The Object of the Study: The author of the given paper describes an unusual combination of two diseases: extramammary Paget’s disease manifested by intraepithelial adenocarcinoma of the vulva and anus combined with i...The Object of the Study: The author of the given paper describes an unusual combination of two diseases: extramammary Paget’s disease manifested by intraepithelial adenocarcinoma of the vulva and anus combined with invasive adenocarcinoma of the ampullary part of the rectum and describes the atypical manifestations of these diseases. The Content: The content of this research paper includes a description of the patient, an analysis of the clinical picture, diagnostic methods and therapeutic interventions used, a report of the following disease, and the result of the presented case. The Result of the Research Work: The result of the research work is the analysis of a clinical case with two different tumors, where such a combination of tumors is rarely described in the literature. Moreover, no large specific sample with this combination of diseases is available. Patient Characteristics: The given case report describes a patient of the Palliative Care Unit of the Gerontology Clinic with a primary diagnosis of C20-rectal adenocarcinoma in the background of the anal canal, perineal skin Paget’s disease, stage IV. The presented complications of the patient’s primary diagnosis are multiple metastases in the liver;status post palliative chemotherapy;hepatomegaly;metastases to abdominal lymph nodes, inguinal lymph nodes;metastases at Th12, L4 level;pain syndrome. The presented above combination of diagnosed diseases is very rare. Applied Diagnostics: In October 2021, it was performed diagnostic manipulation: biopsy and the pathologist have provided a microscopic description. The first tissue fragment had a pronounced electrothermal lesion and the epithelial structures were not valuable. The second skin tissue fragment was covered with hyperplastic and acanthotic epithelium;its basal and middle layers contained multiple large cells proliferates extending into the medial epidermis, and the cytoplasm of these cells reacted positively with PAS (Periodic Acid Schiff reaction). It needs to be noted that the patient had previously had several years of biopsies from the perineal and anal epidermis, where Paget’s disease had also been diagnosed. The performed immunohistochemistry showed these cells to be CK20 positive, CK7 rare positive and p16 negative. The following pathohistological findings were made: morphological and immunohistochemical picture is consistent with Paget’s disease. According to the ICD-10, the patient was diagnosed with C51 malignant neoplasm of the female external genitalia. Using imaging diagnostics, it became clear that the patient’s rectal adenocarcinoma had progressed to metastatic stage with distant liver metastases in the background of anal canal, perineal skin Paget’s disease. Therapeutic Plan of the Patient: Based on the patient’s main diagnoses, the complications of the principal diagnosis, the patient’s overall severe condition, pain syndrome, age and comorbidities, palliative chemotherapy was approved as a therapeutic option in council of doctors. Monitoring and Outcome of the Patient: The patient’s general condition was becoming worse over time, and she was diagnosed with exitus latalis in December 2022. At that time, the patient was discharged from hospital and was on palliative care at home under the control of her family physician.展开更多
Reconstruction of liquid free slosh modes by curved quiet free surface was investigated in the case of small Bond number by means of modal part analysis method in this paper. It is shown that the curved liquid quiet f...Reconstruction of liquid free slosh modes by curved quiet free surface was investigated in the case of small Bond number by means of modal part analysis method in this paper. It is shown that the curved liquid quiet free surface would couple the modes to form new eigen-modes while the orthogonality of the modes which participate the liquid slosh are given only by their Bessel modal parts and it would change their eigen-frequencies respectively while the orthogonality are given by their triangle function modal parts. By studying the laterally forced slosh of the liquid in a cylindrical container based on the new eigen-modes, a characteristic of modes-choosing was found.展开更多
Based on an investigation on the current situation of SPM in some enterprises, this paper presents the common probletns and poor fields existing in SPM in enterprise; analyzes the reasons which resulted in the situati...Based on an investigation on the current situation of SPM in some enterprises, this paper presents the common probletns and poor fields existing in SPM in enterprise; analyzes the reasons which resulted in the situation, and then puts forward some feasible measures to improve it. Lastly, some fields that should be paid more attention in SPM are provided.展开更多
A new concept called intelligent virtual control (IVC), which can be drivenby measuring functions, is put forward. This small 'intelligent measurement instrument unit (IMIU)',carrying with functions of instrum...A new concept called intelligent virtual control (IVC), which can be drivenby measuring functions, is put forward. This small 'intelligent measurement instrument unit (IMIU)',carrying with functions of instrument, consists of different types of intelligent virtualinstrument (IVI) through individual components together as building blocks and can be displayeddirectly on the computer screen. This is a new concept of measuring instrument, and also animportant breakthrough after virtual instrument (VI). Virtual control makes instrument resourcesobtain further exploitation. It brings about a fundamental change to the design and manufacturingmode. The instrument therefore, can not only be produced directly inside a PC, but the product isinvolved in the 'green product' system. So far, all the present digital instruments will grow to bereplaced by intelligent control with green characteristics.展开更多
