optimized to improve its penetration ability. Its formation and penetration mechanism was studied through numerical simulation and experiments. And the influence of different liner geometry sizes...A biconical liner was optimized to improve its penetration ability. Its formation and penetration mechanism was studied through numerical simulation and experiments. And the influence of different liner geometry sizes on the jet performance was analyzed using the orthogonal method. The liner formed the high-speed jet with an explosively formed projectile. The small angle 2α remarkably influenced the jet speed which was inversely proportional to 2α. And the liner thickness t' and large angle 2β had highly significant effect on the projectile speed. The liner was optimized at t' = 0. 14 cm,2α = 50°,2β = 135°,N = 0. 4 or 0. 5,when its jet speed respectively is at 6 613 m /s and 6 839 m /s and projectile speed is at 2 247 m /s and 2 095 m /s,steel target penetration is at 8. 24 cm and 8. 31 cm,and aperture is in 2. 12 cm and 2. 08 cm. The results show that target is penetrated by the high-speed jet and high-speed projectile resulting into double damages. The penetration ability is improved greatly.展开更多
Elastic anisotropy of shales is critical to accurate constraints for rock physical models,quantitative interpretation and hydraulic fracturing.However,the causes of elastic anisotropy of shales are very complicated,an...Elastic anisotropy of shales is critical to accurate constraints for rock physical models,quantitative interpretation and hydraulic fracturing.However,the causes of elastic anisotropy of shales are very complicated,and the understanding of how multiple influence factors affect the elastic anisotropy of shales is still not clear.Hence,the orthogonal experiment,as an effective multiple factors experimental method,is adopted in this study to analyze the effect of multiple factors for shale elastic anisotropy.Three factors,clay content,organic matter(OM)content and compaction stress are selected as independent variables,the orthogonal test table L_(16)(4^(3))with four levels for each factor is adopted.According to the designed orthogonal table,sixteen artificial shales are constructed based on the cold-pressing method,and all the dry artificial shales are measured by the ultrasonic measurements.The influence of each factor on the elastic anisotropy and the sensitivity orders of three factors are obtained using the range analysis.The orders of sensitivity for selected factors follow the sequence clay content>compaction stress>OM content for velocity anisotropy parameters.The compaction mechanism of artificial shales is also discussed by the compaction factor,which are positively correlated with the velocity anisotropy parameters.The clay platelets orientation distribution function(ODF)of samples is evaluated by a theoretical model,the ODF coefficients are significantly affected by the clay content and compaction stress,and W200 are much more sensitive to these factors than W400.The results can provide a critical rock physics basis for quantitative interpretation and reservoir prediction of the low-maturity or maturity shale reservoir.展开更多
Microstructure and mechanical properties of GN9 Ferritic/Martensitic steel for sodium-cooled fast reactors have been investigated through orthogonal design and analysis.Scanning electron microscopy(SEM),transmission e...Microstructure and mechanical properties of GN9 Ferritic/Martensitic steel for sodium-cooled fast reactors have been investigated through orthogonal design and analysis.Scanning electron microscopy(SEM),transmission electron microscopy(TEM),differential scanning calorimeter(DSC),tensile and impact tests were used to evaluate the heat treatment parameters on yield strength,elongation and ductile-to-brittle transition temperature(DBTT).The results indicate that the microstructures of GN9 steel after orthogonal heat treatments consist of tempered martensite,M23C6,MX carbides and MX carbonitrides.The average prior austenite grains increase and the lath width decreases with the austenitizing temperature increasing from 1000°C to 1080°C.Tempering temperature is the most important factor that influences the dislocation evolution,yield strength and elongation compared with austenitizing tempera-ture and cooling methods.Austenitizing temperature,tempering temperature and cooling methods show interactive effects on DBTT.Carbide morphology and distribution,which is influenced by austenitizing and tempering tempera-tures,is the critical microstructural factor that influences the Charpy impact energy and DBTT.Based on the orthogo-nal design and microstructural analysis,the optimal heat treatment of GN9 steel is austenitizing at 1000°C for 0.5 h followed by air cooling and tempering at 760°C for 1.5 h.展开更多
An orthogonal experimental design OA_9(3~3) was used to evaluate the effects of vitamins(A, B_2, and B_6) on the growth and digestive ability of the juvenile Chinese soft-shelled turtle, Pelodiscus sinensis(initial we...An orthogonal experimental design OA_9(3~3) was used to evaluate the effects of vitamins(A, B_2, and B_6) on the growth and digestive ability of the juvenile Chinese soft-shelled turtle, Pelodiscus sinensis(initial weight, 5.9±0.2 g). A total of 135 turtles were divided into 9 groups, which each included 15 individuals. The results revealed that vitamin A(VA) had the strongest impacts on the growth rate and feed utilization among the three vitamins; 35,000 IU kg^(-1) VA had optimal effects on the feeding intake and specific growth rate, and 20,000 IU kg^(-1) VA had optimal effects on protein digestibility and the feed conversion ratio. Vitamin B_2(VB_2) was essential for regulating protein deposition and the energy efficiency for growth of the turtles; 120 mg kg^(-1) VB_2 resulted in increased protein and energy deposition, and 180 mg kg^(-1) VB_2 had greater beneficial effects on the growth rate. Vitamin B_6(VB_6) had important effects on protein and feed efficiency; however, VB_6 at an excessive level(120 mg kg^(-1)) restricted turtle growth. Based on the above growth results, dietary supplementation of VA, VB_2 and VB_6 at levels of 35,000 IU kg^(-1), 180 mg kg^(-1) and 70 mg kg^(-1), respectively, were recommended for the juvenile soft-shelled turtle.展开更多
