An S-scheme heterojunction photocatalyst is capable of boosting photogenerated carrier separation and transfer,thus maintaining high photooxidation and photoredox ability.Herein,a 0D Ag_(3)PO_(4) nanoparticles(NPs)/1D...An S-scheme heterojunction photocatalyst is capable of boosting photogenerated carrier separation and transfer,thus maintaining high photooxidation and photoredox ability.Herein,a 0D Ag_(3)PO_(4) nanoparticles(NPs)/1D TiO_(2) nanofibers(NFs)S-scheme heterojunction with intimate interfacial contact was designed via the the hydro-thermal method.Benefiting from the abundant hydroxyl groups and size confinement effect of TiO_(2) NFs,the average diameter of the Ag_(3)PO_(4) nanoparticles decreased from 100 to 22 nm,which favored the construction of a 0D/1D geometry heterojunction.The multifunctional Ag_(3)PO_(4)/TiO_(2) sample exhibited excellent photocatalytic activity and stability in photocatalytic oxygen production(726μmol/g/h)and photocatalytic degradation of various organic contaminants such as rhodamine B(100%),phenol(60%)and tetracycline hydrochloride(100%).The significant improvements in the photocatalytic performance and stability can be attributed to the intimate interfacial contacts and rich active sites of 0D/1D geometry,fast charge carrier migration,and outstanding photoredox properties induced by the S-scheme charge-transfer route.This work offers a promising strategy for constructing 0D/1D S-scheme heterojunction photocatalysts for improved photocatalytic performance.展开更多
Applying quantitative temporal analysis of products reactor measurements, we studied the reactive removal of active oxygen present on Au/TiO2 catalysts after calcination at elevated temperatures （400 ＆#176;C） by CO...Applying quantitative temporal analysis of products reactor measurements, we studied the reactive removal of active oxygen present on Au/TiO2 catalysts after calcination at elevated temperatures （400 ＆#176;C） by CO pulses and its replenishment by O2 pulses at 80 ＆#176;C, focusing on the nature of the active oxygen species. In contrast to previous studies, which mainly focused on and clarified the nature of the active oxygen species for the catalytic CO oxidation, which is reversibly formed and replenished under typical reaction conditions, this study demonstrates that directly after calcina‐tion an additional oxygen species is present. This species is also active for the CO oxidation, but it is not or only very little formed under typical reaction conditions. Implications of these results on the mechanistic understanding of the CO oxidation on Au/TiO2, in particular on the role of different active oxygen species, will be discussed.展开更多
Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments,such as high-glucose,excessive reactive oxygen species(ROS),hypoxia and malnutrition.Unfortunately,few stra...Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments,such as high-glucose,excessive reactive oxygen species(ROS),hypoxia and malnutrition.Unfortunately,few strategies have been developed to ameliorate the multiple microenvironments simultaneously.In this study,Chlorella sp.(Chlorella)hydrogels were prepared against diabetic wounds.In vitro experiments demonstrated that living Chlorella could produce dissolved oxygen by photosynthesis,actively consume glucose and deplete ROS with the inherent antioxidants,during the daytime.At night,Chlorella was inactivated in situ by chlorine dioxide with human-body harmless concentration to utilize its abundant contents.It was verified in vitro that the inactivated-Chlorella could supply nutrition,relieve inflammation and terminate the oxygen-consumption of Chlorella-respiration.The advantages of living Chlorella and its contents were integrated ingeniously.The abovementioned functions were proven to accelerate cell proliferation,migration and angiogenesis in vitro.Then,streptozotocininduced diabetic mice were employed for further validation.The in vivo outcomes confirmed that Chlorella could ameliorate the undesirable microenvironments,including hypoxia,high-glucose,excessiveROS and chronic inflammation,thereby synergistically promoting tissue regeneration.Given the results above,Chlorella is considered as a tailor-made therapeutic strategy for diabetic wound healing.展开更多
Cycloclypeus carpenteri is the largest extant benthic foraminifer,dwelling in the deep euphotic zone(a water depth between 60 and 130 m)of the warm oligotrophic Indo-West Pacific.This foraminifer harbors diatom endosy...Cycloclypeus carpenteri is the largest extant benthic foraminifer,dwelling in the deep euphotic zone(a water depth between 60 and 130 m)of the warm oligotrophic Indo-West Pacific.This foraminifer harbors diatom endosymbionts and the foraminifer-microalgal association acts like a holobiont.To verify that light is an important limiting factor controlling the vertical(depth)distribution of living Cycloclypeus holobionts,their physiological responses to light intensity were examined by short-term metabolic measurements and long-term incubations.Net oxygen production(OP)rates measured under different light levels using an oxygen microelectrode indicate that Cycloclypeus holobionts are daily net primary producers adapted to low light levels,with slight photoinhibition(reduced net OP rates relative to a light-saturated rate)over 100μmol photons m^(−2)s^(−1).Long-term growth increments of asexually reproduced juveniles incubated for two months at different light levels ranging from 0 to 100μmol photons m^(−2)s^(−1) show that Cycloclypeus holobionts are adapted to a low light level(∼5μmol photons m^(−2)s^(−1)),but can be acclimatized to a certain low light ranges(<50μmol photons m^(−2)s^(−1)).These experimental results confirm that light is an important environmental gradient affecting the vertical distribution of Cycloclypeus holobionts.展开更多