This paper’s simple ecological model to simulate the ecosystem variation and the vertical carbon flux in the central part of the East China Sea in spring, inter-reated the phytoplankton, zooplankton,autotrophic and h...This paper’s simple ecological model to simulate the ecosystem variation and the vertical carbon flux in the central part of the East China Sea in spring, inter-reated the phytoplankton, zooplankton,autotrophic and heterotrophic bacterioplankton, nitrate, and dissolved organic carbon (DOC) in a run lasting 90 days. Except for DOC, because of poor observation precision,the major seasonal features of the vertical distribution for these components can be simulated by this model. The results show that spring bloom is just a short period of 1-2 weeks and that deposit carbon flux at the bottom interface is about 200 mg /m2 ·d in the first 20 days and then reaches its maximum of 1500mg/m2·d about 2 months later after the spring bloom.展开更多
Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 ℃ to 201 ℃ in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarb...Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 ℃ to 201 ℃ in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarbons discovered in the Bohai Bay Basin in eastern China. This discovery suggests favorable exploration prospects for the deep parts of the basin. However, the discovery raises questions regarding the genesis and accumulation of hydrocarbons in deep reservoirs. Based on the geochemical features of the hydrocarbons and characteristics of the source rocks as well as thermal simulation experiments of hydrocarbon generation, we conclude that the oil and gas were generated from the highly mature Sha-4 Member （Es4） source rocks instead of thermal cracking of crude oils in earlier accumulations. The source kitchen with abnormal pressures and karsted carbonate reservoirs control the formation of high-maturity hydrocarbon accumulations in the buried hills （i.e., Niudong-1） in conjunction with several structural-lithologic traps in the ES4 reservoirs since the deposition of the upper Minghuazhen Formation. This means the oil and gas exploration potential in the deep parts of the Baxian Depression is probably high.展开更多
In many fields of high-tech industry the ultra-t hi n wall parts are employed. In this paper the experiments were carried out to dis cuss the surface microstructure of the camera’s guided drawtube by applying ult ras...In many fields of high-tech industry the ultra-t hi n wall parts are employed. In this paper the experiments were carried out to dis cuss the surface microstructure of the camera’s guided drawtube by applying ult rasonic vibration cutting device to the traditional lathe. The influence rule of the cutting condition on the surface roughness was put forward, which was drawn by comparing the ultrasonic cutting with the common cutting by use of the cemen ted carbide tool and the polycrystalline diamond (PCD) tool. The test results sh owed that the ultrasonic cutting performs better than the common cutting in the same condition. According to the test results analyzing, the surface characteriz ation is influenced clearly by the rigidity of the acoustic system and the machi ne tool, as well the setting height of the tool tip. Otherwise, the dense regula r low frequency vibration ripples will be scraped on the machined surface. When the tool tip is set higher than the rotating center of the work piece by three t imes of the amplitude of ultrasonic vibration, the vibration ripples behave alig ht; they turn light and shade alternatively when the tool tip is lower than the rotating center of the work piece by three times of the amplitude of ultrasonic vibration. According to the test result analyzing, the following conclusions are put forward: 1) The surface roughness in ultrasonic cutting is better than that in common cutting. Under a one third critical cutting velocity, the value of th e surface roughness in ultrasonic cutting rise slightly along with the cutting v elocity, while in common cutting it decreases contrast to the cutting velocity; the curves of the surface roughness in ultrasonic cutting and common cutting see m to be alike, both increase along with the feed rate and the cutting depth, but the value in ultrasonic cutting is smaller in the same condition.2) The influen ce of the coolant on the surface roughness cannot be ignored. The kerosene can b e employed to improve the surface roughness in ultrasonic machining.3) In ultras onic cutting process of aluminum alloy ultra-thin wall work piece, the PCD tool performs better than the cemented carbide tools.4) The vibration ripples result from the not enough rigidity of the acoustic system and the improper setting he ight of the tool tip. The departure of the tool tip from the rotating center of the work piece to some extent causes the vibration ripples on the machined surfa ce.展开更多
A novel technique of electroforming with orbital moving cathode was carried out for the fabrication of non-rotating thin-walled parts.This technique features a large number of insulating and insoluble hard particles a...A novel technique of electroforming with orbital moving cathode was carried out for the fabrication of non-rotating thin-walled parts.This technique features a large number of insulating and insoluble hard particles as a real-time polishing to the cathode.When cathode moves,hard particles polish its surface and provide the nickel non-rotating parts with near-mirror finishing.Morphology,microstructure,surface roughness and micro hardness of deposits fabricated by novel method were studied in contrast with the sample produced by traditional electroforming methods.Theoretical analysis and experimental results showed that the novel technique could effectively remove the hydrogen bubbles and nodules,disturb the crystal nucleation,and refine the grains of layer.The mechanical properties were significantly improved over traditional method.The micro-hardness of the layer was in a uniform distribution ranging from 345 HV to 360 HV.It was confirmed that this technique had practical significance to non-rotating thin-walled parts.展开更多