Aerospace electromagnetic relay is an electric component that has been widely used in aerospace industry.Contact bounce and contact breakaway for initial velocity are the key parameters that have strong influence on r...Aerospace electromagnetic relay is an electric component that has been widely used in aerospace industry.Contact bounce and contact breakaway for initial velocity are the key parameters that have strong influence on reliability and electric life of the relay.Generally,it is difficult to optimize these two parameters simultaneously.In this paper,according to kinetics theory and structural mechanics,a dynamic reaction calculation model of the relay that describes contact bounce and breakaway for initial velocity is proposed.Under the constraints of contact gap and contact force,the optimal combination of debugging parameters is obtained by the application of orthogonal design.It considers the reduction of contact bounce and the augmentation of breakaway for initial velocity as the optimization objectives,and takes the debugging parameters as the optimization variables.All these above ensure the increase of contact breakaway for initial velocity and the decrease of contact bounce simultaneously,and contact arc erosion is also reduced.展开更多
[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Usin...[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Using particle size distribution and encapsulation rate as evaluation indicators, the effects of hydration time, ratio of organic phase to aqueous phase, granulation method, as well as thin film dispersion and reverse evaporation methods on liposomes preparation were investigated, and the optimal preparation method was selected. Single factor experiments were used to screen the drug phospholipid ratio, ultrasound time, and phospholipid cholesterol ratio, and the preparation process was optimized through orthogonal experiments. [Results] The optimal process of preparing hydroxypropyl tetrahydropyrantriol liposomes was as below: 1 : 10 of drug phospholipid ratio, 6 min of ultrasound time, 4 : 1 of phospholipid cholesterol ratio, (60.94%±7.24%) of entrapment efficiency, (86.44±6.08) nm of particle size, (0.195±0.077) of PDI. [Conclusions] The optimal preparation process of hydroxypropyl tetrahydropyrantriol liposomes selected by orthogonal experiment could effectively improve the encapsulation efficiency of hydroxypropyl tetrahydropyranotriol and reduce particle size. Moreover, the method was stable and reliable.展开更多
Elementary osmotic pump(EOP)is a unique extended release(ER)drug delivery system based on the principle of osmosis.It has the ability to minimize the amount of the drug,accumulation and fluctuation in drug level durin...Elementary osmotic pump(EOP)is a unique extended release(ER)drug delivery system based on the principle of osmosis.It has the ability to minimize the amount of the drug,accumulation and fluctuation in drug level during chronic uses.Carbamazepine(CBZ),a poorly water-soluble antiepileptic drug,has serious side effects on overdoses and chronic uses.The aim of the present study was to design a new EOP tablet of CBZ containing a solubility enhancers and swellable polymer to reduce its side effects and enhance the patient compliance.Firstly,a combination of solubilizing carriers was selected to improve the dissolution of the slightly soluble drug.Then,designing the new EOP tablet and investigating the effect of different variables of core and coat formulations on drug release behavior by single parameter optimization and by Taguchi orthogonal design with analysis of variance(ANOVA),respectively.The results showed that CBZ solubility was successfully enhanced by a minimum amount of combined polyvinyl pyrrolidone(PVP K30)and sodium lauryl sulfate(SLS).The plasticizer amount and molecular weight(MW)together with the osmotic agent amount directly affect the release rate whereas the swellable polymer amount and viscosity together with the semi-permeable membrane(SPM)thickness inversely influence the release rate.In addition,the tendency of following zero order kinetics was mainly affected by the coat components rather than those of the core.Further,orifice size does not have any significant effect on the release behavior within the range of 0.1 mm to 0.8 mm.In this study we report the successful formulation of CBZ-EOP tablets,which were similar to the marketed product Tegretol CR 200 and able to satisfy the USP criterion limits and to deliver about 80%of CBZ at a rate of approximately zero order for up to 12 h.展开更多
Nowadays,more and more natural or functional fibers are being investigated due to their utilization in thermal underwear.Kapok fiber is one of the natural cellulosic fibers whose source is the kapok plant. It has holl...Nowadays,more and more natural or functional fibers are being investigated due to their utilization in thermal underwear.Kapok fiber is one of the natural cellulosic fibers whose source is the kapok plant. It has hollow body and sealed tail,which exhibits desirable features required for functional textiles of this nature. In this study,cotton / kapok( 80 /20 by mass) blended yarn with two types of yarn size 18. 5 and 14. 8 tex,respectively are knitted into plain stitches. The fabrics are undergone with an optimal preparation plan according to orthogonal design. Then,after dyeing and softening,fabric properties including thermal and water-vapour resistances, wicking property, pilling behaviour, and surface morphology,are tested and scrutinized for their candidacy for thermal underwear. The results showed that cotton / kapok blended fabrics have good thermal resistance which is significantly higher than those of cotton / modal blended fabrics,and the same water vapour resistance compared with cotton / modal blended fabrics which are normally used as underwear. Cotton / modal blended knitted fabrics has better pilling grade than cotton / kapok blended fabrics. Meanwhile, the cotton / kapok blends fabrics have good wicking property. Collectively,it was concluded that cotton / kapok blended fabric was appropriate for thermal underwear. However,the main limitation of these fabrics is their pilling properties.展开更多