The water modelling experiments of 300 t converter concerning combined blowing parameters, the number, and configuration of bottom nozzles are carried out. The results show that the arrangement of 16 bottom nozzles at...The water modelling experiments of 300 t converter concerning combined blowing parameters, the number, and configuration of bottom nozzles are carried out. The results show that the arrangement of 16 bottom nozzles at 0. 40D and 0. 45D （hearth diameter） concentric circles is the reasonable solution. The combined blowing steel- making technique of 300 t converter has been developed through experiments and studies relating to optimizing the top-bottom combined blowing pattern, the number and configuration of the bottom nozzles, the type selection of bot- tom nozzle, and bottom nozzle maintenance techniques. The results show that the product of w[c] ＂ w[o] at endpoint is reduced from 0. 002 62 to 0. 002 43, average TFe content is decreased by %, phosphorus distribution is raised from 70.85 to 78.95, sulfur distribution is raised from 3.43 to 4.32 and manganese content is raised by 0.02%.展开更多
Stimuli-responsive delivery systems hold promise in cancer treatments.However,their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy ...Stimuli-responsive delivery systems hold promise in cancer treatments.However,their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy in tumors,resulting in undesirable therapeutic outcomes.Herein,we have developed a novel redox-sensitive pegylated phospholipid,termed as DOPE-SS-PEG,which can form a glutathione(GSH)-triggered precision explosive system(GPS)for simultaneously improving circulation stability,tumor specificity,and chemosensitivity,leading to explosive anticancer effects.GPS is constructed of liposomal doxorubicin(DOX)functionalized with DOPE-SS-PEG and MnO_(2) nanoparticles,which can protect liposome structure in the presence of serum GSH(20μM),whereas converts to cationic liposome in response to intracellular GSH(10 mM),thereby enhancing circulation stability,tumor specificity,endosomal escape,and cytoplasmic delivery.Importantly,GPS can not only generate oxygen to relieve hypoxia and consequently enhance chemosensitivity,but quench GSH antioxidability to elevate the accruement of intracellular reactive oxygen species(ROS),leading to an explosion of oxidative stress induced cell injury.Particularly,in vivo studies show that GPS selectively accumulates in tumor tissues,effectively inhibits tumor growth,exhibits minimal systemic adverse effects,and consequently prolongs the survival time of tumor-bearing mice.Therefore,GPS is a unique stimuli-responsive treatment with programmed and on-demand drug delivery,as well as explosive therapeutic efficacy,and provides an intelligent anticancer treatment.展开更多
The design and operation of radial flow adsorber are crucial in large-scale industrial oxygen production,which necessitate accurate prediction of gas-solid transfer behavior.In this work,a developed Computational Flui...The design and operation of radial flow adsorber are crucial in large-scale industrial oxygen production,which necessitate accurate prediction of gas-solid transfer behavior.In this work,a developed Computational Fluid Dynamics-Discrete Element Method(CFD-DEM)model combined with the adsorption model is proposed.The developed CFD-DEM model is validated by comparing simulated results with experimental data and empirical correlation.Subsequently,the effect of particle packing structure and particle shapes on the dynamic adsorption process are analyzed in detail.The results reveal the mechanism of particle packing structure affecting axial velocity distribution,showing that uneven distribution of resistance on the outer flow channel side leads to uneven axial velocity distribution in the bed.Compared to cylindrical adsorbents,the use of spherical adsorbents results in a more uniform axial velocity distribution,consequently reducing bed pressure drop.The study holds significant potential for optimizing gas distribution and improving separation efficiency in future industrial applications.展开更多
