Objective To explore interaction and interrelationship between TGF - β/Smad signal pathway and Wnt/β - catenin signal pathway in pathogenesis of pathological scar. Methods Three cases of keloid ( K group) ,3 of hype...Objective To explore interaction and interrelationship between TGF - β/Smad signal pathway and Wnt/β - catenin signal pathway in pathogenesis of pathological scar. Methods Three cases of keloid ( K group) ,3 of hyperplastic scar ( H group) and 3 of normal skin ( N group) were selected randomly, and then展开更多
Objective To explore the efficacyof Scar Infusion Instrument on expression of Type I Collagen and Cell Proliferation Markers in Pathological Scars.Methods 70 cases patients with pathologic scar admitted in our hospita...Objective To explore the efficacyof Scar Infusion Instrument on expression of Type I Collagen and Cell Proliferation Markers in Pathological Scars.Methods 70 cases patients with pathologic scar admitted in our hospital from Augst 2016 to July 2017 were randomly divided into study group and control group.The control group was treated with scar ointment.The treatment group was treated with scar ointment combined with scar The expression of COL-I in scar tissue was determined by enzyme-linked immunosorbent assay(ELISA).The expression of ki-67 nuclear protein was determined by immunohistochemical staining(sp).Results The efficacy of the study group was significantly better than the control group,the total efficiency of the study group was significantly higher than the control group after 6 months treatment(P<0.05);The average COL-I and Ki67 nuclear protein expression in the single slice of the study group was significantly lower than that of the control group at the 3th months,6th months after treatment(P<0.001).Conclusions The scarring device is more effective in the treatment of pathological scar,and its mechanism may be related to the better inhibition of COL-I and ki-67 nucleoprotein expression.展开更多
There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases....There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars.展开更多
The morphological and functional barriers caused by pathological scars are extremely painful for patients.Up to now,pathological scar poses a big unmet medical challenge for plastic surgeons and dermatologists worldwi...The morphological and functional barriers caused by pathological scars are extremely painful for patients.Up to now,pathological scar poses a big unmet medical challenge for plastic surgeons and dermatologists worldwide.Macrophage polarization has shown a non-negligible effect on wound healing and scar formation.However,the role of macrophages in wound healing and pathological scar formation is still controversial.To summarize the latest data on probing biological functions of macrophage polarization in wound healing and scar formation and target macrophages in wound healing,we particularly paid attention to studies on different groups of macrophages,the transition among those groups,and modulators regulating the transition process.A comprehensive understanding of macrophage polarization in wound healing is certain to facilitate the development of new and efficient therapeutic modalities for pathological scar.展开更多
文摘Objective To explore interaction and interrelationship between TGF - β/Smad signal pathway and Wnt/β - catenin signal pathway in pathogenesis of pathological scar. Methods Three cases of keloid ( K group) ,3 of hyperplastic scar ( H group) and 3 of normal skin ( N group) were selected randomly, and then
文摘Objective To explore the efficacyof Scar Infusion Instrument on expression of Type I Collagen and Cell Proliferation Markers in Pathological Scars.Methods 70 cases patients with pathologic scar admitted in our hospital from Augst 2016 to July 2017 were randomly divided into study group and control group.The control group was treated with scar ointment.The treatment group was treated with scar ointment combined with scar The expression of COL-I in scar tissue was determined by enzyme-linked immunosorbent assay(ELISA).The expression of ki-67 nuclear protein was determined by immunohistochemical staining(sp).Results The efficacy of the study group was significantly better than the control group,the total efficiency of the study group was significantly higher than the control group after 6 months treatment(P<0.05);The average COL-I and Ki67 nuclear protein expression in the single slice of the study group was significantly lower than that of the control group at the 3th months,6th months after treatment(P<0.001).Conclusions The scarring device is more effective in the treatment of pathological scar,and its mechanism may be related to the better inhibition of COL-I and ki-67 nucleoprotein expression.
文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars.
基金the National Natural Science Foundation of China(No.81701907)the Pujiang Program of SSTC(No.18PJ1407100)。
文摘The morphological and functional barriers caused by pathological scars are extremely painful for patients.Up to now,pathological scar poses a big unmet medical challenge for plastic surgeons and dermatologists worldwide.Macrophage polarization has shown a non-negligible effect on wound healing and scar formation.However,the role of macrophages in wound healing and pathological scar formation is still controversial.To summarize the latest data on probing biological functions of macrophage polarization in wound healing and scar formation and target macrophages in wound healing,we particularly paid attention to studies on different groups of macrophages,the transition among those groups,and modulators regulating the transition process.A comprehensive understanding of macrophage polarization in wound healing is certain to facilitate the development of new and efficient therapeutic modalities for pathological scar.