Weld bead morphology plays an important role in welding procedure specification and welding process planning.In order to obtain the quantitative relationship between process parameters and weld morphology of DH36 mari...Weld bead morphology plays an important role in welding procedure specification and welding process planning.In order to obtain the quantitative relationship between process parameters and weld morphology of DH36 marine steel plate,grey correlation method was used to study multiple morphology characteristics simultaneously.Eighteen experimental runs were proposed according to orthogonal method.With grey correlation theory,three response objectives,aspect ratio,depth of penetration and weld were transformed into a single grey correlation grade(GRG).The process parameters were quantitatively correlated to the GRG value and optimized with the target of maximum aspect ratio,minimum depth of penetration and maximum weld area.The results show that the optimized weld bead morphology is better than other weld bead morphology.The relative error of the predicted GRG with respect to the actual value is 5.06%,which further verifies the accuracy of the established model.The microstructure and hardness analysis suggests that the optimized welded joint has obtained required mechanical properties.The research outcomes provide a theoretical basis for multi-objective optimization of arc welding morphology in practical applications.展开更多
Boiling heat transfer and the controllability of the thermal load of the cylinder head were studied.The thermodynamic phase change characteristics of the cylinder head coolant were considered and the mass,momentumand ...Boiling heat transfer and the controllability of the thermal load of the cylinder head were studied.The thermodynamic phase change characteristics of the cylinder head coolant were considered and the mass,momentumand energy transfers between two phases were calculated with the interface transfer submodels by using the computational fluid dynamics software CFX. Results showed that compared with the single-phase flow without considering the boiling heat transfer,the sub-cooled boiling heat transfer of the cylinder head was greatly increased. According to the results of the numerical simulation,an optimized structure of the water jacket was proposed. Finally,temperature and velocity of coolant,diameter of flow passage and mean bubble diameter that influences sub-cooled boiling were studied using the orthogonal experiment method.展开更多
Due to the geological body uncertainty,the identification of the surrounding rock parameters in the tunnel construction process is of great significance to the calculation of tunnel stability.The ubiquitous-joint mode...Due to the geological body uncertainty,the identification of the surrounding rock parameters in the tunnel construction process is of great significance to the calculation of tunnel stability.The ubiquitous-joint model and three-dimensional numerical simulation have advantages in the parameter identification of surrounding rock with weak planes,but conventional methods have certain problems,such as a large number of parameters and large time consumption.To solve the problems,this study combines the orthogonal design,Gaussian process(GP)regression,and difference evolution(DE)optimization,and it constructs the parameters identification method of the jointed surrounding rock.The calculation process of parameters identification of a tunnel jointed surrounding rock based on the GP optimized by the DE includes the following steps.First,a three-dimensional numerical simulation based on the ubiquitous-joint model is conducted according to the orthogonal and uniform design parameters combing schemes,where the model input consists of jointed rock parameters and model output is the information on the surrounding rock displacement and stress.Then,the GP regress model optimized by DE is trained by the data samples.Finally,the GP model is integrated into the DE algorithm,and the absolute differences in the displacement and stress between calculated and monitored values are used as the objective function,while the parameters of the jointed surrounding rock are used as variables and identified.The proposed method is verified by the experiments with a joint rock surface in the Dadongshan tunnel,which is located in Dalian,China.The obtained calculation and analysis results are as follows:CR=0.9,F=0.6,NP=100,and the difference strategy DE/Best/1 is recommended.The results of the back analysis are compared with the field monitored values,and the relative error is 4.58%,which is satisfactory.The algorithm influencing factors are also discussed,and it is found that the local correlation coefficientσf and noise standard deviationσn affected the prediction accuracy of the GP model.The results show that the proposed method is feasible and can achieve high identification precision.The study provides an effective reference for parameter identification of jointed surrounding rock in a tunnel.展开更多
To address the issue of rule premise combination explosion in the construction of the traditional complete conjunctive belief rule base(BRB),this paper introduces an orthogonal design method to reduce the conjunctive ...To address the issue of rule premise combination explosion in the construction of the traditional complete conjunctive belief rule base(BRB),this paper introduces an orthogonal design method to reduce the conjunctive BRB.The reasoning method based on reduced conjunctive BRB is designed with the help of the conversion technology from conjunctive BRB to disjunctive BRB.Finally,the operational mission effectiveness evaluation is taken as an example to verify the proposed method.The results show that the method proposed in this paper is feasible and effective.展开更多