文摘An S-scheme heterojunction photocatalyst is capable of boosting photogenerated carrier separation and transfer,thus maintaining high photooxidation and photoredox ability.Herein,a 0D Ag_(3)PO_(4) nanoparticles(NPs)/1D TiO_(2) nanofibers(NFs)S-scheme heterojunction with intimate interfacial contact was designed via the the hydro-thermal method.Benefiting from the abundant hydroxyl groups and size confinement effect of TiO_(2) NFs,the average diameter of the Ag_(3)PO_(4) nanoparticles decreased from 100 to 22 nm,which favored the construction of a 0D/1D geometry heterojunction.The multifunctional Ag_(3)PO_(4)/TiO_(2) sample exhibited excellent photocatalytic activity and stability in photocatalytic oxygen production(726μmol/g/h)and photocatalytic degradation of various organic contaminants such as rhodamine B(100%),phenol(60%)and tetracycline hydrochloride(100%).The significant improvements in the photocatalytic performance and stability can be attributed to the intimate interfacial contacts and rich active sites of 0D/1D geometry,fast charge carrier migration,and outstanding photoredox properties induced by the S-scheme charge-transfer route.This work offers a promising strategy for constructing 0D/1D S-scheme heterojunction photocatalysts for improved photocatalytic performance.
文摘Applying quantitative temporal analysis of products reactor measurements, we studied the reactive removal of active oxygen present on Au/TiO2 catalysts after calcination at elevated temperatures （400 ＆#176;C） by CO pulses and its replenishment by O2 pulses at 80 ＆#176;C, focusing on the nature of the active oxygen species. In contrast to previous studies, which mainly focused on and clarified the nature of the active oxygen species for the catalytic CO oxidation, which is reversibly formed and replenished under typical reaction conditions, this study demonstrates that directly after calcina‐tion an additional oxygen species is present. This species is also active for the CO oxidation, but it is not or only very little formed under typical reaction conditions. Implications of these results on the mechanistic understanding of the CO oxidation on Au/TiO2, in particular on the role of different active oxygen species, will be discussed.
基金financially supported by the National Natural Science Foundation of China(81673830)Six Talent Peaks Project in Jiangsu Province(YY053,China)+1 种基金Major Project and Double firstclass innovative team(CPU2018GY28,China)National Science and Technology Major Project(2017zx09101001005,China)。
文摘Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments,such as high-glucose,excessive reactive oxygen species(ROS),hypoxia and malnutrition.Unfortunately,few strategies have been developed to ameliorate the multiple microenvironments simultaneously.In this study,Chlorella sp.(Chlorella)hydrogels were prepared against diabetic wounds.In vitro experiments demonstrated that living Chlorella could produce dissolved oxygen by photosynthesis,actively consume glucose and deplete ROS with the inherent antioxidants,during the daytime.At night,Chlorella was inactivated in situ by chlorine dioxide with human-body harmless concentration to utilize its abundant contents.It was verified in vitro that the inactivated-Chlorella could supply nutrition,relieve inflammation and terminate the oxygen-consumption of Chlorella-respiration.The advantages of living Chlorella and its contents were integrated ingeniously.The abovementioned functions were proven to accelerate cell proliferation,migration and angiogenesis in vitro.Then,streptozotocininduced diabetic mice were employed for further validation.The in vivo outcomes confirmed that Chlorella could ameliorate the undesirable microenvironments,including hypoxia,high-glucose,excessiveROS and chronic inflammation,thereby synergistically promoting tissue regeneration.Given the results above,Chlorella is considered as a tailor-made therapeutic strategy for diabetic wound healing.
基金partly supported by the JSPS KAKENHI(No.JP17740341)。
文摘Cycloclypeus carpenteri is the largest extant benthic foraminifer,dwelling in the deep euphotic zone(a water depth between 60 and 130 m)of the warm oligotrophic Indo-West Pacific.This foraminifer harbors diatom endosymbionts and the foraminifer-microalgal association acts like a holobiont.To verify that light is an important limiting factor controlling the vertical(depth)distribution of living Cycloclypeus holobionts,their physiological responses to light intensity were examined by short-term metabolic measurements and long-term incubations.Net oxygen production(OP)rates measured under different light levels using an oxygen microelectrode indicate that Cycloclypeus holobionts are daily net primary producers adapted to low light levels,with slight photoinhibition(reduced net OP rates relative to a light-saturated rate)over 100μmol photons m^(−2)s^(−1).Long-term growth increments of asexually reproduced juveniles incubated for two months at different light levels ranging from 0 to 100μmol photons m^(−2)s^(−1) show that Cycloclypeus holobionts are adapted to a low light level(∼5μmol photons m^(−2)s^(−1)),but can be acclimatized to a certain low light ranges(<50μmol photons m^(−2)s^(−1)).These experimental results confirm that light is an important environmental gradient affecting the vertical distribution of Cycloclypeus holobionts.
