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Estrogen/Huntingtin:a novel pathway involved in neuroprotection
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作者 Maria Teresa Nuzzo Maria Marino 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第3期402-403,共2页
Neurodegenerative diseases(NDs)include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cogniti... Neurodegenerative diseases(NDs)include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive deficits.The pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or degradation.In most cases, 展开更多
关键词 programmed mitochondrial pathogenesis progressively aggregation oxidative abnormal neuronal caspase physiological
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Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons 被引量:4
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作者 Bin Yang Xiaqin Sun +1 位作者 Hilal Lashuel Yan Zhang 《Neuroscience Bulletin》 SCIE CAS CSCD 2012年第3期233-239,共7页
Objective To investigate whether intracellular amyloid β (iAβ) induces toxicity in wild type (WT) and APP/PS1 mice, a mouse model of Alzheimer's disease. Methods Different forms of Aβ aggregates were microinje... Objective To investigate whether intracellular amyloid β (iAβ) induces toxicity in wild type (WT) and APP/PS1 mice, a mouse model of Alzheimer's disease. Methods Different forms of Aβ aggregates were microinjected into cultured WT or APP/PS1 mouse hippocampal neurons. TUNEL staining was performed to examine neuronal cell death. Reactive oxidative species (ROS) were measured by MitoSOXTM Red mitochondrial superoxide indicator. Results Crude, monomer and protofibrilAβ induced more toxicity inAPP/PS1 neurons than in WT neurons. ROS are involved in mediating the vulnerability of APP/PS1 neurons to iAβ toxicity. Conclusion Oxidative stress may mediate cell death induced by iAβ in neurons. 展开更多
关键词 amyloid reactive oxidative species APP/PS1 aggregation toxicity.
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