The purpose of this study was to prepare glycyrrhizic acid nanoliposomes and evaluate the encapsulation efficiency and other properties of glycyrrhizic acid nanoliposomes, which would provide a reference for further r...The purpose of this study was to prepare glycyrrhizic acid nanoliposomes and evaluate the encapsulation efficiency and other properties of glycyrrhizic acid nanoliposomes, which would provide a reference for further research on Glycyrrhizic Acid in the treatment of liver diseases. Firstly, the preparation conditions of glycyrrhizic acid liposomes were optimized by the orthogonal design method. Then, glycyrrhizic acid liposomes were prepared by ultrasonic-film dispersion method and the encapsulation efficiency was determined by the HPLC method. Finally, the properties of glycyrrhizic acid nanoliposomes were also studied. The results showed that the optimal preparation conditions of liposomes were as follows: the ratio of drug to lipid was 1:30;Lecithin: cholesterol = 1:1;Hydration medium: pure water;Ultrasonic time: 120 s. The encapsulation efficiency of liposomes was about 90%. The final liposomes were round and uniform in distribution, with an average particle size of about 50 nm and absolute zeta potential of −28.9 mV. In this study, glycyrrhizic acid liposomes were prepared and the optimal preparation conditions were optimized. The encapsulation efficiency of the liposomes under the optimized conditions was determined. The evaluation of the morphology, size, particle size and stability of the liposomes was completed.展开更多
In recent decades,modified asphalt materials have been used in enhancing the traffic load on the roads.The main objective of this paper is to explore the modifi cation effect of direct coal liquefaction residue(DCLR)o...In recent decades,modified asphalt materials have been used in enhancing the traffic load on the roads.The main objective of this paper is to explore the modifi cation effect of direct coal liquefaction residue(DCLR)on as-phalt binders and investigate the effectiveness of DCLR in improving the performance of asphalt road.This paper prepared modifi ed petroleum as-phalt under diff erent process conditions and tested its penetration,softening point and ductility index.Based on the experimental data,according to gray correlation degree,the performance for the asphalt was compared.The performance for the modified asphalt is simulated and predicted using poly-nomial functions.The modifi ed asphalt was analyzed by FT-IR,TGA,SEM and HPLC.The results show that the optimal process conditions for DCLR modifi ed asphalt are shear mixing time of 45 min,shear mixing tempera-ture of 150℃ and shear mixing rate of 4000 r/min.The predicted fit with the experimental data of 0.993 further demonstrates the effectiveness of the method.The characterization results show no significant chemical change between the DCLR and the asphalt.DCLR can significantly improve the high temperature performance and water stability of the asphalt,but it has little impact on its low temperature performance.展开更多
基金This work was supported by the National Natural Science Foundation of China(51834001,52104129)a project supported by the China Postdoctoral Science Foundation(2020M672226,2022T150195)Key Laboratory of Mine Ecological Effects and Systematic Restoration,Ministry of Natural Resources,Open Fund(MEER-2022-09).
文摘In order to improve the comprehensive utilization rate of highfines sand(HFS)produced by the mine,full solid waste shotcrete(HFS-BFRS)was prepared with HFS asfine aggregate in cooperation with basaltfiber(BF).The strength growth characteristics of HFS-BFRS were analyzed.And thefitting equation of compressive strength growth characteristics of HFS-BFRS under the synergistic effect of multiple factors was given.And based on the orthogonal experimental method,the effects on the compressive strength,splitting tensile strength andflex-ural strength of HFS-BFRS under the action of different levels of influencing factors were investigated.The effect of three factors on the mechanical properties of HFS-BFRS,3,and 28 d,respectively,was revealed by choosing the colloidal sand ratio(C/H),basaltfiber volume fraction(BF Vol)and naphthalene high-efficiency water reducing agent(FDN)as the design variables,combined with indoor tests and theoretical analysis.The results show that the sensitivity of the three factors on compressive strength andflexural strength is C/H>FDN>BF Vol,and split-ting tensile strength is BF Vol>FDN>C/H.Finally,thefitting ratio of HFS-BFRS was optimized by the factor index method,and the rationality was verified by thefield test.For thefluidity of HFS-BFRS,the slump can be improved by 139%under the action of 1.2%FDN,which guarantees the pump-ability of HFS-BFRS.
基金Innovation and Entrepreneurship Training Program for Undergraduates of Xiamen Medical College(201812631035,201912631026).
文摘[Objectives]This study aimed to optimize the ultrasonic-assisted extraction process of quercetin from Flos Sophorae Immaturus.[Methods]The natural product quercetin in Flos Sophorae Immaturus was extracted by ultrasonic-assisted method,and the content of quercetin in the extract was determined by ultraviolet spectrophotometry.The effect of ethanol concentration,solid/liquid ratio,temperature,time and ultrasonic power on the yield of quercetin in Flos Sophorae Immaturus was investigated by using single-factor experiments.Based on the results of single-factor experiments,an orthogonal experiment was designed to optimize the extraction process.The experimental data obtained were subjected to range analysis,analysis of variance and SSR test using SPSS 20.0 software to obtain the optimal extraction process.The results concluded were verified.[Results]The optimal ultrasonic-assisted extraction process for quercetin in Flos Sophorae Immaturus was as follows:temperature of 85℃,time of 30 min,solid/liquid ratio of 1∶20 g/mL,ethanol concentration of 50%.Under the optimal extraction conditions,the yield of quercetin in Flos Sophorae Immaturus was the highest.[Conclusions]This study provides a theoretical basis for the application of quercetin in Flos Sophorae Immaturus.
基金This work was supported by the Shanghai Municipal Commission of Health and Family Planning(No.20174Y0034)the Third batch of specialized subject construction of traditional Chinese medicine in Jiading District-Traditional Chinese Medicine(No.2020-JDZYYZDXK-01).
