期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques 被引量:2
1
作者 Mo Chen Yuan Zhang +4 位作者 Xiao-Ting Que Ya Ding Lin Yang Ai-Dong Wen Tai-Jun Hang 《Journal of Pharmaceutical Analysis》 SCIE CAS 2013年第6期387-393,共7页
Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokiuetic properties o... Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokiuetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02-10 pg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.0540 pg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA. 展开更多
关键词 Inosiplex N N-dimethylamino-2-propanol p-acetaminobenzoic acid LC/MS/MS HPLC Pharmacokinetics
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部