Objective To ascertain the coexistence of osteoarthritis and osteoporosis in the femoral head. Methods During total hip replacement for osteoarthritis of hip joint in 12 female patients with an average age of 56 years...Objective To ascertain the coexistence of osteoarthritis and osteoporosis in the femoral head. Methods During total hip replacement for osteoarthritis of hip joint in 12 female patients with an average age of 56 years, the femoral heads were procured. After processing the femoral had, specimens were studied under scanning electron microscope. Results Different degrees of osteoarthritic lesions (characterized by degeneration of articular cartilage and hyperplasia of subchondral bone tissues) could coexust with osteoporotic lesions (characterized by icicle-like trabeculae ) in the femoral had. The hyperplas- tic bone tissues of osteoarthritis lay in the vicinity of icicle-like trabeculae. However, they did not care into contact, nor did they exert influence on each other. Coexistence of these two different lesions covered a brood territory extending from the deep surface of subchondral bone plate to the head-neck junction of femoral head. Conclusion The results suggest that osteoarthritis and osteoporosis do coexist in the femoral head.展开更多
目的探讨壮骨止痛胶囊对去卵巢大鼠体质量及脂/骨代谢的影响。方法选用健康雌性SD大鼠30只,随机分为空白(Blank)组、假手术(Sham)组、模型(OVX)组、壮骨止痛胶囊(ZGZTC)组和雌激素(EV)组,每组6只。OVX组、ZGZTC组以及EV组均摘除双侧卵巢...目的探讨壮骨止痛胶囊对去卵巢大鼠体质量及脂/骨代谢的影响。方法选用健康雌性SD大鼠30只,随机分为空白(Blank)组、假手术(Sham)组、模型(OVX)组、壮骨止痛胶囊(ZGZTC)组和雌激素(EV)组,每组6只。OVX组、ZGZTC组以及EV组均摘除双侧卵巢,Sham组仅在卵巢周围切除相应体积的脂肪。ZGZTC组(567 mg/kg)、EV组(0.21 mg/kg)灌胃相应药物,Sham组和OVX组灌胃相应体积生理盐水,Blank组不做处理。每周检测体质量,干预12周后用显微CT检测大鼠右股骨骨密度(bone mineral density, BMD),扫描电镜分析左股骨骨小梁超微结构,HE染色评价胫骨组织微结构的变化,ELISA法测定血清雌激素(estrogen, E2)、脂联素(adiponectin, ADP)、瘦素(leptin, LEP)、骨碱性磷酸酶(bone alkaline phosphatase, BALP)、骨钙素(boneGla-protein, BGP)、I型前胶原N端前肽(N-terminal propeptide of type I procollagen, PINP)水平。结果与Blank组和Sham组比较,OVX组大鼠BMD显著降低(Ρ<0.001),骨小梁孔隙率增加,骨小梁厚度变薄,间距增大,内部骨微结构紊乱,BALP及ADP水平显著升高(Ρ<0.05,Ρ<0.01,Ρ<0.001)。与Blank组比较,OVX组大鼠E2水平显著下降(Ρ<0.05)。与OVX组比较,ZGZTC组大鼠胫骨、股骨骨小梁形态结构改善,骨髓腔内脂肪空泡面积及数目减少(Ρ>0.05),体质量降低(Ρ<0.001),血清E2水平和PINP水平显著升高(Ρ<0.05), BALP水平显著降低(Ρ<0.01);其血清LEP水平升高,ADP、BGP水平降低,但差异无统计学意义(Ρ>0.05)。结论壮骨止痛胶囊可能通过调节血清E2、脂肪因子ADP、LEP水平,抑制成脂分化过度,促进成骨分化,减少骨髓脂肪堆积,抑制过度骨代谢,改善骨小梁微结构,防治绝经后骨质疏松症,并维持体质量稳定,减少骨折的发生。展开更多
Twelve femoral heads were collected during total hip replacement forosteoarthritis of hip joint. The areas on the femoral head denuded of articular cartilageand the ivory bone were studied with scanning electron micro...Twelve femoral heads were collected during total hip replacement forosteoarthritis of hip joint. The areas on the femoral head denuded of articular cartilageand the ivory bone were studied with scanning electron microscope. The following findingswere observed: 1. Over the area denuded of articular cartilage, the subchnodral bone platerevealed flake-like trabeculae whick were unequal in size and haphazard in array. Therewas a transformation of the flake-like trabeculae into lamellar bone tissues. 2. Over theivory bone, the lamellar bone tissues turned into Haversian systems and interstitiallamellae, thereby revealing characteristics of compact bone and became extremely hard. 3.Over the surface of the ivory bone could be seen fibrocartilaginous islands, representingreparative response from the marrow tissues.展开更多
文摘Objective To ascertain the coexistence of osteoarthritis and osteoporosis in the femoral head. Methods During total hip replacement for osteoarthritis of hip joint in 12 female patients with an average age of 56 years, the femoral heads were procured. After processing the femoral had, specimens were studied under scanning electron microscope. Results Different degrees of osteoarthritic lesions (characterized by degeneration of articular cartilage and hyperplasia of subchondral bone tissues) could coexust with osteoporotic lesions (characterized by icicle-like trabeculae ) in the femoral had. The hyperplas- tic bone tissues of osteoarthritis lay in the vicinity of icicle-like trabeculae. However, they did not care into contact, nor did they exert influence on each other. Coexistence of these two different lesions covered a brood territory extending from the deep surface of subchondral bone plate to the head-neck junction of femoral head. Conclusion The results suggest that osteoarthritis and osteoporosis do coexist in the femoral head.