文摘Background:To facilitate the preparation of traditional Chinese medicines they are pre-mashed,i.e.,mashed in advance.However,storage conditions for pre-mashed traditional Chinese medicines are based on subjective judgments of pharmacists,and the best storage conditions have not generally been determined.Semen Zizyphi Spinosae is a commonly used traditional Chinese medicine,and it is usually used after it is fried.The medicine needs to be mashed in a timely manner to ensure its effectiveness.The Chinese Pharmacopoeia provides a limit for its aflatoxin content.Methods:The orthogonal experimental design method optimizes the best plan for pre-mashed fried Semen Zizyphi Spinosae.Experimental conditions were defined using the L^(9)(3^(4))orthogonal design table.Four factors and three levels were used to study storage conditions.The four factors and three levels are as follows:storage temperature(10°C,20°C,and 30°C),storage humidity(45%,60%,and 75%),storage times(10,20 and 30 days),and particle sizes for the powder(coarsest,coarse and medium powders).The contents of jujuboside A,spinosin,aflatoxin B1,total aflatoxins(aflatoxins B1,B2,G1,and G2),moisture,total ash,acid value,and saponification values were measured.Results:The results demonstrated that the highest jujuboside A and spinosin contents were obtained using a storage temperature of 20°C,a storage humidity of 75%,a storage time of 10 days,and with a coarse powder particle size.Aflatoxin B1 and total aflatoxins(aflatoxins B1,B2,G1 and G2)were not detected under these conditions.Conclusion:There is no requirement for traditional Chinese medicines to be pre-mashed.This study evaluated various storage conditions for pre-mashed fried Semen Zizyphi Spinosae,and considered the influence of four factors on the contents of jujuboside A,spinolin and aflatoxin for quality control to provide a reference for other pre-mashed traditional Chinese medicines.
基金supported by the First Batch of Teaching Reform Projects of Zhejiang Higher Education“14th Five-Year Plan”(jg20220434)Special Scientific Research Project for Space Debris and Near-Earth Asteroid Defense(KJSP2020020202)+1 种基金Natural Science Foundation of Zhejiang Province(LGG19F030010)National Natural Science Foundation of China(61703183).
文摘As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the population in SMO is not abundant.Thus,this paper focuses on how to reconstruct SMO to improve its performance,and a novel spider monkey optimization algorithm with opposition-based learning and orthogonal experimental design(SMO^(3))is developed.A position updatingmethod based on the historical optimal domain and particle swarmfor Local Leader Phase(LLP)andGlobal Leader Phase(GLP)is presented to improve the diversity of the population of SMO.Moreover,an opposition-based learning strategy based on self-extremum is proposed to avoid suffering from premature convergence and getting stuck at locally optimal values.Also,a local worst individual elimination method based on orthogonal experimental design is used for helping the SMO algorithm eliminate the poor individuals in time.Furthermore,an extended SMO^(3)named CSMO^(3)is investigated to deal with constrained optimization problems.The proposed algorithm is applied to both unconstrained and constrained functions which include the CEC2006 benchmark set and three engineering problems.Experimental results show that the performance of the proposed algorithm is better than three well-known SMO algorithms and other evolutionary algorithms in unconstrained and constrained problems.
基金National Natural Science Foundation of China(No.51863020)。
文摘As a kind of natural fiber,ramie fiber has distinctive advantages in textile application,but the application is limited due to the traditional degumming mode.Compared with the traditional degumming process,the microbial degumming process has many advantages.To obtain the optimal conditions for degumming ramie with Bacillus subtilis DZ_(5)(BS DZ_(5)),a combined statistical approach of orthogonal array design(OAD)and response surface methodology(RSM)was used.The influences of initial pH of the bacteria medium,culture temperature,shaking speed,degumming time and inoculum size on submerged fermentation degumming were evaluated by using fractional factorial design.The main factors in the analysis were culture temperature,shaking speed and initial pH.The residual gum mass fraction was used as the optimization index,and the optimal conditions for degumming were determined by central composite design and RSM.Thus with only a limited number of experiments,an optimal ramie microbial degumming condition was found as the culture temperature of 40℃,the initial pH in the culture medium of 8.5,the shaking speed of 205 r/min,the degumming time of 96 h and the inoculum size of 5%.After microbial degumming of ramie under the optimal conditions,there was only 10.6%residual gum by mass in the fiber.In addition,the effective degumming of BS DZ_(5)was also confirmed by a scanning electron microscope(SEM).
基金supported by the National Natural Science Foundation of China(52174154).
文摘When the amphibious vehicle navigates in water,the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics.In the relevant research on reducing the navigation resistance of amphibious vehicles by adjusting the angle of the anti-wave plate,there is a lack of scientific selection of parameters and reasonable research of simulation results by using mathematical methods,and the influence of the center of gravity position on navigation characteristics is not considered at the same time.To study the influence of the combinations of the angle of the anti-wave plate and the position of the center of gravity on the resistance reduction characteristics,a numerical calculation model of the amphibious unmanned vehicle was established by using the theory of computational fluid dynamics,and the experimental data verified the correctness of the numerical model.Based on this numerical model,the navigation characteristics of the amphibious unmanned vehicle were studied when the center of gravity was located at different positions,and the orthogonal experimental design method was used to optimize the parameters of the angle of the anti-wave plate and the position of the center of gravity.The results show that through the parameter optimization analysis based on the orthogonal experimental method,the combination of the optimal angle of the anti-wave plate and the position of the center of gravity is obtained.And the numerical simulation result of resistance is consistent with the predicted optimal solution.Compared with the maximum navigational resistance,the parameter optimization reduces the navigational resistance of the amphibious unmanned vehicle by 24%.
基金Supported by the National Natural Science Foundation of China(51174183)the Anhui Natural Science Foundation of China(1508085ME85)
文摘A biconical liner was optimized to improve its penetration ability. Its formation and penetration mechanism was studied through numerical simulation and experiments. And the influence of different liner geometry sizes on the jet performance was analyzed using the orthogonal method. The liner formed the high-speed jet with an explosively formed projectile. The small angle 2α remarkably influenced the jet speed which was inversely proportional to 2α. And the liner thickness t' and large angle 2β had highly significant effect on the projectile speed. The liner was optimized at t' = 0. 14 cm,2α = 50°,2β = 135°,N = 0. 4 or 0. 5,when its jet speed respectively is at 6 613 m /s and 6 839 m /s and projectile speed is at 2 247 m /s and 2 095 m /s,steel target penetration is at 8. 24 cm and 8. 31 cm,and aperture is in 2. 12 cm and 2. 08 cm. The results show that target is penetrated by the high-speed jet and high-speed projectile resulting into double damages. The penetration ability is improved greatly.