Two new saponins named mongholicoside A （1） and mongholicoside B （2） were isolated from the aerial part of Astragalus membranaceus var mongholicus. Their structures were determined by 1D and 2D NMR, ESI-MS techniq...Two new saponins named mongholicoside A （1） and mongholicoside B （2） were isolated from the aerial part of Astragalus membranaceus var mongholicus. Their structures were determined by 1D and 2D NMR, ESI-MS techniques and chemical methods.展开更多
Currently, simultaneously ensuring the machining accuracy and efficiency of thin-walled structures especially high performance parts still remains a challenge. Existing compensating methods are mainly focusing on 3-ai...Currently, simultaneously ensuring the machining accuracy and efficiency of thin-walled structures especially high performance parts still remains a challenge. Existing compensating methods are mainly focusing on 3-aixs machining, which sometimes only take one given point as the compensative point at each given cutter location. This paper presents a redesigned surface based machining strategy for peripheral milling of thin-walled parts. Based on an improved cutting force/heat model and finite element method（FEM） simulation environment, a deflection error prediction model, which takes sequence of cutter contact lines as compensation targets, is established. And an iterative algorithm is presented to determine feasible cutter axis positions. The final redesigned surface is subsequently generated by skinning all discrete cutter axis vectors after compensating by using the proposed algorithm. The proposed machining strategy incorporates the thermo-mechanical coupled effect in deflection prediction, and is also validated with flank milling experiment by using five-axis machine tool. At the same time, the deformation error is detected by using three-coordinate measuring machine. Error prediction values and experimental results indicate that they have a good consistency and the proposed approach is able to significantly reduce the dimension error under the same machining conditions compared with conventional methods. The proposed machining strategy has potential in high-efficiency precision machining of thin-walled parts.展开更多
文摘The Object of the Study: The author of the given paper describes an unusual combination of two diseases: extramammary Paget’s disease manifested by intraepithelial adenocarcinoma of the vulva and anus combined with invasive adenocarcinoma of the ampullary part of the rectum and describes the atypical manifestations of these diseases. The Content: The content of this research paper includes a description of the patient, an analysis of the clinical picture, diagnostic methods and therapeutic interventions used, a report of the following disease, and the result of the presented case. The Result of the Research Work: The result of the research work is the analysis of a clinical case with two different tumors, where such a combination of tumors is rarely described in the literature. Moreover, no large specific sample with this combination of diseases is available. Patient Characteristics: The given case report describes a patient of the Palliative Care Unit of the Gerontology Clinic with a primary diagnosis of C20-rectal adenocarcinoma in the background of the anal canal, perineal skin Paget’s disease, stage IV. The presented complications of the patient’s primary diagnosis are multiple metastases in the liver;status post palliative chemotherapy;hepatomegaly;metastases to abdominal lymph nodes, inguinal lymph nodes;metastases at Th12, L4 level;pain syndrome. The presented above combination of diagnosed diseases is very rare. Applied Diagnostics: In October 2021, it was performed diagnostic manipulation: biopsy and the pathologist have provided a microscopic description. The first tissue fragment had a pronounced electrothermal lesion and the epithelial structures were not valuable. The second skin tissue fragment was covered with hyperplastic and acanthotic epithelium;its basal and middle layers contained multiple large cells proliferates extending into the medial epidermis, and the cytoplasm of these cells reacted positively with PAS (Periodic Acid Schiff reaction). It needs to be noted that the patient had previously had several years of biopsies from the perineal and anal epidermis, where Paget’s disease had also been diagnosed. The performed immunohistochemistry showed these cells to be CK20 positive, CK7 rare positive and p16 negative. The following pathohistological findings were made: morphological and immunohistochemical picture is consistent with Paget’s disease. According to the ICD-10, the patient was diagnosed with C51 malignant neoplasm of the female external genitalia. Using imaging diagnostics, it became clear that the patient’s rectal adenocarcinoma had progressed to metastatic stage with distant liver metastases in the background of anal canal, perineal skin Paget’s disease. Therapeutic Plan of the Patient: Based on the patient’s main diagnoses, the complications of the principal diagnosis, the patient’s overall severe condition, pain syndrome, age and comorbidities, palliative chemotherapy was approved as a therapeutic option in council of doctors. Monitoring and Outcome of the Patient: The patient’s general condition was becoming worse over time, and she was diagnosed with exitus latalis in December 2022. At that time, the patient was discharged from hospital and was on palliative care at home under the control of her family physician.
