The electrochemical oxygen generator has been popularized for its virtues, such as high oxygen concentration output, electricity saving, easy operation and maintenance. The key part of electrochemical oxygen generator...The electrochemical oxygen generator has been popularized for its virtues, such as high oxygen concentration output, electricity saving, easy operation and maintenance. The key part of electrochemical oxygen generator is carbon electrode used as the cathode. The preparation of high performance carbon electrode was introduced in this paper. The properties of carbon electrode was tested. The electrochemical oxygen generator using carbon electrode as the cathode was prepared. The oxygen concentration and flow of this machine is hi,yher thnn ｜hal of others in china.展开更多
Baosteel＇s 60000 m^3/h air separation unit （ASU） is the largest oxygen generating system in China. The operational cost of such a giant system is very high. How to reduce the operational cost is a critical issue. T...Baosteel＇s 60000 m^3/h air separation unit （ASU） is the largest oxygen generating system in China. The operational cost of such a giant system is very high. How to reduce the operational cost is a critical issue. This paper discusses the system＇s characteristics,the current operational status and the difficulties in reducing the cost,and analyzes relevant indicators, such as the technical and economical indicators of individual units and systems as well as the indicators concerning the costs. The relationship between the cost and each economical indicator and measures to optimize an economical operation of the oxygen generating system are also discussed in this paper.展开更多
The immunological implications of cuproptosis,a form of cell death highly sensitive to oxygen presence,remain largely unexplored in the context of tumor immunother-apy.Herein,we initially investigate the positive corr...The immunological implications of cuproptosis,a form of cell death highly sensitive to oxygen presence,remain largely unexplored in the context of tumor immunother-apy.Herein,we initially investigate the positive correlation between cuproptosis and tumor immunotherapy through bioinformatics analysis.Subsequently,an oxygen generator loaded with copper ions(Cu/APH-M)has been constructed,which serves as an effective carrier of copper ions and crucially enhances the oxygenation of the tumor microenvironment.Importantly,Cu/APH-M-mediated dual strengthening of cuproptosis and radiotherapy could not only trigger a powerful antitumor immunity related to immunogenic cell death by RNA-sequencing analysis,but also effec-tively inhibit the growth of both distal and in situ low rectal tumors after combined immunotherapy,creating a robust immune memory effect.Our work reveals the ben-eficial effects of enhanced cuproptosis in radio-immunotherapy and elucidates its underlying mechanisms,which provides a novel approach for the synergistic inte-gration of cuproptosis with immunotherapy and radiotherapy,broadening the scope of cuproptosis-mediated tumor therapy.展开更多
Photothermal therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention owing to their great potential for tumor treatment.However,two main issues hamper the antitumor performance of PDT:overexpressio...Photothermal therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention owing to their great potential for tumor treatment.However,two main issues hamper the antitumor performance of PDT:overexpression of glutathione(GSH)in tumors,which consumes PDT-induced reactive oxygen species(ROS),and hypoxia within the tumor microenvironment.The drawbacks of PTT include uneven temperature distribution and the upregulation of the heat-shock proteins in tumors,both of which result in ineffective treatment.To address these issues,a MnO_(2)doped nano-delivery system(HTIM-PMs)was synthesized by one-step self-assembly of disulfide bond bridged copolymers for indocyanine green(ICG)and MnO_(2)loading.The surface of polymeric micelles was layered with hyaluronan(HA)and transactivator(TAT)peptides to improve active targeting and increase cell penetration.After internalization,HTIM-PMs showed responsiveness to the tumor microenvironment(acid pH,high glutathione,high H_(2)O_(2)).Breaking the disulfide bond reduced the intratumoral GSH level and simultaneously released the MnO_(2)and ICG.The released MnO_(2)further reduced the GSH level and promoted O_(2)generation,thus enhancing the PDT effect.The PTT-mediated hyperthermia accelerated blood flow,which is beneficial for O_(2)distribution,and promotes ROS diffusion.These PTT-mediated adjuvant effects further overcame the limitations of PDT and the robust PDT effect in turn compensated for the deficiency of PTT.This promising platform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previously reported nanostructures.展开更多
文摘The electrochemical oxygen generator has been popularized for its virtues, such as high oxygen concentration output, electricity saving, easy operation and maintenance. The key part of electrochemical oxygen generator is carbon electrode used as the cathode. The preparation of high performance carbon electrode was introduced in this paper. The properties of carbon electrode was tested. The electrochemical oxygen generator using carbon electrode as the cathode was prepared. The oxygen concentration and flow of this machine is hi,yher thnn ｜hal of others in china.