基金supported by the National Natural Science Fund Projects(42104107)the Fundamental Research Funds for the Central Universities(2022XJDC06).
文摘Elastic anisotropy of shales is critical to accurate constraints for rock physical models,quantitative interpretation and hydraulic fracturing.However,the causes of elastic anisotropy of shales are very complicated,and the understanding of how multiple influence factors affect the elastic anisotropy of shales is still not clear.Hence,the orthogonal experiment,as an effective multiple factors experimental method,is adopted in this study to analyze the effect of multiple factors for shale elastic anisotropy.Three factors,clay content,organic matter(OM)content and compaction stress are selected as independent variables,the orthogonal test table L_(16)(4^(3))with four levels for each factor is adopted.According to the designed orthogonal table,sixteen artificial shales are constructed based on the cold-pressing method,and all the dry artificial shales are measured by the ultrasonic measurements.The influence of each factor on the elastic anisotropy and the sensitivity orders of three factors are obtained using the range analysis.The orders of sensitivity for selected factors follow the sequence clay content>compaction stress>OM content for velocity anisotropy parameters.The compaction mechanism of artificial shales is also discussed by the compaction factor,which are positively correlated with the velocity anisotropy parameters.The clay platelets orientation distribution function(ODF)of samples is evaluated by a theoretical model,the ODF coefficients are significantly affected by the clay content and compaction stress,and W200 are much more sensitive to these factors than W400.The results can provide a critical rock physics basis for quantitative interpretation and reservoir prediction of the low-maturity or maturity shale reservoir.
基金Supported by Natural Science Foundation Guidance Plan of Liaoning Province of China(Grant No.2019-ZD-0362)CAS Key Laboratory of Nuclear Materials and Safety Assessment,Institute of Metal Research,Chinese Academy of Sciences(Grant No.2021NMSAKF02).
文摘Microstructure and mechanical properties of GN9 Ferritic/Martensitic steel for sodium-cooled fast reactors have been investigated through orthogonal design and analysis.Scanning electron microscopy(SEM),transmission electron microscopy(TEM),differential scanning calorimeter(DSC),tensile and impact tests were used to evaluate the heat treatment parameters on yield strength,elongation and ductile-to-brittle transition temperature(DBTT).The results indicate that the microstructures of GN9 steel after orthogonal heat treatments consist of tempered martensite,M23C6,MX carbides and MX carbonitrides.The average prior austenite grains increase and the lath width decreases with the austenitizing temperature increasing from 1000°C to 1080°C.Tempering temperature is the most important factor that influences the dislocation evolution,yield strength and elongation compared with austenitizing tempera-ture and cooling methods.Austenitizing temperature,tempering temperature and cooling methods show interactive effects on DBTT.Carbide morphology and distribution,which is influenced by austenitizing and tempering tempera-tures,is the critical microstructural factor that influences the Charpy impact energy and DBTT.Based on the orthogo-nal design and microstructural analysis,the optimal heat treatment of GN9 steel is austenitizing at 1000°C for 0.5 h followed by air cooling and tempering at 760°C for 1.5 h.
基金supported by the National Natural Science Foundation of China (Nos.30972261,31172085,31272315 and 41606137)
文摘An orthogonal experimental design OA_9(3~3) was used to evaluate the effects of vitamins(A, B_2, and B_6) on the growth and digestive ability of the juvenile Chinese soft-shelled turtle, Pelodiscus sinensis(initial weight, 5.9±0.2 g). A total of 135 turtles were divided into 9 groups, which each included 15 individuals. The results revealed that vitamin A(VA) had the strongest impacts on the growth rate and feed utilization among the three vitamins; 35,000 IU kg^(-1) VA had optimal effects on the feeding intake and specific growth rate, and 20,000 IU kg^(-1) VA had optimal effects on protein digestibility and the feed conversion ratio. Vitamin B_2(VB_2) was essential for regulating protein deposition and the energy efficiency for growth of the turtles; 120 mg kg^(-1) VB_2 resulted in increased protein and energy deposition, and 180 mg kg^(-1) VB_2 had greater beneficial effects on the growth rate. Vitamin B_6(VB_6) had important effects on protein and feed efficiency; however, VB_6 at an excessive level(120 mg kg^(-1)) restricted turtle growth. Based on the above growth results, dietary supplementation of VA, VB_2 and VB_6 at levels of 35,000 IU kg^(-1), 180 mg kg^(-1) and 70 mg kg^(-1), respectively, were recommended for the juvenile soft-shelled turtle.
基金Sponsored by the National Natural Science Foundation of China(Grant No.50777010)
文摘Aerospace electromagnetic relay is an electric component that has been widely used in aerospace industry.Contact bounce and contact breakaway for initial velocity are the key parameters that have strong influence on reliability and electric life of the relay.Generally,it is difficult to optimize these two parameters simultaneously.In this paper,according to kinetics theory and structural mechanics,a dynamic reaction calculation model of the relay that describes contact bounce and breakaway for initial velocity is proposed.Under the constraints of contact gap and contact force,the optimal combination of debugging parameters is obtained by the application of orthogonal design.It considers the reduction of contact bounce and the augmentation of breakaway for initial velocity as the optimization objectives,and takes the debugging parameters as the optimization variables.All these above ensure the increase of contact breakaway for initial velocity and the decrease of contact bounce simultaneously,and contact arc erosion is also reduced.