文摘目的探讨壮骨止痛胶囊对去卵巢大鼠体质量及脂/骨代谢的影响。方法选用健康雌性SD大鼠30只,随机分为空白(Blank)组、假手术(Sham)组、模型(OVX)组、壮骨止痛胶囊(ZGZTC)组和雌激素(EV)组,每组6只。OVX组、ZGZTC组以及EV组均摘除双侧卵巢,Sham组仅在卵巢周围切除相应体积的脂肪。ZGZTC组(567 mg/kg)、EV组(0.21 mg/kg)灌胃相应药物,Sham组和OVX组灌胃相应体积生理盐水,Blank组不做处理。每周检测体质量,干预12周后用显微CT检测大鼠右股骨骨密度(bone mineral density, BMD),扫描电镜分析左股骨骨小梁超微结构,HE染色评价胫骨组织微结构的变化,ELISA法测定血清雌激素(estrogen, E2)、脂联素(adiponectin, ADP)、瘦素(leptin, LEP)、骨碱性磷酸酶(bone alkaline phosphatase, BALP)、骨钙素(boneGla-protein, BGP)、I型前胶原N端前肽(N-terminal propeptide of type I procollagen, PINP)水平。结果与Blank组和Sham组比较,OVX组大鼠BMD显著降低(Ρ<0.001),骨小梁孔隙率增加,骨小梁厚度变薄,间距增大,内部骨微结构紊乱,BALP及ADP水平显著升高(Ρ<0.05,Ρ<0.01,Ρ<0.001)。与Blank组比较,OVX组大鼠E2水平显著下降(Ρ<0.05)。与OVX组比较,ZGZTC组大鼠胫骨、股骨骨小梁形态结构改善,骨髓腔内脂肪空泡面积及数目减少(Ρ>0.05),体质量降低(Ρ<0.001),血清E2水平和PINP水平显著升高(Ρ<0.05), BALP水平显著降低(Ρ<0.01);其血清LEP水平升高,ADP、BGP水平降低,但差异无统计学意义(Ρ>0.05)。结论壮骨止痛胶囊可能通过调节血清E2、脂肪因子ADP、LEP水平,抑制成脂分化过度,促进成骨分化,减少骨髓脂肪堆积,抑制过度骨代谢,改善骨小梁微结构,防治绝经后骨质疏松症,并维持体质量稳定,减少骨折的发生。
文摘Twelve femoral heads were collected during total hip replacement forosteoarthritis of hip joint. The areas on the femoral head denuded of articular cartilageand the ivory bone were studied with scanning electron microscope. The following findingswere observed: 1. Over the area denuded of articular cartilage, the subchnodral bone platerevealed flake-like trabeculae whick were unequal in size and haphazard in array. Therewas a transformation of the flake-like trabeculae into lamellar bone tissues. 2. Over theivory bone, the lamellar bone tissues turned into Haversian systems and interstitiallamellae, thereby revealing characteristics of compact bone and became extremely hard. 3.Over the surface of the ivory bone could be seen fibrocartilaginous islands, representingreparative response from the marrow tissues.