文摘Baosteel＇s 60000 m^3/h air separation unit （ASU） is the largest oxygen generating system in China. The operational cost of such a giant system is very high. How to reduce the operational cost is a critical issue. This paper discusses the system＇s characteristics,the current operational status and the difficulties in reducing the cost,and analyzes relevant indicators, such as the technical and economical indicators of individual units and systems as well as the indicators concerning the costs. The relationship between the cost and each economical indicator and measures to optimize an economical operation of the oxygen generating system are also discussed in this paper.
基金Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20190946Gusu Leading Talent Program for Innovation and Entrepreneurship,Grant/Award Number:ZXL2021441+5 种基金Suzhou health youth backbone talent“national tutorial system”training project,Grant/Award Number:Qngg2023005Key Research and Development Program of Social Development of Jiangsu Province,Grant/Award Number:BE2022725Natural Science Foundation of Anhui Province,Grant/Award Number:2308085QH281Beijing Sisko Clinical Oncology Research Foundation,Grant/Award Number:Y-tongshu2021/qn-0366Key Scientific Research Project of Colleges and Universities of Anhui Province of China,Grant/Award Number:2022AH050683National Natural Science Foundation of China,Grant/Award Numbers:12275003,32171382,32301169,U1932208。
文摘The immunological implications of cuproptosis,a form of cell death highly sensitive to oxygen presence,remain largely unexplored in the context of tumor immunother-apy.Herein,we initially investigate the positive correlation between cuproptosis and tumor immunotherapy through bioinformatics analysis.Subsequently,an oxygen generator loaded with copper ions(Cu/APH-M)has been constructed,which serves as an effective carrier of copper ions and crucially enhances the oxygenation of the tumor microenvironment.Importantly,Cu/APH-M-mediated dual strengthening of cuproptosis and radiotherapy could not only trigger a powerful antitumor immunity related to immunogenic cell death by RNA-sequencing analysis,but also effec-tively inhibit the growth of both distal and in situ low rectal tumors after combined immunotherapy,creating a robust immune memory effect.Our work reveals the ben-eficial effects of enhanced cuproptosis in radio-immunotherapy and elucidates its underlying mechanisms,which provides a novel approach for the synergistic inte-gration of cuproptosis with immunotherapy and radiotherapy,broadening the scope of cuproptosis-mediated tumor therapy.
基金financial support from the National Natural Science Foundation of China(Nos.82172090 and 82072059)CAMS Innovation Fund for Medical Sciences(CIFMS,Nos.2021-I2M-1-058 and 2022-I2M-1-023)+1 种基金Fundamental Research Funds for the Central Universities(No.2019PT320028)Tianjin Municipal Natural Science Foundation(No.20JCYBJC00030)。
文摘Photothermal therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention owing to their great potential for tumor treatment.However,two main issues hamper the antitumor performance of PDT:overexpression of glutathione(GSH)in tumors,which consumes PDT-induced reactive oxygen species(ROS),and hypoxia within the tumor microenvironment.The drawbacks of PTT include uneven temperature distribution and the upregulation of the heat-shock proteins in tumors,both of which result in ineffective treatment.To address these issues,a MnO_(2)doped nano-delivery system(HTIM-PMs)was synthesized by one-step self-assembly of disulfide bond bridged copolymers for indocyanine green(ICG)and MnO_(2)loading.The surface of polymeric micelles was layered with hyaluronan(HA)and transactivator(TAT)peptides to improve active targeting and increase cell penetration.After internalization,HTIM-PMs showed responsiveness to the tumor microenvironment(acid pH,high glutathione,high H_(2)O_(2)).Breaking the disulfide bond reduced the intratumoral GSH level and simultaneously released the MnO_(2)and ICG.The released MnO_(2)further reduced the GSH level and promoted O_(2)generation,thus enhancing the PDT effect.The PTT-mediated hyperthermia accelerated blood flow,which is beneficial for O_(2)distribution,and promotes ROS diffusion.These PTT-mediated adjuvant effects further overcame the limitations of PDT and the robust PDT effect in turn compensated for the deficiency of PTT.This promising platform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previously reported nanostructures.