基金Supported by Innovation and Entrepreneurship Training Program Project of Southwest Minzu University(S202210656134)Project of Sichuan Department of Science and Technology(2022NSFSC1437)Project of Sichuan Administration of Traditional Chinese Medicine(2021MS121).
文摘[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Using particle size distribution and encapsulation rate as evaluation indicators, the effects of hydration time, ratio of organic phase to aqueous phase, granulation method, as well as thin film dispersion and reverse evaporation methods on liposomes preparation were investigated, and the optimal preparation method was selected. Single factor experiments were used to screen the drug phospholipid ratio, ultrasound time, and phospholipid cholesterol ratio, and the preparation process was optimized through orthogonal experiments. [Results] The optimal process of preparing hydroxypropyl tetrahydropyrantriol liposomes was as below: 1 : 10 of drug phospholipid ratio, 6 min of ultrasound time, 4 : 1 of phospholipid cholesterol ratio, (60.94%±7.24%) of entrapment efficiency, (86.44±6.08) nm of particle size, (0.195±0.077) of PDI. [Conclusions] The optimal preparation process of hydroxypropyl tetrahydropyrantriol liposomes selected by orthogonal experiment could effectively improve the encapsulation efficiency of hydroxypropyl tetrahydropyranotriol and reduce particle size. Moreover, the method was stable and reliable.
基金This work was financially supported by the major project of the National Science and Technology of China for new drugs development(2009ZX09310-004).
文摘Elementary osmotic pump(EOP)is a unique extended release(ER)drug delivery system based on the principle of osmosis.It has the ability to minimize the amount of the drug,accumulation and fluctuation in drug level during chronic uses.Carbamazepine(CBZ),a poorly water-soluble antiepileptic drug,has serious side effects on overdoses and chronic uses.The aim of the present study was to design a new EOP tablet of CBZ containing a solubility enhancers and swellable polymer to reduce its side effects and enhance the patient compliance.Firstly,a combination of solubilizing carriers was selected to improve the dissolution of the slightly soluble drug.Then,designing the new EOP tablet and investigating the effect of different variables of core and coat formulations on drug release behavior by single parameter optimization and by Taguchi orthogonal design with analysis of variance(ANOVA),respectively.The results showed that CBZ solubility was successfully enhanced by a minimum amount of combined polyvinyl pyrrolidone(PVP K30)and sodium lauryl sulfate(SLS).The plasticizer amount and molecular weight(MW)together with the osmotic agent amount directly affect the release rate whereas the swellable polymer amount and viscosity together with the semi-permeable membrane(SPM)thickness inversely influence the release rate.In addition,the tendency of following zero order kinetics was mainly affected by the coat components rather than those of the core.Further,orifice size does not have any significant effect on the release behavior within the range of 0.1 mm to 0.8 mm.In this study we report the successful formulation of CBZ-EOP tablets,which were similar to the marketed product Tegretol CR 200 and able to satisfy the USP criterion limits and to deliver about 80%of CBZ at a rate of approximately zero order for up to 12 h.
基金Technical Standards for the Development of Kinitted Jinlong Underw ear Factory of Guangdong Province,China(No.HX201303000008)
文摘Nowadays,more and more natural or functional fibers are being investigated due to their utilization in thermal underwear.Kapok fiber is one of the natural cellulosic fibers whose source is the kapok plant. It has hollow body and sealed tail,which exhibits desirable features required for functional textiles of this nature. In this study,cotton / kapok( 80 /20 by mass) blended yarn with two types of yarn size 18. 5 and 14. 8 tex,respectively are knitted into plain stitches. The fabrics are undergone with an optimal preparation plan according to orthogonal design. Then,after dyeing and softening,fabric properties including thermal and water-vapour resistances, wicking property, pilling behaviour, and surface morphology,are tested and scrutinized for their candidacy for thermal underwear. The results showed that cotton / kapok blended fabrics have good thermal resistance which is significantly higher than those of cotton / modal blended fabrics,and the same water vapour resistance compared with cotton / modal blended fabrics which are normally used as underwear. Cotton / modal blended knitted fabrics has better pilling grade than cotton / kapok blended fabrics. Meanwhile, the cotton / kapok blends fabrics have good wicking property. Collectively,it was concluded that cotton / kapok blended fabric was appropriate for thermal underwear. However,the main limitation of these fabrics is their pilling properties.
基金Natural Science Foundation of Fujian Province(Grant No.2020J01873)Technology Major Project of Fujian Province(Grant No.2020H03018).
文摘Weld bead morphology plays an important role in welding procedure specification and welding process planning.In order to obtain the quantitative relationship between process parameters and weld morphology of DH36 marine steel plate,grey correlation method was used to study multiple morphology characteristics simultaneously.Eighteen experimental runs were proposed according to orthogonal method.With grey correlation theory,three response objectives,aspect ratio,depth of penetration and weld were transformed into a single grey correlation grade(GRG).The process parameters were quantitatively correlated to the GRG value and optimized with the target of maximum aspect ratio,minimum depth of penetration and maximum weld area.The results show that the optimized weld bead morphology is better than other weld bead morphology.The relative error of the predicted GRG with respect to the actual value is 5.06%,which further verifies the accuracy of the established model.The microstructure and hardness analysis suggests that the optimized welded joint has obtained required mechanical properties.The research outcomes provide a theoretical basis for multi-objective optimization of arc welding morphology in practical applications.