文摘The water modelling experiments of 300 t converter concerning combined blowing parameters, the number, and configuration of bottom nozzles are carried out. The results show that the arrangement of 16 bottom nozzles at 0. 40D and 0. 45D （hearth diameter） concentric circles is the reasonable solution. The combined blowing steel- making technique of 300 t converter has been developed through experiments and studies relating to optimizing the top-bottom combined blowing pattern, the number and configuration of the bottom nozzles, the type selection of bot- tom nozzle, and bottom nozzle maintenance techniques. The results show that the product of w[c] ＂ w[o] at endpoint is reduced from 0. 002 62 to 0. 002 43, average TFe content is decreased by %, phosphorus distribution is raised from 70.85 to 78.95, sulfur distribution is raised from 3.43 to 4.32 and manganese content is raised by 0.02%.
基金This work were supported by the National Key Research and Development Program of China(No.2019YFA0802800)the National Key Research and Development Program of China(No.2018YFB1105400)+3 种基金the National Natural Science Foundation of China(No.21472090)the Natural Science Foundation of Jiangsu Province(No.BK20180334)the Fundamental Research Funds for Central Universities Nanjing University,the Scientific Research Foundation of Graduate School of Nanjing University(No.2018CL12)The Key Research and Development Program of Jiangsu Provincial Department of Science and Technology of China(No.BE2019002).
文摘Stimuli-responsive delivery systems hold promise in cancer treatments.However,their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy in tumors,resulting in undesirable therapeutic outcomes.Herein,we have developed a novel redox-sensitive pegylated phospholipid,termed as DOPE-SS-PEG,which can form a glutathione(GSH)-triggered precision explosive system(GPS)for simultaneously improving circulation stability,tumor specificity,and chemosensitivity,leading to explosive anticancer effects.GPS is constructed of liposomal doxorubicin(DOX)functionalized with DOPE-SS-PEG and MnO_(2) nanoparticles,which can protect liposome structure in the presence of serum GSH(20μM),whereas converts to cationic liposome in response to intracellular GSH(10 mM),thereby enhancing circulation stability,tumor specificity,endosomal escape,and cytoplasmic delivery.Importantly,GPS can not only generate oxygen to relieve hypoxia and consequently enhance chemosensitivity,but quench GSH antioxidability to elevate the accruement of intracellular reactive oxygen species(ROS),leading to an explosion of oxidative stress induced cell injury.Particularly,in vivo studies show that GPS selectively accumulates in tumor tissues,effectively inhibits tumor growth,exhibits minimal systemic adverse effects,and consequently prolongs the survival time of tumor-bearing mice.Therefore,GPS is a unique stimuli-responsive treatment with programmed and on-demand drug delivery,as well as explosive therapeutic efficacy,and provides an intelligent anticancer treatment.
基金financially supported by the National Key R&D Program of China(grant No.2019YFB1505000).
文摘The design and operation of radial flow adsorber are crucial in large-scale industrial oxygen production,which necessitate accurate prediction of gas-solid transfer behavior.In this work,a developed Computational Fluid Dynamics-Discrete Element Method(CFD-DEM)model combined with the adsorption model is proposed.The developed CFD-DEM model is validated by comparing simulated results with experimental data and empirical correlation.Subsequently,the effect of particle packing structure and particle shapes on the dynamic adsorption process are analyzed in detail.The results reveal the mechanism of particle packing structure affecting axial velocity distribution,showing that uneven distribution of resistance on the outer flow channel side leads to uneven axial velocity distribution in the bed.Compared to cylindrical adsorbents,the use of spherical adsorbents results in a more uniform axial velocity distribution,consequently reducing bed pressure drop.The study holds significant potential for optimizing gas distribution and improving separation efficiency in future industrial applications.