文摘Reconstruction of liquid free slosh modes by curved quiet free surface was investigated in the case of small Bond number by means of modal part analysis method in this paper. It is shown that the curved liquid quiet free surface would couple the modes to form new eigen-modes while the orthogonality of the modes which participate the liquid slosh are given only by their Bessel modal parts and it would change their eigen-frequencies respectively while the orthogonality are given by their triangle function modal parts. By studying the laterally forced slosh of the liquid in a cylindrical container based on the new eigen-modes, a characteristic of modes-choosing was found.
文摘Based on an investigation on the current situation of SPM in some enterprises, this paper presents the common probletns and poor fields existing in SPM in enterprise; analyzes the reasons which resulted in the situation, and then puts forward some feasible measures to improve it. Lastly, some fields that should be paid more attention in SPM are provided.
基金This project is supported by National Natural Science Foundation of China(No.50135050).
文摘A new concept called intelligent virtual control (IVC), which can be drivenby measuring functions, is put forward. This small 'intelligent measurement instrument unit (IMIU)',carrying with functions of instrument, consists of different types of intelligent virtualinstrument (IVI) through individual components together as building blocks and can be displayeddirectly on the computer screen. This is a new concept of measuring instrument, and also animportant breakthrough after virtual instrument (VI). Virtual control makes instrument resourcesobtain further exploitation. It brings about a fundamental change to the design and manufacturingmode. The instrument therefore, can not only be produced directly inside a PC, but the product isinvolved in the 'green product' system. So far, all the present digital instruments will grow to bereplaced by intelligent control with green characteristics.
文摘This paper’s simple ecological model to simulate the ecosystem variation and the vertical carbon flux in the central part of the East China Sea in spring, inter-reated the phytoplankton, zooplankton,autotrophic and heterotrophic bacterioplankton, nitrate, and dissolved organic carbon (DOC) in a run lasting 90 days. Except for DOC, because of poor observation precision,the major seasonal features of the vertical distribution for these components can be simulated by this model. The results show that spring bloom is just a short period of 1-2 weeks and that deposit carbon flux at the bottom interface is about 200 mg /m2 ·d in the first 20 days and then reaches its maximum of 1500mg/m2·d about 2 months later after the spring bloom.
文摘Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 ℃ to 201 ℃ in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarbons discovered in the Bohai Bay Basin in eastern China. This discovery suggests favorable exploration prospects for the deep parts of the basin. However, the discovery raises questions regarding the genesis and accumulation of hydrocarbons in deep reservoirs. Based on the geochemical features of the hydrocarbons and characteristics of the source rocks as well as thermal simulation experiments of hydrocarbon generation, we conclude that the oil and gas were generated from the highly mature Sha-4 Member （Es4） source rocks instead of thermal cracking of crude oils in earlier accumulations. The source kitchen with abnormal pressures and karsted carbonate reservoirs control the formation of high-maturity hydrocarbon accumulations in the buried hills （i.e., Niudong-1） in conjunction with several structural-lithologic traps in the ES4 reservoirs since the deposition of the upper Minghuazhen Formation. This means the oil and gas exploration potential in the deep parts of the Baxian Depression is probably high.