基金Supported by the National Key Basic Research Program of China(1030021210710)
文摘Boiling heat transfer and the controllability of the thermal load of the cylinder head were studied.The thermodynamic phase change characteristics of the cylinder head coolant were considered and the mass,momentumand energy transfers between two phases were calculated with the interface transfer submodels by using the computational fluid dynamics software CFX. Results showed that compared with the single-phase flow without considering the boiling heat transfer,the sub-cooled boiling heat transfer of the cylinder head was greatly increased. According to the results of the numerical simulation,an optimized structure of the water jacket was proposed. Finally,temperature and velocity of coolant,diameter of flow passage and mean bubble diameter that influences sub-cooled boiling were studied using the orthogonal experiment method.
基金This work was supported by the National Natural Science Foundation of China(Nos.51678101,52078093)Liaoning Revitalization Talents Program(No.XLYC1905015).
文摘Due to the geological body uncertainty,the identification of the surrounding rock parameters in the tunnel construction process is of great significance to the calculation of tunnel stability.The ubiquitous-joint model and three-dimensional numerical simulation have advantages in the parameter identification of surrounding rock with weak planes,but conventional methods have certain problems,such as a large number of parameters and large time consumption.To solve the problems,this study combines the orthogonal design,Gaussian process(GP)regression,and difference evolution(DE)optimization,and it constructs the parameters identification method of the jointed surrounding rock.The calculation process of parameters identification of a tunnel jointed surrounding rock based on the GP optimized by the DE includes the following steps.First,a three-dimensional numerical simulation based on the ubiquitous-joint model is conducted according to the orthogonal and uniform design parameters combing schemes,where the model input consists of jointed rock parameters and model output is the information on the surrounding rock displacement and stress.Then,the GP regress model optimized by DE is trained by the data samples.Finally,the GP model is integrated into the DE algorithm,and the absolute differences in the displacement and stress between calculated and monitored values are used as the objective function,while the parameters of the jointed surrounding rock are used as variables and identified.The proposed method is verified by the experiments with a joint rock surface in the Dadongshan tunnel,which is located in Dalian,China.The obtained calculation and analysis results are as follows:CR=0.9,F=0.6,NP=100,and the difference strategy DE/Best/1 is recommended.The results of the back analysis are compared with the field monitored values,and the relative error is 4.58%,which is satisfactory.The algorithm influencing factors are also discussed,and it is found that the local correlation coefficientσf and noise standard deviationσn affected the prediction accuracy of the GP model.The results show that the proposed method is feasible and can achieve high identification precision.The study provides an effective reference for parameter identification of jointed surrounding rock in a tunnel.
基金supported by the Military Scientific Research Program(41401020301).
文摘To address the issue of rule premise combination explosion in the construction of the traditional complete conjunctive belief rule base(BRB),this paper introduces an orthogonal design method to reduce the conjunctive BRB.The reasoning method based on reduced conjunctive BRB is designed with the help of the conversion technology from conjunctive BRB to disjunctive BRB.Finally,the operational mission effectiveness evaluation is taken as an example to verify the proposed method.The results show that the method proposed in this paper is feasible and effective.
文摘The purpose of this study was to prepare glycyrrhizic acid nanoliposomes and evaluate the encapsulation efficiency and other properties of glycyrrhizic acid nanoliposomes, which would provide a reference for further research on Glycyrrhizic Acid in the treatment of liver diseases. Firstly, the preparation conditions of glycyrrhizic acid liposomes were optimized by the orthogonal design method. Then, glycyrrhizic acid liposomes were prepared by ultrasonic-film dispersion method and the encapsulation efficiency was determined by the HPLC method. Finally, the properties of glycyrrhizic acid nanoliposomes were also studied. The results showed that the optimal preparation conditions of liposomes were as follows: the ratio of drug to lipid was 1:30;Lecithin: cholesterol = 1:1;Hydration medium: pure water;Ultrasonic time: 120 s. The encapsulation efficiency of liposomes was about 90%. The final liposomes were round and uniform in distribution, with an average particle size of about 50 nm and absolute zeta potential of −28.9 mV. In this study, glycyrrhizic acid liposomes were prepared and the optimal preparation conditions were optimized. The encapsulation efficiency of the liposomes under the optimized conditions was determined. The evaluation of the morphology, size, particle size and stability of the liposomes was completed.
文摘In recent decades,modified asphalt materials have been used in enhancing the traffic load on the roads.The main objective of this paper is to explore the modifi cation effect of direct coal liquefaction residue(DCLR)on as-phalt binders and investigate the effectiveness of DCLR in improving the performance of asphalt road.This paper prepared modifi ed petroleum as-phalt under diff erent process conditions and tested its penetration,softening point and ductility index.Based on the experimental data,according to gray correlation degree,the performance for the asphalt was compared.The performance for the modified asphalt is simulated and predicted using poly-nomial functions.The modifi ed asphalt was analyzed by FT-IR,TGA,SEM and HPLC.The results show that the optimal process conditions for DCLR modifi ed asphalt are shear mixing time of 45 min,shear mixing tempera-ture of 150℃ and shear mixing rate of 4000 r/min.The predicted fit with the experimental data of 0.993 further demonstrates the effectiveness of the method.The characterization results show no significant chemical change between the DCLR and the asphalt.DCLR can significantly improve the high temperature performance and water stability of the asphalt,but it has little impact on its low temperature performance.