文摘In many fields of high-tech industry the ultra-t hi n wall parts are employed. In this paper the experiments were carried out to dis cuss the surface microstructure of the camera’s guided drawtube by applying ult rasonic vibration cutting device to the traditional lathe. The influence rule of the cutting condition on the surface roughness was put forward, which was drawn by comparing the ultrasonic cutting with the common cutting by use of the cemen ted carbide tool and the polycrystalline diamond (PCD) tool. The test results sh owed that the ultrasonic cutting performs better than the common cutting in the same condition. According to the test results analyzing, the surface characteriz ation is influenced clearly by the rigidity of the acoustic system and the machi ne tool, as well the setting height of the tool tip. Otherwise, the dense regula r low frequency vibration ripples will be scraped on the machined surface. When the tool tip is set higher than the rotating center of the work piece by three t imes of the amplitude of ultrasonic vibration, the vibration ripples behave alig ht; they turn light and shade alternatively when the tool tip is lower than the rotating center of the work piece by three times of the amplitude of ultrasonic vibration. According to the test result analyzing, the following conclusions are put forward: 1) The surface roughness in ultrasonic cutting is better than that in common cutting. Under a one third critical cutting velocity, the value of th e surface roughness in ultrasonic cutting rise slightly along with the cutting v elocity, while in common cutting it decreases contrast to the cutting velocity; the curves of the surface roughness in ultrasonic cutting and common cutting see m to be alike, both increase along with the feed rate and the cutting depth, but the value in ultrasonic cutting is smaller in the same condition.2) The influen ce of the coolant on the surface roughness cannot be ignored. The kerosene can b e employed to improve the surface roughness in ultrasonic machining.3) In ultras onic cutting process of aluminum alloy ultra-thin wall work piece, the PCD tool performs better than the cemented carbide tools.4) The vibration ripples result from the not enough rigidity of the acoustic system and the improper setting he ight of the tool tip. The departure of the tool tip from the rotating center of the work piece to some extent causes the vibration ripples on the machined surfa ce.
基金Funded partly by the National Natural Science Foundation of China(No.50975143)the Aviation Science Funds,China (No.2009ZE52048)
文摘A novel technique of electroforming with orbital moving cathode was carried out for the fabrication of non-rotating thin-walled parts.This technique features a large number of insulating and insoluble hard particles as a real-time polishing to the cathode.When cathode moves,hard particles polish its surface and provide the nickel non-rotating parts with near-mirror finishing.Morphology,microstructure,surface roughness and micro hardness of deposits fabricated by novel method were studied in contrast with the sample produced by traditional electroforming methods.Theoretical analysis and experimental results showed that the novel technique could effectively remove the hydrogen bubbles and nodules,disturb the crystal nucleation,and refine the grains of layer.The mechanical properties were significantly improved over traditional method.The micro-hardness of the layer was in a uniform distribution ranging from 345 HV to 360 HV.It was confirmed that this technique had practical significance to non-rotating thin-walled parts.
基金This research was financially supported by the key program of National Natural Science Foundation of China （No. 30530870）.
文摘Two new saponins named mongholicoside A （1） and mongholicoside B （2） were isolated from the aerial part of Astragalus membranaceus var mongholicus. Their structures were determined by 1D and 2D NMR, ESI-MS techniques and chemical methods.
基金supported by Key Program of National Natural Science Foundation of China (Grant No. 50835001) General Program of National Natural Science Foundation of China (Grant No. 50775023)Program for New Century Excellent Talents of Ministry of Education of China (Grant No. NCET-08-081)
文摘Currently, simultaneously ensuring the machining accuracy and efficiency of thin-walled structures especially high performance parts still remains a challenge. Existing compensating methods are mainly focusing on 3-aixs machining, which sometimes only take one given point as the compensative point at each given cutter location. This paper presents a redesigned surface based machining strategy for peripheral milling of thin-walled parts. Based on an improved cutting force/heat model and finite element method（FEM） simulation environment, a deflection error prediction model, which takes sequence of cutter contact lines as compensation targets, is established. And an iterative algorithm is presented to determine feasible cutter axis positions. The final redesigned surface is subsequently generated by skinning all discrete cutter axis vectors after compensating by using the proposed algorithm. The proposed machining strategy incorporates the thermo-mechanical coupled effect in deflection prediction, and is also validated with flank milling experiment by using five-axis machine tool. At the same time, the deformation error is detected by using three-coordinate measuring machine. Error prediction values and experimental results indicate that they have a good consistency and the proposed approach is able to significantly reduce the dimension error under the same machining conditions compared with conventional methods. The proposed machining strategy has potential in high-efficiency precision machining of thin-walled parts.
